서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates Oxidative Stress

Kim, Hyun Young,Sin, Seung Mi,Lee, Sanghyun,Cho, Kye Man,Cho, Eun Ju The Korean Society of Food Science and Nutrition 2013 Preventive Nutrition and Food Science Vol.18 No.1

To investigate radical scavenging effects and protective activities of bitter melon (Momordica charantia) against oxidative stress, in vitro and a cellular system using LLC-$PK_1$ renal epithelial cells were used in this study. The butanol (BuOH) fraction of bitter melon scavenged 63.4% and 87.1% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals at concentrations of 250 and $500{\mu}g/mL$, respectively. In addition, the BuOH fraction of bitter melon effectively scavenged hydroxyl radicals (${\cdot}OH$). At all concentrations tested, the scavenging activity of the BuOH fraction was more potent than that of the positive control, ascorbic acid. Furthermore, under the LLC-$PK_1$ cellular model, the cells showed a decline in viability and an increase in lipid peroxidation through oxidative stress induced by pyrogallol, a generator of superoxide anion ($O_2{^-}$). However, the BuOH fraction of bitter melon significantly and dose-dependently inhibited cytotoxicity. In addition, 3-morpholinosydnonimine (SIN-1), a generator of peroxynitrite ($ONOO^-$) formed by simultaneous releases of nitric oxide and $O_2{^-}$, caused cytotoxicity in the LLC-$PK_1$ cells while the BuOH fraction of bitter melon ameliorated oxidative damage induced by $ONOO^-$. These results indicate that BuOH fraction of bitter melon has protective activities against oxidative damage induced by free radicals.

生長調節物質의 處理가 고추의 着果 및 果實特性에 미치는 影響

金永信,呂承淑,李禧珠,李政明 경희대학교 부설 식량자원개발연구소 1991 硏究論文集 Vol.12 No.-

A series of experiments were conducted to investigate the effect of some growth regulator treatment on the fruit set and fruit growth in a male sterile inbred line of hot pepper(Capsicum annuum ) which normally bears bean-sized tiny fruits only. Major results can be summarized as follows. 1. In the first experiment, which was consisted of Tomtlane treatments alone or in combination with gibberellic acid, fruit growth was not significantly influenced by any of the treatments. Only the hand-pollinated flowers with viable pollens from other fertile plants gave rise to significantly larger fruits suggesting that competition for nutrients within a plant may reduce the effectiveness of the chemicals treated. 2. 2, 4-D treatment, dipping the flowers in l00ppm solution, was found to be the most effective in inducing parthenocarpic fruit enlargement as compared to other chemicals in the second experiment. 3. In the 3rd experiment, which included all the treatments tested in the first and second experiments, 2,4-D treatment was found to be the most effective followed closely by Tomatotone (p-CPA) treatment. 4. Addition of gibberellic acid to Tomatotone appeared to increase the effectiviness of Tomatotone treatment. Addition of gibberellic acid to NAA or Tomatlane failed to show any significant additive effect. 5. Highly significant postitive correlation was found between the fruit fresh weight and the fresh weight of the placentae tissue thus suggesting the important role of placentae tissue in enlargement of fertilized fruits.

흙의 密度와 含水比가 剪斷强度에 미치는 影響

趙成燮,姜信業,姜乂默,金成完,金聲來 충남대학교 농업과학연구소 1978 農業技術硏究報告 Vol.5 No.1

It has been known that the shear strength of soil is an important design parameter for the foundation of structures, the retaining walls, the slope failures and so forth. In this study, the shear test was performed by using the direct shear apparatus under various degree of the moisture content and the density of the sample soils. The results of the study were summarized as follows; 1. The shear strength of soil increased with increase in the dry density of soil, and at the same level of density of the sample the shear strength of soil showed large values on a good grading of the sample. 2. The cohesion of the soil varied directly with the dry density of it, however the internal friction angle of soil was not affected by the dry density of the sample. 3. The shear strength of sample varied inversly with the moisture content of it, and this phenomenon was apparent on a good grading of sample. 4. The cohesion of soil showed maximum value when the moisture content of the soil reached optimum level and the internal friction angle decreased with increase in the moisture content of it. These phenomena were very obvious on a good grading sample, SDC-1. 5. The cohesion of the soil decreased with increase in void ratio of the sample, but the internal friction angle of the sample didn't show such tendency.

HPLC에 의한 복어 및 생체시료 중 Tetrodotoxin의 분리정량에 관한 연구

민승식,정진일,손행자,노미정,박유신,김춘삼 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

화농성 수막염에 대한 고찰

박승함,김신규 한양대학교 의과대학 1982 한양의대 학술지 Vol.2 No.1

The introduction of antimicrobial agents has converted bacterial meninitis from a disease that was almost always fatel to one in which the majority of patients survive without significant neurologic residua. However, since then, there have been no outstanding changes in the mortality rate of purulent meningitis. Based on the bacteriological and clinical data observed from May 1972 to July 1981 at the Hanyang University Hospital, the following findings were obtained. (The unusual organisms defined as those other than S. pneumoniae, H. influenzae and N. meningitidis.) (1) The average annual incidence per 1,000 admissions was approximately 0.5. (2) Of 1,342 cerebrospinal fluid specimens submitted, 83 cases were positive for cultures, and the positive rate was 6.2%. (3) About sixty four percent of isolated organisms were S. pneumoniae, H. influenzae, and N. meningitidis. Others were Gram negative bacilli in 21.7% and gram positive cocci in 9.6%. There were three cases of C.neoformans and one case of C. albicans was also isolated. (4) The positive rate of culture in unusual organisms was slightly increased since 1979. (5) Nearly one-fourth of the cases could be considered as hospital actuired infection and majority(78.9%) of them occurred in the adult and elderly age groups. Thirty percent of pneumococcal meningitis and 44.4% of meningitis due to Gram negative bacilli were hospital acquire infections. (6) Male to female ratio of menngitis was approximately 2:1 and the male preponderance was observed especially in H. influenzae and S. pneumoniae infections. (7) Approximately ten percent of the cases occurred under 1 month of age, 45% before 1 year of age, 60% before 5 years and 72% before 15 years of age. (8) H. influenzae was isolated only between 3 months and 15 months of age. (9) The incidence of purulent meningitis was highest in winter This was especially true for those due to S. pneumoniae and H. influenzae. (10) Most of the predisposing factors were respiratory infections, head trauma and recent neurosurgical procedures. (11) The protein content of CSF was highest in the meningitis due to S. pneumoniae. Leukocyte count was most increased in N. meningitidis. (12) Serum sodium cencentrations were below 130mEq/L at the time of admission in half of the patients. (13) Bacteremia was demonstrable in about half of patients with purulent meningitis. (14) Most of the strians of H. influenzae were resistant to ampicillin. (15) Mortality rate for purulent meningitis was approximatly 30% and the mortality from H. influenzare meningitis was highest, in which the rate was about 50%. There was no fatal case in meningococcal meningitis. Both extreme age groups revealed the highest mortality rate

하루 콩단백질 25g 섭취를 위한 메뉴작성 및 영양성분 분석

한재숙,김정애,서봉순,이연정,서향순,조연숙,한경필,이신정,오옥희,우경자,조은자,구성자,김수진,李承彦,南出隆久 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.2

The purpose of this study was to develop menus for daily intake of 25g soybean protein and to analyse nutrients of these foods. Analytical values were compared to the theoretical one using the food composition table and recommended dietary allowances for Koreans (7th revision). The results are as follows. 1. Soybean curd residue stew, Soybean curd, Kimchi saute, and hard boiled soybean and lotus root were selected for the menu for January, of which the content of soy bean protein(SBP) was 33.1g, soybean stew, soybean curd and soybean sprout saute, and Italian deep fried soybean curd were for February, of which the content of SBP was 35.0g. The content of SBP in soybean paste soup with soybean curd, fried soybean curd and fried soybean curd roll, the menu for March, was 24.9g. That of April were soybean curd gratin with soymilk, soybean curd and ham with garlic dressing and the content of SBP was 26.3g. That of May were soybean porridge, soybean flour cake with honey (Dasik), soybean sprout soup and the content of SBP was 26.7g. That of June were soymilk, pan-fried soybean curd, steamed soybean curd with chicken and the content of SBP was 28.4g. That of July were noodle with soymilk, mapatofu, soybean curd salad and the content of SBP was 24.7g. That of August were soybean sprout with mustard dressing, Tossed green pepper with raw soybean flour, Tofu and Kimchi stew, soybean curd steak and the content of SBP was 26.2g. That of September were Chinese cabbage soup with raw soybean flour, sweet and sour tofu and the content of SBP was 23.2g. That of Oct. were Fermented soybean stew, soybean pan cake and the content of SBP was 24.3g. That of November were not-pressed soybean curd casserole, pan-fried mashed soybean curd with egg, stir frying deep-fried soybean curd with vegetables and the content of SBP was 22.4g. That of December were soybean curd and mushroom casserole, fried soybean curd and vegetables, hard boiled soybean curd and the content of SBP was 28.9g. 2. The ratio of the analytical value over theoretical value (A/B%) of one serving in kcal, carbohydrate, protein, fat, ash and dietary fiber were 57.7~107.7%, 42.9~131.9%, 79.2~118.3%, 54.5~100%, 40.7~80.8% and 42.1~113.2%, respectively. 3. The ratio of A/B% of one serving in Ca, K, Na, P and Fe were 44.1~93.6%, 59.0~153.1%, 53.1~117.7% 64.6%~138.8 and 33.8~77.3%, respectively. That in Fe was the lowest among minerals. 4. The ratio of analytical value over Korean R.D.A(A/C%) in Ca was relatively higher (22.0~85.9%) than that in kcal(18~63%). 5. The ratio of A/C% in Fe was 25.1~64.3% and lower than that in Ca and protein in general.

참깨에서 추출한 Sesamin 섭취가 혈청 지질 농도에 미치는 영향

윤명호,신준한,김한수,탁승제,최병일 아주대학교 1997 아주의학 Vol.2 No.2

Objectives : High serum cholesterol is one of the major risk factors of coronary artery disease. We investigated the lipid-towering property and the side effects of sesamin, an unsaturated fatty add extracted from sesame oil, for the primary prevention of coronary artery disease. Methods : The 37 patients (20 mates and 17 females) with hyperlipidemia, ages ranging from 22 years to 70 years old (48±12), who did not have atherosderotic diseases except essential hypertension were given three capsules of sesamin once daily for 6 weeks. The lipid profile of the patients were examined before and after sesamin treatment, and the patients were grouped according to the presence or abscence of hypertension, smoking habit and obesity. Result : Compared with pretreatment, the total cholesterol level of sesamin treated group decreased significantly (254.2±29.6 versus 241.6 34.0 ㎎/dl, p< 0.05). The level of LDL-cholesterol (162.6±24.3 versus 156.6±32.8 ㎎/dl)HDL- cholesterol (47.5±10.0 versus 47.0±8.7 ㎎/dl) and triglyceride (196.5±95.4 versus 179.3±96.7 ㎎/dl) and the ratio of LDL/HDL- cholesterol (3.6±0.9 versus 3.4±0.9) were not significantly different. The effect of cholesterol lowering property of sesamin was predominant in hypertensive, non- smoking and obese group (P< 0.05 vs pretreatment). The laboratory tests including complete blood cell counts, serum transaminases, total protein, albumin, blood urea nitrogen, creatinine and blood glucose did not change significantly. Conclusion : The lipid lowering effect of sesamin was statistically significant on the total cholesterol particularly with obese, non-smoking and hypertensive patients. There was no significant side effect during sesamin administration. Therefore, three capsules of sesamin as a single daily dose were effective in lowering total cholesterol and safe to administer in patients with hyperlipidemia.

The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates Oxidative Stress

Hyun Young Kim,Seung Mi Sin,Sanghyun Lee,Kye Man Cho,Eun Ju Cho 한국식품영양과학회 2013 Preventive Nutrition and Food Science Vol.18 No.1

To investigate radical scavenging effects and protective activities of bitter melon (Momordica charantia) against oxidative stress, in vitro and a cellular system using LLC-PK₁ renal epithelial cells were used in this study. The butanol (BuOH) fraction of bitter melon scavenged 63.4% and 87.1% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals at concentrations of 250 and 500 ㎍/mL, respectively. In addition, the BuOH fraction of bitter melon effectively scavenged hydroxyl radicals (ㆍOH). At all concentrations tested, the scavenging activity of the BuOH fraction was more potent than that of the positive control, ascorbic acid. Furthermore, under the LLC-PK₁ cellular model, the cells showed a decline in viability and an increase in lipid peroxidation through oxidative stress induced by pyrogallol, a generator of superoxide anion (O₂^-). However, the BuOH fraction of bitter melon significantly and dose-dependently inhibited cytotoxicity. In addition, 3-morpholinosydnonimine (SIN-1), a generator of peroxynitrite (ONOO^-) formed by simultaneous releases of nitric oxide and O₂^-, caused cytotoxicity in the LLC-PK₁ cells while the BuOH fraction of bitter melon ameliorated oxidative damage induced by ONOO^-. These results indicate that BuOH fraction of bitter melon has protective activities against oxidative damage induced by free radicals.

光質이 채소作物의 種子發芽와 初期生育 및 除草劑의 活性에 미치는 效果

李政明,金侊來,權臣漢,曺哉銑,朴啓仁,全尙根,李承雨 경희대학교 부설 식량자원개발연구소 1987 硏究論文集 Vol.8 No.-

Studies were conducted to investigate the response of some horticultural plants to various light qualities provided by different kind of materials such as cellophane sheets, EVA, PVC(polyvinyl chloride,. and polyethylene (FE) films of different color. Major findings are summarized as follows. White fluorescence light and red light promoted seed germination of lettuce and inhibited that of radish seeds. Blue light inhibited the seed germination of both types of light-sensitive seeds. The light sensitivity varied considerably depending upon the kind of crops, cultivars, and the seed batches of the same cultivar. The blue light was equally or more strongly effective in inhibiting the seed germination as compared to the farred light. The growth of young seedlings developed from seeds was considerably promoted when grown under orange colored plastic film coverings The growth of larger seedlings was, however. not influenced by the color of plastic films Mulching pepper field with colored PVC film did not show further advantages over the commonly -used black PE film. Herbicidal activity of oxyfluorfen was very strong under natural light or red light conditions, and weak under blue or green light conditions The degree of oxyfluorfen-induced phytotoxicity varied considerably depending upon the light quality and the kind of vegetable crops.