http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shin, Na-Rae,Jung, Tae-Yang,Seo, Chang-Seob,Park, So-Won,Ko, Je-Won,Kim, Jong-Choon,Shin, In-Sik Korean Association for Laboratory Animal Science 2018 Laboratory Animal Research Vol.34 No.3
<P>Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to investigate the protective effects of GB on pulmonary inflammation induced by cigarette smoke (CS) and lipopolysaccharide (LPS). C57BL/6 mice were used to develop a pulmonary inflammation model by exposing them to CS for 1 h per day for 7 days. LPS was intranasally administered to mice under mild anesthesia on day 5. GB was administered 1 h before CS exposure at doses of 50 or 100 mg/kg for 7 days. Our results showed that GB suppressed the CS and LPS induced elevation in inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), with significant reductions in protein, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 levels. Histological studies revealed that GB decreased the inflammatory cell infiltration into lung tissue caused by CS- and LPS-exposure. GB also significantly decreased the CS and LPS-induced expression of inducible nitric oxide synthase (iNOS) in the lung tissue. Taken together, GB effectively attenuated airway inflammation caused by CS and LPS. These results indicate that GB is a potential therapeutic herbal formula for pulmonary inflammatory disease.</P>
Bio-based chiral dopants having an isohexide skeleton for cholesteric liquid crystal materials
Shin, Seunghan,Seo, Jae Won,Cho, Jin Ku,Kim, Sangyong,Cha, Jaeryung,Gong, Myoung Seon The Royal Society of Chemistry 2012 Green chemistry Vol.14 No.4
<P>Chiral dopants were synthesized from bio-based epimeric isohexides (glucose-derived isosorbide and mannose-derived isomannide) and their phase transition behaviors and abilities for developing cholesteric liquid crystal (CLC) films were examined with a consideration of the core structure. In spite of lower reactivity of the <I>endo</I> hydroxy group of isomannide caused by the steric hindrance and intermolecular hydrogen bonding, final synthetic yields of chiral dopants bearing an isomannide core (64.5% for IH-2 and 65.0% for IH-4) did not show conspicuous difference compared with chiral dopants bearing isosorbide (68.4% for IH-1 and 74.0% for IH-3). On the other hand, in phase transition behaviors, chiral dopants bearing an isomannide core showed lower crystalline and melting temperatures than IH-1, IH-3 despite of the same substituents. The helical twisting power (HTP) of chiral dopants bearing isosorbide (IH-1 and IH-3) was higher than that of chiral dopants bearing isomannide (IH-2 and IH-4). The calculated HTPs of IH-1 and IH-3 were 26.6 and 42.1 μm<SUP>−1</SUP>, respectively. In the case of IH-3, the helical pitch length of CLC could be adjusted to reflect visible light by controlling its amount and showed best performance in the range 5.0 to 7.0 mol%. In contrast to IH-1 and IH-3, it was found that IH-2 and IH-4 could not induce CLC films that reflect visible light.</P> <P>Graphic Abstract</P><P>Chiral dopants were synthesized from bio-based isohexides and applied to cholesteric liquid crystal materials. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2gc16261j'> </P>
Seo, Han Sol,Lee, Sunmin,Singh, Digar,Shin, Hye Won,Cho, Sun A,Lee, Choong Hwan Elsevier 2018 Food chemistry Vol.266 No.-
<P><B>Abstract</B></P> <P>Untargeted metabolomics unraveled the effects of varying substrates (soybean, wheat, and rice) and inocula (<I>Aspergillus oryzae</I> and <I>Bacillus amyloliquefaciens</I>) on metabolite compositions of <I>koji</I>, a starter ingredient in various Asian fermented foods. Multivariate analyses of the hyphenated mass spectrometry datasets for different <I>koji</I> extracts highlighted 61 significantly discriminant primary metabolites (sugars and sugar alcohols, organic acids, amino acids, fatty acids, nucleosides, phenolic acids, and vitamins) according to varying substrates and inocula combinations. However, 59 significantly discriminant secondary metabolites were evident for <I>koji</I>-types with varying substrates only, <I>viz.</I>, soybean (flavonoids, soyasaponins, and lysophospholipids), wheat (flavones and lysophospholipids), and rice (flavonoids, fatty acids derivatives, and lysophospholipids). Independently, the substrates influenced primary metabolite compositions in <I>koji</I> (soybean > wheat, rice). The inocula choice of <I>A. oryzae</I> engendered higher carbohydrates, organic acids, and lipid derivative levels commensurate with high <I>α</I>-amylase and <I>β</I>-glucosidase activities, while <I>B. amyloliquefaciens</I> affected higher amino acids levels, in respective <I>koji</I> types.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Metabolomics revealed optimal substrate and inocula combination for preparing <I>koji</I>. </LI> <LI> Primary metabolites in <I>koji</I> were affected by substrates and microbial inocula. </LI> <LI> Primary metabolites except amino acids were higher in soybean substrate. </LI> <LI> Secondary metabolites varied largely according to substrate types. </LI> <LI> Flavonoids and soyasaponins abundant in soybean were higher in soybean <I>koji</I>. </LI> </UL> </P>
Precise Expression Profiling by Stuffer-Free Multiplex Ligation-Dependent Probe Amplification
Shin, Gi Won,Na, Jeongkyeong,Seo, Mihwa,Chung, Boram,Nam, Hong Gil,Lee, Seung-Jae,Jung, Gyoo Yeol American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.19
<P>In systems biological studies, precise expression profiling of functionally important gene sets is crucial. Real-time polymerase chain reaction is generally used for this purpose. Despite its widespread acceptance, however, this method is not suitable for multiplex analysis, resulting in an inefficient assay process. One alternative technology in the spotlight is multiplex ligation-dependent probe amplification (MLPA). But MLPA depends on length-based discrimination of amplified products, which complicates probe design and compromises analysis results. Here, we devised a variation of MLPA that utilizes conformation-sensitive capillary electrophoresis, and demonstrated the simplicity of the probe-design process and improved precision of the assay in analyses of 33 <I>Escherichia coli</I> metabolic genes and 16 <I>Caenorhabditis elegans</I> longevity-related genes. The results showed that relative expression could be quantitatively measured over a relevant dynamic range by using similar-sized probes. Importantly, the improved precision compared to conventional MLPA promises a wider application of this method for various biological systems.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-19/ac402314h/production/images/medium/ac-2013-02314h_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac402314h'>ACS Electronic Supporting Info</A></P>
Effect of Solvent Annealing for Efficient Polymer Solar Cells
Seo, Min Ho,Kim, Kyu Jin,Han, Bao Yin,Anand, Gopalan Sai,Kim, Su Hwan,Lee, Sang Won,Kang, Shin Won Trans Tech Publications, Ltd. 2013 Advanced materials research Vol.724 No.-
<P>In this paper, we investigate an active layer treatment method that is referred to as solvent annealing. Organic solar cell was fabricated and an isopropanol (IPA) solvent annealing process was carried out. The experiment result should that the value of absorbance and the crystallinity is improved by isopropanol solvent annealing of active layer. Moreover, the current density, series resistance and the efficiency improved, leading to enhanced efficiency of 3.22%, whereas a pristine sample showed an efficiency of 3.04%</P>
Shin, Weon Ho,Ahn, Kyunghan,Jeong, Mahn,Yoon, Jeong Seop,Song, Jae Min,Lee, Soonil,Seo, Won Seon,Lim, Young Soo Elsevier 2017 Journal of alloys and compounds Vol.718 No.-
<P><B>Abstract</B></P> <P>We investigate the thermoelectric properties of reduced graphene oxide (RGO) incorporated Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB> composites. A melt spinning process enables RGO to be uniformly distributed with Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB> matrix and the incorporated RGO increases the carrier mobility of Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB> matrix with the enhancement of the power factor by 20%. The grain sizes of the Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB> materials decrease with the RGO amount, leading to the reduction in lattice thermal conductivity by enhancing grain boundary scattering. Owing to the above effects, the thermoelectric figure of merit (ZT) can be enhanced in the measured temperature range, where the optimum ZT value is reached to 1.16 at 393 K, ∼15% higher ZT value than pristine Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB>. Consequently, this RGO incorporation method could be widely used to improve thermoelectric performances in other conventional thermoelectric materials.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The single step synthesis of reduced graphene oxide/Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB> composites is proposed. </LI> <LI> The enhanced thermoelectric properties are obtained by incorporating reduced graphene oxide in Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB>. </LI> <LI> The reduced graphene oxide prevents the matrix diffusion during the sintering process in order to reduce BST grain size. </LI> <LI> The reduced graphene oxide in Bi<SUB>0.36</SUB>Sb<SUB>1.64</SUB>Te<SUB>3</SUB> provides an increment of charge carrier mobility. </LI> </UL> </P>