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KITSAT-3 Image Product Generation System
Shin, Dong Seok,Choi, Wook Hyun,Kwak, Sung Hee,Kim, Tag Gon 대한원격탐사학회 1999 International Symposium on Remote Sensing Vol.15 No.1
In this paper, we describe the configuration of the KTTSAT-3 image data receiving, archiving, processing and distribution system in operation. Following the low-cost and software-based design concept, the whole system is composed of three PCs : two for data receiving, archiving and processing which provide a full dual redundant configuration and one for image catalog browsing which can be accessed by public users. Except that receiving and archiving PCs have serial data ingest boards plugged in, they are configured by general peripherals. This basic and simple hardware configuration made it possible to show that a very low cost system can support a full ground operation for the utilization of high-resolution satellite image data.
Shin Ok Jeong,You Jung Han,Si Won Lee,Dong Wook Kwak,Jin Hoon Chung,Hyun Kyong Ahn,June Seek Choi,Jung Yeol Han,Moon Young Kim,So Yeon Park,Hyun Mee Ryu,Min Hyoung Kim 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.2
Purpose: Increased maternal age is a major risk factor for chromosomal abnormalities. The maternal age-specific risk of fetal trisomy was theoretically calculated. We investigated the actual frequency of fetal trisomy between 16 and 24 gestational weeks in pregnant women over the age of 34 at delivery. Materials and Methods: We retrospectively, over a four-year period, reviewed the medical records of women with singleton pregnancies that started their antenatal care before the 10th week of pregnancy. Pregnant women aged 34 to 45 years at the time of delivery were enrolled and divided into groups of one-year intervals. We investigated the frequency of Down syndrome and all trisomies as a function of the maternal age and compared with the theoretical maternal-age-specific risk. Results: Of the 5,858 pregnant women enrolled in the study, the rate of trisomy 21 was 0.29% (17 cases). The observed frequencies of trisomy 21 in women with maternal ages of 35 years and 40 years were 1:1,116 and 1:141, respectively. The rate of all trisomies was 0.39% (23 cases). The observed frequencies of all trisomies in women with maternal ages of 35 years and 40 years were 1:372 and 1:56, respectively. Conclusion: The frequencies of Down syndrome and all trisomies were proportional to the maternal age. However, the observed frequencies of Down syndrome and all trisomies between the 16 and 24 gestational weeks were lower than the theoretical rates.
Kwak, Hyeon Sook,Choi, Eun Hwa,Jang, Kuem Hee,Ryu, Shi Hyun,Kim, Young Shin,Hwang, Ui Wook Informa UK Ltd. 2015 Mitochondrial DNA Vol.26 No.4
<P>The mitochondrial genome of <I>Dendronephthya putteri</I> (Octocorallia, Alcyonacea) which is an endangered species was completely sequenced. It is 18,853 bp in length and identical to those of <I>Dendronephthya</I> species in its gene arrangement and genome organization. Nucleotide sequence comparison of the mitochondrial genomes of the two <I>D. putteri</I> individuals obtained from this study and the previously reported one (GenBank accession number JQ290079) showed that they are identical perfectly. We found useful candidate for DNA barcode markers for <I>D. putteri</I> species identification.</P>
숙성 중 체다치즈에서 분리한 Pseudomonas fluorescens SDR901 의 단백질분해 효소의 특성
곽해수,이경욱,신용국 한국낙농학회 1992 韓國酪農學會誌 Vol.14 No.2
체다치즈의 숙성촉진을 위한 우수한 형질의 단백질분해효소를 선발하기위하여 숙성 중 체다치즈에 존재하는 Pseudomonas fluorescens SDR901로 부터 분리한 단백질분해효소의 특성을 연구하였다. P. fluorescens SDR901이 생산하는 단백질분해효소는 Sephadex G-100 gel filtration으로 부분정제한 결과 220㎖∼270㎖ elution volume에서 용출되었으며, 분자량은 47,900이었다. 효소 분리시 최종 회수율은 17.924%이었으며, 단백질분해효소는 alkaline protease로서 반응최적조건이 pH 9.5, 40℃이었다. 효소의 활력은 Mn^(2+)에 의해 2배로 증가한 반면 Fe^(3+)에 의해서는 1/4로 감소되었다. 단백질 분해효소에 의한 casein의 분해시 초기에는 α_(s1)-casein과 β-casein이 분해되어 α_(s1)-I-peptide와 γ-casein이 증가한 반면 반응시간이 경과함에 따라 α_(s1)-casein, α_(s1)-I-peptide, α_(s2)-casein 및 β-casein은 감소하고 peptide fragment는 증가되었다. The characteristics of protease isolated from Pseudomonas fluorescens SDR901 being in Cheddar cheese during ripening was studied to select a superior protease for acceleration of ripening Cheddar cheese. This protease was eluted between 220㎖ and 270㎖ during purification by the Sephadex G-100 gel filtration, and the molecular weight was 46,900. The final yield of this protease was 17.924%. The optimum pH and temperature for the reaction of this protease were pH 9.0 and 40℃, so this protease was an alkaline protease. The protease activity increased doubly by Mn^(2+), but it decreased to one fourth by Fe^(3+). When casein was hydrolyzed by this protease, α_(s1)-I-peptide and α_(s1)-casein increased with the break up of α_(s1)-casein and β-casein at early stage of hydrolysis, but as reaction proceeded, α_(s1)-casein, α_(s1)-I-peptide, α_(s2)-casein and β-casein decreased with the increase of peptide fragments.
Shin, Dong Hee,Kwak, Gyea Young,Kim, Jong Min,Jang, Chan Wook,Choi, Suk-Ho,Kim, Kyung Joong Elsevier 2019 JOURNAL OF ALLOYS AND COMPOUNDS Vol.773 No.-
<P><B>Abstract</B></P> <P>The efficiency and long-term stability of graphene (GR)/Si quantum dots-embedded SiO<SUB>2</SUB> heterojunction solar cells are remarkably enhanced by employing bis(trifluoromethane sulfonyl)–amide (TFSA) as a dopant for GR. With increasing the doping concentration (n<SUB>D</SUB>) to 30 mM, the sheet resistance of the TFSA-doped GR transparent conductive electrode sharply decreases to ∼191 Ω/sq with only 1% reduction in its transmittance at 550 nm. The DC conductivity/optical conductivity ratio saturates to ∼62.5 at n<SUB>D</SUB> = 20 mM, resulting in maximum power conversion efficiency (PCE) of 16.61% and almost no loss of the PCE under 25 °C and 40% humidity atmosphere for 700 h. The solar cell also maintains ∼94% (absolutely from 16.61 to 15.57%) of its initial PCE even under continuous light soaking of 1 Sun at 60 °C and 30% humidity for 1000 h.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A dopant of TFA is first used in graphene/Si quantum dots solar cells. </LI> <LI> The power conversion efficiency (PCE) is 16.61%, larger than ever achieved. </LI> <LI> ∼94% of initial PCE is maintained even under light soaking at 60 °C for 1000 h. </LI> </UL> </P>
( Shin Ok Jeong ),( You Jung Shin ),( Sue Yeon Park ),( Dong Wook Kwak ),( You Jung Han ),( Si Won Lee ),( Min Hyoung Kim ),( Jin Hoon Chung ),( June Seek Choi ),( Hyun Kyeong Ahn ),( Hyun Mee Ryu ),( 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: Urinary concentrations of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) could be used as a reliable biomarker of exposure to tobacco smoke. We therefore developed a relatively simple high-throughput analytical method using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) to quantify total urinary NNAL concentrations in the general population. 방법: We developed and validated the UPLC-MS/MS method to quantify total NNAL concentrations in urine. And we studied quantified this biomarker of exposure in n=232 first-trimester pregnant women, of which n=17 were smokers, n=34 non-smokers, and n=181 with second-hand smoke exposure. 결과: Standard curves for total NNAL concentrations in urine were linear between 20-1500 pg/mL, with coefficients of determination >0.95, with precision ranging from 2.2 to 8.6% (CV), and accuracy from -5.6 to 10.9% (percent error). The lowest limit of quantitation was 6.7 pg/mL, and 2.0 pg/mL the lowest limit of detection (LLOD). Total urinary NNAL concentrations in non-smoker subjects (phase 1) non-smoker pregnant women (phase 2) were <LLOD, whereas in smokers total NNAL concentrations were between 0-35.2 pg/mL. Second-hand smoke exposure in pregnancy resulted in total urinary concentrations varying between 0-7.7 pg/mL. NNAL and cotinine in non-smoker samples were not detected. Measurement of urinary cotinine could be up to 14 days after last smoking. Measurement of urinary total NNAL could be up to 35 days after last smoking. 결론: We successfully developed an UPLC-MS/MS analytical method to quantify total urinary NNAL concentrations in the pregnant women. NNAL is better biomarker than cotinine to detect smoker in early pregnancy.
Systematic Review of Chuna Manipulative Treatment for Ankle Sprain
Kwak, Min Kyung,Kim, Min Wook,Jeong, Sang Jun,Kim, Shin Ae,Jeong, Mi Young,Kim, Jae Hong Korean AcupunctureMoxibustion Medicine Society 2018 대한침구의학회지 Vol.35 No.2
Background: This study was performed to review the efficacy of national and international randomized controlled trials (RCT) investigating Chuna manipulative treatment for ankle sprains. Methods: Online databases (PubMed, Cochrane, EMBASE, CNKI, NDSL, OASIS), were searched for studies where Chuna treatment was performed for ankle sprains up to October 12th, 2017. Only RCT were selected that fulfilled the inclusion/exclusion criteria. Data were analyzed using the Cochrane risk of bias tool. Results: There were 676 studies retrieved from the databases, resulting in analysis of 24 RCT. There was an average of 7 treatment visits over a 7 day period and the most frequent evaluation tool used was efficacy rate, with drug therapy being the most common control used in the trials. In 15 RCT, several Chuna methods were used in combination, amongst which, the osteopathic technique was most common. Statistically significant improvement in evaluation indices was reported in 19 RCT, and in 3 RCT, statistically significant improvement was reported, but not for all indices. In the remaining 2 RCT, there were no significant differences in any of the evaluation indices. No adverse reactions were reported in any of the RCT, although it was unknown whether all the trial protocols indicated that adverse reactions should be monitored, and for this reason, the risk of bias was unclear. Conclusion: The review of 24 studies suggest that Chuna manipulative treatment for ankle sprains was effective in most cases, although, potential bias in these studies was difficult to evaluate.
Kwak, Seong Shin,Lee, Eun Seok,Yoon, Ho Yub,Kim, Chang Hyun,Goo, Yoon Tae,Kang, Myung Joo,Lee, Sangkil,Lee, Bong Sang,Jeon, Hong Ryeol,Oh, Chang Hyun,Choi, Young Wook Dove Medical Press 2018 Drug design, development and therapy Vol.12 No.-
<P><B>Purpose</B></P><P>To develop an immediate release-type tablet containing varenicline salicylate (VRC-S), a smoking cessation agent, formulation and stability studies were performed. The in vitro dissolution and in vivo pharmacokinetic (PK) behavior of the tablets were compared with those of the commercial product (Champix) as a reference.</P><P><B>Materials and methods</B></P><P>The characteristics of the powder were investigated by particle morphology, size distribution, solubility, hygroscopicity, differential scanning calorimetry, and powder X-ray diffraction. Based on the drug–excipient compatibility test, different VRC-S tablets were prepared with the selected excipients through direct compression or wet granulation method and subjected to a dissolution test. The stability of the most promising VRC-S tablet (F4) was evaluated under accelerated conditions (40°C and 75% relative humidity). Further, the dissolution and human pharmacokinetic profiles of the F4 tablet and Champix were compared.</P><P><B>Results</B></P><P>VRC-S showed a positively skewed unimodal size distribution with a specific surface area of 2.02 m<SUP>2</SUP>/g, single endothermic peak of 225.2°C in differential scanning calorimetry, crystalline internal structure in powder X-ray diffraction, aqueous solubility of 244.7 mg/mL, and hygroscopicity of 0.256 mg/g. The wet granulation method was preferred for tablet preparation and employed the following excipients: microcrystalline cellulose and anhydrous dibasic calcium phosphate as diluents, croscarmellose sodium as a disintegrant, and colloidal silicon dioxide and magnesium stearate as lubricants. The F4 tablet was stable for 6 months under accelerated conditions. The dissolution of VRC was pH independent, revealing <I>f</I><SUB>2</SUB> values of 76.49 and 68.38 at pH 1.2 and pH 6.8, respectively. After the oral administration of F4 tablet and Champix to healthy human volunteers, pharmacokinetic parameters, including time to reach the maximum plasma concentration (T<SUB>max</SUB>), maximum plasma concentration (C<SUB>max</SUB>), and area under the curve from 0 to infinity (AUC<SUB>inf</SUB>), were compared. The values of 90% CI were 0.972–1.035 for C<SUB>max</SUB> and 0.982–1.075 for AUC<SUB>inf</SUB>, which was indicative of the bioequivalence of both products.</P><P><B>Conclusion</B></P><P>VRC-S–containing F4 tablet might be a good candidate for smoking cessation treatment.</P>