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      • SCIESCOPUSKCI등재

        A Case of Hobnail Hemangioma

        (Shin Taek Oh),(In Gang Jang),(Sung Wook Kim),(Baik Kee Cho),(Seung Dong Lee) 대한피부과학회 2002 Annals of Dermatology Vol.14 No.1

        N/A Hobnail hemangioma(HH)is a benign acquired vascular tumor of endothelial origin which should be differentiated from other malignant vascular neoplasm such as Kaposi`s sarcoma or angiosarcoma.We report a case of hobnail hemangioma in a 21-year-old woman who had a dusky-red patch on her left shin.Histologically,ectatic vascular channels with a single layer of plumped endothelial cells were seen and the vascular channels seemed to dissect the collagen bundles.She underwent treatment with surgical excision with primary closure. (Ann Dermatol 14(1)45-47, 2002).

      • SCIESCOPUSKCI등재
      • 8-Azaxanthine과 그 유도체의 합성 및 시험관내 항암 활성

        李奉憲,辛貞姬,張太植,朴章洙,姜信源 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

        8-Azaxanthine(1), 3-β-D-ribofuranosyl-8-azaxanthine(2),3-β-D-ribofuranosyl-8-azaxanthine-5'-monophosphate(3), 그리고 3-β-D-ribofuranosyl-8-azaxanthine-5'-(3-pyridinylcarbonyl)monophosphate(4)를 합성한 후 Mouse leukemia P388,Murine mammary carcinoma FM3A, Human histiocytic lymphoma U937암세포들에 대해 시험관내 항암활성을 MTT를 이용한 방법으로 예측하고 IC_50(μmol/mL)으로 나타내었다. 그 결과, 비정상적인 염기의 N-3와 당의 C-1'glycoside결합을 가진 2는 세가지의 암세포에 대해 감수성이 좋아 IC_50이 각각 0.05, 0.06,0.06μmol/mL이었으나 항세균 활성 예측에서는 감수성을 보이지 않았다. Human histiocytic lymphoma U937세포에 대한 IC_50은 1이 0.33,2는 0.06,3은0.25그리고 4는 0.33μmol/mL로 구조 변화에 따라 서로 다른 값을 보였다. 8-Azaxanthine(1), 3-β-D-ribofuranosyl-8-azaxanthine(2),3-β-D-ribofuranosyl-8-azaxanthine-5'-monophosphate(3), 3-β-D-ribofuranosyl-8-azaxanthine-5'-(3-pyridinylcarbonyl)monophosphate(4) were synthesized. The in vitro antitumor activities of the synthesized compounds against P388 mouse leukemia,FM3A mammary carcinoma, and U937 human histiocytic lymphoma cells were determined by MTT assay. 2 with unnatural N-3 and C-1'glycoside bond had activityagnist three tumor cell lines and IC_50s of these compounds were 0.05,0.06μmol/mL against three tumor cell lines, repectively. But these compounds had no antibacterial activity. IC_50s aganist U937 human histiocytic lymphoma cells were verfied with the structural modification:IC_50s of 1,2,3, and 4 were 0.33,0.06,0.25, and 0.33μmol/mL, respectively.

      • KCI등재

        지하역사 승강장 및 대합실 평상시/비상시 급ㆍ배기 환기 Large Eddy Simulation

        장용준(Yong-Jun Jang),류지민(Ji-Min Ryu),박덕신(Duck-Shin Park) 한국전산유체공학회 2013 한국전산유체공학회지 Vol.18 No.3

        The turbulent flow behavior of air supply and exhaustion in the Shin-gum-ho subway station is analyzed for ordinary and emergency state. The depth of Shin-gum-ho station is 43.6m which consists of the island-type platform(8th floor in underground) and a two-story lobby (first & second floor in underground). An emergency stairway connects between the platform and the lobby. Ventilation operation mode for ordinary state is set up as a combination of air supply and exhaustion in the lobby and platform, while for emergency state it is set up as a full air supply in the lobby and a full exhaustion in the platform. The entire station is covered for simulation. The ventilation diffusers are modeled as 95 square shapes of 0.6m?0.6m in the lobby and as 222 square shapes of 0.6m×0.6m and 4 rectangular shapes of 1.2m×0.8m in the platform. The total of 7.5million grids are generated and whole domain is divided to 22 blocks for MPI efficiency of calculation. Large eddy simulation(LES) is applied to solve the momentum equation and Smagorinsky model(C<SUB>s</SUB>=0.2) is used as SGS subgrid scale) model. The time-averaged velocity fields are compared to experimental data and show a good agreement with it.

      • KCI등재

        재벌의 기업집단화에 관한 연구 : 日本の事例を中心に 일본의 사례를 중심으로

        申章澈 韓日經商學會 1999 韓日經商論集 Vol.18 No.-

        本硏究は,近代化以降の急激な政治および經濟的變化の過程なかで日本の大企業が果たした役割,なかでも戰前の'財閥'と戰後の'企業集團'の成長と變遷の過程に焦点を合わせたものである. すなわち,日本における戰前の財閥の企業集團化過程を時系列的にアブロ-チすることによつて,現在韓國で無分別に使われている財閥と企業集團との槪念を明確にし,その基本的な性格を明らかにすることに硏究の目的をおく. 本硏究をつうじて,日本の場合,少なくとも財閥と企業集團とは國民經濟に える影響やその位置において相當異なる側面が多いとんう認識が一般的であるごとが明らかになつた.さらに財閥と企業集團とは,その生成と歷史的な發展過程,企業形態および構造,そしてその性格と特徵が互いに偉う特質をもつ企業體として區別され通用されている. 一方,韓國では,近年において政府當局によつて進められている一連の'財閥改革'から見られるように,大企業,財閥,企業集團,企業グル-プなど,個別企業體の樣 な形態にたいする明確ながイドラインがいまだ示されていない狀況にある. 韓國經濟がごの頃の'IMF 制'から早期に脫出し,成長基調のもとの力を回復するためには,'大企業(30大)=財閥'だという一般國民が持つている歪んだ企業關と,韓國企業に對する外國からの否定的な認識を改めなければならない.ごのためには,學術的に財閥の觀念を明確にし,その本質的な側面を的確に把握するごとによつて,'大企業政策'または'財閥改革'の正當性と實效性を確保するごとが하よりも肝心であろう.

      • 비타민 복합섭취가 고강도 운동 후 면역세포에 미치는 영향

        신장호,위승두 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

        The purpose of this study is to investigate the effect of antioxidant-vitamins supplementation on exercise-induced acute phase response of T lymphocyte and natural killer cell(NK cell). B healthy college students(M, 27.9±2.2 yr) were participated in exercise sessions before and after 5 weeks antioxidant-vitamins supplementation. The exercise sessions included treadmill running at 110% AT level(high-intensity) until each subject reached to target exercise volume(301.3± 20.5 ㎉). Venous blood samples were drown at the forearm antecubital vein at rest, immediately after exercise, and 30min/90min recovery(15㎖ each). The results of this study can be summarized as follows: 1) There were significant changes in T lymphocyte proliferation responses after high-intensity exercise, and antioxidant-vitamins supplementation affected on the acute phase response(P<.05). 2) There were no significant changes in per-cell T lymphocyte proliferation responses after high-intensity exercise, but antioxidant-vitamins supplementation made it significantly higher(P=.05). 3) There were significant changes in NKCA after high-intensity exercise(P<.01), and antioxidant-vitamins supplementation affected on the acute phase response(P<.05). 4) There were significant changes in per-cell NK cell lytic unit after high-intensity exercise(P<.01), and antioxidant-vitamins supplementation made it significantly higher(P=.05).

      • 다공질 실리콘 광검출 소자의 개발(Ⅱ)

        신장규 경북대학교 센서기술연구소 1994 연차보고서 Vol.1994 No.-

        본 연구에서는 먼저 SOS 구조의 다공질 실리콘 광검출 소자를 제조하였다. 측정결과 소자의 I-V 특성은 높은 직렬 저항과 측면방향의 양극반응으로 인한 다공질 층의 불균일성 등의 문제점이 나타났다. 이러한 문제점을 해결하기 위해 본 연구에서는 양극 반응에 의해 생성되는 다공질 실리콘을 이용한 수직구조의 n-ITO/p-PSL 이종접합형 광검출 소자를 제조하였다. 제조된 소자에 0∼300Lux의 백색광을 조사하여 I-V 특성을 구하였으며 광의 세기에 따라 선형적인 광전류의 변화를 관찰하였다. 소자들은 매우 낮은 온도에서도 상당히 큰 광응답도를 나타냈다. 또한 -4OV의 역방향 바이어스를 인가했을때도 매우 안정된 특성을 보였으며 매우 낮은 암전류를 보였다. 약 0.5V 이상의 순방향에서의 반대수 I-V 데이타로 부터 구한 이상계수는 2.7∼3 사이의 값이었다. 소자에 제논램프를 사용하여 400∼1100㎚ 파장의 광을 조사하여 600∼700㎚ 파장에서 약 0.6A/m의 최대광응답도를 나타내었다. 또한 약 5V의 순방향 바이어스에서 가시광방출이 일어남을 보았다. ITO층은 PSL층을 보호 하므로써 표면을 안정시킬 뿐 아니라 가시광 영역에서 90% 정도의 광 투과성을 가지므로 높은 효율의 광검출 소자를 제조할 수 있었다. SOS porous silicon photodetectors have been designed and fabricated. Ⅰ-Ⅴ characteristics of the device has also been measured. The characteristics was not as good as expected due to high series resistance and nonuniformity of lateral anodization. n-ITO/p-PSL heterojunction photodetectors with a vertical structure have been fabricated by using PSL(porous silicon layer) formation method. From Ⅰ-Ⅴ characteristics of fabricated devices with white light from 0 to 3000 Lux, it is found that the photocurrent vary linearly with incident light intensity. The devices show considerable photo responsivity even though the temperature is very low. The reverse characteristics of fabricated devices are very stable at a bias of -40V and show very small dark current. At biases greater than about 0.5V, the semilog Ⅰ-Ⅴ data indicates an ideality factor of 2.7∼38. When

      • 아라키돈산 및 아이코사펜타엔산 생성 곰팡이의 분리 및 생산

        신효선,오인호,이장한 동국대학교 산업기술환경대학원 1994 산업기술논총 Vol.2 No.-

        Fungal strains producing extraordinary high amounts of arachidonic acid(ARA) and eicosapentaenoic acid(EPA) were isolated from soil samples and the effects of various culture condition on the production of ARA and EPA were investigated. Three strains of fungi with the high acids yields were identified as Mortierella alpina 49, M. parvispora 58 and M. horticola 73. Highest amounts of EPA and ARA were produced when three strains were cultivated at 18℃ for 4 and 6 days, respectively. When the three strains of fungi were grown in a medium with increase of 5% glucose, EPA production was decreased in every case, whereas ARA production not decreased in every case. There was no significant effect of oxygen on the fungi growth. But the production of EPA and ARA as well as the total fatty acids decreased when cultivated in 200 ml of culture volume in 500 ml flask. When the fungi cultivated for 6 days at 18℃ and stand for 6 days at room temperature, there was no difference in growth amount, while there was increase in the total fatty acid production, i.e., 36% increase as for M. parvispora 58 and 10∼20% as for the other two fungi. Aging didn't influence the EPA production much. the amount of the fungi growth and the total fatty acid production increased with more soybean oil addition as a nutrient of culture medium.

      • KCI등재후보

        국내 디자이너브랜드 업체의 패턴업무 실태 분석 : 입체재단을 중심으로 for Draping

        신장희,나수임 服飾文化學會 2003 服飾文化硏究 Vol.11 No.2

        The purpose of the study is to indentify the designers' and the patterner's pattern making, draping and the use of dress form in domestic companies of designer's brand to present basic information for effective pattern works. It turned out that the designer brand companies at home use flat pattern and draping at the same time rather than draping only. The effects of the use of draping lies in unique designs and elastic materials, which seems proper phenomena for the current design trend such as high quality and diversification. But, draping has such problems that the pattern takes long time to be finished and that the staffs don't acquire well the needed skills due to the lack of draping education. To secure the high added value of fashion, it is required to develop education programs for new skills and to apply draping actively. Also, it requires an educational system in which practice oriented skills are cultivated, and efficient investment into apparel business.

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