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Lee, Dongyeop,Jeong, Dae-Eun,Son, Heehwa G.,Yamaoka, Yasuyo,Kim, Hyunmin,Seo, Keunhee,Khan, Abdul Aziz,Roh, Tae-Young,Moon, Dae Won,Lee, Youngsook,Lee, Seung-Jae V. Cold Spring Harbor Laboratory Press 2015 Genes & development Vol.29 No.23
<P>In this study, Lee et al. show that SREBP and MDT-15 prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in <I>C. elegans</I>. By using a genome-wide screen, they found that inhibition of SREBP or MDT-15 further accelerated aging in glucose-rich conditions, and up-regulation of SREBP or MDT-15 reversed accelerated aging.</P><P>Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in <I>Caenorhabditis elegans</I>. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients.</P>
Frontiers of biophysical techniques: unraveling molecular and cellular complexities
Seung-Chul J. Lee,Nam-Chul Ha,Seung-Jae V. Lee 한국구조생물학회 2024 Biodesign Vol.12 No.1
Recent biophysics research employs cutting-edge methods to decode complex biological phenomena, encompassing the analysis of biomolecular phase behaviors, the study of mechanobiology using single-molecule tweezers, and structural investigations of proteins. These approaches offer deep insights into cellular functionality, protein dynamics, and gene expression, substantially enhancing our comprehension of molecular and cellular processes. This editorial highlights these advancements in biophysical techniques, with a focus on recent publications in the journal ‘Molecules and Cells’.
Lee, Suk-Ha,Agashe, Mandar V.,Suh, Seung-Woo,Yoon, Yong-Cheol,Song, Sang-Heon,Yang, Jae-Hyuk,Lee, Hanna,Song, Hae-Ryong Lippincott Williams & Wilkins 2012 Spine Vol.37 No.13
STUDY DESIGN.: A retrospective observational study. OBJECTIVE.: The objective of this study was to analyze the cases of paravertebral ossification in vitamin D–resistant rickets (VDRR) and elucidate its incidence and clinical significance, and report specific genetic mutations uniquely associated with this phenomenon. SUMMARY OF BACKGROUND DATA.: Paravertebral ligament ossification has been described in VDRR in a few cases previously. However, supraspinous and interspinous ligament ossification has so far not been described to occur in association with VDRR. We reviewed 6 cases of paravertebral ligament ossification with the added feature of supraspinous and interspinous ligament calcification. METHODS.: Forty-four patients with clinical, radiological, and biochemical diagnoses of VDRR, who were positive for mutations in the PHEX gene, were screened for the presence of paravertebral ossification with plain radiographs and computed tomography/magnetic resonance imaging if necessary. This was correlated with the severity of disease, and we looked for specific genetic mutations. RESULTS.: Six patients had paravertebral ligament ossification, which included supraspinous and interspinous ligament ossification. These patients had a more severe systemic disease, with all patients requiring at least 1 surgery for deformity correction of the limbs, with a total of 10 surgical procedures performed in these 6 patients. c.1601C>T, c.1699C>T, c.1363G>T, and c.466_467insAC were the genetic mutations associated with these cases. CONCLUSION.: The spinal changes with paravertebral ligament ossification in VDRR were described in this study. Four different gene mutations related to the PHEX gene were detected in them. The presence of these changes was suggestive of a more severe systemic disease.
Combinatorial Approach Using Caenorhabditis elegans and Mammalian Systems for Aging Research
Lee, Gee-Yoon,Sohn, Jooyeon,Lee, Seung-Jae V. Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.7
Aging is associated with functional and structural declines in organisms over time. Organisms as diverse as the nematode Caenorhabditis elegans and mammals share signaling pathways that regulate aging and lifespan. In this review, we discuss recent combinatorial approach to aging research employing C. elegans and mammalian systems that have contributed to our understanding of evolutionarily conserved aging-regulating pathways. The topics covered here include insulin/IGF-1, mechanistic target of rapamycin (mTOR), and sirtuin signaling pathways; dietary restriction; autophagy; mitochondria; and the nervous system. A combinatorial approach employing high-throughput, rapid C. elegans systems, and human model mammalian systems is likely to continue providing mechanistic insights into aging biology and will help develop therapeutics against age-associated disorders.
Shin, Seung Wook,Han, Jun Hee,Park, Yeon Chan,Agawane, G. L.,Jeong, Chae Hwan,Yun, Jae Ho,Moholkar, A. V.,Lee, Jeong Yong,Kim, Jin Hyeok The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.40
<P>In this paper, we report a facile, low cost synthesis and characterization of kesterite Cu<SUB>2</SUB>ZnSn(S<SUB><I>x</I></SUB>,Se<SUB>1−<I>x</I></SUB>)<SUB>4</SUB> (CZTSSe) nanocrystals (NCs) by a two-step process involving a solution-based precursor and a post-annealing route. The effects of different Se vaporization temperatures, ranging from 350 °C to 550 °C, on the structural, chemical, compositional, and optical properties of CZTSSe NCs were investigated. X-ray diffraction patterns, Raman spectroscopy, and transmission electron microscopy results indicated that the precursor powder showed several broad peaks that could not be assigned to Cu<SUB>2</SUB>ZnSnS<SUB>4</SUB> (CZTS), ZnS, Cu<SUB>2−<I>x</I></SUB>S, Sn<SUB>2</SUB>S<SUB>3</SUB> and Cu<SUB>2</SUB>SnS<SUB>3</SUB>. However, the post-annealed NCs with and without Se vaporization were a single kesterite CZTS phase without a secondary phase. UV-vis spectroscopy results showed that the absorption coefficients of all the post-annealed NCs were over 10<SUP>4</SUP> cm<SUP>−1</SUP> in the visible region, and the optical band gap energy decreased systematically from 1.46 eV to 1.14 eV with increasing Se vaporization temperatures.</P> <P>Graphic Abstract</P><P>In this paper, we report a facile, low cost synthesis and characterization of kesterite Cu<SUB>2</SUB>ZnSn(S<SUB><I>x</I></SUB>,Se<SUB>1−<I>x</I></SUB>)<SUB>4</SUB> (CZTSSe) nanocrystals (NCs) by a two-step process. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm33802e'> </P>
Choi, Seung-Kyu,Kang, Sung-Man,Lee, Jae-Bok,Shenderey, S. V.,Jung, Hyun-Hak,Jung, Jun-Young,Kim, Ho-Dong American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.12
<P>This paper deal with the surge energy capability of ZnO-based varistors according to the Sb2O3 and Bi2O3. For the purpose of surge test for the class 1 grade. The direct lightning current (10/350 mu S) with high energy injected to the sample varistor. The thermal conductivity and the electrical properties, such as the nonlinear coefficient, leakage current, varistor voltage and dielectric constant were investigated. Among these, the thermal conductivity had a proportional correlation with the energy surge withstanding capability. Five ZnO varistors were prepared with varied compositions (the Bi/Sb ratio was set at 1/2), but the other processes that were conducted were the same, such as sintering, milling, and pressing. As a result, the energy capacity of the ZnO varistor was found to have a strong correlation with the microstructure. FESEM was used to observe the microstructure of the ZnO varistor.</P>
Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegans
Hanseul Lee,Seung-Jae V. Lee 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.11
Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF- 1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.