In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

점증적 요통 체조와 교육이 만성 요통환자의 근지구력, 유연성 및 통증에 미치는 영향

유승희,공성아,이만균 경희대학교 체육대학 한국체육과학연구소 2004 體育學論文集 Vol.32 No.-

This study was designed to investigate the effects of a 6-week progressive exercise, mainly calisthenics, and education for low back pain on muscular endurance, flexibility, and self-perceived pain in low back patients. Eighteen female patients, aged 48±6.84 years, were volunteered to participate in the study as subjects. Standing height, body weight, percent body fat, waist-hip ratio(WHR), sit-and-reach trunk extension, sit-up, back sit-up, and pain ratings were measured in pre test. Upon the completion of the pre test, they went through the six weeks of interventions composed of progressive exercise and education for the first four weeks and the exercise only for the last two weeks. Then, they were tested in the post test by the same manner as the pre test. The results of pre and post test were compared by the paired t-test. The main results of the present study were as fellows: First, there were no significant changes by the interventions in body weight and WHR, whereas percent body fat were reduced significantly by the interventions. Second, flexibility and muscular endurance were enhanced significantly by the interventions. Third, self-perceived low back pain ratings and perceive ratings of pain in the daily activities were reduced significantly by the six weeks of interventions. It was concluded that low back pain would be relieved by the progressive exercise and education for low back pain, and that the interventions would be helpful to prevent additional injuries by increasing the flexibility and muscular endurance.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

유기용제에 장기간 폭로된 근로자의 정신의학적 기능과 삶의 질

김석재,강순아,유지숙,국승희,윤진상,문재동,이형영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 본 연구는 Y공단의 제조공정에서 저농도의 유기용제(solvent)에 장기간 노출된 근로자의 정신의학적 기능과 삶의 질을 평가하고자 하였다. 방법: 총 142명의 남성근로자 중 유기용제에 폭로된 군(이하 폭로군) 82명과 폭로되지 않는 군(이하 비폭로군) 60명에게 간이정신진단검사(Symptom Checklist-90-R, SCL-90-R), 인지 및 정신운동성검사 (Critical Flicker Fusion Threshold. CFFT; Choice Reaction Time, CRT;Compensatory Tracking Task, CTT;Digit-Symbol Substitution, DDS) 및 한국판 스미스클라인 비챰 삶의 질 척도(Korean version of the SmithKline Beecham 'Quality of Life' Scale, KvSBQOL) 등을 적용하였다. 두 군간의 비교는 평가치의 평균에 대해 t-검증을 하였고 또한 연령과 학력을 공변인으로한 공변량분석(ANCOVA)을 하였다. 결과: SCL-90-R의 9개 증상 차원과 3개 전체 지표 점수는 두 군이 각각 정상범위였다. 그러나 신체화 (Somatization, SOM), 우울(Depression, DEP), 적대감(Hostility, HOS), 공포불안(Phobic anx-iety, PHOB)의 증상차원과 전체심도지수(Global Severity Index, GSI), 표출증상합계(Positive Symptom Total, PST)의 전체 지표는 폭로군이 비폭로군보다 유의하게 높았다. 인지 및 정신운동성 검사와 삶의 질은 두 군간에 유의한 차이는 없었다. 결론: 이상의 결과는 유기용제가 허용치 이하일지라도 장기간 폭로되는 경우에는 정신의학적 문제를 다소 일으킬 수 있음을 시사하였다. 중심단어:유기용제·근로자·정신건강·정신운동성 기능·삶의 질. Objectives: The aim of this study was to evaluate the psychiatric function and quality of life of the chemical workers who had been exposed to long-term, low-level organic solvents in the Y industrial complex. Method: A total of 144 male workers, of whom 82 were in the exposed group and 60 in the unexposed-control group, were evaluated by using Symptom Checklist-90-R(SCL-90-R), series of neuropsychological tests(critical flicker fusion threshold, CFFT) ; choice reaction time, CRT ; compensatory tracking task, CTT) ; digit symbol substitution test, DSS), and the Korean version of the SmithKline Beecham Quality Of Life scale(KvSBQOL). For the statistical analyses, comparisons of the means of the two groups were performed for each variable with two-tailed t-test as well as ANCOVA including age and education as covariates. Results: For the SCL-90-R, the nine symptom scales and the three global indices were clinically within normal range in both groups. However, the scores on the symptom scales of 'somatization','depression','hostility' and 'phobic anxiety', and those on the global indices of 'global severity index' and 'positive symptom total', were significantly higher in the exposed group than in the unexposed group. In terms of the neuropsychological function and the quality of life, there wes no significant difference between the two groups. Conclusion: These findings suggested that the long-term eposure to mixed organic solvents, even at the low level below the permissible exposure limit, might induce some psychiatric problems. KEY WORDS: Organic solvent·Worker·Mental health·Psychomotor function·Quality of life.

A case of tatto-acquired verruca plana

( Seung Ah Yoo ),( Joon Ho Son ),( Hwa Jung Yook ),( Ju Hee Han ),( Chul Hwan Bang ),( Ji Hyun Lee ),( Jun Young Lee ),( Young Min Park ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

Angioimmunoblastic T cell lymphoma associated with adult Henoch-Schonlein purpura

( Seung Ah Yoo ),( Hyo Jung Kim ),( Hyun Ji Lee ),( Yu Mee Song ),( Ju Hee Han ),( Chul Hwan Bang ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

A 78-year-old man presented with tender, multiple erythematous purpura on the trunk and extremities. He had abdominal pain, diarrhea, arthralgia and edema of both lower legs for 2 months. The patient had a history of chronic obstructive pulmonary disease, hypertension and prostate cancer operation. Laboratory findings showed pancytopenia, elevated blood urea nitrogen and creatinine. Urinalysis showed hematuria and proteinuria. A punch biopsy specimen of left arm revealed leukocytoclastic vasculitis without immunoglobulin and complement deposits. Lymph node biopsy showed small clusters of neoplastic cells around follicles with CD 3, CD 4, CD 10 positivity. Bone marrow aspiration showed increased plasma cells with infiltration of CD 3, CD 5, CD 10-positive atypical lymphocytes. After 1 cycle of cyclophosphamide-hydroxydaunorubicin-oncovin-prednison e (CHOP) chemotherapy, patient died due to acute respiratory distress syndrome. Angioimmunoblastic T cell lymphoma (AITL) accounts for approximately 15-20% of peripheral T-cell lymphomas. The most common cutaneous presentation of AITL consists of macules and papules, while Henoch-Schonlein purpura (HSP) is a rare clinical manifestation. HSP can behave like a paraneoplastic syndrome in malignancy including lymphoma through several mechanisms. Herein, we report a first case of AITL associated with HSP in Korea.

A case of scabies resembling Darier’s disease

( Seung Ah Yoo ),( Eun Hee Yoo ),( So Yeon Yun ),( Ju Hee Han ),( Chul Hwan Bang ),( Young Min Park ),( Ji Hyun Lee ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population

Yoo, Seung Soo,Hong, Mi Jeong,Choi, Jin Eun,Lee, Jang Hyuck,Baek, Sun Ah,Lee, Won Kee,Lee, So Yeon,Lee, Shin Yup,Lee, Jaehee,Cha, Seung Ick,Kim, Chang Ho,Cho, Sukki,Park, Jae Yong The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.3

<P>Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I–IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.</P>

A case of kerion celsi caused by Microsporum gypseum in an elderly patient

( Seung Ah Yoo ),( Eun Jung Byun ),( Jae Yeon Ryu ),( Hyun Ji Lee ),( Yeong Ho Kim ),( Ju Hee Han ),( Chul Hwan Bang ),( Young Min Park ),( Jun Young Lee ),( Ji Hyun Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

A 66-year-old woman presented with tender and pruritic, diffuse, erythematous nodules and pustules with crusts on vertex of the scalp 2 months. The patient had been treated with steroid lotions and antibiotic ointment for 1 month previously, but the lesion was worse. Tinea capitis was diagnosed by Wood’s lamp examination and KOH examination on the lesion. Species identification was performed by observation of morphologic and biochemical characteristics and sequencing of the internal transcribed spacers (ITS), and Microsporum gypseum was confirmed. Treatment with oral itraconazole and topical flutrimazol cream after washing the hair with sertaconazole shampoo for 2 months was effective. Kerion celsi is a type of tinea capitis often caused by the zoophilic dermatophyte species of the genus Microsporum, and almost always seen in children. Kerion celsi is a severe inflammatory or suppurative type of tinea capitis, characterized by a painful, inflamed, crusty mass and often associated with purulent drainage and regional lymphadenopathy. Microsporum gypseum complex is a group of dermatophytes with a worldwide distribution and is a rare cause of dermatomycoses in humans and also rarely infects the scalp. Kerion celsi in the elderly is unusual and may be misdiagnosed as many other disease as dissecting cellulitis or seborrheic dermatitis. Herein, we report a rare case of kerion celsi caused by Microsporum gypseum.

<i>MIF</i> allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

Yoo, Seung-Ah,Leng, Lin,Kim, Bum-Joon,Du, Xin,Tilstam, Pathricia V.,Kim, Kyung Hee,Kong, Jin-Sun,Yoon, Hyung-Ju,Liu, Aihua,Wang, Tian,Song, Yan,Sauler, Maor,Bernhagen, Jurgen,Ritchlin, Christopher T. National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.49

<P>Fibroblast-like synoviocytes mediate joint destruction in rheumatoid arthritis and exhibit sustained proinflammatory and invasive properties. CD44 is a polymorphic transmembrane protein with defined roles inmatrix interaction and tumor invasion that is also a signaling coreceptor for macrophage migration inhibitory factor (MIF), which engages cell surface CD74. High-expression MIF alleles (rs5844572) are associated with rheumatoid joint erosion, but whether MIF signaling through the CD74/CD44 receptor complex promotes upstream autoimmune responses or contributes directly to synovial joint destruction is unknown. We report here the functional regulation of CD44 by an autocrine pathway in synovial fibroblasts that is driven by high-expression MIF alleles to up-regulate an inflammatory and invasive phenotype. MIF increases CD44 expression, promotes its recruitment into a functional signal transduction complex, and stimulates alternative exon splicing, leading to expression of the CD44v3-v6 isoforms associated with oncogenic invasion. CD44 recruitment into the MIF receptor complex, downstream MAPK and RhoA signaling, and invasive phenotype require MIF and CD74 and are reduced by MIF pathway antagonists. These data support a functional role for high-MIF expression alleles and the two-component CD74/CD44 MIF receptor in rheumatoid arthritis and suggest that pharmacologic inhibition of this pathway may offer a specific means to interfere with progressive joint destruction.</P>