관상동맥 시술 도중 발생한 좌주간부 관상동맥 박리에 대한 스텐트 삽입 치료의 단장기 임상 결과 : acute and long-term results

이세환,이승환,홍명기,김영학,이철환,한기훈,송종민,강덕현,송재관,김재중,박성욱,박승정 대한내과학회 2004 대한내과학회지 Vol.66 No.6

목적 : 심도자 사용 시술과 관련된 좌주간부 관상동맥박리에 대한 적절한 치료는 아직 확실히 정립되지 않은 상태이다. 이에 본 연구는 좌주간부 관상동맥 박리에 대한 스텐트 삽입술의 단장기 임상결과를 후향적으로 분석하였다. 방법 : 좌주간부 관상동맥 박리에 대한 치료로 즉각적인 스텐트 삽입술을 시행하는 것이 안전하고 효과적인 방법임을 가설하였고, 이러한 즉각적인 스텐트 삽입을 시행한 10명의 환자를 대상으로 단장기적 임상경과를 의무기록 고찰과 전화 면담을 통해서 평가하였다. 결과 : 전체 환자 모두 처음부터 좌주간부 관상동맥에 유의한 협착을 가진 환자는 없었으며, 8명의 환자는 심도자의 조작으로 인한 박리가 발생한 경우였고(진단적 혈관 조영술 중에 3명, 유도 도자 조작 중에 5명), 나머지 2명은 다른 병변에 스텐트 삽입시술을 하는 중에 박리가 발생하였다. 이 10명의 환자에서 모두 즉각적인 스텐트 삽입술이 시행되었고, 4명의 환자에서 시술 도중 혈압 저하로 Intra-aortic Ballon Pump (IABP)를 장착하였다. 모든 환자에서 성공적으로 스텐트가 삽입되었고, 병원내 사망은 1명도 없었다. 6개월 추적 관상동맥 조영술은 8명의 환자에서 시행되었다. 혈관 조영상의 재협착(직경 협착 50% 이상)은 8명 모두에게서 관찰되지 않았으며, 퇴원 후 평균 31±25개월의 추적관찰 결과 주요 심장사건은 1건도 발생하지 않았다. 결론 : 비록 대상 환자가 적은 연구였지만 좌주간부 관상동맥 박리에 대한 스텐트 삽입술은 기술적으로 안전하고 빠르게 시행 할 수 있으며, 훌륭한 단장기적인 치료 효과를 보여준다. Background : The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter-based procedure remains uncertain. We retrospectively analyzed the acute and long-term results of bail-out stenting for LMCA dissection. Methods : In cases with significant LMCA dissection occurring during catheter-based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome. We evaluated the acute and long-term results of bail-out stenting for LMCA dissection occurring during catheter-bases procedure in 1- patients. Results : Initially, there was significant stenosis of LMCA segment in these patients. Catheter-induced dissection occurred in 8 patients (during diagnostic angiography in 3 patients and guiding catheter manipulation in 5 patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail-out stenting LMCA dissection was performed in a total of 10 patients. In 4 patients, hypotension developed and intra-aortic balloon pump was placed during procedure. Stents were successfully deployed in all patients. There was no in-hospital mortality. Six-month angiographic follow-up was performed in 8 patients. Angiographic restenosis(diameter stenosis 50%) was not observed in all patients at follow-up study. During a mean follow-up of 31±25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization). Conclusion : Bail-out LMCA stenting is technically feasible, and showed good acute and long-term results in a small series of patients.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer

오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.

좌전하행지 관동맥 개구부위의 망사형의 관(Slotted Tube)스텐트와 나선형 코일(Coil)스텐트 삽입후 단기 및 장기 암상 경과의 비교

박훈기,박성욱,이일수,이상곤,김진우,이근,정상식,이철환,홍명기,김재중,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

강원도 중학교 체육교사의 보건학습 지도 실태

이동욱,김승재,박기동,김세환 강원대학교 체육과학연구소 2000 江原大學校附設體育科學硏究所論文集 Vol.- No.23

The purpose of this study was to investigate current situations on middle school physical education(PE) teacher's health instruction in Kangwon-do. The results attained from 165 middle school physical education teacher's in Kangwon-do are listed below: 1.Although physical education recognize the absolute necessity of health instruction in middles schools in Kangwon-do, it can't be acknowledged that sufficient instruction is being performed due to numerous other reasons. 2.Mostly, physical education teachers are in change of health instruction, but sometime it is refered to nurse-teachers, 3.For appropriate health instruction, first of all, related teaching materials and training opportunities should be more available. Based on above conclusion, following suggestions are made: 1.Information about health instruction must be sought with a great weight when teachers have any training opportunity. 2.School classroom must equip necessary teaching materials for health instruction. 3.There have to be more opportunity for intensive training to teachers. 4.Health instruction includes subtle subjects like problems relates sex education. Physical education teachers be in change of course but it can asked to nurse teachers if it for a better quality of health instruction.(It should be more rational to request nurse-teachers if a young male physical education teacher is in a girl's school) Also, issues related to independence on health instruction subject must be carefully examined.

SHS 공정에 의한 텅스텐 산화물로부터 고순도 텅스텐분말 제조

이승영,윤여훈,이종현,원창환 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.1

99% Pure tungsten powders were prepared by self-propagating high temperature synthesis (SHS) process from a mixture of ammonium paratungsten(APT) and Mg powders. The concurrently formed MgO in the product was leached with an HCI solution. The optimum molar ratio of APT to Mg is 1:46 and the compaction pressures range from 2000 to 4000 psi. The propagation velocity and combustion temperature increased, as the compact diameter increased. The weight change and elongation of the SHS product were affected by compaction pressure on the green pellet. The tungsten product had a purity of 99% and mean size of 2∼3 μm.

인체 지방 및 간장조직 중 유기염소제류의 확인 및 정량기법 체계화

이상기,양자열,인상환,김기욱,이수연,오승민,김미영,정규혁 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

고순도 투광성 알루미나 Yarn Guide의 제조 및 특성

이승환,나상웅,이재형 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

High purity translucent alumina yam guides were fabricated by injection molding. The green density was 54% of the theoretical after injection molding and debinding. Heat treatment in an argon atmosphere at 1750℃ for 5h to obtain translucency resulted in huge grain sizes in the specimens. Therefore, isostatical hot pressing was necessary for translucency and fine microstructure. After presintering in an oxygen atmosphere at 1550℃ for 5h followed by isostatical hot pressing at 1600℃ for 1h, the translucent alumina was highly dense, over 99.9% of the theoretical, and had 5 to 10㎛ size grains with a high hardness of 14.1GPa. The color was slightly dark due to the carbon atmosphere in the hot isostatic press, however, it would not affect the performance as yarn guides. Owing to the ultra high density, high hardness and fine microstructure, the isostatically hot pressed yarn guides would satisfy the requirements for the application in the high-speed textile machine.

고강도 철근콘크리트 기둥의 화해 거동

이승환,이차돈,신영수,홍성걸 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

Fire-damaged structural behavior of high strength reinforced concrete columns mostly depends on duration of heating time, geometrical shape of a section, constituent material properties, loading conditions and moisture content. Unlike beam element, all boundaries of a column suffer from heat-induced damages and this requires real-size experiments be conducted in order for accurate assess of the fire-damaged structural behavior of columns. Ten real-sized high strength concrete columns with different parameters are exposed to fire for three different time intervals in this research. Observations are made for the effect of these parameters on the degree of spalling, axial expansion and contraction, member buckling, failure based on ISO standard in addition to data of heat propagation in a section during the heating.

급성 심근경색후 생존심근 진단에서 Dobutamine 심초음파도와 Thallium 심근스캔의 정확성 비교

이근,강덕현,송재관,이철환,최기준,홍명기,김재중,박성욱,박종훈,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2