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Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis
Jin, Junghee,Ko, Heejae,Sun, Tao,Kim, Seung-Nam Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>It has been known that the dorsal and ventral areas of the dentate gyrus in the hippocampus have distinct roles in memory and mood behaviors. We previously reported that microRNA <I>miR-17-92</I> regulates adult hippocampal neurogenesis and mood disorders. Here, we suggest that the <I>miR-17-92</I> cluster is highly expressed in the ventral than the dorsal dentate gyrus in the adult mouse hippocampus. Deletion of <I>miR-17-92</I> in the adult hippocampus only affects development of neural progenitors in the ventral dentate gyrus, and <I>miR-17-92</I> knockout mice have no defects in memory functions. Our results suggest that regional expression of <I>miR-17-92</I> in the dentate gyrus is associated with their distinct functions in hippocampal neurogenesis and related behaviors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> miR-17-92 is highly related with hippocampal neurogenesis and mood behavior. </LI> <LI> The expression of miR-17-92 cluster is regionally different in hippocampus. </LI> <LI> miR-17-92 KO less affect development of neural progenitors in ventral hippocampus. </LI> <LI> Interestingly, memory function was not altered by miR-17-92 KO. </LI> <LI> These findings suggest the distinct function of regional expression of miR-17-92. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고
양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.
A2024-T4 同種材 마찰용접시 업셋압력이 접합특성에 미치는 영향
고봉학,장승수,여상은,민택기 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.2
The study deal with the strength of weld zone, the effect of upset pressure and microstructure of weld zone which are obtained from the variation of upset pressure in the friction welding A2024-T4 similar materials. The welding conditions was fixed welding condition of rotation speed 1000rpm, friction pressure 150Mpa, friction time 1.0sec and upset time 4.0sec. The upset pressure was variationed from 200Mpa to 320Mpa. The result are summarized as follows: 1. As a result of tensile test, the maximum tensile strength was obtained 503Mpa and it corresponds to about 104% of base metal tensile strength. tensile fracture surfaces appeared deep Dimple in heat affected zone(HAZ) 2. As a result of vickers hardness test, the maximum hardness was obtained 136Hv in friction welding interface and width of heat affected zone(HAZ) appeared 0.2mm. 3. As a result of analyzing th microstructure of weld zone. Me or Mn compounds of friction welding interface come out flash zone by centrifugal force and upset pressure, the microstructure of weld zone is recrystallized.
고용서,김승태,정진도 공주대학교 자원재활용 신소재 연구센터 1999 1차년도 센터 성과집 Vol.1999 No.-
본 연구는 독일 Schumacher의 1m 크기의 세라믹 캔들 필터가 1개 설치된 실험장치를 구성하여 집진시 단일 필터 주위에서의 분진 속도분포를 PDPA를 이용하여 측정하고, 분진층의 유무와 분진 투입 위치에 따른 분진 속도분포의 변화를 관찰하였다. 측정 결과 집진이 계속되어 분진층이 발달함에 따라 접진 속도가 감소됨을 알 수 있었다. 특히, 투입구가 위치하는 필터표면에서 집중적으로 분진층이 발달하여 이곳에서의 분진 속도 감소가 크게 나타났다. 그리고 필터내부와 압력용기부사이의 압력 차에 의한 필터 표면에서의 분진 속도 평균값은 0.28m/sec 이었다. 또한 분진 투입을 암력용기부 하단에 위치한 투입구로 투입하였을 때 필터 주위의 분진의 고른 속도분포를 관찰할 수 있었다. The experimental set-up with a 1m long ceranic candle filter of Schumacher(Germany) was built in this work. The dust velocity field around the filter was measured using PDPA. The effects of dust cake laver and dust inlet position on the dust velocity field were also analyzed. It was found that the filtration velocity decreases as the dust cake builds up on the filter. The filtration velocity largely decreases around the filters near the dust inlet since the dust cake tlevelops fast there. The average dust velocity on the filter due to the pressure difference through the filter was measured to be 0.28m/s. More uniform dust velocity field around the filter was obtained when feeding dust in a lower position of the pressure vessel.
高承禧 단국대학교 1982 論文集 Vol.16 No.-
This paper is dealt with the essential mature of generally accepted accounting principles. The term of this accounting principles have been used from the period 1930s in the United Stated of America. The correspondence was exchanged between the AIA's Committee (May's Committee) and the Exchange's Committee on Stock List from 1932 to 1934. The transactions between these committees were published in 1934 by AIA under the tittle, Audits of Corporate Account. They introduced the terms accepted principles of accounting for business enterpeises and accounting standards in the working vocabulary of accountants. The principle of accounting are, therefore, the more general propositions describing the procedure which should be followed in the making of records and the preparation of financial statements, if the functions enumerated are to be properly performed. It is believed that there is a corpus of principles of accounting which are generally accepted. It is true that they are not written law; they have not been codified; they must be sought in accounts and financial statements, and in other evidences of professional opinion. It is true that they have not been adopted by vote of the profession. But that they have been accepted is evidenced by the common ways of thought and speech which make communication in accounting matters possible, by the generally uniform practice of all accountants when dealing with some situations, by the general agreement that, among all the possible ways of dealing with other situations, only a few can be used with propriety. So fully is the existence of a body of accepted accounting principles recognized that accountants the statements presented have been prepared in accordance with accepted principles of accounting. The existence of a body of generally accepted accounting principles does not mean that there is only on proper accounting treatment for every situation with which the accountant must deal. For many situations, there are available a number of treatments which are in accordance with the generally accepted accounting principles. But the affirmation of the general acceptance of accounting principles does mean that many and most of the possible treatments are inappropriate. Accounting principles for business enterprises is composed of two types, normative accounting principles and desciptive accounting principles. The former is formulated, it is believed, by deductive reasoning, and the latter is made by inductive reasoning in accounting practices.
고경덕,이동원,정승현,신길조,이원철 동국대학교 한의학연구소 1997 東國韓醫學硏究所論文集 Vol.6 No.1
朱震亨은 金元四大家중 가장 후대의 인물로서 朱子學의 철학적 배경에 근거하여 劉河間, 張子和, 李??의 장점을 흡수하여 醫論을 펼쳤으므로, 金元四大家의 中風 內因論을 인식하는데 있어 그 의미가 크다. 朱震亨 中風論의 특징은 그가 거처한 純域的 特性에 근거하여 肥瘦人과 半身不遂의 左右에 따라 각각 治法을 달리하였으나, 中風 病因病理를 濕痰生熱로 보고 內因의 주요소로 痰을 중시하여 中風入方藥物은 治痰한다는 원칙에 기준하여 藥物을 사용하였다. 이러한 독특한 中風論은 후대 中風 內因論의 발전에 지대한 영향을 주었으므로, 이에 관한 연구는 中風 內因論 측면에서 韓醫學發展에 寄與할 것으로 恩慮된다. We inquired into the origins, pathologies, theraphies and prescriptions of Jungpung(中風) especially on the ground of Keokchiyeron(格致餘論)ㆍDangeosimbub(丹溪心法) written by JuJinHyoung(朱震亨) as modical blocks, from this study we could get that conclusions. 1. According to special feature of the theroies of JuJinHyoung's(朱震亨) Jungpung(中風) he thought pathologies of Jungpung(中風) as 「sub seong dam dam seong yeol yeol seong puns 濕疾痰痰生熱 熱生_風」through studying stress on regional characteristics and thought much of dam(疲) as one of major elements of internal causes. 2. He suggested chi-dam(治痰) in the first place in the treatment of Jungpung(中風) and emphasises the treatment using Succus Pyllostachyos(竹瀝), waterly extracted Rhizoma Zingiberis(鐘汁) in that they had the virtues of sodam-ganghwa(消痰降火), geo-gyeongrak(開經絡), haeng-heolgi(行血氣). 3. He treated differently whether a man in fat and thin, and have right or left hemiplegia, but he prescribed herb-medications on the principle that medications should have the virtues of chi-dam(治痰).
고성택,김경식,김경연,최영복,고승일 濟州大學校工科大學産業技術硏究所 1998 尖端技術硏究所論文集 Vol.9 No.2
ATM(asynchronous transfer mode) is able to realize the full integration of various kinds of services. Effective bandwidth allocations using statistical multiplexing gain haute been studied for the full integration of different kinds of services. In this paper. we present call admission control algorithm using complete bandwidth sharing and reserved bandwidth sharing. Complete bandwidth sharing is an efficient way for utilization of bandwidth. Reserved bandwidth sharing is an efficient way for preventing reverse pecking order. Using these two bandwidth allocations is an effective way for bandwidth utilization and stopping reverse pecking order. A computer simulation shows the results of the algorithm.
고승식 문화관광연구학회 2002 문화관광연구 Vol.4 No.1
The purpose of this study is to suggest an effective annual salary system for desirable management development in tourism hotels. Considering aggressive targeting of famous foreign chain hotels, Korean hotels should set up effective annual salary system for self-development.Basic standard for personnel system of Korean local hotels are changing rapidly from working period in one hotel to ability of staff, and finally to production or result of the staff. Changes of circumstances like growth rate of economy and automation of each department in hotel will accelerate the alteration of personnel system. From this point of view, Korean hotels should change the personnel system to concentrating on production and result of the staffs. They should focus on creating a good production and result. Service quality and interest of the staffs will increse if the pay between staffs are different according to the evaluation. If the owners or the management of the hotels guarantee objectivity and reasonableness, annual salary system focusing on the production of the staff will be the best plan against management crisis in current hotel industry. Finally, hotel management should make sure that annual salary system focusing on the production points at much better hotel management strategy than before even if it cannot be the perfect standard for evaluating hotel staffs. It must be accurate, fair, and equal to all the staffs in hotel.