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Protein Kinase C(PKC)-mediated regulation of murine myometrial contraction
( Seung Hwa Hong ),( Jin-young Choi ),( Bitna Kim ),( Hyeonkyeong Yeon ),( Il Woon Ji ),( Eun-hwan Jeong ),( Hak Soon Kim ),( Seung Myeung Son ),( Chan Hyung Kim ),( Woong Choi ),( Young Chul Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: In uterine smooth muscle, several factors such as hormones, Ca2+ and protein kinases are involved in the regulation of its contractility. Especially, intracellular Ca2+ and Ca2+-dependent protein kinases like a protein kinase C (PKC) is also involved in the ligand-mediated responses such as oxytocin (OXT). In this study, we tried to figure out the role of PKC in the spontaneous and OXT-induced contraction in murine uterus smooth muscle. Methods: Conventional vertical contractile measuring system was used to evaluate the mechanical contraction of murine uterus. Results: Uterine smooth muscle showed tonic contraction by application of high K+ condition (50 mM) in a nifedipine-sensitive manner. Phorbol 12-myristate 13-acetate (PMA, 10 M), activator of PKC, decreased the frequency of spontaneous contraction to 16% of the control. However, bis-indolylmaleimide II (Bis II, 2 M), an inhibitor of PKC, recovered the frequency of spontaneous contraction to 44.7% of the control. It might implies that uterine smooth muscle contraction might be regulated by PKC system. Oxytocin (OXT, 10 nM) produced tri-phasic contraction such as initial peak contraction followed by tonic contraction superimposed by phasic contraction. Its phasic contraction was blocked by Ca2+ channel inhibitor. Another PKC activator such as phorbol dibutyrate (PDBu, 10-20 M) completely blocked OXT-induced phasic contraction in a Bis II-sensitive manner. Bis II (2 M) recovered and even enhanced the frequency of OXT-induced phasic contraction to 1.87/min to 7.5/min compared to control of OXT-induced contration. The amplitude of OXT-induced phasic contraction was also partially recovered by Bis II to 17% of the control. Conclusion: From above results, it strongly implies that PKC system might be one of the potent regulator of contraction in murine uterine smooth muscle. The subtypes of PKCs will be studied in the following study too.
A Case of Verrucous Carcinoma Occurring in Patient with Diabetes Mellitus and Chronic Renal Failure
Song, Kye Yong,Ro, Byung In,Kim, Myeung Nam,Ahn, Seung Won,Chong, You Son 대한피부과학회 2001 Annals of Dermatology Vol.13 No.3
Verrucous carcinoma is a slow growing, low grade squamous cell carcinoma, which usually occurs on oropharynx, genitalia and soles. When it occurs on feet, it is known as epithelioma cuniculatum. Epithelioma cuniculatum is characterized by its histologic sinuses and cystic formations in a cuniculate(rabbit burrow-like) pattern. A 59-year-old man was consulted to our department for a well circumscribed, 5×5 ㎝ sized, round, hyperkeratotic, verrucous plaque on the right great toe. He suffered from diabetes mellitus for 16 years and was managed by peritoneal dialysis three times a week due to chronic renal failure for last two years. The plaque had gradually increased in size. The biopsy specimen taken from the tumor mass showed chronic ulcerative inflammation with atypical squamous cell proliferation. We herein report a case of verrucous carcinoma occurring in a patient with diabetes mellitus and chronic renal failure.