비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

백서의 심실세동성 심정지 모델에서 해마신경세포 손상에 대한 단백질 합성저해제의 효과

오동렬,채장성,박승현,김세경,최세민,박제영 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The goal of successful resuscitation is not only to stop the process of ischemia as soon as possible but also to overcome the secondary injury process after resuscitation, which involves a complex interplay of mechanisms. Brain damage accompanying cardiac arrest and resuscitation is frequent and devastating. Cells die by one of two mechanisms: necrosis or delayed neuronal death. Delayed neuronal death may require protein synthesis. Neurons in the CA1 subfield of the hippocampus are selectively vulnerable to death after injury by ischemia and reperfusion. Death of these neurons occurs after an interval of 1 or 2 days. We assessed the effects of a protein synthesis inhibitor, cycloheximide(CHX), on hippocampal neuronal death of rats by using the ventricular fibrillation cardiac arrest(VFCA) model. Methods: The effect of CHX(3 mg/kg, s.c.) on hippocampal neuronal death was studied in two groups of 18 rats each, one group being subjected to a 2-min VFCA and the other to a 3-min VFCA. Each group was divided into three subgroups: control(groupⅠ,Ⅱ) without subcutaneous injection of CHX, "esp-12" of group Ⅰ/Ⅱ treated with CHX 12 hours after return of spontaneous circulation (ROSC), and "exe-24" of group Ⅰ/Ⅱ treated with CHX 24 hours after ROSC. The coronal sections of the hippocampus levels were stained with hematoxylin-eosin after 72 hours of survival. The histologic damage score(HDS) was used to assign a score to the total number of damaged neurons counted in each of the hippocampal CA1 subfields. Results: 1. There were not significant differences in heart rates, blood pressures, blood sugar, and blood gas in group I & Ⅱ during the pre-arrest steady state or at 5 min and 30 min after ROSC. 2. In group I & Ⅱ, the HDS, were significantly reduced in rats(I exp-12, 1.1 ±0.6;Ⅰexp-24, 1.3 ±0.5;Ⅱ exp-12, 1.4±0.7; and Ⅱ exp-24, 1.8±0.8) treated with CHX 12 hours or 24 hours after ROSC than control rats(1,2.5 ±0.9;Ⅱ,2.9±0.8)(p<0.05). Conclusion: These results suggest that delayed hippocampal neuronal death from ischemic insult after ventricular fibrillation cardiac arrest followed by resuscitation can be prevented by a protein synthesis inhibitor, CHX. Further experimental studies of the action mechanism of protein synthesis inhibitors to delayed neuronal death and clinical applications are required.

投資信託會社의 業務領域擴大 方案

吳賢鐸,李憲相,鄭承佑 全北大學校 1992 論文集 Vol.34 No.-

Enlargement of business field is required for the Investment Trust Companies in serious financial trouble to survive. We can think of two basic directions to take which are specialization in the basic investment trust business and acceptance of universalization including the securities business. Considering the current situation of domestic financial industry, a scheme of having a securities company as the mother company while seperating the investment trust business as its subsidiary would be particularly beneficial.

볼록성 행렬을 이용한 옵션부 채권 포트폴리오 관리전략

吳承炫 水原大學校 2005 論文集 Vol.23 No.-

Duration vector strategies have been developed to allow various types of term structure movements. The duration vector strategies assume multi-factor models for the term structure movement. When a duration vector strategy is considered as a generalization of a duration strategy which is a single factor model for the term structure movement, there will be a generalized concept which measures convexity of a bond under the duration vector model. Recently, Oh(2004) identified the generalized convexity property of an option embedded bond portfolio under 'key rate duration model' which is a kind of duration vector model suggested by Ho(1992). Oh(2004) also developed a bond portfolio management strategy under his generalized convexity model. But the strategy can be applied under very specific situation. This paper identifies the problem of the strategy and suggests an alternative portfolio management strategy which is supported by mathematical proof.

건축설계 프로세스별 협력설계 의사결정 지원모델 구성 방안

오승준,신창현,이경국,전재열 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

In Korea construction project case, architectural construction project is curtailed production because information network process within multidisciplinary isn't smooth. Particularly, the construction is not insufficient about performance, cost and material, construction process, etc. in result various question arises because of design error in construction step. And various mistake is made because communication path within multidisciplinary isn't smooth in architectural design and design change process. Therefore The final object of this study is to propose the establishment method of decision support model for the cooperative design in order to provides improved design coordination and optimize the building system.

경동맥 죽종의 색혈류 도플러 초음파 소견

오연희,김승현,이성우,어경윤 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

한국인의 뇌경색의 가장 중요한 원인은 경동맥 죽종으로 알려져 있다. 저자들은 경동맥 죽종의 복식 초음파 및 색혈류 도플러 초음파영상을 비교·분석 하였다. 죽종 침범의 범위는 총경동맥+내경동맥+외경동맥 혹은 분지부 47.9%, 총경동맥 24.4%, 총경동맥+분지부+내경동맥 11.1%등이었다. 경동맥 협착은 중등도 53.6%, 경도 26.1%, 중도 16.3%, 위험도 3.1%, 완전폐쇠 0.9%. 표면의 형태는 매끄러운 경우 53.1%, 경도 불규칙 41.3%, 심한 불규칙 3.9% 그리고 표면 궤양이 동반된 경우 1.7%였다. 또한 죽종 내부구조의 음영도상 균일한 경우 90.5% 였고 죽종의 음영은 등에코성 40.2% 석회화 25.1%, 저에코서 22.3%등이었다. 결론적으로 복식 초음파와 색혈류 도플러 영상은 경동맥 죽종 진단에 있어서 정확하고 안전한 비침습적인 진단방법이다. Several reports have been documented that carotid atheroma presented as the mostimportant cause of cerebral infarction in Korea. Authors analysed the atheroma imaging of the carotid artery in the patients with cerebral infarction patients using duplex sonography and color flow imaging. The atheroma extents were CCA(common carotid artery)+ICA(intemal carotid artery)+ECA(external carotid artery) or BIF(bifurcation) 47.9%. CCA(common carotid artery) 24.4%, CCA(common carotid artery)+BIF(bifurcation)+ICA(lntemal carotid artery) 11.1 %. The percents of stenosis of carotid arteries were moderate 53.6%, mild 26.1 %. severe 16.3%, critical 3.1 % and occlusive 0.9%. The surface characters were smooth 53.1 %, mild irregular 41.3%, severe irregular 3.9% and ulcerated 1.7%. The atheroma texture was homogenous 90.5%, and the echogenicities of atheroma were isoecboic 40.2%, calcification 25.1 %, hypoechoic 22.3%. We concluded that duplex sonography and color flow imaging were accurate and safe non-invasive method detecting of carotid atheroma.

공공기관 엔터프라이즈아키텍처 성숙도 측정을 통한 정책 시사점 연구

오승운,박현우 한국정보사회진흥원 2008 정보화정책 Vol.15 No.4

정보화 발전과 함께 정보시스템의 투자규모가 확대됨에 따라 중복투자가 발생하고 시스템 간 연계가 복잡하게 되면서 이를 해결할 수 있는 수단이 필요하게 되었다. 이로 인해 엔터프라이즈아키텍처(EA) 도입 및 활용이 의무화 되었다. 더불어 EA의 지속적인 발전 및 고도화 방향 설정을 하기 위한 도구로 범정부 EA 통합 성숙도 모델 v2.0이 개발되었다. 공공기관 성숙도 측정 결과는 2006년 및 2007년 자료를 활용하였으며 2006년 자료는 개별기관의 EA 도입계획을 분석하였고 2007년은 EA 실태조사 및 성숙도 측정 결과를 분석하였다. 연구결과 공공기관 성숙도 수준은 전체 영역 평균 2.0 수준으로 관리영역은 2단계인 정의 수준, 수립 영역은 2단계인 기준수립 수준, 활용 영역은 1단계인 인식 수준이며 국내는 아직까지 EA 활용을 통한 성과를 얻기에는 아직 이른 시점으로 분석되었다. 본 연구는 국내 EA 성숙도 측정을 통한 정책시사점을 얻기 위한 연구로 이를 위해 선진국가의 EA 성숙도 모델 및 측정 제도를 연구하고 국내 EA 성숙도 측정 결과를 분석하였다. 그 결과 국내 EA 성숙도 측정 제도와 공공기관의 EA 현 수준의 문제점 및 개선방향 제시가 이 연구의 목적이다. The size of investment in information systems is magnified along with informatization development. Expenditures are frequently sourced from many different uncoordinated budgets, resulting in significant duplication, redundancy as well as conflict in the demand for resources. As a result of these problems, the introduction and management of Enterprise Architecture (hereinafter referred to as "EA") in organizations has been mandated by law in Korea. The data from 2006 and 2007 has been applied to the public agency maturity assessment results. The 2006 data was used in analyzing EA introduction plans of the individual agencies, and the 2007 data was used in maturity assessment results as well as the actual conditions of EA. Research results of the public agency maturity level showed an overall average level of 2.0: Level 2 (Definition Level) in the Management Area, Level 2 (Baseline Establishment Level) in the Establishment Area, and Level 1(Recognition Level) in the Use Area. The results reflect that achieving performance from EA use is still too early to calculate. The purpose of this study is to get the current political implications on EA via the assessment of domestic EA maturity. For this, we analyzed the domestic EA maturity assessment results and studied maturity models and EA assessment systems of other advanced countries. By using these results, the aim of this research is to recognize the problems and to suggest some directions for improvement of domestic EA maturity assessment systems and the current levels of public agency EA.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

외부 프리스트레스트 콘크리트 보의 휨강도 산정을 위한 근사계산 방법

오승현,강원호 東亞大學校 建設技術硏究所 2008 硏究論文集 Vol.32 No.1

Since externally prestressed concrete structures have visible profile of prestressing steel, it has advantage of maintenance to investigate and to re-tension the prestressing steel in service state. The flexural moment capacity of extetnally prestressed concrete members can be calculated by the analysis of internally statically indeterminate members, which is different from internally prestressed concrete members. Therefore, it needs nonlinear analysis considering complex ultimate state behavior after cracking. While most of the design codes and empirical formulas proposed approximate methods of calculation based on test results, it is only possible to apply them for the same condition as test specimens. Since they have problems of poor theoretical ground for influencing parameters, it is difficult to apply them for the calculation of flexural moment capacity for arbitrary conditions of tendon profiles. To reduce the discrepancy between accurate analysis and empirical formulas, many experiments and studies are continued. In this study, we proposed an approximate method to calculate the flexural moment capacity of prestressed concrete members with extemal tendons through sectional analysis considering internal indeterminacy. In order to examine not only the proposed method but also the design codes, we carried out beam test, which includes two simple beams of various external tendon profiles. The proposed method shows better agreements than the design specifications.

조기위함에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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