비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

한우, 칡소 및 제주 흑우 Calpain-Calpastatin 유전자 다양성

이승환,김승창,조수현,최봉환,Aditi Sharma,임다정,당창권,장선식,김재환,고문석,양보석,강희설 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The aim of study was to investigate genetic diversity for the calpain/calpastatin gene in three Hanwoo breeds [(Brown (n=62), Brindle (n=81) and Jeju Black (n=30)]. Random samples from three breeds of Hanwoo were selected and genotyped for the 7 SNPs of calpain/calpastatin using TaqMan method. Allele frequencies were investigated for CAPN1/CAST gene. Allele frequency of CAST2 SNP was 0.75, 0.59 and 0.22 for Brown, Brindle and Jeju black, respectively. The CAST3 revealed allele frequency of 0.59 and 0.57 in Brown and Jeju Black, while it showed very low allele frequency (0.07) in Brindle. In particular, favorable allele (G allele) for the CAPN1-2 SNP which was shown a strong association with tenderness in Taurine and Indicine cattle revealed 16% and 17% higher allele frequency in Brown Hanwoo (0.82) comparing Brindle (0.66) and Jeju Black Hanwoo (0.65). AMOVA demonstrated that among population variance occupied only 10% of total variance and among individual variance was 0%, while within individual variance was 90% of total variance. This result showed that population effect contributed very small portion of genetic to these three Hanwoo breeds, while within individual variance contributed large portion of genetic diversity within these Hanwoo breeds. In conclusion, three Hanwoo breeds (Brown, Brindle and Jeju black) showed a genetically homogeneous based on the 7 SNPs of CAPN1/CAST gene and it came from same ancestor to form modern Hanwoo breed.

고출력 다이오드 레이저를 이용한 SKD11 표면 열처리 특성

최성대,정선환,양승철,김잠규 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

An experimental investigation with high power diode laser system was carried out to study the effect of surface heat treatment on the SKD11. The surface heat treatment characteristics of the laser beam were evaluated using hardness tests, optical microscopy, X-ray diffraction and energy dispersive X-ray spectroscopy(EDS). Results indicated that the Hardness were changed by beam size, focal length, feed rates. The micro grain structure was observed retained austenite grain at hardened zone and globular cementite grain at fine grain zone and base metal zone by optical microscopy. The intensive X-ray diffraction patterns of (110)-(200)-(211) was detected on the surface and the hardened surface intensity level was bigger than the unhardened surface. The intensive X-ray diffraction patterns of (110)-(200)-(211) was detected hardened surface and the hardened surface distributed plenty of carbon density than metal zone.

인접건물에 의한 반사주광 성능에 대한 평가

최원기,이동권,안명환,서승직 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6

This paper is focused on evaluation of daylight reflecting performance from the adjacent building for improvement of poor environment conditions in a metropolitan area. The numerical model developed can be used for evaluation of daylight reflecting performance. As a result comparison of our simulation programs and commercial softwares, it was verified that there was no difference between two results. In this study, the sensitivity analysis of environmental performance factors of daylight reflecting from the adjacent building were examined, analysed and presented as a solution method for improvement of building environments. The results were proved to be an effective control methods for improvement of building environment, especially in a metropolitan area.

각막형태검사법을 이용한 각막양상과 눈의 굴절력과의 관계

최시환,민병무,김용백,김창식,안승일 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

We evaluated the topography of 200 normal cornea of Korean. The mean age was 37 years and mean refractive astigmatism was 0.82±0.69D. The corneal patterns were classified by Dr. Bogan such as round, oval, symmetric bow tie, asymmetric bow tie, and irregular pattern. Its incidence was 14.0%, 11.0%, 16.0%, 30.0% and 29.0%, respectively. There was no statistically significant difference in the distribution of topographic pattern in male and female and among age groups. The symmetric bow tie type had the greatest spherical equivalent and astigmatism and there was no statistically significant difference in those two values between round and oval group. Two bow-tie groups were not also statistically significantly different from each other in spherical equivalent and astigmatism. However, two bow tie groups were significantly different from round and oval group. So, it was possible to divide corneal topographic pattern into three groups such as round and oval, two bow tie, and irregualr group. We could understand normal corneal status related to corneal pattern and refractive power through this qualitative system for classifying corneal topography.

익산시 주변 하천 담수조류군집의 다양성에 대하여

최환석,김미연,김백호,최민규,박승택 원광대학교 환경과학연구소 2000 環境科學硏究誌 Vol.9 No.1

고추 PCR 조건의 최적화

최근원,이승우,남승현,설일환,유일웅 경희대학교 부설 식량자원개발연구소 1996 硏究論文集 Vol.17 No.-

신품종에 대한 육종가의 권리보호용 고추 RAPD 마커를 개발하기 위한 기초연구로 PCR에 영향을 주는 요인들에 대한 최적화가 이루어졌으며 주요 결과를 요약하면 다음가 같다. 1. MgCl₂ 농도는 DNA증폭에 직접적인 영향을 주었으며 본 실험의 결과는 고추 PCR에 요구되는 MgCl₂의 최소농도는 3mM임을 보였다. 2. 공시된 2고추 조합간데 차이는 있었지만 Taq DNA polymerase는 1.5U이상의 조건일 때 DNA증폭에 효과적임이 관측되었다. 3. 본 실험에 사용된 template DNA양 중 최소인 10ng의 수준으로도 성공적인 DNA증폭을 보였다 4. dNTPs농도는 200~400μM 수준이 적당하였다. 5. Primer의 농도가 높아짐에 따라 band의 선명도가 증가하는 경향을 보였으며 200nM이상의 농도에서 뚜렷한 band가 관측되었다. 6. 공시된 두조합에서 모두 annealing 온도가 높아짐에 따라 minor band의 수가 줄어들고 major band의 선명도가 증가했다. 7. 본 실험의 결과는 3mM의 MgCl₂, 1.5U의 Taq, DNA polymerase, 10ng의 template DNA, 200μM의 dNTPs, 200nM의 primer, 그리고 42℃의 annealing 온도가 고추의 random primer를 이용한 PCR이 적정수준이 될 수 있음을 제시하였다. Factors affecting PCR have been optimized as a fundamental study in developing RAPD markers to protect breeder's right for new cultivars in Capsicums. DNA amplification was directly influenced by MgCl₂ concentration and the result showed that the minimum concentration required for PCR in Capsicums was 3mM. Although there was a difference between two pepper combinations tested, it was observed that over 1.5U of Taq. DNA polymerase was effective in DNA amplification. A successful DNA amplification was obtained with 10ng of template DNA, the smallest amount tested in this experiment. The proper level of dNTPs was the range between 200 and 400μM. There was a tendency that the intensity of bands was increased as the concentration of random primer increased and clear bands were observed with the concentration above 200nM. In both pepper combinations tested, the number of nonspecific bands was decreased and the intensity of major bands was increased as the annealing temperature was increased. The results suggested that the optimum conditions for PCR with random primer in Capsicums could be obtained with 3mM of MgCl₂, 1.5U of Taq. DNA polymerase, 10ng of template DNA, 200μM of dNTPs, 200nM of random primer, and 42℃ of annealing temperature.

체외 충격파 쇄석기에 의해 발생된 음향 흐름 현상 연구

최민주,이승환,홍경진,김호찬,박재우,이헌주 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

Acoustic streaming produced by an extracorporeal shock wave lithotripter was visualized for the first time in the present study. It was observed that the streaming velocity increased with the shock wave amplitude and was reaching up to 3 cm/s at the highest output setting of the lithotripter.

3個의 耕耘날을 利用한 平衡振動式 耕耘裝置(Ⅴ) : 運動解析과 要因分析

金成泰,金容煥,崔圭洪,金成泰 慶尙大學校 1988 論文集 Vol.27 No.1

This is the fifth part of series of reports on the study on a blanced-type oscillating tillage implement using triple blades system. Previous reports were made on the characteristics of power requirement and vibration with which tillage implements were oscillated parappep and perpendicular to the travelling direction. In this paper, the locus and motion analysis of the tillage blade and factor analysis were carried out. Obtained results are as follows : 1. The loci od the blade edge were described as helix curve at vertical oscillation and as lacerated curve at horizontal oscillation to the soil bin movement. 2. The motion equations of blade edge are estimated as follows. Vertical forced vibration ?? ?? Horizontal forced vibration ?? ?? 3. The multiple regression equations for resultant oscillating acceleration draft, specific resistance, and torque were established by using frequency, amplitude, life angle of tillage blade, and velocity of carriage as indepentent vibrations, respectively. 4. By reducing the velocity ratio is increased providing higher effect of the reduced draft. But this effect contradicted to achieve the reduced osillating acceleration. Both effects should be considered simultaneously to find out the optimum operating condition. 5. The reduction effect of the oscillating acceleration was slightly favoured to the horizontal forced vibration type, but traction efficiency could be lowered due to the increased slippage. Therefore, it can be concluded that the vertical forced vibration type is more appropriate considering overall performances. 6. From the experimental results, the optimum operating conditions of the vertical forced vibration type are recommended as follow ; life angle 30 degree, operation velocity 0.15 metre per second, amplitude 4-6 millimetre, and frequency 22.5 hertz.

춘천 중도 선사유적 발굴조사 연구 : 고인돌을 중심으로;Concentrated on the Dolmen Site

최복규,원영환,손승철,신종원 江原大學校 江原文化硏究所 1983 강원문화연구 Vol.3 No.-

The Joong-do prehistoric site is located in the Lake of ?am dam of Chuncheon City, the capital of Kangweon province situated on the confluence of the North Han River and the Soyang River. This island site, it is washed away by the differance between the rise and fall of the lake water level, every year since 1967. The appoximate locations of Joong-do site is at 37℃ 52′;northern latitude, and 127℃ 51′ eastern longitude. The elevation of the present cultivation area is appoximately 80 meter above sea-level. This prehistoric sites, possibly ranges from Neolithic and Bronze Age to early lron Age, was brought to light in the consecutive excavations and surveys from 1981 to 1983 by the Institute of Kangweon Community Culture and the Museum of Kangweon National University. Some dolmens and ancient tombs (stone mounded), various stone tools, potteries and other relics of Neolithic, Bronze Age and early Iron Age were discovered by survey work of our excavation team from the surface and disturbed areas in the island site since 1981. During the excavation work from November 2 to December 1 in 1983, we were excavated a dolmen at center in the inland. The dolmen have four pieces of stone slab were used to make an oblong chamber covered by a large flat top stone of triangular form(size;270×196×40㎝, weight;3 ton). Both the top stone and the stone chamber surrounded by stone mounds for burial is buried under the surface. Three stone slabs of chamber coffin are required to support, but rest one inverse trapezoid stone slab of westward was not to support the top stone. The subsistance of unsupported stone slab suggested the existence of a stone chamber of which one side is open. We presumed the open side was used as a door of stone coffin. The bottom of the stone coffin under top stone was made by means of small pebble stones and large pebble stone slabs from the adjacent river beds. Size of stone slabs of coffin is at 191×94×13㎝;southern, 171×81×13㎝;northern, 80×72×9㎝;eastern. It seems, however, chronology of the dolmen are comparable to the later period of the plain coarse pottery culture(B.C.3~2C) in late Bronze Age.