정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

MATLAB을 이용한 자동차 정속주행 시뮬레이션

한창훈,김승철,박종오,박재현,임영도 東亞大學校 附設 情報通信硏究所 1997 情報通信硏究所論文誌 Vol.5 No.1

An advanced Fuzzy Controller to cruise on the longitudinal road intelligently is proposed in this paper. Typically the vehicle model is represented by velocity, due to its dynamic property and non-linearity. Linear acceleration controller described as the first Fuzzy Controller of most effective control method is applied mainly and the second one based on linguistic description for riding sensitivity is linked with the first and applied. A designed controller is evaluated under MATLAB SIMULINK simulation after it being adapted for virtual vehicle model.

조기위함에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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근자외선 레이저를 위한 Ar 섬광관의 방전 특성과 BBQ의 형광 강도

吳喆漢,林春雨,朴成珍 慶北大學校 1992 論文集 Vol.52 No.-

The fluorescence characteristics of near UV dye, BBQ, pumped by Ar flashlamp have been studied for various electrical input energies applied to the flashlamp and argon fill pressures in the flash tube. The peak wevelength of fluorescence is about 380nm when the fluorescence intensity is at the peak value. The rise time of the fluorescence pluse is about 7μsec and its FWHM is about 55μ sec When the input energy is 72J. The fluorescence energy increases linearly with the input energy and the fluorescence energy in creases as Ar fill pressure in the flash tube increases, but it decreases over 170Torr of Ar pressure. Therefore, the optimum pressure of the tube for fluorescence emission is 170Torr.

간 발생과정에 따른 Metallothionein 발현에 관한 연구

오승한,고정식,김완종 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

Metallothionein(MT) is a group of low molecular weight proteins, with a unique amino acid composition such as a large content (approximately 30%) of cysteine residues. The protein has been shown to play a physiological role in the absorption, transport, and metabolism, such as zinc, copper, and cadmium, but its actual functions are still not clear. This study was carried out to examine the expression of MT in developing or growing rat liver through immunohistochemical and RT-PCR method. Positive reactions against MT started to appear predominantly in the parenchmal cells of liver from the 13th day after gestation. Reaction products, or brown colorations, were localized at both the nucleus and the cytoplasm of the parenchymal cells. The intensity of this reaction gradually increased, and exhibited the strongest at birth. The intensity of MT staining diminished with growth, and by the 15th day after birth weak positive reaction was observed in the cells. In brief, positive reactions for MT were observed in the oval cells and the parenchymal cells during fetal stage, meanwhile they were present only in the parenchymal cells after birth. MT mRNA by RT-PCR seemed to be expressed from the 15th day after gestation till 15 days after birth and it was highest in the neonatal rats. These expression pattern showed similar to those that shown in the immunoistochemical results.The present results suggest that MT possibly contributes to parenchyma cell proliferation and differentiation through the storage or the supply of various metal ions in the developing rat liver.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

ESO기법을 이용한 신뢰성 기반 형상 최적설계

오영규,박재용,황승민,임민규,박재용,한석영 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

This paper presents a reliability-based shape optimization (RBSO) using the evolutionary structural optimization (ESO). An actual design involves uncertain conditions such as material property, operational load and dimensional variation. The deterministic optimization (DO) is obtained without considering uncertainties related to uncertainty parameters. However, the RBSO can consider the uncertainty variables because it has the probabilistic constraints. In order to determine whether the probabilistic constraint is satisfied or not, simulation techniques and approximation methods are developed. In this paper, the reliability-based shape design optimization method is proposed by utilizing the reliability index approach (RIA), performance measure approach (PMA), single-loop single-vector (SLSV), adaptive-loop (AOL) are adopted to evaluate the probabilistic constraint. In order to apply the ESO method to the RBSO, a sensitivity number is defined as the change in the displacement. Numerical examples are presented to compare the DO with the RBSO. The results of design example show that the RBSO model more reliable than deterministic shape optimization.

시판 탁주의 품질과 휘발성 향기 성분

한은혜,김성연,박성오 서울여자대학교 자연과학연구소 1998 자연과학연구논문집 Vol.10 No.-

시판품인 살균하지 않은 탁주 2종(탁주 A, B)과 살균한 탁주 2종(탁주 C, D)에 대찬 알코올와 향기 성분 등을 분석한 과는 다음과 같다. 탁주 A와B의 ethanol 농도는 각각 7.5, 6.5%로서 주세법 규정 농도인 6~8%에 충족 되지만 탁주 B와 C는 각각 5.0, 4.8%로서 약 1% 정도 미달되었다. 총산은 0.27~0.42%로서 주세법에서 0.5% 이하의 규정한 농도에 적합 하였으나 아미노태 질소 함량(0.38~0.56%), 총당 함량(2.35~3.42%) 그리고 고형분 함량(3.25~12.20%)은 비교적 낮았다. 미량 알코올은 17종이 검출되었으며 이중에서 fuse1 oil성분인 3-methyl-1-butanol(1.495~2.595), 2-phenyl ethanol(1.032~l.923), 2-methyl-1-propanol(0.081~0.151), 2,3-butanediol(0.005~0.015) 등의 면적 비을이 높게 검출 되었다. 유기산은 acetic acid(0.052~0.146) 와 ethyl benzoic acid(0.071~0.140)의 면적 비율이 높게 나타났으며 탁주 B와 D 에서는 10종의 유기산이 검출되였으나 탁주 A에서는 8종, 탁주 C에서는 7종이 검출되었다. Ester는 총 20종이 검출 되었으며 butanoic acid, ethyl ester(0.005~0.299), acetic acid, ethyl ester(0.002~0.072), methyl phenidate(0.025~0.070)가 높은 면적 비을로 검출되였다. 그외에 4-hydroxy-3-hexanone, butyrolactone methylthio propanone과 같은 carbonyl 화합물과 N-methyl octyl amine과 같은 amine류도 미량 검출 되였다. Two kinds of unsterilized market takju(takju A, B) and two kinds of sterilized market takju(takju C, D) were analyzed for their conponents and the results were as follows. According to the Liquor Tax Law the alcohol contents of market takju are allowed in the range of 6 to 8% and the total acid contents are provided under 0.5%. And the alcohol contents of takju A and B were 7.5 and 6.5%, respectively which were satisfied to the Law but the alcohol contents of takju B and C were 5.0 and 4.8% respectively which were less than about 1% to the Law. The total acid contents of takju were in the range of 0.27 to 0.42% which were proper concentrations to the Law. The amino nitrogen contents(0.38~0.56%), the total sugar contents(2.35~3.42%) and the extract contents(3.25~12.20%) were detected relatively low. Seventeen kinds of alcohols were detected in four kinds of takju and 3-methy-1-butanol(1.495-2.595), 2-phenyl ethanol(1.032~1.923), methyl-1-propanol(0.081~0.151) and 2, 3-butanediol(0.005~0.015) were detected in higher percentages of peak area than other alcohols. Ten kinds of organic acids were detected in takju B and D restectively but in takju A eight kinds and in takju C seven kinds of organic aicds were detected. Among these acids acetic acid(0.052~0.146) and ethyl benzoic acid(0.071~0.140) were detected in higher percentages of peak area than other organic acids in the four kinds of takju. Total twenty kinds of esters were decteted in the four kinds of takju and butanoic acid, ethyl ester(0.005~0.299), acetic acid, ethyl ester(0.002~0.072) and methyl phenidate(0.025~0.070) were detected in higher percentages of peak area than other esters in the four kinds of takju. Besides, minor amounts of carbonyl compounds such as 4-hydroxy-3-hexanone, butyrolactone, 3-methyl thio-1-propanone and an amine compound such as N-methyl octyl amine were also detected in takju.

아미노글리코사이드 사용제한에 따른 병원성 균혈증 유발 그람음성간균의 내성변화 및 임상적 의의

오종택,김신우,손종원,도병훈,한승우,신병철,박지현,이종명,김능수 대한감염학회 2003 감염과 화학요법 Vol.35 No.4

목적 : 항균제 오남용으로 인한 내성균의 출현, 약물부작용의 발생 및 약제 비용의 증가는 환자 개인뿐만 아니라 사회적으로 문제가 되고 있다. 본 연구는 항생제의 오남용을 막기 위한 제도의 일환으로 시행한 아미노글리코사이드 사용 제한정책의 비용 효과적인 측면을 조사하고 그람음성간균에 의해 병원성 균혈증이 발생한 환자들을 대상으로 이 정책이 항생제 내성률과 환자 사망률에 미치는 영향을 연구하였다. 방법 : 930병상 규모의 3차 병원인 일개 대학병원에서 아미노글리코사이드 사용제한정책이 시행된 직후인 2002년 3월에서 9월 사이에 그람음성간균(Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Stenotrophomonas maltophilia, Burkholderia cepacia)에 의해 발생한 병원성 균혈증 환자 60명(실험군)과, 이 정책이 시행되기 전에 입원한 환자들 중 균주별로 같은 수만큼 선별한 병원성 균혈증 환자 60명(대조군)의 의무기록을 후향적으로 조사하였다. 결과 : 아미노글리코사이드 사용제한정책이 시행된 시기인 2002년 3월에서 9월 사이에 처방된 아미노글리코사이드 사용량 및 비용을 이 정책이 시행되기 전인 2001년 3월에서 9월 사이와 비교한 결과, 아미노글리코사이드의 사용량(antimicrobial utilization density)은 사용제한 후 225.2에서 130.3으로 42% 감소하였고 약제 비용은 44% 감소하였다. 아미노글리코사이드 사용제한 후 병원성 균혈증을 유발한 그람 음성간균의 이 항생제에 대한 내성률은 유의한 변화를 보이지 않았으며 균혈증과 직접 연관된 사망률도 환자의 나이, 성별, 기저질환 및 원발병소 등을 보정할 경우 유의한 차이를 보이지 않았다(40.4% vs. 24.1%, P=0.11). 결론 : 아미노글리코사이드를 5일을 초과한 사용 시 감염전문가의 사전 승인을 필요로 하는 사용제한정책은 아미노글리코사이드의 사용량과 비용을 유의하게 감소시켰다. 또한 이 정책 시행 후 그람음성간균에 의한 균혈증 환자에서 균혈증으로 인한 사망률과 아미노글리코사이드에 대한 내성률은 유의한 차이가 없었다. Objective : To evaluate the effects of an aminoglycoside restriction policy on expenditures for aminoglycosides, antimicrobial resistance rates and clinical outcome of nosocomial bacteremia caused by Gram-negative bacilli (GNB). Methods : Starting in February, 2002, a prior consultation with an infectious disease specialist for using aminoglycoside antibiotics over 5 days was required in a 930-bed university hospital. In retrospective analysis of medical records 7 months after initiation of the aminoglycoside restriction policy, sixty cases of clinically relevant nosocomial bacteremia caused by GNB were found. These bacteremic patients were compared with sixty, species-matched, control patients with nosocomial Gramnegative bacteremia before the policy for total expenditures for aminoglycosides, susceptibility to antibiotics and clinical outcomes of bacteremia. Results : During the same period of 7 months before and after the restriction policy, total expenditures for aminoglycosides decreased by 44% in cost (from 465,030,841 Won to 259,618,337 Won) and the antimicrobial utilization density of aminoglycosides decreased by 42% (from 225,2 to 130.3). On the other hand, the patterns of antibiotic susceptibility and bacteremia-related in-hospital mortality rates after the policy did not show a significant change, compared with those before the policy. Conclusion : Antibiotic restrictions are among the most popular methods to diminish the practice of antibiotic overuse in hospitals. In this study, requirement for prior approval of aminoglycoside use over 5 days led to a significant decrease in the amount and cost of total aminoglycosides without a significant change in susceptibility patterns and bacteremia-related mortality rates.

참나무 亞屬 주요 수종의 물리적 성질에 따른 역학적 성질에 관한 연구(Ⅱ) : 휨강도 Bending strength

吳承源,韓哲洙 全北大學校 1995 論文集 Vol.40 No.-

This study was carried out in order to get some basic data for wood rationally utilization by means of clearing mechanical properties which were lived in korea. Six lepidobalanus such as Quercus variabilis, Q. aliena, Q. serrata, Q. mongolica, Q. acutissima, Q. dentata were used for this research. The summarised results of this study were as following. 1) To the moisture content increased, bending strength and modulus of elasticity were inclined to decrease. 2) To the specific gravity increased, bending strength and modulus of elasticity were inclined to increase.