A case of primary cutaneous γ/δ T-cell lymphoma

( Seung Dohn Yeom ),( Hee Sung Yoon ),( Si Hyub Lee ),( Hye Soo Ko ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Primary cutaneous γ/δ T-cell lymphoma(CGD-TCL) is a rare variant of peripheral T-cell lymphoma and highly aggressive tumor that is often resistant to treatment. Ulcero-necrotic nodules develop commonly on the extremities, especially thighs and gluteal region. Histopathology shows proliferation of small/medium to large sized pleomorphic lymphocytes. On immunohistochemical staining, it usually has a CD2+, CD3+, CD7+/-, CD8+/-, and CD56+/- with strong expression of cytotoxic proteins such as TIA-1, granzyme B, and perforin. It is need to be differentiated from other cutaneous lymphoma. Cutaneous α/β T-cell lymphoma usually has a CD4-, CD8+, CD56-, and TCRβF1+. Cutaneous anaplastic large cell lymphoma is composed of palisading large anaplastic cells with strong positivity for CD30 and extranodal NK/T cell lymphoma has a CD56+, and EBV. A 63-year-old woman presented with 2 month history of ulcerative lesion on the left thigh. Histopathological examination showed complete necrosis of the epidermis and dense infiltration of medium to large sized lymphocytes with conspicuous apoptotic figures. The results of immunohistochemical staining showed expression of CD8, CD56, TIA-1, and granzyme B. She was diagnosed as CGD-TCL and cutaneous lesions were improved after chemotherapy at hemato-oncologic department.

P0100 : A case of Vancomycin-induced Linear IgA dermatosis

( Seung Dohn Yeom ),( Hye Soo Ko ),( Jong Hyuk Moon ),( Min Ji Kang ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

Chondroid syringoma: a clinical and histopathological review of 14 patients

( Seung-dohn Yeom ),( Hee-sung Yoon ),( Si-hyub Lee ),( Hye-soo Ko ),( Jeonghyun Shin ),( Gwang-seong Choi ),( Ji-won Byun ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Chondroid syringoma is a skin adnexal tumor composed of mixed epithelial and mesenchymal components, and is known as a mixed tumor. It is usually asymptomatic solitary and most often affects the head and neck. Most tumors are classified as apocrine type and shows well-defined nodule in which a dominant component has chondroid appearance. In some cases, the epithelial components show additional foci of follicular and sebaceous differentiation. The myoepithelial components may show hyaline, spindled cells and clear cells differentiation, and rarely osteoid with marrow spaces. Objectives: To determine the clinical and histolopathological findings of the cases diagnosed with chondroid syringoma. Methods: Seventeen skin biopsy specimens from total 14 patients diagnosed as chondroid syringoma were selected and reevaluated clinically and histopathologically. Results: The mead age of patients was 50.1 years(from 36 to 66). There were 10 male and 4 female. The biopsy specimens of all 14 patients showed the combination of epithelial and myoepithelial cells within chondromyxoid and fibrous stroma. Two patients who presented with the tumor on the scalp showed ossification. The folliculosebaceous differentiation was found in 3 patients who presented with the tumor on the eyelid and scalp. In two patients, hyaline metaplasia was found. Conclusion: Chondroid syringoma shows a variety of histopathological differentiation including ossification, folliculosebaceous and hyaline metaplasia.

Efficacy of low-dose intravenous immunoglobulin for treating chronic urticaria

( Seung Dohn Yeom ),( Si Hyub Lee ),( Ji Hye Heo ),( Hee Seong Yoon ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: The several treatment of chronic urticaria (CU) have been studied in several trials, but there have been few studies on the effect of low-dose IVIG. Objectives: The authors investigated the quality of life(CU-Q2oL), urticaria severity score(USS), urticaria activity score(UAS), and Skindx29 of the Korean patients with CU before the IVIG treatment, and assessed the quality of life and clinical outcome after IVIG treatment. Methods: A total six patients who suffered from persistent CU despite conventional treatments were administered 150mg/kg/month of IVIG at every 4 weeks. All of patients were asked to complete a questionnaire about the effect of CU of their QOL and assessed the clinical symptoms of CU at each treatment. Results: All of patients completed the medication at least 3 months. All of patients reported improvement of the symptoms and QOL after treatment of low-dose IVIG. In all patients, the UAS and USS score were improved from 5.6 to 2.8, and from 45.7 to 31, respectively. The CU-Q2oL score and Skindex29 score were measured from 69.0 to 48.6 and from 85.4 to 65.6, respectively. CU-Q2oL and Skindex29 had a statistically significant correlation. In addition, UAS had a statistically significant correlation with USS. There was a statistically significant correlation between CU-Q2oL and USS. Conclusion: This study shows that IVIG may be an efficacious treatment option for recalcitrant patients with CU.

A case of localized bullous pemphigoid (Brunsting- Perry type)

( Seung Dohn Yeom ),( Jong Hyuk Moon ),( Hye Soo Ko,Si ),( Hyub Lee ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Brunsting-Perry type pemphigoid is a rare subtype of bullous pemphigoid characterized clinically by recurrent blisters and vesicles localized on the face and scalp. The pathogenic antigen of Brunsting-Perry type pemphigoid is not fully understood. A 53-year-old man presented with seven-month history of pruritic erythematous vesicles, bullae and crusts on the face and scalp. Histopathological examination showed subepidermal vesicle formation containing neutrophils, lymphocytes and eosinophils. Infiltration of lymphocytes and eosinophils in perivascular, periadnexal, and interstitial dermis were seen. The results of direct immunofluorescence staining showed linear IgG deposition at the dermo-epidermal junction. He is treated with dapsone and topical corticosteroid. Localized bullous pemphigoid was reported to have a better prognosis than bullous pemphigoid.

Efficacy and safety of adipocyte-derived stem cell conditioned media in the treatment of androgenic alopecia

( Seung Dohn Yeom ),( Seon Bok Lee ),( Ji Hye Heo ),( Heo Seong Yoon ),( Si Hyub Lee ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Androgenic alopecia(AGA) is a common disease and characterized by the gradual hair loss. Although several treatments have been developed to treat AGA, there are still limitations. Adipocyte-derived stem cell conditioned media (SCM2^®-Black) contains several growth factors, extracellular matrix, and cytokines, therefore it induce cell proliferation, tissue reproduction, and anti-apoptotic effects. Objectives: To evaluate AGA improvement and safety of stem cell conditioned media in AGA patients. Methods: A total 20 patients with AGA were enrolled. AGA area of each patient was divided into 2 sides, the control and test side. Each side had the hair cut in 1㎠ and had been applied normal saline and stem cell conditioned media, respectively. MTS-roller stamp was immediately used to penetration of the materials and the same amount of each material was applied once again. Patients had been applied both materials while visiting every week for the first month and every 2 weeks after 3 months. All patients took phototrichogram in 1㎠ to count number of hair at every 2 weeks. Results: The test side show statistically significant increase the number of hair compare with the control site (p = 0.024). The number of hair in the test side increased from 129.45 to 147.05, however, the control side showed increase from 133.05 to 142.60. No patients had adverse effects. Conclusion: Stem cell derived agents, in this study, can be an alternative treatment for the patients with recalcitrant AGA.

A case of warty carcinoma

( Seung Dohn Yeom ),( Jong Hyuk Moon ),( Hye Soo Ko ),( Si Hyub Lee ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Warty carcinoma(WC) is a rare variant of low to intermediate-grade, slow-growing squamous cell carcinoma.WC is considered as a subtype of verruciform penile tumor and commonly develops in the penis and anogenital area. WC is characterized by exophytic, cauliflower-like or verrucous appearance and primarily associated with human papilloma virus-16 infection. The precursor lesion of WC may be preexisting condyloma acuminatum that underwent malignant transformation or a squamous intraepithelial lesion with warty features. Histologic features of WC are central fibrovascular cores, koilocytotic atypia, and irregular or broad pattern of tumor base. The differential diagnosis of WC is verrucous carcinoma and typical squamous cell carcinoma(SCC). Verrucous carcinoma arises on the oral cavity, genitoanal, and plantar area, and histologically shows lack of a central fibrovascular core and koilocytotic atypia. SCC arises most commonly in sun-damaged skin and histologically shows no koilocytotic atypia. As compares with conventional SCC, WC shows a less aggressive clinical course and confers a better prognosis. A 71-year-old man presented with a 3.5-year history of an asymptomat, 4.0 x 3.0cm sized verrucous nodule on the Lt. perineum area. Excisional biopsy was taken on the lesion and it showed typical histologic features of WC with focal microscopic invasion. We report the first case report of warty carcinoma in Korean dermatologic literature.

A case of bullous lichen planus

( Seung Dohn Yeom ),( Jong Hyuk Moon ),( Hye Soo Ko,Si ),( Hyub Lee ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Lichen planus(LP) is a relatively common chronic inflammatory dermatosis involving the skin, mucous membranes, nails, and the scalp. Bullous LP is a rare variant which usually presents with blisters occurring over typical lesions of LP. The bullae, which appear most commonly on the extremities, arise from existing papules of LP and rarely from normal-appearing skin. 29-year-old woman presented with recurrent pruritic erythematous scaly crusted patches and tense bullae with erosion on the back, chest, forearms, and ulcerative mucosal lesion for 4 years. Histologic finding showed massive necrotic keratinocytes with subepidermal seperation, lichenoid lymphohistiocytic infiltrations and perivascular lymphocyte infiltrations. The result of direct immunofluorescence staining was no specific finding

[P347] Iatrogenic kaposi sarcoma by capecitabine

( Seung Dohn Yeom ),( Ji Hye Heo ),( Hee Sung Yoon ),( Si Hyub Lee ),( Ji Won Byun ),( Gwang Seong Choi ),( Jeonghyun Shin ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Kaposi sarcoma (KS) is a lymphoangioproliferative neoplasm induced by human herpes virus 8 (HHV-8). Four clinical variants have been recognized: classical, African endemic, AIDS-related, and KS induced by iatrogenic immunocompression. The latter is typically associated with the use of immunosuppressive therapy in organ transplant recipients, cancer and autoimmune disorders. It shows painless purplish-red patches or nodules particularly on the lower limb, especially toes and soles. We describe a 61-year-old man presented with asymptomatic dusky erythematous patches on the left toes and asymptomatic dusky erythematous nodule on the left ear-helix for a month. He had been diagnosed with rectosigmoid cancer 16 months ago and treated with chemotherapy (capecitabine, Xelobig^®) before the visit to the dermatologic outpatient clinic. Histopathological findings of the left ear-helix lesion revealed that spindle cell proliferations in dermis and irregular vascular structures among collagen bundles. In immunohistochemical staining, CD31 and HHV-8 were positive. The lesions improved without specific treatment within 2 months after discontinuation of capecitabine. To the best of our knowledge, this is the second case of iatrogenic KS induced by chemotherapy and the first case induced by capecitabine in Korean dermatologic literature.

Two cases of basal cell nevus syndrome improved with oral COX-2 inhibitor

( Seung Dohn Yeom ),( Jong Hyuk Moon ),( Hye Soo Ko ),( Si Hyub Lee ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Basal cell nevus syndrome(BCNS) is a rare autosomal dominant disorder characterized by developmental anomalies and postnatal tumors, especially basal cell carcinomas(BCCs). The therapeutic options to treat BCC includes surgical treatment, cryosurgery, CO2 laser, topical photodynamic therapy, and topical agent such as imiquimod and 5-FU. Recently, cyclo-oxygenase(COX)-2 inhibitors has been reported as a potentially useful treatment in the chemoprevention of non-melanoma skin cancer and has known to decrease BCC development and reduce tumor burden. The first case was a 62-year-old woman who presented with asymptomatic multiple black colored papules and plaques on the face and scalp. She was diagnosed as BCNS and treated with oral COX-2 inhibitor for 5 months. The multiple small BCCs on her face and scalp decreased in the number and the burden of BCCs. The second case was a 81-year-old woman who presented with a hemorrhagic nodule on the left temporal scalp and multiple black colored papules and plaques on the neck. She was diagnosed as BCNS and treated with oral COX-2 inhibitor for 6 months after Mohs microscopic surgery. The multiple small BCCs on her neck decreased in the number and prevented development of new lesions. We present the first two cases of BCNS improved with COX2 inhibitor(celecoxib) in Korean dermatologic literature.