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A Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer
Seul Gi Lee,Seung Hyuk Yim,Woo Kyung Lee,Sun Hyung Choi,Hyunji Kim,Seonhyang Jeong,Cho Rok Lee,Sang Wook Kang,Jong Ju Jeong,Kee-Hyun Nam,Woong Youn Chung,Young Suk Jo,Jandee Lee 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11
( Seul Kee Kim ),( Jae Kwan Lee ),( Se Hwan Park ),( Beom Seok Chang ),( Si Young Lee ),( Heung Sik Um ) 조선대학교 구강생물학연구소 2016 Oral Biology Research (Oral Biol Res) Vol.40 No.1
Although various instruments have been devised to treat peri-implantitis, none has become the technique of choice. Recently, a new implant cleaning bur was introduced. We compared the surface roughness and bacterial adhesion on implants after surface cleaning with various instruments. Two types of titanium disks - resorbable blasting media (RBM) and sandblasting with large grit and acid etching (SLA) - were used. Following treatments were administered: (1) no treatment; (2) tetracycline; (3) implant cleaning bur; (4) air polisher with glycine powder; and (5) copper alloy ultrasonic scaler tip. We measured the titanium surface roughness after cleaning. We also observed surface changes with scanning electron microscopy, and evaluated the bacterial adhesion related to changes in surface roughness. The surface roughness of RBM disks decreased significantly only in the third group. SLA disks in the third and fifth groups showed significantly decreased roughness. No significant difference in bacterial adhesion was found on treated RBM surfaces. The third and fifth groups also had significantly decreased bacterial adhesion on the SLA surfaces. The implant cleaning bur reduced the roughness of RBM and SLA titanium implants, and decreased the adhesion of bacteria on SLA surfaces, which may help prevent the recurrence of peri-implantitis.
( Seul Kee Lee ),( In Young Kim ),( Hye Min Jeong ),( Hyung Jin Kim ),( Jae Joon Lee ),( Hoon Suk Cha ),( Eun Mi Koh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background/Objectives: The aim of this study was to investigate the radiographic changes in patients with gout in association with the control of serum uric acid level. Methods: Sixty one patients who had at least one erosive change on baseline radiography were included. Follow up radiography was taken at least 5 years apart from baseline radiograph. The primary endpoint was changes in the radiographic damage scores based on modifi ed Sharp/van der Heijde (mSvH) score in association with the control of serum uric acid level. Patients were divided by three groups which consist of improved, no change, aggravated patients for subgroup analysis. Results: The mean age was 55±13 years and 60 (98%) patients were male. Disease duration was 11±7 years and mean serum uric acid level was 8.8±1.9 mg/dL at baseline. Follow up duration between two radiographies was 10.8±3.6 years. All patients were receiving urate-lowering therapy. The change in the mean mSvH score between baseline and follow visit was not statistically signifi cant (6.77 vs. 6.69, respectively). The number of patient in improved, no change, aggravated groups was 22, 14, and 25 and the baseline plain radiographic damage score was 12.1, 4.85, and 3.7 respectively. As expected, the change in damage scores was positively correlated to AUC of uric acid level (r = 0.32, p=0.01). The patients with longer disease duration at baseline were more likely to have improvement in the follow up radiograph. (r = -0.46, p=0.004). In improved group, only the change of damage scores was negatively associated with disease duration at baseline (r = -0.48, p = 0.024). Conclusions: Our study demonstrated that radiographic damage in gout may be reversible to some extent and that the magnitude of improvement depends on the degree of serum uric acid control.
Lee, Seul-Kee,Moon, Kyung-Sub,Lee, Kyung-Hwa,Jung, Shin The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.53 No.6
The abducens nerve paresis generally can aid in the presumptive diagnosis of abducens schwannoma along with the typical radiological features of schwannomas. The authors present a case of a 76-year-old male patient with a abducens schwannoma without abducens nerve paresis. Peroperatively, abducens nerve located in the cerebellopontine cistern had normal in contour and diameter, despite the mass originated from this nerve. We hypothesize that anatomic location of abducens nerve may affect the vector of tumor growth to prevent destruction of its origin, the abducens nerve.
Optimal Cut-Off Values of Lymph Node Ratio Predicting Recurrence in Papillary Thyroid Cancer
Lee, Seul Gi,Ho, Joon,Choi, Jung Bum,Kim, Tae Hyung,Kim, Min Jhi,Ban, Eun Jeong,Lee, Cho Rok,Kang, Sang-Wook,Jeong, Jong Ju,Nam, Kee-Hyun,Jung, Sang Geun,Jo, Young Suk,Lee, Jandee,Chung, Woong Youn Wolters Kluwer Health 2016 Medicine Vol.95 No.5
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Regional lymph node (LN) metastasis has a significant impact for prediction of recurrence in patients with papillary thyroid cancers (PTC); however, the prognostic value of the lymph node ratio (LNR), which is defined as the ratio of the number of metastatic LNs to the total number of investigated LNs, is controversial. In this study, we determined the optimal cut-off values of LNRs for the prediction of recurrence in PTC patients.</P><P>This large cohort study retrospectively evaluated 2294 patients who had undergone total thyroidectomy for PTC at a single institution from October 1985 to June 2009. The prediction probability of central LNR (cLNR, level VI) and total LNR (tLNR, levels II–VI) were estimated by binominal logistic regression analysis. Hazard ratios of the cut-off LNR values for cancer recurrence were calculated for relevant covariates using multivariate Cox regression analyses. Kaplan–Meier analyses were also utilized to assess the effects of estimated LNR cut-off values on recurrence-free survival (RFS).</P><P>Of the 2294 patients, 138 (6.0%) presented cancer recurrence during the follow-up period (median duration = 107.1 months). The prediction probability indicated that LNRs of 0.4 and 0.5 for central LN and total LN, respectively, are optimal cut-off values for precise prediction with minimization of outliers. Multivariate Cox regression analyses revealed that cLNR ≥0.4 was independently predictive of recurrence in patients with N0 and N1a PTCs (hazard ratio [HR]: 7.016, 95% confidence interval [CI]: 3.72–12.986, <I>P</I> < 0.001) and that tLNR ≥0.5 indicated a significantly increased risk of recurrence in patients with N1b PTCs (HR: 2.372, 95% CI: 1.458–3.860, <I>P</I> < 0.001). In addition, Kaplan–Meier analyses clearly demonstrated that these LNR cut-off values are precisely operational in RFS estimation.</P><P>The cut-off LNR values of 0.4 and 0.5 for cLNR and tLNR, respectively, were identified. Risk stratification combined with these LNR cut-off values may prove useful to determine treatment and follow-up strategies for PTC patients.</P></▼2>