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박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3
부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.
경과 관찰 중에 폐감염이 동반된 선천성 낭성 선종양 기형 1예
김정아,이석현,오동훈,김종연,허진원,이성순 인제대학교 2006 仁濟醫學 Vol.27 No.-
We reported a case of congenital cystic adenomatoid malformation (CCAM), diagnosed two years ago, has been infected during medical observation. She underwent VATS guided right lower lobectomy because of little response to the medical treatment. The prognosis turned out to be excellent and now she is under regular medical observation. Management of asymptomatic CCAM still has a likelihood of controversy but the early surgical resection is recommended on a basis of a variety of reference and literature to verify the diagnosis and lessen the risk of infection or malignant degeneration. Moreover the early surgical intervention has a good prognosis settling complications. Recently VATS lobectomy is considered as an alternative strategy for CCAM, and the early surgical resection may be an ideal approach for asymptomatic CCAM.
쌀보리 품종 및 도정률에 따른 항산화 및 Tyrosinase 저해 활성 평가
이석기(Seuk Ki Lee),우관식(Koan Sik Woo),이해림(Haelim Lee),이지혜(Jihae Lee),이병원(Byong Won Lee),이유영(Yu-Young Lee),이병규(Byoungkyu Lee),김선림(Sun Lim Kim),김현주(Hyun-Joo Kim) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.12
쌀보리를 식품 및 공중보건산업에서 기능성 소재로서의 활용가능성을 알아보고자 쌀보리 품종(새찰쌀, 흰찰쌀, 새쌀) 및 도정률(95%, 85%, 75%)에 따른 항산화 및 tyrosinase 저해 활성을 평가하였다. 각각의 시료를 70% 에탄올에 1:10의 비율로 48시간 추출하여 여과 후 동결건조 하여 실험에 사용하였다. 95% 도정률을 기준으로 한 쌀보리 추출물의 DPPH 라디칼 소거능이 각각 5.90, 4.63 및 17.57 mg TE/g sample로 나타났으며, FRAP 값을 측정한 결과 새쌀보리 추출물이 1,041.53 μM로 가장 높은 환원력을 가지는 것으로 확인되었다. 새찰쌀, 흰찰쌀 및 새쌀보리 추출물의 tyrosinase 저해 활성이 각각 30.64, 38.62 및 60.64%로 새쌀보리 추출물이 가장 높은 활성을 보였다. 총 폴리페놀 함량 측정 결과 새쌀보리 추출물은 172.51 μg GAE/g sample, 새찰쌀보리 48.87 μg GAE/g sample, 흰찰쌀보리 44.58 μg GAE/g sample로 높은 수치를 나타냈으며, 품종 및 도정률에 따른 플라보노이드 함량 측정 결과 총 폴리페놀 함량 결과와 경향이 동일하게 나타났다. 쌀보리의 도정률이 증가할수록 맥강에 함유되어 있는 폴리페놀 및 플라보노이드 등과 같은 기능성분이 제거됨에 따라 항산화 및 미백 등의 생리활성에 영향을 미친 것으로 판단된다. 이상의 결과를 종합하여 볼 때 쌀보리의 품종 및 도정률에 따라 항산화 및 tyrosinase 저해 활성의 차이를 보였으며, 쌀보리를 이용한 기능성 제품의 개발에 있어서 중요한 기초자료로 활용될 수 있을 것이라고 판단된다. The purpose of this study was to evaluate the effects of barley cultivars [Saechalssalbori (SC), Huinchalssalbori (H), and Saessalbori (S)] and different milling recovery rates (95%, 85%, and 75%) on antioxidant and tyrosinase inhibitory activities. Results show that the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities of SC, H, and S extracts based on 95% coverage were 5.90, 4.63, and 17.57 mg Trolox equivalent/g sample, respectively. The ferric-reducing antioxidant potential (FRAP) value of S extract with 95% milling recovery was the highest at 1,041.53 μM. Tyrosinase inhibitory activities of SC, H, and S extracts were 30.64, 38.62, and 60.64%, respectively. Total polyphenol contents of SC, H, and S extracts based on 95% coverage were 48.87, 44.58, and 172.51 μg gallic acid equivalent/g sample, respectively. The total flavonoid content was highest in S extract with 95% milling recovery. The DPPH radical scavenging activity, FRAP value, tyrosinase inhibitory effect, total polyphenol, and flavonoid contents of barley extracts were reduced as milling recovery rate decreased. The results of this study suggest that milling recovery and cultivar of barley are important factors to improve the antioxidant and tyrosinase inhibitory activities of barley.
Lee, Kyung Ha,Woo, Koan Sik,Yong, Hae In,Jo, Cheorun,Lee, Seuk Ki,Lee, Byong Won,Oh, Sea-Kwan,Lee, Yu-Young,Lee, Byoungkyu,Kim, Hyun-Joo Korean Society of Food Science and Technology 2018 Food Science and Biotechnology Vol.27 No.3
The microbial and physicochemical properties of brown and white cooked rice treated by atmospheric pressure plasma (APP). APP was produced (250 W, 15 kHz, ambient air) and applied to brown and white cooked rice for 5, 10, and 20 min. The 20-min plasma treatment reduced in bacterial counts by 2.01 log CFU/g when cooked rice were inoculated with Bacillus cereus or Escherichia coli O157:H7. The pH of the brown cooked rice was decreased by the 5-min plasma. The hardness values of APP-treated brown and white cooked rice were lower than untreated samples. The reducing sugar contents of brown and white cooked rice were significantly higher than those in untreated samples. Lipid oxidation of APP-treated brown and white cooked rice were higher compared to untreated samples. These results indicate that APP improves microbial quality, although further studies should be conducted to change the physicochemical qualities of brown and white cooked rice induced by APP.
Novel Reassortant Influenza A(H5N8) Viruses, South Korea, 2014
Lee, Youn-Jeong,Kang, Hyun-Mi,Lee, Eun-Kyoung,Song, Byung-Min,Jeong, Jipseol,Kwon, Yong-Kuk,Kim, Hye-Ryoung,Lee, Kyu-Jun,Hong, Mi-Seon,Jang, Il,Choi, Kang-Seuk,Kim, Ji-Ye,Lee, Hyun-Jeong,Kang, Min-Su U.S. Department of Health and Human Services * Cen 2014 Emerging Infectious Diseases Vol.20 No.6
Lee, Eun-Kyoung,Kang, Hyun-Mi,Kim, Kwang-Il,Choi, Jun-Gu,To, Thanh Long,Nguyen, Tho Dang,Song, Byung-Min,Jeong, Jipseol,Choi, Kang-Seuk,Kim, Ji-Ye,Lee, Hee-Soo,Lee, Youn-Jeong,Kim, Jae-Hong Elsevier 2015 Poultry science Vol.94 No.4
<P>In spite of highly pathogenic avian influenza H5N1 vaccination campaigns for domestic poultry, H5N1 viruses continue to circulate in Vietnam. To estimate the prevalence of avian influenza virus in Vietnam, surveillance was conducted between November 2011 and February 2013. Genetic analysis of 312 highly pathogenic avian influenza H5 viruses isolated from poultry in Vietnam was conducted and possible genetic relationships with strains from neighboring countries were investigated. As previously reported, phylogenetic analysis of the avian influenza virus revealed two H5N1 HPAI clades that were circulating in Vietnam. Clade 1.1, related to Cambodian strains, was predominant in the southern provinces, while clade 2.3.2.1 viruses were predominant in the northern and central provinces. Sequence analysis revealed evidence of active genetic evolution. In the gene constellation of clade 2.3.2.1, genotypes A, B, and B(II) existed during the 2011/2012 winter season. In June 2012, new genotype C emerged by reassortment between genotype A and genotype B(II), and this genotype was predominant in 2013 in the northern and central provinces. Interestingly, enzootic Vietnamese clade 2.3.2.1C H5 virus subsequently reassorted with N2, which originated from wild birds, to generate H5N2 highly pathogenic avian influenza, which was isolated from duck in the northeast region. This investigation indicated that H5N1 outbreaks persist in Vietnam and cause genetic reassortment with circulating viruses. It is necessary to strengthen active influenza surveillance to eradicate highly pathogenic avian influenza viruses and sever the link between highly pathogenic avian influenza and other circulating influenza viruses.</P>