리네졸리드로 치료한 반코마이신 내성 Enterococcus faecium 뇌수막염 : 증례보고 및 문헌고찰

이창섭,박성주,이용철,이양근,이흥범 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Vancomycin-resistant enterococci (VRE) infection is a serious problem because optimal therapy has not been established. Different agents in various combinations, including teicoplanin, chloramphenicol, and quinupristin/dalfopristin, have been used to treat patients with VRE meningitis, but the efficacy of these agents is not satisfactory because of their limited ability to penetrate into the cerebrospinal fluid. We report a case of nosocomial vancomycin-resistant Enterococcus faecium meningitis in a patient with ventriculoperitoneal shunt that was successfully treated with linezolid. We will also review previously reported cases of vancomycinresistant E. faecium meningitis treated by linezolid.

중학교 과학 교과서 분별 증류 실험의 비교 분석 및 개선

柳五鉉,崔文永,宋周眩,권정근,白盛惠,朴國泰 한국교원대학교 과학교육연구소 2001 청람과학교육연구논총 Vol.11 No.1

이 연구의 목적은 제 6차 교육과정에 의한 중학교 1학년 과학 교과서 분별 증류 실험의 문제점을 파악하고, 중학생들이 분별 증류 실험을 능률적으로 수행할 수 있는 실험 방법을 제시하고자 하는 것이다. 이를 위한 첫 번째 단계로서 현재 사용되고 있는 8종의 과학 교과서를 분별 증류 실험 장치와 액체 혼합물의 종류에 따라 6가지로 분류하였다. 두 번째 단계로서 액체 혼합물을 가열 방법에 따라 직접가열과 물 중탕 가열로 나누어 교과서 실험과정에 따라 같은 실험을 세 번 실시하였다. 세 번째 단계로서 실험 결과의 문제점을 해결하기 위한 대안 실험을 실시하였다. 대안 실험에서는 알코을 램프로 직접가열 하는 방법과 기름 중탕으로 가열하는 방법, 그리고 가열 맨틀을 사용하여 가열하는 방법을 사용하였다. 연구결과, 가지 달린 둥근 플라스크를 직접 가열하는 실험 결과가 가지 달린 시험관을 물 중탕으로 가열하는 실험 결과보다 이론적인 결과에 근접하였다. 그리고 가지 달린 둥근 플라스크를 직접 가열하는 실험에서 플라스크 윗 부분을 보온해 주는 실험이 보온하지 않은 실험보다 실험 결과가 더 나았다. 대안 실험에서는 액체 혼합물의 증류 온도 증가를 보면서 가열 맨틀의 가열 온도를 을려 준 실험의 결과가 이론적인 결과에 가장 가까웠다. 이러한 연구 결과로부터 가지 달린 시험관을 물 중탕으로 가열하는 분별 증류 실험 장치는 탐구실험 수업에 부적절한 것이므로 개선이 요구되며, 중학교 과학실 여건을 고려할 때, 액체 혼합물의 증류 온도 증가를 보면서 가열 맨틀의 가열 온도를 변화시키는 분별 증류 실험이 가장 능률적인 방법임을 알 수 있었다. The purpose of this study was to find out the problems on the fractional distillation experiments in the middle school science textbooks based on the 6th curriculum and to suggest an efficient experiment method for the middle school students. The first step was the classification of the experiments in 8 science textbooks according to heating apparatus and liquid mixtures. The second step was doing each experiment 3 times followed by the experimental process in the textbooks. The third step was developing the alternative experiments for solving the problems found in the second step. The heating method used in the alternative experiments were direct heating, oil bath, and heating mantle. The results of the second step showed that the direct heating experiment of branched round flask was more close to the theoretical prediction than the experiment of water bath heating of branched test tube. Also the direct heating experiment of thermally insulated branched round flask was better than the result of the experiment which was not insulated. The results of the third step showed that the experiment using heating mantle regulated heating power by observing the temperature of distillate gave the closest result to the theoretical prediction. From the above results, it is concluded that the experiment using branched test-tube with water bath heating is not adequate for the fractional distillation and an alternative experiment using insulated branched round flask with heating mantle regulated heating power during experiment is recommended.

Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.

Park, Seoung Ju,Lee, Kyung Sun,Kim, So Ri,Min, Kyung Hoon,Choe, Yeong Hun,Moon, Hee,Chae, Han Jung,Yoo, Wan Hee,Lee, Yong Chul Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.5

<P>Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a critical role in the control of airway inflammation. Recently, IL-17 has been found to be implicated in many immune and inflammatory responses, including airway inflammation. However, no data are available concerning the effect of PPARgamma on IL-17 production in airway inflammatory diseases. In this study, we used a mouse model of asthma to evaluate the effect of two PPARgamma agonists, rosiglitazone or pioglitazone, on IL-17 expression in allergic airway disease. After OVA inhalation, mice developed the typical pathophysiological features of asthma, and the expression of IL-17 protein and mRNA in the lungs was increased. Administration of rosiglitazone or pioglitazone reduced the pathophysiological features of asthma and decreased the increased IL-17 protein and mRNA expression after OVA inhalation. In addition, the attenuating effect of PPARgamma agonist on allergic airway inflammation and bronchial hyperresponsiveness is abrogated by coadministration of rIL-17. This study also showed that the inhibition of IL-17 activity with anti-IL-17 Ab remarkably reduced the increased numbers of inflammatory cells of the airways, airway hyperresponsiveness, and the increased levels of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and OVA-specific IgE in serum. In addition, we found that administration of rosiglitazone or pioglitazone decreased the increased NF-kappaB activity and that a NF-kappaB inhibitor, BAY 11-7085, substantially reduced the increased IL-17 protein levels in the lung tissues after OVA inhalation. These findings suggest that the therapeutic effect of PPARgamma in asthma is partly mediated by regulation of IL-17 expression via NF-kappaB pathway.</P>

Plasma Cell Granuloma Associated with Pulmonary Actinomycosis: A Case Report

Seoung Ju Park,Yong Chul Lee,Yang Keun Rhee,Eui Yong Kweon,Heung Bum Lee 대한의학회 2006 Journal of Korean medical science Vol.21 No.6

P-47 Castleman`s disease in intrapulmonary lymph node presenting as solitary pulmonary nodule

( Seoung Ju Park ),( Seung Yong Park ),( Yeong Hun Choe ),( So Ri Kim ),( Heung Bum Lee ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Castleman`s disease is an uncommon lymphoproliferative disorder which can occur wherever lymph nodes are present. Castleman`s disease in the chest develops usually in mediastinal or hilar lymph node. A 53-year-old woman was admitted to our hospital for further evaluation of a pulmonary nodule detected incidentally in health check-up. Computer tomography demonstrated that this nodule was 27 × 25 mm, well-defined in the right upper lobe. On MRI of chest MRI, which was performed to further diagnosis, the nodule was located on perihilar area of the right upper lobe and showed high signal intensity in T2 weight imaging and rapid and strong enhancement in dynamic contrast image, suspected to be a sclerosing hemangioma. We performed right upper lobectomy with lymph node dissection and the pathologic examination revealed that the pulmonary nodule was Castleman`s disease arising from an intrapulmonary lymph node. We here report a rare case of Castleman`s disease in intrapulmonary lymph node presenting as solitary pulmonary nodule, suggesting that Castleman`s disease should be considered in patients with a nodule in perihilar area.

Change of connexin 37 in allergen-induced airwayinflammation

Seoung Ju Park/Kyung Sun Lee,김소리,Kyung Hoon Min,Ka Young Lee,Yeong Hun Choe,Seung Yong Park,Sang Hyun Hong,이용철 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.5

Gap junction channels formed with connexins directly link to the cytoplasm of adjacent cells and have been implicated in intercellular signaling. Connexin 37 (Cx37) is expressed in the gas-exchange region of the lung. Recently, Cx37 has been reported to be involved in the pathogenesis of inflammatory disease. However, no data are available on the role of Cx37 in allergic airway inflammatory disease. In the present study, we used a murine model of ovalbumin (OVA)- induced allergic airway disease and primary murine epithelial cells to examine the change of Cx37 in allergic airway disease. These mice develop the following typical pathophysiological features of asthma: airway hyperresponsiveness, airway inflammation, and increased IL-4, IL-5, IL-13, intercellular adhesion molecule- 1, vascular cell adhesion molecule-1, eotaxin, and RANTES levels in lungs. Cx37 protein and mRNA expression were decreased in OVA-induced allergic airway disease. Immunoreactive Cx37 localized in epithelial layers around the bronchioles in control mice, which dramatically disappeared in allergen-induced asthmatic lungs. Moreover, the levels of Cx37 protein in lung tissues showed significantly negative correlations with airway inflammation, airway responsiveness, and levels of Th2 cytokines in lungs. These findings indicate that change of Cx37 may be associated with the asthma phenotype.

A Facile Route for Patterned Growth of Metal–Insulator Carbon Lateral Junction through One-Pot Synthesis

Park, Beomjin,Park, Jaesung,Son, Jin Gyeong,Kim, Yong-Jin,Yu, Seong Uk,Park, Hyo Ju,Chae, Dong-Hun,Byun, Jinseok,Jeon, Gumhye,Huh, Sung,Lee, Seoung-Ki,Mishchenko, Artem,Hyun, Seung,Lee, Tae Geol,Han, American Chemical Society 2015 ACS NANO Vol.9 No.8

<P>Precise graphene patterning is of critical importance for tailor-made and sophisticated two-dimensional nanoelectronic and optical devices. However, graphene-based heterostructures have been grown by delicate multistep chemical vapor deposition methods, limiting preparation of versatile heterostructures. Here, we report one-pot synthesis of graphene/amorphous carbon (a-C) heterostructures from a solid source of polystyrene <I>via</I> selective photo-cross-linking process. Graphene is successfully grown from neat polystyrene regions, while patterned cross-linked polystyrene regions turn into a-C because of a large difference in their thermal stability. Since the electrical resistance of a-C is at least 2 orders of magnitude higher than that for graphene, the charge transport in graphene/a-C heterostructure occurs through the graphene region. Measurement of the quantum Hall effect in graphene/a-C lateral heterostructures clearly confirms the reliable quality of graphene and well-defined graphene/a-C interface. The direct synthesis of patterned graphene from polymer pattern could be further exploited to prepare versatile heterostructures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-8/acsnano.5b03037/production/images/medium/nn-2015-03037u_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b03037'>ACS Electronic Supporting Info</A></P>

Antioxidants as novel agents for asthma.

Park, Seoung Ju,Lee, Yong Chul Bentham Science Publishers 2006 Mini reviews in medicinal chemistry Vol.6 No.2

<P>Oxidative stress plays an important role in the pathogenesis of asthma. Recently several investigators have studied the effects of a variety of antioxidants on asthma. Antioxidants, including L-2-oxothiazolidine-4-carboxylic acid, reduce airway inflammation and hyper-responsiveness of asthma and may be novel therapeutic agents for asthma.</P>

AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.

Park, Seoung Ju,Lee, Kyung Sun,Kim, So Ri,Chae, Han Jung,Yoo, Wan Hee,Kim, Dong Im,Jeon, Myoung Shin,Lee, Yong Chul Birkhäuser 2012 Inflammation research Vol.61 No.10

<P>Occupational asthma is characterized by airway inflammation and hyperresponsiveness associated with increased vascular permeability. AMP-activated protein kinase (AMPK) has been suggested to be a novel signaling molecule modulating inflammatory responses.</P>

Interleukin-17 regulation: an attractive therapeutic approach for asthma

Park, Seoung Ju,Lee, Yong Chul BioMed Central 2010 Respiratory research Vol.11 No.-

<P>Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orchestrates the neutrophilic influx into the airways and also enhances T-helper 2 (Th2) cell-mediated eosinophilic airway inflammation in asthma. Recent studies have demonstrated that not only inhibitor of IL-17 per se but also diverse regulators of IL-17 expression reduce antigen-induced airway inflammation, bronchial hyperresponsiveness, and Th2 cytokine levels in animal models of asthma. This review will summarize the role of IL-17 in the context of allergic airway inflammation and discuss the therapeutic potential of various strategies targeting IL-17 for asthma.</P>