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( Seong Yong Park ),( Min Seok Oh ),( Chul Min Park ),( Dong Won Seo ),( Seong Hoe Yoon ),( Dong Keun Lee ),( Jung Hoon Yoon ),( Seul Ki Lee ),( Soo Yeon Jeon ),( Ju Young Park ),( Dong Soo Shin ),( S 조선대학교 구강생물학연구소 2015 Oral Biology Research (Oral Biol Res) Vol.39 No.2
Florid cemento-osseous dysplasia (FCOD) is a fibro-osseous lesion that characteristically affects the jaw bones of multi-quadrant radiopaque cementum-like masses. FCOD is a rare condition affecting jaw bones and is diagnosed principally by its characteristic clinico-radiological features. As the condition remains asymptomatic, no surgical treatment is required. However, surgical trauma in the form of a biopsy, tooth extraction, or poor fitting dentures can lead to a chronically draining site that does not heal and can progress to osteomyelitis. Treatment of osteomyelitis depends on appropriate antibiotic therapy and often requires surgical removal of infected and necrotic tissue. This paper reports a rare case of FCOD affecting mandible with osteomyelitis.
Yoon, Seong-Hoe,Nam, Woong,Park, Won-Se,Kim, Hyung-Jun The Korean Association of Oral and Maxillofacial S 2007 대한구강악안면외과학회지 Vol.33 No.1
The fibromatoses are a broad group of fibrous proliferations. They have a biologic behavior and histopathologic pattern that is intermediate between those of benign fibrous lesions and fibrosarcoma. Because they are not common diseases, it is important to differentiate the fibromatoses from other similar diseases. In this report, we present a case of fibromatosis, and possible other diseases to be differentiated, with a review of literatures.
윤혜원,김도균,김정란,김승만,양회생,심재철,배철성,최석철,황진석,도은형 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.2
Adenoid basal carcinoma of the cervix is very rare tumor. It is slow-growing and locally invasive tumor amenable to simply hystrectomy. It is common to be associated with severe dysplasia and carcinoma in situ(CIS) of cervix Occasionally, concommitant microinvasive squamous cell carcinoma or adenocarcinoma may also be seen. Differential diagnosis includes adenoid cystic carcinoma, which is more aggressive tumor associated with regional lymph node involvement and late pulmonary metastasis. We have recently experienced a case of adenoid basal carcinoma of the cervix in 61 years-old woman, which is presented with a brief review of the literature.
Targeting of a developmentally regulated epitope of CD43 for the treatment of acute leukemia.
Jeon, Yoon Kyung,Min, Hye Sook,Lee, Yoo Jeong,Kang, Byung Hyun,Kim, Eun Ji,Park, Hyo Jin,Bae, Youngmee,Lee, Hyun Gyu,Park, Weon Seo,Song, Hyung Geun,Jung, Kyeong Cheon,Park, Seong Hoe Springer International 2011 Cancer immunology, immunotherapy Vol.60 No.12
<P>Previously, we developed a JL1 mouse monoclonal antibody that specifically recognizes the leukemic cells of T, B, and myeloid lineages, but not the peripheral blood cells and pluripotent hematopoietic stem cells. Here, we identified that JL1 mAb recognized a specific epitope of human CD43 and validated its potential as an anti-leukemic targeting agent. After the comprehensive screening of JL1 Ag in the human thymocyte cDNA library, multiple fusion gene constructs encoding human CD43 were generated to identify its specific epitope to JL1 antibody. JL1 antibody interacted with a developmentally regulated and non-glycosylated epitope of the human CD43 extracellular domain (AA 73-81, EGSPLWTSI). In an in vivo leukemia model using NOD/SCID mice injected with CCRF-CEM7 cells, JL1 antibody induced effective cytotoxicity in tumor cells and prolonged survival (p < 0.05). Saporin conjugation to JL1 antibody effectively depleted tumor cells in in vitro cytotoxic assays and also prolonged survival in a leukemic mouse model (p < 0.001). These preclinical results further support the therapeutic potential of the JL1 antibody in the management of acute leukemia.</P>
Park, Hyo Jin,Jeon, Yoon Kyung,Lee, An Hi,Oh, Young-ha,Park, Seong Hoe,Jung, Kyeong Cheon Lippincott Williams Wilkins, Inc. 2012 The American journal of surgical pathology Vol.36 No.8
Langerhans cell histiocytosis (LCH) is the collective designation for a group of proliferative disorders of antigen-presenting cells in the epidermis. Over the past several decades, the etiology of LCH has been a controversial issue, particularly with respect to the pathologic process, that is, whether it is a neoplastic or inflammatory process. Recently, it was reported that the JL1 epitope, which encompasses the nonglycosylation site of CD43, is only exposed in the precursor stages of hematopoietic cells or in neoplastic conditions. We sought to investigate the possible utility of the JL1 monoclonal antibody as a diagnostic marker of LCH. In this study, we compared the staining characteristics of antibodies against the JL1 epitope with those of langerin and CD1a, which are widely used for the diagnosis of LCH. We found substantial differences in the staining patterns of these markers. The JL1 epitope could be bound by antibodies in cases of LCH and Langerhans cell (LC) sarcoma. In non-neoplastic lesions, JL1-positive LCs were found only in dermatitis, reflecting the immaturity of LCs in inflamed skin. However, anti-langerin antibodies were able to identify any form of LC, including those in normal skin, dermatitis, dermatopathic lymphadenopathy, and LCH. On the basis of these findings, we propose that the anti-JL1 antibody is a specific marker of immaturity, a feature that is shared in neoplastic LCs, and can be useful in the diagnosis of LCH.
이지윤,윤주영,김정회,송성희,주지수,김은경 대한간호학회 간호행정학회 2008 간호행정학회지 Vol.14 No.3
Purpose: To develop the patient classification system based on the resource utilization for reimbursement of long-term care hospitals in Korea. Method: Health Insurance Review & Assessment Service (HIRA) conducted a survey in July 2006 that included 2,899 patients from 35 long-term care hospitals. To calculate resource utilization, we measured care time of direct care staff (physicians, nursing personnel, physical and occupational therapists, social workers). The survey of patient characteristics included ADL, cognitive and behavioral status, diseases and treatments. Major category criteria was developed by modified delphi method from 9 experts. Each category was divided into 2-3 groups by ADL using tree regression. Relative resource use was expressed as a case mix index (CMI) calculated as a proportion of mean resource use. Result: This patient classification system composed of 6 major categories (ultra high medical care, high medical care, medium medical care, behavioral problem, impaired cognition and reduced physical function) and 11 subgroups by ADL score. The differences of CMI between groups were statistically significant (p<.0001). Homogeneity of groups was examined by total coefficient of variation (CV) of CMI. The range of CV was 29.68-40.77%. Conclusions: This patient classification system is feasible for reimbursement of long-term care hospitals.
Sodium Dodecyl Sulfate 존재하에서 Thionine의 흡수 및 형광분광학적 성질
강성관,박종회,윤민중,Seong Gwan Kang,Chong Hoe Park,Minjoong Yoon 대한화학회 1994 대한화학회지 Vol.38 No.12
Sodium dodecyl sulfate (SDS) 존재하에서 유기색소인 thionine (TH)의 흡수 및 형광분광학적 성질을 조사 연구하였다. SDS 농도 증가에 따라 측정한 흡수 및 형광스펙트럼의 변화들로부터 i) TH-SDS 착화합물의 회합체 형성, ii)TH-SDS 회합체내의 색소분자의 stacking 과정, iii)dye-rich induced micelles의 형성에 의한 staking의 파괴 및 iv) SDS 미셀의 표면에 TH의 재분포과정 등으로 설명하였다. The absorption and fluorescence spectroscopic studies on the interaction between thionine (TH) and sodium dodecyl sulfate (SDS) have been carried out. The absorption and fluorescence spectral changes of TH with the changes of concentration of SDS are interpreted in terms of i) the aggregation of TH-SDS complex, ii) the stacking process of dye molecules by the association of the TH-SDS complex, iii) breakdown of the stacking due to the formation of dye-rich induced micelles, iv) redistribution of dye molecules in the surface of SDS micelles.
Gil-Sung You,Won-Myung Choung,Jeong-Hoe Ku,Il-Je Cho,Dong-Hak Kook,Kie-Chan Kwon,Won-Kyung Lee,Eun-Pyo Lee,Dong-Hee Hong,Ji-Sup Yoon,Seong-Won Park 한국방사성폐기물학회 2007 방사성폐기물학회지 Vol.5 No.4
전세계 주요 원자력선진국들의 사용후핵연료 처리에 대한 기술 및 정책현황을 알아보고 향후 우리나라의 연구방향을 제시해 보았다. 재처리 정책을 가진 소위 핵연료주기 국가들은 최근 선진핵 연료주기기술에 기초한 새로운 사용후핵 연료 관리정책을 발표하였다. 그 정책은 사용후핵연료 내에 함유된 우라늄 또는 초우란 원소들을 재순환하고 고독성의 방사성 물질 및 장반감기를 가진 물질들을 소멸하거나 단반감기 원소로 변환하는데 초점을 맞추고 있다. 이러한 정책은 원자력의 자원 활용성을 높일 뿐만 아니라, 영구 처분할 고준위폐기물의 양을 감소시켜 궁극적으로 원자력의 지속가능성을 높여 준다. PUREX 방법에 기초한 습식재처리를 우선순위로 선택한 대부분의 국가들은 이 습식방법이 건식방법에 비해 실용화에 앞서 있음을 그 선택 의 근거로 든다. 그러나 습식방법은 건식에 비해 핵확산저항성 측면에서 더욱 민감하다. 왜냐하면 이 습식방법은 약간의 공정수정에 의해 순수 플루토늄을 회수 할 수 있기 때문이다. 반면에 아직까지 실용화 단계까지는 도달해 있지 않지만 고온 용융염을 사용하는 Pyroprocess와 같은 건식처리 방법은 순수한 플루토늄을 회수 할 수 없어서 핵비확산성 측면에서 유리하며, 제4세대 원자로로 고려되는 고속로의 핵연료주기 등에도 여러 가지 이점을 가지고 있다. 따라서 우리나라의 경우 현재 이 Pyroprocess에 대한 연구가 활발히 진행되고 있다. Status on the spent nuclear fuel management policy and R&D plan of the major countries is surveyed. Also the prospect of the future R&D plan is suggested. Recently so-called fuel cycle nations, which have the reprocess policy of the spent fuel, announced new spent fuel management policy based on the advanced fuel cycle technology. The policy is focused to transmute highly radioactive material and material having a very long half-life, and to recycle the Pu and U contained in the spent fuel. In this way the radio-foxily of the spent fuel as well as the amount of the high level waste to be eventually disposed can greatly be reduced. Most of countries selected the wet process as a primary option for the treatment of the spent fuel since the advanced wet process, which is based on the existing PUREX process, looks more feasible as compared with the dry process. The wet process, however, is much more sensitive in terms of proliferation-resistance compared with the dry process. The pure Pu can easily be obtained by simply modifying the process. On the other hand the pure Pu can not be extracted in the dry process based on the high temperature molten salt process such as a pyroprocess. Even though the pyroprocess technology is very premature, it has a great merit. Thus it is necessary for Korea to have a long term strategy for pursuing a spent fuel treatment technology with a proliferation resistance and a great merit for the GEN-IV fuel cycles. Pyroprocess is one of the best candidates to satisfy these purposes.