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Park, Jung Sik,Yang, Jun-Mo,Park, Kyung Jin,Park, Yun Chang,Yoo, Jung Ho,Jeong, Chil Seong,Park, Jucheol,He, Yinsheng,Shin, Keesam Oxford University Press 2014 Microscopy Vol.63 No.1
<P>Growing a GaN film on a patterned Al<SUB>2</SUB>O<SUB>3</SUB> substrate is one of the methods of reducing threading dislocations (TDs), which can significantly deteriorate the performance of GaN-based LEDs. In this study, the microstructural details of the GaN film grown on a cone-shaped patterned Al<SUB>2</SUB>O<SUB>3</SUB> substrate were investigated using high-resolution transmission electron microscopy and weak-beam dark-field techniques. Various defects such as misfit dislocations (MDs), recrystallized GaN (R-GaN) islands and nano-voids were observed on the patterned Al<SUB>2</SUB>O<SUB>3</SUB> surfaces, i.e. the flat surface (FS), the inclined surface (IS) and the top surface (TS), respectively. Especially, the crystallographic orientation of R-GaN between the GaN film and the inclined Al<SUB>2</SUB>O<SUB>3</SUB> substrate was identified as [Formula], [Formula]. In addition, a rotation by 9° between [Formula] and [Formula] and between [Formula] and [Formula] was found to reduce the lattice mismatch between the GaN film and the Al<SUB>2</SUB>O<SUB>3</SUB> substrate. Many TDs in the GaN film were observed on the FS and TS of Al<SUB>2</SUB>O<SUB>3</SUB>. However, few TDs were observed on the IS. Most of the TDs generated from the FS of Al<SUB>2</SUB>O<SUB>3</SUB> were bent to the inclined facet rather than propagating to the GaN surface, resulting in a reduction in the dislocation density. Most of the TDs generated from the TS of Al<SUB>2</SUB>O<SUB>3</SUB> were characterized as edge dislocations.</P>
Park, Mi-Hyun,Kim, Hye-Kyung,Kim, Jin-Man,Lee, Byung-Ho,Chang, Mi-He,Lee, Me-Yae,Kim, Hyeon-Jin,Lee, Jong-Young,Hong, Seong-Chool Korean Society of Genetics 2008 Genes & Genomics Vol.30 No.2
Polycystin 2 (PKD2) is an ion channel that regulates the intracellular calcium ion concentration. Amino acid changes in PKD2 are known to cause autosomal dominant polycystic kidney disease(ADPKD), and are possibly associated with many other complex diseases. In an effort to find cSNPs (single nucleotide polymorphisms within cDNA sequence) in PKD2, we used direct sequencing analysis to screen the entire coding region of the PKD2 gene. We identified a major nonsynonymous cSNP, Ala190Thr (A190T), in the N-terminal intracellular domain of PKD2. This nonsynonymous cSNP was previously reported as a mutation for ADPKD. However, this study excluded the possibility that the A190T variation was a missense mutation for ADPKD by a thorough clinical evaluation and population study. In 500 genetically unrelated Koreans, the allele frequencies of G and A at the A190T variation were 64% and 36%, respectively. The genotype frequency of the cSNP was not deviated from Hardy-Weinberg equilibrium. These experimental results indicate that mutational research needs to be confirmed by a thorough clinical evaluation and population study. Furthermore, the A190T variation is implicated as having possible causative roles in the pathogenesis of various ADPKD-related diseases. Intensive population studies should be conducted to address the etiological role of the A190T variation in these ADPKD-related diseases.
Jun, Ikhyun,Park, Hyung Soon,Piao, He,Han, Jung Woo,An, Min Ji,Yun, Byeong Gyu,Zhang, Xianglan,Cha, Yong Hoon,Shin, You Keun,Yook, Jong In,Jung, Jinsei,Gee, Heon Yung,Park, Joon Seong,Yoon, Dong Sup,J Nature Publishing Group 2017 The British journal of cancer Vol. No.
<P><B>Background:</B></P><P>Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer.</P><P><B>Methods:</B></P><P>In an initial screen of ANOs, ANO9/TMEM16J was overexpressed in pancreatic cancer cells, and its role in the pathogenesis of pancreatic cancer was evaluated using an integrated <I>in vitro</I> and <I>in vivo</I> approach. To determine clinical relevance of the experimental findings, the prognostic value of ANO9 was evaluated in patients with pancreatic cancer.</P><P><B>Results:</B></P><P>The ANO9 mRNA and protein levels were increased in pancreatic cancer-derived cells. Exogenous expression of <I>ANO9</I> in PANC-1 cells significantly increased cell proliferation in cell cultures and in mice. In contrast, knockdown of <I>ANO9</I> in AsPC-1, BxPC-3, and Capan-2 cells strongly inhibited cell proliferation. Mechanistic analysis suggested that physical association of ANO9 with epidermal growth factor receptor (EGFR) underlies ANO9-induced cell proliferation. Knockdown <I>of ANO9</I> augmented the effects of the EGFR inhibitor and the cytotoxic agent on pancreatic cancer cell proliferation. In addition, high ANO9 expression is a poor prognostic factor in patients with pancreatic cancer.</P><P><B>Conclusions:</B></P><P>The ANO9/TMEM16J appears to be a clinically useful prognostic marker for pancreatic cancer and a potential therapeutic target.</P>
Kim, Na-Young,Sohn, He-Kwang,Choe, Joon-Ho,Park, Sang-Dai,Seong, Rho-Hyun The Korean Society for Integrative Biology 1999 Korean journal of biological sciences Vol.3 No.3
Hepatitis C virus (HCV) is a positive strand RNA virus of the Flaviviridae family and the major cause of post-transfusion non-A, non-B hepatitis. Vaccine development for HCV is essential but has been slowed by poor understanding of the type of immunity that naturally terminates HCV infection. The DNA-based immunization technique offers the potential advantage of including cellular immune responses against conserved internal proteins of a virus, as well as the generation of antibodies to viral surface proteins. Here, we demonstrate that cell lines expressing the HCV core and/or NS3 proteins can induce a specific CTL response in mice, and these results suggest a possibility that the HCV core and NS3 DNA can be used to induce CTL activity against the antigen in mice and can be further developed as a therapeutic and preventive DNA vaccine.
Single-Crystalline Diluted Magnetic Semiconductor GaN:Mn Nanowires
Choi, H.-J.,Seong, H.-K.,Chang, J.,Lee, K.-I.,Park, Y.-J.,Kim, J.-J.,Lee, S.-K.,He, R.,Kuykendall, T.,Yang, P. WILEY-VCH Verlag 2005 Advanced Materials Vol.17 No.11
<B>Graphic Abstract</B> <P>Single-crystalline diluted magnetic semiconductor GaN:Mn nanowires with controlled Mn concentrations have been successfully synthesized and incorporated into devices (see Figure). These nanowires exhibit Curie temperatures above room temperature, magnetoresistances near room temperature, and spin-dependent transport. The nanowires are used as building blocks for the fabrication of GaN:Mn/n-SiC based light-emitting diodes. <img src='wiley_img/09359648-2005-17-11-ADMA200401706-content.gif' alt='wiley_img/09359648-2005-17-11-ADMA200401706-content'> </P>
Hong Jin,Chujun He,Seong-Taek, Park ASCONS 2021 INTERNATIONAL JOURNAL OF EMERGING MULTIDISCIPLINAR Vol.5 No.1
Background/Objectives: In this study will explore the impact of quantified-self awareness on consumer information sharing behavior in the mobile social network environment. Methods/Statistical analysis: In this study will confirm the impact of consumers’ quantified-self awareness on their information sharing behavior in the mobile social network environment through experimental research and questionnaire survey. Findings: Based on the theory of self discrepancy and through literature review, this study believes that consumers sense the difference between realistic self and ideal self, society realistic self and society ideal self will make them produce quantified-self awareness and willing to share information. To a certain extent, this study enriches the research on the influencing factors of consumers information sharing behavior. It is of certain significance for enterprises to improve consumers’ quantified-self awareness and carry out marketing activities. Improvements/Applications: In the mobile social network, consumers’ quantified-self awareness is gradually popularized and strengthened. It is of certain significance to explore how quantified self awareness can produce information sharing behavior for consumers.
유지원 ( Ji Won Ryu ),남승우 ( Seong Woo Nam ),권혁춘 ( Hyuck Choon Kweon ),최승준 ( Song Jun Choi ),김상용 ( Sang Young Kim ),박현미 ( Heun Mi Park ),안혜선 ( He Sun An ) 전북대학교 의과학연구소 2010 全北醫大論文集 Vol.34 No.2
저자들은 만성 설사와 하지 부종을 주소로 내원한 63세 여자 환자에서 류마티스 관절염과 연관되고 대장에 국한된 속발성 유전분증을 진단하였고 환자의 임상경과를 기존의 문헌 고찰과 함께 보고하는 바이다. Suspicion of gastrointestinal amyloidosis in patients without known history of amyloidosis is difficult, but gastrointestinal amyloidosis should be considered in those older than 30year with unexplained diarrhea, weight loss or malabsorption. We experienced a case of an 63-year-old female in patient with rheumatoid arthritis, who have a chronic watery diarrhea caused by colonic amyloidosis. Congo-red stain and immunohistochemical stain for amyloid A protein of colonoscopic pathologic specimen showed positive response. Other organs such as kidney, heart, liver and skin, were not involved by amyloidosis. She was diagnosed to secondary and localized colonic amyloidosis related with rheumatoid arthritis. In spite of anti-rheumatic therapy, our patient did not recover.