The Korean Association of lnternal Medicine : Poster Session ; PS 1361 : Nephrology ; Plasma Exchange Successfully Treats Central Pontine Myelinolysis after Acute Hypernatremia from Intravenous Sodium Bicarbonate Therapy

( Seong Yul Ryu ),( Kyung Yoon Chang ),( Hyung Wook Kim ),( Hoon Suk Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the fi rst case showing the successful treatment of central pontine myelinolysis (CPM) by plasma exchange, which occurred after rapid development of hypernatremia from intravenous sodium bicarbonate therapy. Case presentation: A 40-year-old woman presented with general weakness, hypokalemia, and metabolic acidosis. She was treated with oral potassium chloride, along with intravenous sodium bicarbonate. Although her bicarbonate defi cit was 365 mEq, we treated her with an overdose of sodium bicarbonate, 480 mEq for 24 hours, due to the severity of her acidemia and altered mental status. The next day, she developed hypernatremia with serum sodium levels rising from 142.8 mEq/L to 172.8 mEq/L. Sixdays after developing hypernatremia, she exhibited tetraparesis, drooling, and dysarthria, and a brain MRI revealed high signal intensity in the central pons with sparing of the peripheral portion, suggesting CPM. We diagnosed her with CPM associated with the rapid development of hypernatremia after intravenous sodium bicarbonate therapy and treated her with plasma exchange. After two consecutive plasma exchange sessions, her neurologic symptoms were markedly improved except for mild diplopia. After the plasma exchange sessions, we examined the patient to determine the reason for her symptoms upon presentation to the hospital. She had normal anion gap metabolic acidosis, low blood bicarbonate levels, a urine pH of 6.5, and a calyceal stone in her left kidney. We performed a sodium bicarbonate loading test and diagnosed distal renal tubular acidosis (RTA). We also found that she had Sjogren`s syndrome after a positive screen for anti-Lo, anti-Ra, and after the results of Schirmer`s

A novel colorimetric chemosensor for detection of Co²⁺ and S²⁻ in an aqueous environment

Ryu, Ka Young,Lee, Seong Youl,Park, Dae Yul,Kim, So Young,Kim, Cheal Elsevier 2017 Sensors and actuators. B Chemical Vol.242 No.-

<P><B>Abstract</B></P> <P>A novel multifunctional and highly selective chemosensor <B>1</B>, N 2-(bis(pyridin-2-ylmethyl)amino)-<I>N</I>-(2-((2,4-dinitrophenyl)amino)phenyl)acetamide, for Co<SUP>2+</SUP> and S<SUP>2−</SUP> was designed and synthesized. Sensor <B>1</B> showed a selective colorimetric sensing ability for cobalt ion by changing color from pale yellow to light green in a near perfect aqueous solution. The detection limit (0.99μM) of <B>1</B> for Co<SUP>2+</SUP> was lower than the Environmental Protection Agency (EPA) guideline (1.7μM) for drinking water. The sensor <B>1</B> could be used to quantify Co<SUP>2+</SUP> in water samples. Moreover, sensor <B>1</B> detected S<SUP>2−</SUP> selectively, which induced an obvious color change from pale yellow to pink over most other competitive anions in aqueous solution. The sensing mechanism of Co<SUP>2+</SUP> by <B>1</B> was proposed to be a ligand-to-metal charge-transfer (LMCT) with the experimental results and theoretical calculations, and that of S<SUP>2−</SUP> by <B>1</B> proposed to be a deprotonation process. Therefore, this sensor <B>1</B> could be used as a practical system for monitoring both Co<SUP>2+</SUP> and S<SUP>2−</SUP> in an aqueous environment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> New dinitrobenzene-containing chemosensor <B>1</B> was developed as a colorimetric sensor for Co<SUP>2+</SUP> and S<SUP>2−</SUP>. </LI> <LI> Sensor <B>1</B> detected Co<SUP>2+</SUP> from pale yellow to light green through LMCT mechanism. </LI> <LI> Sensor <B>1</B> detected S<SUP>2−</SUP> from pale yellow to pink through deprotonation process. </LI> <LI> Detection limit of <B>1</B> for Co<SUP>2+</SUP> was lower than the Environmental Protection Agency guideline. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

호텔 욕조물을 통해 발생한 것으로 추정되는 녹농균 모낭염

조성문 ( Seong Moon Jo ),류형호 ( Hyeong Ho Ryu ),조현회 ( Hyun Hee Cho ),박경열 ( Gyeong Yul Park ),은회철 ( Hee Chul Eun ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.9

Pseudomonas infections can occur from inadequate chemical treatment of water, prolonged exposure to the water source and excessive numbers of bathers in the pool or hot tub. Therefore, pseudomonas folliculitis is also called ?hot tub folliculitis``. We report a 3-year-old boy with Pseudomonas aeruginosa folliculitis suggestively caused by water from the bathing tub of a Hotel. According to the sanitary code of the United States of America, pool staff should regularly check both chlorine and pH levels to prevent swimmers from recreational water infection. However,in Korea, there is no definite regulation regarding chlorine or pH level of recreational water. Thus, we report this issue with a review of the literature.

땅콩의 連作 障害 原因 調査

柳汀(Jeong Ryu),羅鍾城(Jong-Seong Na),黃南悅(Nam-Yul Hwang) 한국토양비료학회 1992 한국토양비료학회지 Vol.25 No.3

고추의 連作 障害 要因과 土壤改良劑 施用效果

黃南悅(Nam-Yul Hwang),柳汀(Jeong Ryu),羅鍾城(Jong-Seong Na),金鎭淇(Jin Key Kim) 한국토양비료학회 1989 한국토양비료학회지 Vol.22 No.3

界火島 干拓地 土壤의 年度別 鹽分含量 變化

黃南悅(Nam-Yul Hwang),柳汀(Jeong Ryu),羅鍾城(Jong-Seong Na),吳東勳(Dong-Hoon Oh),朴建鎬(Keon-Ho Park),崔奉柱(Bong-Ju Choi) 한국토양비료학회 1991 한국토양비료학회지 Vol.24 No.4

GIS를 위한 3차원 공간 연산 처리기 설계 및 구현

이진열(Jin Yul Yi),김대중(Dae Jung Kim),지정희(Jeong Hee Chi),류근호(Keun Ho Ryu),이성호(Seong Ho Lee) 한국정보과학회 2002 한국정보과학회 학술발표논문집 Vol.29 No.2Ⅰ

최근 3D 공간 객체의 효율적인 표현을 위해, 3D 연산 및 다차원 인덱싱 기법에 관한 연구가 활발히 진행되고 있다. 또한 이러한 인덱스나 연산을 기반으로 많은 응용프로그램들이 개발되고 있다. 그러나, 대부분의 응용프로그램들은 단순히 비공간 속성에 대한 질의를 기반으로 한 3D 객체의 시각화에만 치중하고 있기 때문에, 3D 공간 객체에 관한 분석 기능을 제대로 지원하지 못하고 있다. 따라서, 이 논문에서는 3D 공간 객체에 관한 효율적 분석 기능을 제공할 수 있는 3D 공간 연산 처리기를 설계 및 구현하였다. 기존 시스템과의 상호운용을 위해서, 제안한 연산 처리기는 OpenGIS의 2차원 기하 객체 모델을 3차원으로 확장한 3D 기하 객체 모델을 기반으로 하였다. 또한 빠른 공간 연산을 수행하기 위해 인덱스와 연동하여 구현하였다. 이 연산 처리기는 3D GIS에 적용될 경우, 효율적인 공간 분석 기능을 제공할 수 있다.

LETTER TO THE EDITOR : Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome

( Kyung Yoon Chang ),( Seong Yul Ryu ),( Jae Young Cho ),( Hyung Wook Kim ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.5

Primary aldosteronism was originally described by an aldosterone-producing adenoma. Later, primary aldosteronism was recognized to occur as a result of a heterogeneous group of disorders, including adenoma, hyperplasia, or aldosterone- and cortisol- co-producing tumors. Here, we report a rare case of an aldosterone- and cortisol-co-producing adenoma in the presence of primary aldosteronism without the clinical features of Cushing syndrome. A 29-year-old woman with hypertension presented with seizure and lower extremity weakness. The patient was 166 cm tall, weighed 64.5 kg, and her blood pressure was 165/97 mmHg. No features of Cushing syndrome, such as moon face, purple striae, hirsutism, or central obesity, were evident. Laboratory data showed sodium, 145 mEq/L; potassium, 1.5 mEq/L; chloride, 94 mEq/L; calcium, 8.3 mg/ dL; phosphorus, 2.4 mg/dL; magnesium, 2.0 mg/dL; blood urea nitrogen, 6.5 mg/dL; and serum creatinine, 0.5 mg/dL. Spot urine potassium was 37.6 mEq/L, and the transtubular potassium gradient was 14%. Spot urine chloride was 90.2 mEq/L, and a blood gas analysis showed pH, 7.6; pCO2, 42.5 mmHg; pO2, 85 mmHg; HCO3, 44.2 mmol/L; and SpO2, 98%. Thyroid function tests were normal. Fasting plasma glucose and glycated hemoglobin were 96 mg/dL and 4.9%, respectively. Electrocardiography, chest anteroposterior views, brain computed tomography (CT), electroencephalography, and a cerebral spinal fluid study revealed normal findings. As shown in Table 1, hormone studies showed an increased plasma aldosterone concentration (PAC; 29.6 ng/ dL), suppressed plasma renin activity (PRA; 0.1 ng/mL/hr), and an increased PAC:PRA ratio (296), suggesting excess aldosterone. Basal PRA and PAC on the saline infusion test were 0.1 ng/mL/hr and 94.5 ng/dL, respectively. After infusion of 2 L of 0.9% saline over 4 hours, PAC was not suppressed (72.1 ng/dL). The 24-hour urinary free cortisol excretion increased to 566.1 μg/day. Serum cortisol levels were not suppressed with administration of doses of 1 (overnight), 2 (low dose), and 8 mg (high dose) dexamethasone, which were in concentrations of 8.26, 9.54, and 7.79 μg/dL, respectively. Plasma adrenocorticotrophic hormone (ACTH) was < 5 pg/mL, suggesting an ACTH-independent type of Cushing syndrome (Table 1). An adrenal CT scan revealed a 2.1 × 1.6 cm diameter, well circumscribed, homogeneous, low density nodule in the left adrenal gland. PRA was 0.16 ng/mL/hr, PAC was 54.9 ng/dL, and ACTH was 11.0 pg/mL in the supine position. After 4 hours of standing, PRA was 1.23 ng/mL/hr, PAC was 46.7 ng/dL, and ACTH was < 5 pg/mL. These results suggested an adrenal adenoma rather than bilateral adrenal hyperplasia due to the paradoxical drop in aldosterone with standing. We excluded adrenocortical carcinoma and pheochromocytoma based on the results of hormone studies (Table 1). We could not perform bilateral adrenal venous sampling or 131I-iodocholesterol scintigraphy due to patient refusal. We diagnosed this case as an aldosterone- and cortisol- co-producing adrenal adenoma based on the very high PAC, cortisol that was not suppressed by dexamethasone, and the adrenal mass on CT. Preoperative management involved 100 mg spironolactone daily and a potassium correction. Subsequently, a laparoscopic left adrenalectomy was performed. The cut surface of the tumor was homogeneous and golden yellow without necrotic features. A histological examination revealed that the adrenocortical adenoma was composed of both clear and compact cells. We performed immunohistochemistry for 3β-hydroxysteroid dehydrogenase (HSD-3β1) and cytochrome P450-17A1 using anti-HSD3β1 (1:50; Abcam, Cambridge, MA, USA) and anticytochrome P450-17A1 (1:50; Abcam), respectively, which suggested that the adrenal adenoma possibly produced both aldosterone and cortisol (Fig. 1). The patient`s hypertension and hypokalemia improved following the adrenalectomy. Just after the surgery, we injected 100 mg hydrocortisone intravenously to prevent an adrenal crisis and then tapered the oral prednisolone for 5 days. After surgery, hormone studies showed normalized PAC (3.1 ng/dL), PRA (0.32 ng/ mL/hr), PAC:PRA ratio (6.68), and 24-hour urinary free cortisol excretion (60.81 μg/day). The serum cortisol level after administration of a 1 mg dexamethasone dose (overnight) was 1.93 μg/dL. Ten days after surgery, we performed a rapid ACTH stimulation test, which demonstrated insuffi cient cortisol secretion. The preinjection plasma ACTH and cortisol levels were 29.6 pg/mL and 5.06 μg/dL, respectively. Plasma cortisol levels 30 and 60 minutes after a single intravenous injection of 250 μg tetracosactide (Synacthen [Alliance Pharma, Chippenham, UK], synthetic ACTH) were 8.14 and 8.94 μg/dL, respectively, indicating adrenal insuf- ficiency. We restarted oral prednisolone at a daily dose of 7.5 mg and tapered it over 5 months. After the patient decided to stop oral prednisolone 5 months after surgery, we confirmed normal cortisol secretion using the rapid ACTH stimulation test. Several clinical implications are important for aldosterone- and cortisol-co-producing tumors. First, these patients are associated with an increased risk of cardiovascular events, as the incidence of myocardial infarction, heart failure, and stroke increase [1]. Second, there is increased risk for metabolic complications such as glucose intolerance and hypertension [2]. Third, these tumors can lead to decreased bone mineral density and bone quality and an increased risk of fracture [3]. Fourth, cortisol co-secretion may cause false-negative results in adrenal venous sampling [4]. Finally, postoperative adrenal crisis and adrenal insuf- ficiency should be considered in the clinical management [5]. The prevalence of aldosterone- and cortisol-co-producing tumors is not exact. Clinicians should consider a cortisol co-secreting tumor in primary aldosteronism if cortisol is not suppressed by dexamethasone or an adenoma > 2.5 cm is present [4]. Treatment for an aldosterone- and cortisol-co-producing tumor is surgical excision. It should be noted that hydrocortisone replacement is necessary during and after adrenalectomy. In conclusion, we present this case to emphasize that an adrenal adenoma might be capable of secreting both aldosterone and cortisol without clinical features of Cushing syndrome. Therefore, the screening test for Cushing syndrome should be performed in patients with primary aldosteronism even if there are no clinical features of Cushing syndrome.

고추의 연작(連作) 장해(障害) 요인(要因)과 토양개량제(土壤改良劑) 시용효과(施用效果) II. 연작지(連作地) 토양개량제(土壤改良劑) 시용효과(施用效果)

황남열,류정,나종성,김진기,Hwang, Nam-Yul,Ryu, Jeong,Na, Jong-Seong,Kim, Jin-Key 한국토양비료학회 1989 한국토양비료학회지 Vol.22 No.3

고추의 연작지(連作地)에서 토양개량제(土壤改良劑)의 처리(處理)가 고추의 연작(連作) 및 phytotxin에 미치는 영향(影響)을 구명(究明)하기 위하여 1985~1986년(年) 2개년(個年) 동안 고추 규산단지(圭産團地)인 전북(全北) 임실부(任實部) 관촌면(館村面)에서 시험(試驗)을 수행(遂行)하였던 바 그 결과(結果)를 요약(要約)하면 다음과 같다. 1. 과잉(過剩) 축적(蓄積)된 인산(燐酸)(507ppm)은 연작장해요인중(連作障害要因中)의 하나로 생각되며 토양개량제(土壤改良劑) 시용(施用)으로 축적(蓄積)된 인산(燐酸)의 이용도(利用度)를 증가(增加) 시킬 수 있었고, 심경(深耕)과 퇴비(堆肥), 석회고토분말(石灰苦土粉末)을 동시처리(同時處理)함으로써 병발생률(病發生率)을 낮추고 주당과수(株當果數)를 높여 증수(增收) 효과(效果)를 볼 수 있었다. 2. 연작지(連作地)에서 토양중(土壤中) 미량원소(微量元素) 함량(含量)은 동(銅)이 1.86ppm, 아연(亞鉛) 1.09ppm, 붕소(硼素) 0.03ppm, 알미늄 30ppm으로 나타나 아연(亞鉛)(적정치(適正値) 2.0ppm)과 붕소(硼素)(적정치(適正値) 0.3ppm)는 적정수준(適正水準)에 미달(未達)되었다. 3. 시험후(試驗後) 토양중(土壤中) 미량원소(微量元素) 함량(含量)과 수량(收量)과의 관계(關係)는 아연(亞鉛)은 1.53ppm에서 정상관(正相關)(r=0.5525) 붕소(硼素)는 0.83ppm에서 정상관(正相關)(r=0.8647)를 보였으며, 알미늄과는 부(負)의 상관(相關)(r=-0.6872)이었다. 4. 고추 연작지(連作地)의 주요(主要) phytotoxin인 p-hydroxybenzoic acid함량(含量)이 증가(增加)할수록 역병(疫病)(r=0.9157) 및 탄저병(炭疽病)(r=0.6435)의 발생(發生)은 많아지고 수량(收量)은 감소(減少)하였다. 5. 토양(土壤) 개량제(改量劑)인 퇴비(堆肥), 석회고토분말시용(石灰苦土粉末施用)으로 균류(菌類)에 대(對)한 세균수(細菌數)(B/F비(比))와 방선균수(放線菌數)(A/F비(比))를 높일 수 있었으며 토양중(土壤中) phytotoxin의 집적(集積)이 현저히 감소(減少)되었고 이들 물질(物質)의 혼합시용(混合施用)으로 수량(收量)은 관행(慣行)에 비(比)해 22% 증수효과(增收效果)가 있었다. The present experiment was conducted to investigate effects of soil conditioner applied on continuous cropping fields of red pepper from 1985 to 1986 in Imsil, Chunbuk province. 1. The ratios of bacteria/fungi (B/F) and actinomycetes/fungi (A/F) in the soils of continuous cultivation were increased with application of phytotoxin decomposers such as deep tillage (De), compost (Co), magnesium lime (Mg), gypsum silicate, and De + Co + Mg. 2. Degradation of phytotoxin (p-hydrohylenyons aeid) in the continuous soils was promoted with application of De, Co, Mg, gypsum, silicate and De + Co + Mg resulting in yield increase. 3. The infection rate plant by phytophthora were decreased with deep tillage and application of compost and magnesium lime and caused the increase of yield (22%) due to the increase of fruit per hill.

호두 첨가에 따른 양조간장의 맛 성분 및 관능적 특성 변화

최희은 ( Hee-eun Choi ),유범석 ( Beom-seok Ryu ),최호민 ( Ho-min Choi ),김준협 ( Jun-hyub Kim ),정성모 ( Seong-mo Cheong ),이난희 ( Nan-hee Lee ),김나율 ( Na-yul Kim ),최웅규 ( Ung-kyu Choi ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.5

This study was conducted to investigate changes in organoleptic properties and taste components including free sugar, organic acid and free amino acid with addition of walnut. Changes in total nitrogen were insignificantly different with addition of walnut. Amino type nitrogen content was decreased in proportion to supplemental level of walnut. Content of organic acids, of which three kinds were detected, such as citric acid, malic acid and lactic acid increased more than two times with addition of walnut. Contents of free sugar and amino acid were decreased with addition of walnut. The proportion of essential amino acid was 40.6~41.4 percent. Glutamic acid in total amino acid was increased in proportion with addition of walnut. The highest sensory evaluation score was recorded in soy sauce with addition of 2 percent walnut. Together, it was expected that 2 percent addition of walnut to soy sauce has a positive effect on the taste of soy sauce.