생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

수학과 교육과정 실제 및 분석

김민경,노선숙,유현주,조성민,차인숙 이화여자대학교 사범대학 교과교육연구소 2001 교과교육학연구 Vol.5 No.1

21세기 지식기반사회는 자기 주도적으로 정보를 처리하고 해석하며 판단하는 능력과 지적 가치를 창조할 수 있는 능력을 길러주는 학교수학 교육을 요구하고 있다. 이에 수학교육과정에 담겨져야 할 수학적 지식의 구조․내용․범위, 지식기반 사회에 적합한 수학과 교수-학습, 평가, 교사역할 등 역시 새로운 관점에서 재조명될 필요가 있으며, 이러한 연구는 학교 현장에 대한 이해에서 출발하고 개인의 필요성과 사회의 요구를 반영한 것이어야 한다. 이에 본 연구에서는 지식기반사회에 대비하기 위한 수학과 교육과정 개발 연구의 기초 단계로 교사, 학생, 학부모를 대상으로 현장 설문 조사를 전국 규모로 실시하였다. 설문 조사는 Goodlad의 학교 교육과정 탐구의 개념적 구도를 바탕으로 한국 교육의 실정을 반영하여 설계되었다. 수학 교육과정 실체의 다양한 국면을 조사하기 위한 설문 내용은 목적 및 목표, 교과내용, 교수-학습방법, 평가, 수학적 지식의 성격, 교육정보화, 교사교육, 사교육, 교육과정일반으로 구성되었다. 본 고에서는 Goodlad의 교육과정 탐구모형과 그 모형에 기초하여 작성된 본 연구의 수학교육과정 탐구모형, 실시된 설문조사의 방법 및 절차를 소개하였고, 설문조사의 주된 결과를 토대로 수학교육과정 개발연구에의 시사점을 찾고자 하였다. This study is to provide suggestions for the development of better mathematics curriculum model of Korea based on a national survey of teachers (527), students (1314), and parents (638). It is our belief that understanding the perceptions and experiences of those involved in the process of teaching and learning of mathematics education needs to be the first priority in any effort to explore better mathematics curriculum model. For the study, Goodlad's conceptual system for curriculum inquiry has been used, but modified to take into account Korean context and the nature of mathematics curriculum. In this paper we introduce the Goodlad's curriculum inquiry model and mathematics curriculum inquiry model based on the Goodlad's conceptual system as well as the survey process. We made few recommendations from the main results of the survey for the research and development of mathematics curriculum model in Korea.

수학 교수-학습에서의 구성주의적 관점

조성민,노선숙 이화여자대학교 교육과학연구소 1999 교육과학연구 Vol.30 No.-

If constructivism is to be accepted as a fundamental framework for today's information oriented open education, it must offer something more concrete than just "student construct his/her knowledge". In order to clarify the role of constructivism in teaching and learning of mathematics, detailed review of research trend on constructivism widely spread in mathematics education was carried out. The study was conducted focusing on describing the role of the teacher. The study showed that constructivism in mathematics education can be described as a policy of non-interference by the teacher. The teacher needs to have the proper insight into mathematics education to know and recognize the process of student's construction to help the process of learning.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

유전알고리즘을 이용한 수직벽면 이동 로봇의 정·동적 최적설계

김재덕,노민석,정성현,홍대선 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Most shipbuilding works are manually carried out by workers, and safety consideration is an important issue especially in elevated-spot works such as painting and cleaning of outer wall of a ship. To cope with the circumstance, shipbuilding makers start to introduce wall-climbing robots for carrying out such tasks. In designing such a wall-climbing robot, it is essential to minimize its own weight to improve the performance such as moving speed and power saving. For such purpose, this paper proposes a method of optimal design for a wall-climbing robot body using genetic algorithm through static and dynamic analysis. Specifically, the thickness of the robot base is minimized to reduce the weight while maintaining the allowable strength and avoiding resonance frequencies. The proposed method is applied to the design of a wall-climbing robot, and the simulation results show that the method can be successfully adopted to the early stage of design.

복강경 불임시술 후 발생한 자궁외 임신에 관한 임상적 고찰

권선호,김성민,노흥태 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

This study is a clinico-statistical analysis of 19 cases of ectopic pregnancy which developed after laparoscopic tubal sterilization during the period from January 1983 to December 1985 in Chungnam National University Hospital. The results were as follows : 1. Among the 140 cases of ectopic pregnancy during the period, 19 cases(13.6%) were disclosed to occur after laparoscopic tubal sterilization. 2. The most frequent age group was in 26 to 30 years and the mean age was 31.2 years. 3. The average gravidity and number of living children were 4.1 and 2.6, respectively. 4. All patients were easily diagnosed preoperatively by culdocentesis, pregnancy test, diagnostic laparoscopy and sonography. 5. About 74% of the total patients presented themselves within 3 years after tubal sterilization, with shortest interval being 4 months, the longest 12 years, and mean 2 year 5 months. 6. The methods of sterilization was mostly electrocauterization (73.9%) and the rest was silastic band application (26.3%). 7. The average duration from last menstrual period of patients to the diagnosis of ectopic pregnancy was 6.2 weeks. 8. The majority of the patients presented with lower abdominal pain, nausea & vomiting, and bearing down sensation. 9. The most implantation site of ectopic pregnancy was fallopian tube(94.8%). 63.2% of the ectopic gestation was located in the distal of fimbrial segment and 31.6% in the proximal segment. 10. The average amount of intraperitoneal blood loss was 1190ml. 11. 89.6% of total cases was treated by unilateral salpingectomy or unilateral salpingooophorectomy.

창의적 문제해결을 위한 웹기반 교수-학습 모형과 학습 환경 설계 : 수학교과에서의 예시를 중심으로

구양미,김영수,노선숙,조성민 이화여자대학교 사범대학 교과교육연구소 2006 교과교육학연구 Vol.10 No.1

본 연구의 목적은 지식기반사회의 학습도구로서 그 중요성이 증대되고 있는 인터넷과 웹을 활용하여 창의성 계발을 돕는 교수-학습 모형과 웹기반 학습 환경을 설계하는 데 있다. 본 연구에서 웹은 학습도우미(learning agent)로서 문제해결 학습상황에서 의사소통도구, 발견과 탐색도구, 지식과 경험 구성의 도구로 상정되었다. 즉, 중등 수학교과를 사례로 채택, 문제해결 학습상황에서 생각 5단계 모형(생각 열기, 생각 쌓기, 생각 나누기, 생각 다지기, 생각 펼치기)을 토대로 각 단계별로 문제의 구조 유형에 따른 사고 전략과 이에 상응하는 학습자와 교수자 활동, 웹기반 활동을 포함하는 웹기반 교수-학습 모형을 설계하였다. 설계된 웹기반 교수-학습 모형에 따라 실제 교수-학습활동 계획안을 개발하고, 창의적 문제해결 환경 지원을 목적으로 한 웹사이트를 설계하였다. 본 연구의 결과물인 웹기반 교수-학습 모형과 학습 환경은 창의적 문제해결을 위한 핵심요소로 간주되는 확산적 사고, 비판적 사고 및 교과지식이 조화롭게 활용될 수 있도록 하는데 그 주안점을 두고 있다. The purpose of this study is to design a web-based teaching and learning model and learning environment for creative problem solving in Mathematics. In this study, World Wide Web is considered as a learning agent assisting learning process as communication tools, inquiry tool, and knowledge construction tools in problem solving learning environments. The web-based teaching and learning model was developed based on "Five Stage Thinking Model" that consists of uncover ideas, accumulate ideas, share ideas, ensure ideas, and unfold ideas. According to the steps of the model, a web-based lessen plan on coordinates in middle school mathematics was developed. Finally, a web-based their divergent thinking, critical thinking and subject knowledge for mathematical problem solving creatively. Some sample web pages were suggested for developing a web site based on the purposed model and the lessen plan.

시뮬레이션을 활용한 공급사슬 내 재고관리 방법 비교 연구

이재홍,구승환,노승민,장성용,Lee, Jae-Hong,Gu, Seung-Hwan,Noh, Seung-Min,Jang, Seong-Yong 한국시뮬레이션학회 2015 한국시뮬레이션학회 논문지 Vol.24 No.1

본 연구는 다양한 공급망 내 재고관리 방법 중 최적의 방법을 찾아내는 것을 목적으로 하고 있다. 비교대상 재고관리 방법은 Min-Max, 정기, 정량, 목표재고관리 방법으로 각 제품별 리드타임과 수요를 달리하여 구성하였다. 또한 공급사슬 망의 단계가 2단계인 경우와 3단계인 경우를 구분하여 공금망 단계를 줄였을 경우의 결과를 분석한다. 시뮬레이션 모형은 8개의 시나리오로 나뉘며, 각 시나리오는 주문방식과 단계로 구분할 수 있다. 시뮬레이션을 위한 입력 자료는 기존의 선행연구 결과와 실제데이터를 토대로 하였다. 시뮬레이션의 평가는 매출액, 총판매건수, 총배송비, 총결품량, 결품횟수, 결품손실금, 평균 재고량, 재고관리비, 순이익으로 실시한다. 시뮬레이션 결과 목표재고관리 방법이 가장 우수하게 나타났으며, 목표재고관리 시스템은 기존의 재고관리 방법을 사용한 시나리오보다 순이익 및 재고 등의 측면에서 우수한 결과를 나타냈다. 또한 기존의 공급사슬에서 한 단계 공급망을 줄였을 경우 수익이 증가하는 것을 확인할 수 있었다. 본 연구 결과는 목표재고관리 시스템을 추가적으로 고려하고 있다는 것과 공급사슬의 단계를 줄일 수 있는 개선 방안을 논의했다는 것에 의의를 둘 수 있다. This research focuses on the method of inventory management to find out the best way in various SCM. There are several comparable methods of inventory management like Min-Max, regular interval, fixed target inventory that have different lead-time and demand for each product. Also, the inventory performances between the case of three-stages and two-stages in SCM are analyzed. 8 scenarios for the simulation are suggested considering order ways and stages. Input data for the simulation is from the result of the previous studies and actual data in the market. The performance measurements are selected as sales revenue, total number of sales, total delivery cost, total inventory shortages, the number of inventory shortage occurrence, the loss for inventory shortages, average inventory, handling cost, net profit. According to the results of the simulation, fixed target inventory management is better than existing inventory management method by net profit and inventory and so on. Also, it was confirmed that the increase in profit is obtained when SCM stages is reduced from three-stages to two-stages in existing SCM. The result of the research provides significant meaning that newly introduced target inventory management system shows good performance and SCM performance can be improved by reducing the stages.

폐경 전 호르몬 수용체 양성 유방암 환자의 난소기능 측정을 위한 방법

김현아,우주현,최향숙,이석준,최지혜,박찬섭,성민기,노우철 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

The evaluation of menopausal status is an important subject in the field of treatment of hormone receptor positive breast cancer. According to the menopausal status, endocrine therapy should be categorized by individual patient. However, the gonadal injury caused by various therapeutic drugs and its recovery would confuse the interpretation of clinical and biological markers for ovarian reserve. There are some methods to examine the functional ovarian reserve indirectly. Ultrasonography for counting follicles is a relatively reliable procedure, although it is not feasible because of time-labor consumption and high cost. Biological marker from blood samples such as serum follicle stimulating hormone (FSH), serum estradiol (E2), serum inhibin, or anti-Müllerian hormone (AMH) would be a better choice. The examination of serum FSH and E2 is already recommended as biomarkers for measuring functional ovarian reserve in many guidelines. However, there are limitation of serum FSH and E2 in patients with chemotherapy- induced amenorrhea and treated by tamoxifen. AMH is promising biomarker in the field of infertility treatment even in the patients treated by chemotherapy. It might be a possible biomarker to determine the menopausal status for decision-making whether aromatase inhibitor could be applicable or not in hormone positive breast cancer patients with chemotherapy induced amenorrhea or treated by tamoxifen.

A case of sebaceous hyperplasia maintained with Low-dose isotretinoin after CO2 Laser treament (초)

( Seong Min Noh ),( Jin Young Jung ),( Hyun Joong Jee ),( Min Ju Choi ),( Ju Hee Lee ) 대한피부과학회 2011 초록집 Vol.49 No.10