건축설계 교육을 위한 하이퍼미디어 지원 지능형 교습시스템(ITS)의 적용방법에 관한 연구

박익수,신태양,정성구 호남대학교산업기술연구소 1997 산업기술연구논문집 Vol.4 No.-

본 연구의 최종목적은 하이퍼미디어 기법을 이용하여 건축학과 학생들의 설계교육에 필요한 제이론과 실습과정을 학습할 수 있도록 하이퍼미디어 지원 지능형 교습시스템(ITS)을 개발하는 것이다. 본 논문은 이를 위한 기초단계로서 먼저 건축설계 교육에 있어서 이론적 체계화 하이퍼미디어 지원 교습시스템에 적합한 영역구조를 구상해 보았다. 또한 적용방법의 기술적 환경으로서 CAI와 하이퍼텍스트의 개념과 구성 및 역할을 살펴보았으며, 하이퍼텍스트 개념을 적용한 원형모델을 구축하여 건축설계 교육을 위한 ITS 개발의 방법론적 형태를 고찰하였다. 앞으로 건축설계교육을 위한 ITS의 개발을 위해서는 타당성 검증을 통한 체계적인 건축설계교육안의 개발과 이에 적절한 ITS 프로그램 개발이 연구되어야 할 것으로 본다. The purpose of the study was to develope ITS for architectural design education by applying hypertext concept. For the purposes, this paper was the first step for applying architectural design education, dealed with the applicative method. The researchers trided to idealize the situable domain of architectural design education. Then, the researchers studied the concept of CAI and the composition of hypertext, moreover studied the applicative method for ITS development and built a prototype model to apply hypertext concept for architectural design education. The research is needed the development of the systamatic education model and the proper ITS program through a inspection of the propriety.

성견에서 표면처리된 교정용 마이크로임플랜트의 골 접촉률 및 동요도

박승현,김성훈,류준하,강윤구,정규림,국윤아 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

The purpose of this study was to evaluate the mobility and ratio of the bone-implant contact (BIC) of a sandblasted, large grit and acid-etched (SLA) orthodontic micro-implant. Methods: Ninety-six micro-implants (48 SLA and 48 machined) were implanted in the upper and lower buccal alveolar bone, and palatal bone of four beagle dogs. Two weeks after surgery, orthodontic force (150 - 200 g) was applied. Two beagles were sacrificed at 4-weeks and the other two at 12-weeks. Histomorphometric comparisons were made between the SLA experimental group and the machined micro-implant as a control group to determine the ratio of contact between the bone and implant. Micro-implant mobility was also evaluated using Periotest. Results: Periotest values showed no statistically significant difference in the upper alveolar and palatal bone between groups except for the lower buccal area. BIC in the upper buccal area showed no significant difference between groups both at 4-weeks and 12-weeks. However, both the groups showed a significant difference in BIC ratio in the rest of the experimental areas between 4 weeks and 12 weeks. The experimental group showed active bone remodeling around the bone-implant interface compared to the control group. Conclusions: There were significant differences in the BIC and the Periotest values between the surface-treated and machined micro-implants according to bone quality in the early stage. 본 연구는 비글견에 식립된 sandblasted, large grit and acid-etched (SLA) 표면처리된 교정용 마이크로임플랜트와 평활면 마이크로임플랜트에 교정력을 가한 후 시간 경과에 따른 동요도와 골접촉률의 차이를 규명하기 위해 시행되었다. 비글 성견 네 마리를 이용하여 상, 하악 협측과 구개측 골에 대해 SLA 표면처리된 표면처리군 48개, 평활면의 비처리군 48개의 마이크로임플랜트 96개를 식립하고 2주의 치유기간 후 교정력(150 - 200 g)을 지속적으로 가했으며 식립 4주 후에 두 마리를 희생시키고, 12주 후에 나머지 2마리를 희생시켰다. 표면처리군과 비처리군 간의 마이크로 임플랜트의 동요도와 골과 임플랜트 간 접촉률을 조직학적인 측면에서 측정 비교하여 다음과 같은 결과를 얻었다. 상악 협측과 구개측에서는 표면처리군과 비처리군의 동요도에서 유의성 있는 차이가 없었으나 하악협측에서는 표면처리군이 유의하게 안정적인 동요도를 보였다. 마이크로임플랜트와 인접골 간 접촉률은 상악 협측에서는 4주와 12주 모두 표면처리군과 비처리군 간에 유의한 차이가 없었으나 하악 협측과 구개측의 경우 4주와 12주 모두 표면처리군이 비처리군에 비해 유의하게 높은 접촉률을 보였다. 표면처리군은 비처리군에 비해 임플랜트 주변에서 활발한 골개조가 관찰되었으며 모든 군에서 이물반응은 관찰되지 않았다. 본 연구를 통해 SLA 표면처리된 마이크로임플랜트는 평활면 마이크로임플랜트에 비하여 식립 초기에는 식립 부위에 따라 유의하게 높은 인접골 간 접촉률과 동요도의 안정성을 보임으로써 다양한 크기와 방향의 교정력의 적용이 가능할 것이라 생각한다.

천연두 백신 접종 후 발생된 급성 심근염 1예

박옥성,김종환,이광욱,윤성훈,강동구,이승욱,조상기 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Acute myocarditis complicating coronary vasospasm after smallpox vaccination is very rare complication that can be generally developed within less than 30 days after vaccination. Clinically and biochemically, this disorder is often mimic and highly suggestive of acute myocardial infarction. We report 21 years old man that had a history of a smallpox vaccination 3 weeks ago and prodromal symptoms(fever, malaise etc) a few days ago. hIe visited to our hospital because of abrupt onset of severe substernal chest pain, dyspnea and diaphoresis. At admission, electrocardiography was ST elevation in lead Ⅰ, aVL, V4, V5, and V6. The CK-MB level was 68 U/L, LDH level was 760 U/L, Troponin-Ⅰ was 24.64 ng/㎖, and Troponin-T was positive. 2D-echocardiograpy was normal left ventricular function, Clinically we presumed this disorder as acute myocardial infarction and we promptly performed the coronary angiography and revealed focal spasm in distal left coronary artery territory without critical stenosis in both coronary arteries. We diagnosed this disorder as coronary vasospam complicating acute myocarditis that is different with acute myocardial infarction, and we prescribed nitroglycerin and nifedipine. After discharge, he is now well without any symptoms and has been following up monthly at our outward department for 6 months.

부산지역 산성강우의 특성과 주영향인자 해석에 관한 연구

황성욱,유수영,조정구,박정호,최금찬 동아대학교 환경문제연구소 2003 硏究報告 Vol.25 No.2

Acid rain was strongly raised in regional air pollution problems. All of researchs have been focused in plt tendency in a limited area. But, chemical composition data are important because of the control strategy are also necessary to reduce source emission from various air pollution sources. Longtime may be helpful to evaluate acid rain effect to regional area for a long time. We have accumulated acid data from Sep. 1993 to Jan. 2003. In this study, data which was given from Sept., 1993 to 2000 is measured pH and EC, analyzed cations anions by ion chromatography. All of analyzed data were calculated to fit average and standard by SAS package.

관동맥연축의 진단을 위한 Ergonovine Echocardiography의 안전성 및 임상적 유용성

송재관,박성욱,강덕현,조구영,나득영,이내희,이철환,홍명기,김재중,박승정 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

원격 영상 정보 시스템의 개발

김선호,유선국,김용구,박성욱,김성림,김남현 대한의료정보학회 1996 Healthcare Informatics Research Vol.2 No.1

간헐적 복통과 혈변이 동반된 성인의 맹장-결장 회전결여증 1예

정서진,박성흠,윤서구,박치구,최경우 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

장기간 Furosemide 의 복용으로 발생한 신수질 석회화가 동반된 가성 Bartter 씨 증후군

박성수,박경주,박송자,박성훈,윤여학,조윤숙,채봉남,이가희,김윤구,최진용 대한내과학회 1993 대한내과학회지 Vol.45 No.2

A 30-year-old married woman showed hypokalemic metabolic alkalosis, normotensive hyperreninemia, hyperaldosteronism and a high urinary sodium and chloride level. She was thought have Bartter's syndrome because she denied taking diuretics. But all the five tests of urine for furosemide by high performance liquid chromatography (HPLC) gave positive results. On being confronted with the results of urine analysis showing the presence of furosemide, she did admit to the taking of furosemide for 11 years. Renal radiologic studies including intravenous pyelography, ultrasonography, and computed tomography showed medullary nephrocalcinosis. This case is unique in that nephrocalcinosis have been related to long term furosemide ingestion in adults and we concluded that this apparent case of Bartter's syndrome with nephrocalcinosis was caused by long term surreptitious diuretic ingestion and suggest that this may occur more frequently than is generally appreciated.

Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of transferrin receptor

( Seong Heon Kim ),( Jin-hwa Cho ),( Bi-oh Park ),( Byoung Chul Park ),( Jeong-hoon Kim ),( Sung Goo Park ),( Sunhong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2021 BMB Reports Vol.54 No.5

RalBP1 associated EPS domain containing 1 (REPS1) is conserved from Drosophila to humans and implicated in the endocytic system. However, an exact role of REPS1 remains largely unknown. Here, we demonstrated that mitogen activated protein kinase kinase (MEK)-p90 ribosomal S6 Kinase (RSK) signaling pathway directly phosphorylated REPS1 at Ser709 upon stimulation by epidermal growth factor (EGF) and amino acid. While REPS2 is known to be involved in the endocytosis of EGF receptor (EGFR), REPS1 knockout (KO) cells did not show any defect in the endocytosis of EGFR. However, in the REPS1 KO cells and the KO cells reconstituted with a non-phosphorylatable REPS1 (REPS1 S709A), the recycling of transferrin receptor (TfR) was attenuated compared to the cells reconstituted with wild type REPS1. Collectively, we suggested that the phosphorylation of REPS1 at S709 by RSK may have a role of the trafficking of TfR. [BMB Reports 2021; 54(5): 272-277]