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홍정표,최선희,조만종,이성주,박종,김기순,김양옥 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
The main purpose of this study is to identify and evaluate the depressive states for the patients with chronic pulmonary tuberculosis. A questionnaire(Self-rating Depression Scale, SDS) survey was performed toward 57 pulmonary tuberculosis patients with initial treatment who started chemotherapy and 53 pulmonary tuberculosis patients with retreatment, admitted to one tuberculosis-centered hospital and two general hospital. Fifty three healthy persons as control group were investigated with the same questionnaire for comparison. The survey was performed from July to August 1996. The results are as follws : 1. The patients had significantly high scores in the depression than control and the patient with retreatment showed significantly high scores in the depression than the patient with initia1treatment(P<0.01). 2. The depressive levels of the patients were associated with duration of admission and the expectancy of recovery (P<0.05). 3. The percentage of the subjects with 40 or more scores tentatively classifiable as psychologically depressed was 67.1% of the total subjects, 48.4% of the control groups, 75.0% of the patient with initial treatment and 84.1% of the patient with retreatment. Because patient with pulmonary tuberculosis with initial treatment showed higher depression scores than normal persons, and patients with retreatment due to failure of initial treatment showed higher depression scores than initial treatment, it is necessary to give attention to depression of the patients during treatment of pulmonary tuberculosis.
Swivel joint를 이용한 비대칭 발치증례의 교정적 공간폐쇄
고창희,임성훈,김광원,정동기,김도영,박선주,양용근 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1
Extraction therapy is popular treatment protocol in orthodontics. Generally, symmetric premolar extraction is performed. But, in some cases, asymmetric extraction is required to solve asymmetric dental alignment. But asymmetric extraction treatment has side effects and disadvantages like a) collapse of dental arch form. b) canting of occlusal plane, c) extended treatment duration. For a good treatment result, we applied the orthodontic space closing arch wire with swivel joint to allow rotational movement of arch wire segments during space closure, Now we present a case treated with orthodontic space closing arch wire with swivel joint.
( Yang Seon Yi ),( Sang Soo Kim ),( Won Jin Kim ),( Min Jung Bae ),( Ji Hyun Kang ),( Bo Gwang Choi ),( Yun Kyung Jeon ),( Bo Hyun Kim ),( Byung Joo Lee ),( Soo Geun Wang ),( In Joo Kim ),( Yong Ki Ki 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2
Background/Aims: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer. Methods: All 2D data were interpreted in real time and 3D data were stored, rendered using tomographic ultrasound imaging (TUI), and then reviewed retrospectively. Results: Extrathyroidal extension was present in 17 papillary thyroid cancers 24.3%) on pathology reports. The presence of contact was significantly associated with extrathyroidal extension on both 2D and 3D US (p = 0.007 and p = 0.003), and the sensitivity and specificity were not significantly different between 2D and 3D US (p = 1.000 and p = 0.754). The coexistence of protrusion and contact was not significantly associated with extrathyroidal extension on either 2D or 3D sonogram. Conclusions: Three-dimensional images rendered with TUI algorithms alone do not seem to be markedly superior to real-time 2D US in predicting the extrathyroidal extension of papillary thyroid cancer.
Phenotypic and Genotypic Detection of Metallo-β-Lactamase Producing Pseudomonas aeruginosa
Yang, Byoung-Seon,Hong, Keun-Seok,Jung, Seung-Bong,Kwon, Young-Hoon,Jeong, Jong-Yoon,Lee, Min-Joo,Lee, Hye-In,Park, Mi-Seon,Choi, Seung-Gu 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.2
This study was undertaken to evaluate phenotypic and genotypic methods for detection of Metallo-Beta-Lactamases (MBLs) among nosocomial Pseudomonas aeruginosa. Of the 50 P. aeruginosa isolates from clinical specimens, 20 were evaluated for carbapenem resistance and screened for MBL by double-disk synergy test and combined-disk test. Nineteen strains (95%) were found to be MBL producers among the 20 P. aeruginosa. MBL positives were further confirmed by Polymerase Chain Reaction (PCR). For the IMP and VIM types of MBLs, PCR analysis was performed on 19 of the 20, and 10 were positive for VIM MBL type. This study reports the validation of a simple and accurate MBL detection method that can be easily incorporated into the daily routine of a clinical laboratory. Early detection of MBL-carrying organisms, including those with susceptibility to carbapenems, is of paramount clinical importance, as it allows rapid initiation of strict infection control practices as well as therapeutic guidance for confirmed infection.Key Words : Hepatitis A virus (HAV), Anti-HAV, Hospital workers, Prevalence, Vaccination
Phenotypic and Genotypic Detection of Metallo-ß-Lactamase Producing Pseudomonas aeruginosa
( Byoung-seon Yang ),( Keun-seok Hong ),( Seung-bong Jung ),( Young-hoon Kwon ),( Jong-yoon Jeong ),( Min-joo Lee ),( Hye-in Lee ),( Mi-seon Park ),( Seung-gu Choi ) 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.2
This study was undertaken to evaluate phenotypic and genotypic methods for detection of Metallo-Beta-Lactamases (MBLs) among nosocomial Pseudomonas aeruginosa. Of the 50 P. aeruginosa isolates from clinical specimens, 20 were evaluated for carbapenem resistance and screened for MBL by doubledisk synergy test and combined-disk test. Nineteen strains (95%) were found to be MBL producers among the 20 P. aeruginosa. MBL positives were further confirmed by Polymerase Chain Reaction (PCR). For the IMP and VIM types of MBLs, PCR analysis was performed on 19 of the 20, and 10 were positive for VIM MBL type. This study reports the validation of a simple and accurate MBL detection method that can be easily incorporated into the daily routine of a clinical laboratory. Early detection of MBL-carrying organisms, including those with susceptibility to carbapenems, is of paramount clinical importance, as it allows rapid initiation of strict infection control practices as well as therapeutic guidance for confirmed infection.Key Words : Hepatitis A virus (HAV), Anti-HAV, Hospital workers, Prevalence, Vaccination
고분자 마이셀을 이용한 레티놀 제형개발: 레티놀 안정성
양희선(Hee Seon Yang),안주영(Joo Young An),김채진(Chae Jin Kim),구태성(Tea-Sung Koo),이은희(Eun Hee Lee),육순홍(Soon-Hong Yuk),이재휘(Jae-Hwi Lee),신병철(Byung Cheol Shin),조선행(Seon-Hang Cho) 한국고분자학회 2021 폴리머 Vol.45 No.1
레티놀은 빛, 열 및 산소에 대해 불안정하다는 특징이 있어 레티놀에 대한 안정화 기술이 계속해서 요구되고 있다. 이러한 추세에 따라 안정성이 개선된 레티놀 폴리머 마이셀 연구를 수행하게 되었다. 레티놀 조성에 산화방지제를 함량별 첨가하였고 입도 측정, 장기 및 가속 안정성, 피부투과 등 실험을 진행하였다. 입자 크기는 산화방지제 함량에 따라 차이를 나타내었다. 이 중 레티놀과 butylated hydroxyanisole(BHA) 비율이 1:1인 M3 조성은 80.83% 및 81.18%의 장기 및 가속안정성을 나타내었다. 이 제형을 대상으로 피부투과 실험을 진행하였을 때, 대조군으로 사용된 S1보다 M3의 피부투과율(52.8%)이 더 크게 나타났다. 종합적으로 레티놀 안정성을 개선할 수 있는 산화방지제와 계면활성제의 적합한 비율을 확립하였다. Retinol is unstable to the external environment and its properties can deteriorate. Therefore, new stabilization techniques for retinol are needed. According to this trend, a lot of research to improve the stability of retinol is ongoing. Antioxidants were added to the core part of the retinol polymeric micelle particle by content. After preparting the retinol micelle formulation with antioxidants by content, experiments such as particle size measurement, long-term and accelerated stability test, and skin permeation were performed. The micelle particle size depended on the antioxidant ratio. The retinol proportion of M3 composition with a ratio of retinol to butylated hydroxyanisole (BHA) of 1:1 did not show any change in both long-term stability test (80.83%) and accelerated stability test (81.18%). Skin permeation experiments were performed on this formulation. As a result, the skin permeability of M3 (52.8%) was greater than that of S1 used as a control. As a comprehensive result, retinol stability was improved by establishing an appropriate ratio of antioxidants and surfactants.
( Hyo Joon Yang ),( Chang Hyun Lee ),( Seon Hee Lim ),( Jong In Yang ),( Seung Joo Kang ),( Min Jung Park ),( Su Jin Chung ),( Jong Pil Im ),( Sang Gyun Kim ),( Joo Sung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: This study aimed to identify the clinical characteristics and prognosis of primary gastric lymphoma detected by screening upper endoscopy in high prevalence area of Helicobacter pylori ( H. pylori) infection. Methods: Between October 2003 and May 2013, consecutive subjects who were diagnosed with primary gastric lymphoma by screening upper endoscopy were retrospectively enrolled at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea. Results: During the study period, a total of 101,103 subjects received 207,114 screening upper endoscopy. Among them, primary gastric lymphoma was detected in 49subjects. They were 53.0 ± 10.5 years of age, and 72.9% (35/49) were female. Histologic type of primary gastric lymphoma was predominantly (98.0%, 48/49) extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), and one remaining case (2.0%) was diffuse large B-cell lymphoma. Initial stage was IEa in 95.9% (47/49), and H. pylori was positive in 91.8% (43/49). Among 41 H. pylori-positive patients with gastric MALT lymphoma stage IEa, H. pylori eradication achieved complete remission in 95.1% (39/41). There were three cases of recurrence with (n = 2) or without (n = 1) reinfection of H. pylori. Conclusions: Upper endoscopy as a screening for upper gastrointestinal malignancymay detect gastric MALT lymphoma in early stage, which can be successfully treated with H. pylori eradication, especially in H. pylori endemic area. For those who achieved complete remission, it is needed to undertake surveillance for recurrence.