Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Validation of the oxford classification of iga nephropathy: A Single-Center Study in Korean Adults

( Ho Young Lee ),( Sul Hee Yi ),( Mi Seon Seo ),( Jin Nam Hyun ),( Jin Seok Jeon ),( Hyunjin Noh ),( Dong Cheol Han ),( Seung Duk Hwang ),( So Young Jin ),( Soon Hyo Kwon ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.3

Background/Aims: The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population. Methods: In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee`s classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly. Results: The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ± 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan-Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions. Conclusions: Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

2-Thenoyltrifluoroacetone에 의한 구리의 용매 추출에서 Tri-n-Octylamine 상승작용이 추출속도에 미치는 영향

이동선,장윤식,장진규 동의공업대학 1998 論文集 Vol.24 No.1

The extraction of Copper from aqueous perchloric add into a solution of 2-Thenoyltrifluoroacetone(TTA) in benzene is known to be very slow. The system does not reach equilibrium within a practical contact time of the two phase. The addition of tri-n-octylamine(TOA) and a mixture tri-n-octylamine with chloride ion was found to increase the rate considerably from the results of a detailed investigation, the reason for this effect is considered to be the replacement of a slow step, the direct formation of the Cu(TTA)_(2) in the aqueous phase, by a series of fast reactions to the formation of a Copper-tri-n-Octylamine oxide species in the aqueous phase, followed by its extraction into the organic phase and its reaction with TTA in the organic phase.

Eysenck의 성격차원과 수면특성의 관계

이형영,국승희,윤진상,신일선 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 수면은 생리적 현상이므로 이를 성격과 관련짓기 위해서는 생물학적 이론에 기초한 성격평가도구의 선택이 바람직하다. 따라서 본 연구는 생물학적 성격차원이론을 체계화한 Eysenck의 성격차원과 수면특성의 관계를 알아보고자 하였다. 방 법 : 종합대학교 남녀학생 532명을 대상으로 주중 수면습관과 수면장애를 묻는 설문지, Eysenck의 성격차원 검사를 실시하여 509명의 자료를 얻었다. 네가지 성격차원(정신병적 경향성, 신경증적 경향성, 외향성, 허위성)점수, 주중 수면습관과 수면장애의 기술 통계치를 산출하였으며, 이들 성격차원과 수면특성(주중 수면습관, 수면장애)의 관계를 알아보기 위해 Pearson의 적률상관을 산출하였다. 결 과 : 연구대상자의 네가지 성격차원 점수와 주중 수면습관은 정상범위였고, 가장 빈도가 높은 수면장애는 입면의 어려움이었으며, 가장 빈도가 낮은 수면장애는 몽유였다. 정신병적 경향성과 주중 취침시각, 기상시각, 수면잠복기, 깨는 빈도, 수면의 규칙성, 낮잠과 깜박잠의 빈도와 지속시간 및 입면의 어려움을 포함한 수면장애는 정적 상관이 있었고, 수면의 질, 일주기 리듬의 점수는 유의미한 부적 상관이 있었다. 신경증적 경향성과 수면습관 및 수면장애의 관계도 이와 유사하였다. 외향성은 수면의 질 및 일주기 리듬의 점수와 정적 상관이 있었으나 수면장애와는 관계가 없었다. 허위성은 일주기 리듬의 점수와 정적 상관이 있었으며, 수면잠복기, 수면의 규칙성, 낮잠과 깜박잠의 빈도 및 지속시간, 수면장애와 부적 상관이 있었다. 결 론 : 정신병적 경향성과 신경증적 경향성이 높을수록 수면습관이 더 좋지 않았고, 수면장애의 빈도가 높았다. 외향성이 높을수록 수면의 질이 좋았고, 아침형에 근접하였다. 허위성이 높을수록 아침형에 근접하고, 수면이 더 규칙적이었으며, 주간의 졸음이 적었고, 수면장애의 종류 및 빈도가 적었다. 이러한 결과는 Eysenck의 성격차원과 수면특성이 밀접한 관련이 있음을 시사한다. Objectives : In order to evaluate the possible relationship between sleep and personality characteristics, it is desirable to adopt the personality theory with biological basis because sleep is a physiological phenomenon. The purpose of this study was to investigate their possible relationship using the personality dimensions of Eysenck, which is well known as a biological personality theory. Methods : Sleep Questionnaires regarding the weekday sleep habits and the sleep disorders and Eysenck's Personality Questionnaire were administered to 532 university students. Data analysis was based on 509 students who gave reliable information. Firstly, the descriptive statistics of the scores on four personality dimensions(psychoticism, neuroticism, extraversion, lie) and sleep characteristics were obtained. Secondly, the possible relationships between each personality dimension and sleep characteristics(the weekday sleep habits and sleep disorders) were tested by calculating Pearson's product moment correlations. Results : The four personality dimensions' scores and weekday sleep habits of subjects were within a normal range. The highest frequency of sleep disorder was induction difficulty of sleep and the lowest was sleep walking. Psychoticism was positively correlated with bedtime, rise time, sleep latency, number of awakening, regularity of sleep, frequency and duration of nap and doze, frequency of sleep disorders, while negatively correlated with the quality of sleep, and the score of circadian rhythm. The correlations between neuroticism and sleep characteristics were similar to those of psychoticism. Extraversion was positively correlated with the quality of sleep and the score of circadian rhythm, while not correlated with sleep disorders. Lie was positively correlated with the score of circadian rhythm, but negatively correlated with sleep latency, regularity of sleep, frequency and duration of nap and doze, and sleep disorders. Conclusions : The higher psychoticism and neuroticism, the poorer sleep habits and the higher frequency of sleep disorders. The higher extraversion, the better quality of sleep and the closer morningness. The higher lie, the closer morningness, the more regularity of sleep, the less sleepiness of daytime, and the less frequency of sleep disorders. These findings suggest that there exist the close relationships between Eysenck's personality dimensions and sleep characteristics.

Base Emitter Codiffusion 소자 제조 및 전기적 특성 고찰

李善東,金政彦,朴淳太,梁光鎭,洪昌熹 동아대학교 공과대학 부설 한국자원개발연구소 1990 硏究報告 Vol.14 No.2

In the time when we fabricated the NPH bipolar transistor the temperature annealing was needed. Then the properties of transistor was damaged because of inducing the silicon lattice defects. In this paper, proposed codiffusion method was able to control of junction depth by implant energy, dose concentration, diffusing temperature and annealing time control. In addition to, we studied for developed the transistor of high speed switching.

저밀도 세라믹 필터의 특성 및 내구성에 관한 연구

이동섭,이선하,박진식 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

This study was Designed to examine the applicability of low density ceramic filters to actual processes through long term experiment to reveal the characteristics ceramic filter, durability against thermal and mechanical shocks. The experiment was also conducted at 600℃ and 300℃. 1m long low density ceramic filter with 60㎜ outer diameter and 10㎜ thickness was tested with dust collected from cokes process of P-steel. Collection efficiency ranged 99.98∼99.99% and conditioning was completed after 150∼200hrs. Resistance coefficients of filters range 5.9×10^10 at 600℃, 1.2×10^10 at 300℃. Long term experiments show that conditioning was completed after 155 hours of test at 300℃ and 165 hours at 600℃ with high collections efficiencies. Also tested filters show mechanical stabilities at different particulate feed rates ranging 0.5g/min to 1.0g/min. Results show that tested filters can be applied to commercial processes with one year guarantee.