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개 이자의 Somatostatin 양성세포의 발달에 관한 면역조직화학적 연구
장인엽,윤상필,정윤영,김종중,문정석,한길현,김영택,안계훈,선희매 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Cells immnunoreactive for somatostatin(SOM) and glucagon(GLU) were investigated in postnatal day 0, 7, 14, 28, 90, 180 and adult canine pancreas using light microscopic immunohistochemistry. Pancreatic SOM-immunoreactive cells were found in pancreatic acini, pancreatic duct, and pancreatic islet gradually. Pancreatic SOM-immunoreactive cells were more located in pancreatic parenchyme than pancreatic islet throughout pancreas by postnatal day 28. But there was change by the postnatal 3 months : pancreatic SOM-immunoreactive cells were more located in pancreatic islet than acini and duct. It is suggested that the number of the SOM-immunoreactive cells may not increase with age apparently. A small number of SOM-immunoreactive cells that showed GLU-immunoreactivity were also observed in canine pancreatic islet. The physiologic consequences of these changes remain to be determined. These results sugegest that SOM in the developing pancreas may relate to the secretion of pancreatic hormones.
( Sang Youb Han ),( Kyung Hwan Jeong ),( Chun-gyoo Ihm ),( Young Sun Kang ),( Dae Ryong Cha ) 대한신장학회 2021 Kidney Research and Clinical Practice Vol.40 No.1
Background: Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods: Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls (age, 44.84 ± 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/Th2 cytokines and the response to glucocorticoid treatment. Results: The levels of serum interferon-gamma (IFNγ) and urinary monocyte chemoattractant peptide (MCP)-1 were higher in the IgAN group than in the control group. The levels of MCP-1 in urine and secreted by peripheral blood mononuclear cells (PBMCs) were significantly different among three groups categorized based on daily proteinuria. The level of urinary MCP-1 was significantly correlated with proteinuria. The levels of urinary MCP-1, serum interleukin (IL)-4, IFNγ, and IL-2 secreted by PBMCs and intrarenal IL-1 messenger RNA (mRNA) were significantly correlated with the ratio of proteinuria at 6 months to baseline proteinuria in patients undergoing glucocorticoid treatment. MCP-1 mRNA and protein levels were significantly upregulated in mesangial cells stimulated with IFNγ among representative Th1/Th2 cytokines. Conclusion: IFNγ was shown to be a key cytokine in the pathogenic processes underlying IgAN, and its upregulation induced an increase in urinary MCP-1 production. These findings suggest that Th1 cytokines may play an important role in the development of IgAN.
ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy patients
Sang Youb Han,Young Joo Kwon,Sang Kyung Jo,Jin Ho Shin,Dae Ryong Cha,Won Yong Cho,Heui Jung Pyo,Hyoung Kyu Kim 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.1
We examined the renal responsiveness to ACE inhibitor in IgA nephropathy (IgAN) patients according to the grouping of ACE gene polymorphism. Sixty one patients diagnosed as IgAN by renal biopsy and prescribed with ACE inhibitors were enrolled. Genomic DNA
Nonocclusive Mesenteric Ischemia in a Patient on Maintenance Hemodialysis
Sang Youb Han,Young Joo Kwon,Jin Ho Shin,Heui Jung Pyo,Ae Ree Kim 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.1
Nonocclusive mesenteric ischemia(NOMI) is known to occupy about 25% to 60% of intestinal infarction. NOMI has been reported to be responsible for 9% of the deaths in the dialysis population and the postulated causes of NOMI include intradialytic hypotensio
당뇨병성 신증쥐에서 retinoid와 PPAR-γ 촉진제 병합투여에 관한 연구
한상엽 ( Sang Youb Han ),김시현 ( Cy Hyun Kim ),한금현 ( Kum Hyun Han ),차대룡 ( Dae Ryong Cha ),김한성 ( Han Seong Kim ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.5
Purpose : An inflammatory mechanism has been suggested to contribute to the progression of diabetic nophropathy. Both retinoid and PPAR-7 agonist, known anti-inflammatory agents, have been reported to be beneficial in diabetic nephropathy. Because they form heterodimer for transcription within the nucleus, we investigated the effect of a combination treatment with them in streptozotocin (STZ)-induced diabetic rats. Methods: STZ-induced diabetic rats were treated with retinoid and PPAR- r agonist. The effects were determined by measuring urinary monocyte chemoattractant peptide (MCP)-i, proteinuria, and intrarenal ED-1 expression. Results Blood glucose concentration was higher in diabetic rats than in control rats. Retinoid and PPAR- r agonist did not affect blood glucose concentration. Urinary protein excretion (8.6 I 0.69 vs. 22.1 mg/mgCr, p<0.0l) and urinary MCP-1 (19.8z3.4 vs. 61.5±6.1 pg/mgCr, p`cO.Ol) were significantly higher in diabetic rats at four weeks after the induction of diabetes compared with controls. Proteinuria in the group with retinoic acid (16.9 1.4, mg/mgCr, pcz0.05) and PPAR-7 agonist (14.6 `1.5 mg/mgCr, pc0.05) were decreased. Retinoic acid (42.2±2.7 pglmgCr, p<O.05) and PPAR- agonist (40.5 `4.2pg/mgCr, pc0.05) significantly suppressed MCP-1 level in diabetic rats. However, combination treatment ment was not effective to proteinuria and urinary MCP-1 concentration. Urinary protein excretion was significantly correlated with MCP-1 (r0.9, p`c0.0i). Immunohistochemistry revealed a significant increase in staining for ED-i protein in the diabetic kidneys. Both retinoid and PPAR-γagonist significantly suppressed intrarenal ED-i synthesis. However combination treatment didnt show any additional beneficial effects. Conclusion: Both retinoic acid and PPAR-γagonist suppressed preteinuria and inflammatory changes in diabetic rats. However, there were no additional effects of the combination treatment present. Further ressrch is needed to determine the effect of the combination treatment on diabetic nephropathy.
( Tae Wan Kim ),( Seung Dae Kang ),( Han Sang Lee ),( Sang Youb Han ),( Yee Gyung Kwak ),( Keon Cheol Lee ),( Han Seong Kim ),( Kum Hyun Han ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
Renal and perirenal abscesses are disease entities caused by infections in or around the kidneys. As imaging modalities have improved in quality and convenience, diagnosing these diseases has become easier. Some cases are refractory to conventional treatment and require surgical correction, although most patients can be cured by antibiotic treatment and percutaneous drainage. We here report the case of a patient with a perirenal abscess that recurred twice after appropriate antibiotic treatment and percutaneous drainage. Although Gram-negative bacilli are the most common pathogenic cause of these diseases, we isolated methicillin-resistant Staphylococcus aureus and Mycobacterium tuberculosis in our patient. Thus, poor responses to appropriate treatment in patients with a perirenal abscess can result not only from antimicrobial resistance or a co-infection but also from the 2 conditions existing concomitantly.