TERUDERMIS를 이용한 골 혹은 건이 노출된 창상의 치료

최민호,이상복,황정욱,양완석,이강길 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Deep skin and soft tissue defects with exposed bone and tendon is difficult to treat, because skin graft rarely survives and flap surgery is sacrifice of donor site. Since "Stage I" membrane was developed by Yannas and Bruke in 1980, numerous kinds of artificial skin have been developed. The adaptability of "Terudermis", developed by the Terumo Co., as an artificial skin composed of sponge made of a fibrillar atelocollagen and a heat-denatured atelocollagen, was clinically evaluated on application to 13 cases presenting deep skin and soft tissue defect with exposed bones and tendons from October 1997 to march 1998. Terudermis has the advantage of allowing early incorporation of fibroblasts and capillaries into its collagen sponge due to very weak dehydrothermal cross-linking. Before Terudermis graft, several days of wet dressing and debridement were required to prepare healthy well- vascularized bed because Terudermis was weak on unsanitary wounds. After bed preparation, Terudermis was grafted like usual skin graft. Tie-over bolster dressing or compressive dressing was used case by case. The dressing was opened 2~3 days after Terudermis grafting. Wet dressing was done daily until the skin graft was done. Autologous skin graft was done 2∼3 weeks after Terudermis graft. Our clinical results indicated that Terudermis was beneficial in treating 77% of our patients. Through the use of this new method, treatment of severe skin and soft tissue defects that are usually treated by musculocutaneous or other conventional skin flaps can be replaced by Terudermis as an new artificial dermis.

뉴로메드정(옥시라세탐 800㎎)에 대한 뉴라세탐정의 생물학적동등성

최성업,김종석,윤미경,김정일,박석,한상범,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

The purpose of the present study was designed to evaluate the bioequivalence of two oxiracetam tablets, Neuromed tablet (Korea Drug Co., reference drug) and Neuracetam tablet (Sam Jin Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Release of oxiracetam from the tablet in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty-four healthy volunteers, 23.7 ± 2.4 year in age and 68.9 ± 6.2 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was performed. After oral administration of a tablet containing 800 ㎎ of oxiracetam, blood samples were taken at predetermined time intervals and concentrations of oxiracetam in plasma were determined using HPLC-MS-MS. The dissolution profiles of two formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as AUCt, C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, and C_(max), untransformed T_(max). The results showed that the differences between two formulations based on the reference drug were 0.42%, 0.45% and -12.58% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log0.94 ~ log1.06 and log 0.90 - log 1.07 for AUCt and C_(max), respectively), indicating that Neuracetam tablet is bioequivalent to Neuromed tablet. The major pharmacokinetic parameters, AUCt, and C_(max), met the criteria set by KFDA for bioequivalence indicating that Neuracetam tablet is bioequivalent to Neuromed tablet.

Langmuir-Blodgett 초박막의 전기적 특성

최병호,김성진,정순욱 金烏工科大學校 1998 論文集 Vol.19 No.-

Ultrathin film of 100Å-order is fabricated by Langmuir-Blodgett technique. By measure of UV-vis spectra and capacitance, deposition status was confirmed together with the thickness of natural oxidized aluminum film inside a device and dielectric constant of (N-docosyl pyridinium)-TCNQ(1:2) complex. The conductivity of this film measured by the direction of either vertical or horizontal axis is results in a quite different value.

급속응고된 Al-Zr 합금의 시효현상에 미치는 Si첨가의 영향

최상욱,박홍일,김명호 울산대학교 1987 연구논문집 Vol.18 No.2

본 연구에서는 급속응고된 Al-Zr 합금의 과포화 고용도에 미치는 제3첨가 원소 Si의 영향 및 급속응고된 Al-Zr-Si 합금계의 시효특성에 관하여 실험적으로 조사하였다. Twin-roller 장치에 의하여 급속응고시킨 시편의 응고속도는 10?? K/s 정도였으며, 이때 Al기지내에 Zr은 약 1 wt.% 정도만이 과포화 고용되었다. 그러나 Si의 첨가량이 증가됨에 따라 Zr의 과포화 고용도는 증대되어 Si의 첨가량이 1 wt.% 일때 Zr은 1.7 wt.% 정도 Al기지내에 완전 과포화 고용되었다. 그리고 Si의 첨가량이 증가됨에 따라 Al-Zr 합금의 미소경도는 증대되었다. Al -1.7wt.%Zr -1.0wt.%Si 합금을 시효처리하면 Si이 우선 미세한 구상석출물을 형성하며 초기 시효경화를 일으킨 후, 잇따라 Zr의 준안정 석출물이 불연속 석출되어 성장하며 최대 시효경화를 나타냄을 알 수 있었다. An experimental investigation has been made about the effects of the third alloying element silicon on the sold solubility of zirconium in the aluminium, and on the ageing phenomena of Al-Zr-Si alloys. Rapidly solidified specimens were prepared by a twin-roller quenching apparatus in the form of long, thin ribbon, whose cooling rate was estimated to be about 10?? K/s. Under such a cooling rate, the maximum solubility of zirconium in solid aluminum was extended to about 1.0wt.%. However, it was extended up to 1.7wt.% by addition of 1.0wt.% silicon. With the increase of silicon content, the microhardness of Al-Zr alloys were increased as well. Ageing of supersaturated Al-1.7wt.% Zr-1.0wt.% Si solid solution appeared to occur in three sequential stages; Ⅰ. precipitation of silicon as fine spherical particles which harden the alloys, followed by Ⅱ. discontinuous precipitation of metastable zirconium phases which produce remarkable age hardening of the alloys, and finally Ⅲ. formation of coarse equilibrium zirconium phases.

발작성상심실성 빈맥환자에서 Adenosine과 Verapamil의 치료효과

최성욱,오진호,김승호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Background. According to the 1992 version of ACLS guideline, adenosine is recommended as the first line drug for the treatment of paroxysmal supraventricular tachycardia(PSVT). But adenosine is not used frequently in our country, despite currently proven effect and safety. Therefore we tried to compare the efficacy and safety of adenosine with verapamil for the treatment for PSVT. Materials and Methods. We prospectively reviewed charts of PSVT patients admitted to YongDong Severance Hospital from Jan. 1995 to Dec. 1996. These patients were randomly divided into two groups. The first group was given 6mg of adenosine initially , and another 12mg was given within 5minutes if first dose failed. The other group was given 5mg of verapamil initially, and if failed, 10mg was given within 10minutes. The results were analyzed by Chi-square test and student- t method Results. In converting PSVT to normal rhythm, adenosine and verapamil showed similar results and there was no difference between the two groups in frequency of side effects, but serious arrhythmia such as ventricular fibrillation and ventricular tachycardia was not seen in the adenosine group. Conclusion. Adenosine not only showed comparable effect and safety, but also had shorter action time than verapamil. Therefore we recommand sdenosine, as a safe and effective first line drug for PSVT.

흉추 경막외강으로 침윤한 흉선종 1례 : Metstasis to Thoracic Epidural Space

최정훈,백욱성,박대곤,오경구,최천식,배상도 高麗病院 1987 高醫 Vol.10 No.-

UV 센서를 위한 Spiroxazine LB 단분자막 특성에 대한 연구

최성욱,박은진,장지훈,김재호,강신원 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

다국소 망막전위도를 통한 특발성 망막전막 제거술 전, 후의 황반 기능 평가

최성욱,이상엽,김현웅,윤일한 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Objectives: To assess macular function after vitrectomy and membrane removal in eyes with idiopathic epiretinal membrane by means of multifocal electroretinogram (mfERG). Methods: Visual acuity, macular thickness measured by optical coherence tomography (OCT), and mfERG recordings were achieved for 14 eyes of 14 patients with idiopathic epiretinal membrane. All exams were performed before epiretinal membrane surgery and 1, 3, and 6 months after surgery. The average retinal response density and implicit time of each local response were estimated as anatomic macular areas corresponding roughly to 5 rings. Preoperative and postoperative responses of visual acuity, macular thickness, and mfERG were compared. The correlations of the change of retinal response density, visual acuity, and macular thickness were analyzed. Results: There were no significant changes in amplitude and implicit time measured by mfERG before and after the surgery (p>O.05). There were no significant correlations between the changes of amplitude and implicit time and visual acuity and macular thickness. Conclusion: Changes in mfERG recordings were not useful for predicting clinical prognosis after epiretinal membrane surgery.

골수강내 금속정 및 나사못 맞물림을 이용한 경골의 치료

최창혁,권굉우,김신근,이상욱,강창진 대구효성카톨릭대학교 1997 연구논문집 Vol.56 No.2

Fracture of the tibial shaft is the most common among the long bone fractures, and it is difficult to treat because of a high incidence of delayed union, nonunion and malunion. Interlocking Intramedullary mailing is considered to be valuable method in treating long bone fracture such as tibial fracture these days because it enables rigid fixation, early joint motion exercise and weight bearing. Between April 1993 and March 1997, we treated 63 cases of tibia fractures with interlocking intramedullary nailing. The results were as follows: 1. Among the 63 cases, 51 cases were closed fractures and 12 cases were open fractures. 2. Static interlocking nailing was done in all cases and dynamization was done in 7 cases in postoperative 13 weeks. 3. Average union time was 19.9 weeks, 19 weeks with closed tibia fracture and 2.4 weeks with open tibia fracture. According to fracture site, 22 weeks with proximal tibia fracture, 19.2 weeks with mid-tibia fracture and 21.4 weeks with distal tibia fracture. According to the Winquist-Hansen classification, Type I was 19.8 weeks, Type Ⅱ was 20.4 weeks, Type Ⅲ was 22 weeks and Type Ⅳ was 26 weeks. 4. Weight bearing was started at the time of subsidence of pain and tenderness of the fracture site, 11.5 weeks with closed fracture and 12.3 weeks with open fracture. 5. According to the functional result of Klemm and Borner, 44 cases were excellent, 9 cases were good, 7 cases were fair and 3 cases were poor.

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.