항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구

성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.

생약제제인 이공산(異功散)의 Cisplatin 유도 신장독성 보호 및 항산화 효과

Lee, Kyung-Tae,Ahn, Kyoo-Seok,Chang, Sung-Goo,Oh, Soo-Myung,Jung, Jee-Chang 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung-Tae Lee, Kyoo-Seok Ahn¹, Sung-Goo Chang², Soo-Myung Oh²and Jee-Chang Jung²¹College of Pharmacy, ²Oriental Medicine and ³College of Medicine, and East-West Medical Reserch Institute, Kyung Hee University, Seoul, Korea. Preventive and Antioxidative Effects of Crude Drug Preparation(E-kong-san) on Cisplatin Induced Nephrotoxicity. Proceedings of International Symposium on East-West Medicine, Seoul. 201-211, 1999. -Nephroprotective effects of a crude drug-prearation (E-kong-san) were determined from cisplatin on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on ciplatin-induced human renal cortical tissue. Levels of creatinine and blood ure nitrogen(BUN) in serum after administration of cisplatin(0.75mg/kg,i.p.) to E-kong-san(0.75g/kg/day,p.o.)-pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of E-kong-san significantly inhibited the loss of body weight of cisplatin injected rts. These findings suggest that E-kong-san on the cisplatin induced nephrotoxicity led us to investigate whether the effect of this water extract was a result of anti-oxidation. E-kong-san showed strong free radical scavenger activities on 1,1-dipheny1-2picrylhydrazil(DPPH) radical and xanthine/xanthine oxidase(XOD) generated superoxide anion radical(O2-). We further studied the effects of E-kong-san on lipid peroxidation in rat liver microsomes induced by enzymatic and nonenzymatic methods. E-kong-san exhibited significant inhibition on both ascorbic acid/Fe2+and ADP/NADPH/Fe3+ induced lipid peroxidation in rat liver microsomes. Based on these results, we suggest that-E-kong-san attenuate the cisplatin induced cytotoxicity and its mechanism can be eplained by antioxidant.

The effect of neuropeptides on secretion of Interleukin-8(IL-8)

Kim, Kyung-Jun,Park, Sang-Hyuk,Choi, Kyoung-Kyu,Park, Sang-Jin 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.3

본 연구는 치수조직, 치은, 치주인대로부터 배양된 조직을 SP (Substance P)로 4시간, SP, CGRP (Calcitonin Gene-related Peptide), Tumor necrosis factor-α (TNF-α)로 8시간 자극 후 RNase Protection Assay를 시행하고, IL-8의 분비량을 측정해 다음 결과를 얻었다. 1. IL-8 mRNA는 모든세포에서 발현됐다. 2. IL-8 mRNA 발현은 SP (10^(-5)M)와 SP (10^(-8)M)로 4시간 자극 시 증가되지 않았다. 3. IL-8 mRNA 발현은 SP (10^(-4)M)와 CGRP (10^(-6)M)로 8시간 자극 시 증가되지 않았다. 4. TNF-α (2 ng/㎖) 자극 시, IL-8 mRNA 발현이 증가됐다. 5. 치은 세포를 CGRP (10^(-6)M)로 8시간 자극 시, IL-8 분비량이 증가했다 (p < 0.05). 6. 치주인대 세포를 SP (10^(-4)M)로 8시간 자극 시 IL-8 분비량이 증가했다 (p < 0.05). We investigated the secretion of Interleukin-8 (IL-8) from ginviva and periodontal ligament stimulated with Substance P (SP) and Calcitonin Gene-related Peptide (CGRP). Gingiva (GF), periodontal ligament (PDLF) and pulp (PF) tissues were collected from extracted instact 3rd molars. Cultured cells were stimulated with different concentrations of SP for 4 hrs, and stimulated with SP, CGRP and Tumor Necrosis Factor-α (TNF-α) for 8 hrs. Then RNase Protection Assay was carried out. ELISA was performed using supernatants of stimulated cells for quantitative analysis of IL-8. Results were assessed using supernatants of stimulated cells for quantitative analysis of IL-8. Results were assessed using student t-test with significance of P < 0.05. According to this study, the results were as follows: 1. IL-8 mRNA was detected in all type of cells studied (PF, GF and PDLF). 2. IL-8 mRNA expression was not increased after stimulating 4 hrs with SP (10^(-5)M) and SP (10^(-8)M) compared with Mock stimulation in all type of cells studied. 3. IL-8 mRNA expression was not increased after stimulating 8 hrs with SP (10^(-4)M) and CGRP (10^(-6)M) compared with Mock stimulation in all type of cells studied. 4. TNF-α (2 ng/㎖) increased the expression of IL-8 mRNA in all kind of cells studied. 5. The secretion of IL-8 from GF was increased 8 hrs after the stimulation with CGRP (10^(-6)M) (p < 0.05). 6. The secretion of IL-8 from PDLF was increased 8 hrs after the stimulation with SP (10^(-4)M) (p < 0.05). Calcitonin Gene-related Peptide (CGRP) increased Interleukin-8 (IL-8) which plays an important role in chemotaxis of neutrophil in Calcitonin Gene-related Peptide (CGRP) gingival tissue, whereas Substance P increased the secretion of IL-8 from periodontal ligament.

자연휴양림 이용자 요구사항 및 만족

서경석 ( Kyung Seok Seo ),윤성훈 ( Sung Hun Yoon ),김갑열 ( Gab Youl Kim ) 한국감정평가학회 2011 감정평가학논집 Vol.10 No.2

The research was studied about measure how each element affect to recreational forest visitors. And I can provide the useful information for the strategic decision-making to make value-up through characterization and differentiation of recreational forest. Those who use recreational forest were studied. Survey area was divided into five regions; Kyung-gi province, Kang-won province, Chung-chong province, Kyung-sang province and Jeon-ra province. And then national and local governments, individuals were classified as operating principals. Empirical analysis were analyzed by applying the Kano model. The questionnaire was analyzed by statistical methods; for data processing, along with a test of reliability in the measuring tools, frequency analysis. Human services and nature management components of recreational forest were classified as one-dimensional quality. Most users are more concerned about these elements. Recreational forest visitors are more concerned about quality associated with software components rather than hardware components. Recreational forest visitors with high interests and a high level of satisfaction about recreational forest has more concerned about the quality.

도시지역 초등학생에서 주의력결핍 과잉운동장애의 유병율

표경식,박상학,김상훈,조용래,김학렬,문경래 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : To study the prevalence of ADHD in urban elementary school children using the Korean version of the disruptive behavior disorders parent rating scale. Materials and methods : 6,372 students from seven urban elementary schools were targeted using the parent rating scale. Results : (1)The total ADHD prevalence was 6.1%. It can be broken down as follows: 4.1% was the Inattentive type, 1.0% was the Hyperactive-impulsive type and 1.1% was the Combined type. 8.3% occurred in male students and 3.9% occurred in female students. The prevalence in boys was significantly higher. (2) The prevalence of Conduct Disorder(CD) was 0.3%: 0.2% for male students and 0.3% for female students. There was no significant difference between girls and boys. (3) The prevalence of Oppositional Defiant Disorder(ODD) was 4.4%: 5.0% for boys and 3.9% for girls. The value for boys was significantly higher. (4) A statistically significant difference between grades was found with ADHD, but no significant difference between grades was found with CD and ODD. (5) In the results of the comorbidity research, ADHD accompanied by CD was 2.3%. ADHD accompanied by ODD was 25.5%. ADHD accompanied by both CD and ODD was 4.1%. (6) Mild forms of ADHD, CD and ODD were found four times more often than that observed in typical cases. Conclusion : Prevalence of ADHD in urban elementary schools is high and CD or ODD is accompanied more frequently. In the future, the school mental health project should be focused mainly on ADHD. From the beginning of urban elementary schools, ADHD should be screened for. Intervention is required depending on whether or not there are accompanying diseases.

한국에서 한 일간지 신문기사 검색을 통한 IMF 전과 후의 자살 양상 비교

박상학,김경환,김학렬,김상훈,표경식,조용래 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Objectives : Under an IMF bailout program, our country's financial situation forced people to change many things suddenly. Therefore, this study was attempted to search the aspects of changes of suicide attempts in order to find out how the financial crisis affects people's suicide attempts, the extreme repertoire for psychological change Method : November 21, 1997, the day issued the application of IMF bailout program, is the basic date for comparing the changes, on a certain newspaper(Dong-A daily newspaper). The condition was divided into two, namely before and after the basic date, and the characteristics of suicide were compared between two conditions. Results : The news of suicide increased more after than before the application of IMF situation. (before:105, after:158) Specially, for 30-50 years old, active age in community, the rate of suicide attempts reached twice than that of the others. After the IMF situation, the prominent reason of suicide was the financial crisis. For the type of suicide, the family suicide was remarkably increased after the IMF situation. Conclusion : The frequency of the news of suicide was higher after than before IMF bailout program. The major reason of suicide was the financial crisis. Considering that the social and economic crisis affects people's view of death, psychosocial interventions are necessary for their mental health.

구조주의적 영어억양분석방법에 대한 고찰

김희경,이상도 釜山大學校 1996 人文論叢 Vol.49 No.1

Abstract A Survey of Structural Analyses on English Intonation Lee, Sang-Do·Kim, He-Kyung Intonation is narrowly defined as the melody of speech in the papeer. One of the approaches on English intonation is structural analysis, which can be applied to teaching English as a foreign language. The structural approach aims at postulating intonation unit and intonation inventory to describe the form and meaning of intonation. The teaching of English intonation is often considered as a difficult task. Thompson(1995) argues that the average teacher is uncomfortable with intonation, treating it as a difficult subject and difficult to fomulate rules. As such it tends to receive little explicit focus in the classroom. In order to be helpful to teaching, intonation model, which is teachable, learnable, and simple, should be devised unlike the existing ones proposed by various specialists. To devise the model, structural analyses should be examined since they focus on the linguistic functions and meaning of intonation in English to choose the most appropriate analysis that capture general behaviors of intontion. This paper, thus, examines structural analyses on English Intonation. Structural analyses are divided into level and configuration approach. Level approach by Pike(1945). Trager/Smith(1957) and Prator/Robinett(1985) fails to capture general linguistic behaviors of intonation compared to other linguistic elements by proposing that the pitch contour are sequences of pitch phonemes. Configuration approach includes tune analysis, tone analysis, and tone-tune analysis. Tune approach by Armstrong/Ward(1931) prescribes two basic tones showing that pitch movement only plays a contrastive role. The approach unlike the level one shows the important role of pitch movement but also fails to show that the pitch pattern of pre-tonic which adds or modifies the whole meaning of the contour. Tone approach by Kingdon(1958) recognizes the role of pitch height and postulates kinetic and static tones. But it also prescribes pitch pattern of English intonation rather than describing. Tone-tune approach by O'Connor/Arnold(1972) and Hallway(1985) shows that the pitch contour has the internal structure. O'Connor/Arnold argues that the pitch contour consists of three optional elements and one obligatory element. Halliday(1985) argues that the pitch contour consists of one optional elements and one obligatory elements. By showing that the pitch pattern or so called INTONATION UNIT has the internal structure, the tone-tune approach captures generality of English intonation . Thus it can be concluded that the tone-tune approach can be employed to the field of Teaching English as a Foreign Langauge.

‘식민지 조선’의 맥락에서 읽은 인도 시인 사로지니 나이두

이상경(Lee, Sang-Kyung) 한국어문학회 2018 語文學 Vol.0 No.140

The Indian female poet Sarojini Naidu (1879∼1949) was introduced to colonial Joseon in the 1920s as a highly reputed Asian poet in the West along with Tagore, an Indian politician who led the Salt March with Gandhi in 1930. Due to the uniqueness of her association with Tagore and Gandhi—two prominent figures from India—Naidu rarely received much attention as a foreign female poet in colonial Joseon. However, since Naidu was introduced to Joseon after she had stopped writing and was more actively involved in political activities led by Gandhi, some regarded her as a poet, while others viewed her as a politician. This study highlights Naidu and her works, aiming to reveal the context in which emphasis is changed depending on time period, and attempts to build an integrated understanding of Sarojini Naidu. In the early 1920s, Kim Eok focused on poet Naidu, with a focus on her love poems. Then, in the mid 1920s, Naidu’s poetry was introduced as an example of sympathetic linguistic literature for oppressed people. Around 1930, Jeong, In-seop and Lee, Ha-yun regarded Naidu as more of a politician and introduced poems directly expressing the voice of Indian nationalism. The writers and poets of colonial Joseon felt an affinity for Naidu, who came from a colonized country herself, and used her works based on their own areas of interest. In India, Naidu’s literary and political activities are considered outdated. It is often said that her “aesthetics is feudal, although her politics is democratic nationalism.” Recently, it has been proposed that Naidu’s poems require reinterpretation as both a collusion with and resistance to colonialism. Her works are retrogressive in the use of India’s traditional customs and nature as subject matter but, at the same time, stem from a resistance to modern urbanization. Heo Jeong-suk, a socialist feminist who translated Naidu’s poems into the Korean language for readers in colonial Joseon, seemed to have been well aware of their contextual framing, that is, “a collusion with and resistance to colonialism.”

노인의 성격과 죽음태도에 관한 탐색적 연구

유경원,박상하,김혜숙,정경인 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Background and Objectives: The purpose of this study was to analyze how the personality of elderly people affects their attitude toward death. Method: For this study, we investigated 86 old men and women with over the age of 60 in C and J nursing home for the old at Gwang ju city during January 5 to March 31, 2003. As a research tool, the total 20 questions of modified Shanans assorted survey method to measure personality style were used and the reliability of this study was Cronbach's α= 0.7507. For determination of attitude of death, the total 36 questions of FODS, which has been used by Suh, Hye-Kyung were used and the reliability of this study was Cronbach's α= 0.60. Using SPSS program, the collected data were analyzed by Frequency, ANOVA and Pearson correlation coefficient, respectively. Results: In the analyze of the results of personality complying with general characteristics, there were statistically significant differences in age. It was shown that the personality of the old with the age of 61-65 is positive. There were no significant differences in thee attitude toward death complying with general characteristics. The hypothesis in this study, the correlation that the more positive personality of the old, the more positive attitude toward death was supported. Conclusion: Since the elderly people with more positive personality may have more positive attitude toward death, it is considered that the old themselves, their family and workers might help to haw positive personality for the positive attitude toward death.