부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

百濟의 遼西經略에 對하여

金庠基(Kim Sang-kee) 백산학회 1967 白山學報 Vol.- No.3

Sung-shu(宋書)gives an account for the first time that Bekje (百濟) brought Liao-Hsi(遼西)area (an area west of Liao-ho (遼河) under its rule and established there its own administrative districts with Chinp’ing Hsien(晋平縣), Chin-p’ing Chun(晋平郡)as the center. This occupation seems to have been realized toward the end of the thirteenth king Kŭnch’oko-wang’s (近育古王) reign. It was in his time that Bekje was powerful enough to emulate with Kokuryo(高句麗), and eventually after repeated battles in the Debang (帶方) (now, Hwanghe-do 黃海道) area, its army killed Kokuryŏ’s sixteenth king Kokukwŏn-wang(故國原王)below the Pyongyang(平壤) Castle. Before during the era of its fifteenth king Mich’ŏn-wang 美川王, Kokuryŏ occupied the Liao-Tung(遼東)area(or the Liaotung Peninsula) and evacuated from the area thereafter with no fear of threat from the north. Thus it is probable that by advancing into Liao-Hsi area by sea, Bekje as a naval power attempted to check Kokuryŏ’s southward force. The reason why Kokuryŏ and Bekje could so easily seize Liao-Tung and Liao-Hsi areas respectively is that in the continent the so-called Wu-hu Shih-liu-kuo (五胡十六國) were at odds with each other in a chaotic situation, and there was no force that could reach their eastern frontier. Later the Liao-Hsi area occupied by Bekje was attacked by Hou-wei(後魏)(Pei-wei 北魏), and there was a time in the era of the twenty-fourth king Tongsong-wang(東城王)when Bekje defeated a large force of Hou-wei, and according to a record in Nan-ch’i-shu(南齊書), it requested the Ch’i(齊)Dynasty (of Nan-ch’ao 南朝), which was then against Hou-wei, to confer a peerage on the victorious general named Sabŏbmyŏng(沙法名). No historical record is available as to how Bekje’s power changed in Liao-Hsi area thereafter, but from the fact that Hou-wei finally unified areas north of the Yangtze River, we can infer that Bekje’s influence in Liao-Hsi area was crippled by Hou-wei, Bekje’s occupation of Liao-Hsi area is recorded mostly in Sung-shu and Nan-Ch’i-shu. Compiled by Shên Yüeh(沈約), who wrote history for both the Sung and Ch’i Dynasties and was an official in the Liang(梁) Dynasty, Sung-shu was published in the sixth year of Ch’i’s King Wu(武)(A.D.488). And Hsiao Tzŭ-hsien(蕭子顯), compiler of Nan-ch’i shu, was a member of Nanch’i’s(南齊)royal household, and upon the fall of the dynasty, he went to serve King Wu of the Liang (梁) Dynasty and presented him with the book. As the two books were compiled by witnesses to the days, their reliability is unquestionable.

세라믹-세라믹 관절면의 Bicontact^(�)형 인공 고관절 전치환술의 단기 추시 결과

김영민,김상림,유기형,김재광,유정준,김희중 대한고관절학회 2001 Hip and Pelvis Vol.13 No.1

Drosophila quinaria Species Group의 遺傳的 近緣關係

成耆昌,金正洙,金大鎰,金彧,金溶聲 성균관대학교 기초과학연구소 1985 論文集 Vol.36 No.2

The genetic relatedness among the Korean Drosophila quinaria species group, including D. nigromaculata, D. unispina, D. brachynephrose, and D. angularis, has been examined by using horizontal starch gel electrophoresis. The results showed that none of the ten isozyme patterns examined for these four species was identical. The average genetic similarity among the four species was found to be 0.440. The similarity among three species. D. unispina, D. brachynephrose, and D. angularis was 0.466. The relatedness was found to be closest between D. nigromaculata and D. unispina, showing 0.640. D. nigromaculata and D. angularis showed relatedness of 0.258. The results suggested that these four species appear to be genetically related at the level of sibling species. The percent polymorphism in D. brachynephrose was found to be 76.9%, showing significant genetic variations.

사상체질론의 정신의학적 타당성에 대한 연구

민성길,김동기,박진균,전세일 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 건간한 의대상 312명과 신경증적 장애를 가진 환자 288명을 대상으로 하였다. 사상체질의 구별은 노정우 및 김달래 두 전문가에 의한 판정, 그리고 경희의대 사상체질 설문지(QSCC Ⅱ)에 의한 판정 등 3가지 방법에 의하였다. 연구 대상에게 정신과적 증상척도(SCL-90), 체질특성척도 및 성격척도를 사용하여 자가 평가하게 하였다. 각종 척도들의 타당도와 신뢰도는 입증되었다. 이 척도들을 통계적으로 분석하고 고전적 설명과 어느 정도 일치하는 지를 검토하였다. 연구결과 : 1) 3가지 분류방법간에 차이가 컸었다. 그 중 전문가의 직접적 면담에 의한 감별보다 QSCCⅡ 설문지형이 비교적 감별력이 컸다. 3) QSCCⅡ가 감별력이 비교적 크다고 하더라도 그 결과가 소음군의 대인공포-강박증, 불면-식용상실, 무력-예민-소화기-한기-피부증후군 그리고 정력부족등 신경증적 증상과 소극-비사교적, 내향형 성격 및 이성적 성격특징 등 몇가지 특징을 감별하는 데에만 비교적 유의하였고, 태음군의 특정인 독특한 신념, 온기, 활달-사교적 성격에 대해서는 부분적으로 그 특징을 감별하였다. 또한 소양군의 활달-사교형 성격과 감정형 성격의 특징 등은 극히 부분적으로 감별하였다. 결 론 : 이러한 결과는 현존하는 사상체질 구분방법에 일치점이 결여되어 있다는 것, 각종척도를 사용한 결과는 사상체질에 관한 고전적 설명을 부분적으로만 입증하고 있다는 것, 따라서 사상체질구분에 대한 향후보다 객관적인 연구가 필요하다는 것을 시사한다. Object : This study is to examine the validity of constitutional classification of Sa-sang medical theory. This theory classifies the human constitution to 4 types according to classical oriental philosophy on yin and yang. Subjects and Method : Subjects were 312 medical students and 288 neurotic patients with diagnosis of neurotic, stress related and somatoform disorders and minor depressive episodes according to ICD-10. Medical students were classified to 4 Sa-sang Constitution Classification(QSCCⅡ). For assessmnent of symptoms and signs, Korean version of SCL-90, a constitution scale and personality scale which were designed for this study were used. These instruments were found to be reliable and valid through statistical analysis. Subjects were asked to rate these scales. The data were analysed with factor analysis and factor scores were compared among 4 Sa-sang constitutions by ANOVA and t-test. The data from patient group were analysed with factor analysis and the results were compared with the Sa-sang medical theory. Results : Results of classification by 3 ways were inconsistent showing a significant difference among them. Among them, QSCCⅡ was most reliable. In QSCC Ⅱ, only the factor scores of factors of homophobia-obsession, weakness-sensitiveness-indigestion-chillness-skin syndrome, sexual weakness, passive-unsociable personality, introverted personality and rational, personality, were significantly high in So-um (small yin) group of medical students. A factor of warmnes and active-sociable personality were significantly high in Tae-um(big yin)group. Also active-sociable and effective pesonality was partly related with So-yang(small yang)group. Conclusion : These results suggest that those present classification methods inconsistent, that these methods are proving only parts of Sa-sang medical theory, and that objective and scientific studies are needed for reliability and validity of Sa-sang medical theory.

RC T형 교각에서 매개변수 해석에 의한 수화열과 건조수축의 균열저감방안

박성규,김기대,전상채 대구대학교 산업기술연구소 2011 産業技術硏究 Vol.22 No.1

Amidst increasingly growing demand for large concrete structure or high strength / high durability concrete in line with economic development, the risk of ydrothermal cracking resulting from hydration heat and drying shrinkage has been on the rise, In fact, thermal stress caused by hydration heat or contraction stress due to drying shrinkage has considerable effect on design or construction of the structure. The cracks in concrete structure spoils the aesthetic aspect of the structure as well as deteriorates the load bearing capacity of the structure, thereby worsening the usability and safety and reducing the service life of the structure eventually. Moreover harmful substances penetrated into the crack causes the rebar to be corroded more rapidly and other numerous problem. In this study, inspection of the urban railway pier structure was performed to check the cracks and in a bid to identify the cause of the cracks, modelling to simulate the field condition was implemented and the temperature distribution and thermal stress variat ion occurred inside and outside the members were estimated using 3D finite element analysis program, MIDAS/FEA and the thermal cracking index was calculated and analyzed.

학국에서 심방세동의 임상양상에 관한 연구

이선미,조정휘,홍순조,최윤식,안신기,김성순,김영훈,김윤년,조정관,차태준,김유호,최기준,김준수,이상민,신동구 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.5

유량측정기법에 관한 연구 : 실험수로에서 희석법을 중심으로 Dilution Method in Experimental Channel

김성원,지홍기,이순탁 嶺南大學校 環境問題硏究所 1996 環境硏究 Vol.16 No.1

실험수로에서 희석법을 이용한 유량측정의 기법은 일정량주입법과 일시주입법으로 나누어 진다. 본 연구에서는 일정량주입법에 의한 유량측정 결과치가 일시주입법보다 좀 더 실험유량값에 근접한 것으로 분석되었고, 만약 측정장치의 설치오차, 주입용액의 완전 혼합오차와 농도 측정오차 등을 최소로 한다면, 실험수로에서의 유량측정에 있어서 보다 정확한 유량측정을 할 수 있을 것이다. 이와같은 연구분석의 결과로서, 유속계를 사용할 수 없는 하천유역이나 다른수로에서는 희석법을 이용한 유량측정기법이 적용되어 높은 정밀도를 구할 수 있다고 고려된다. It is divided into constant-rate injection method and sudden-injection method in the technique of discharge measurement using the dilution method for experimental channel. It is analyzied that the value of constant-rate injection method is approached more exact than that of sudden-injection method in this research. In this study, if it is minimized for the exact installation error of the testing equipment, the perfect mixing error of the injection-solution and concentration measurement error and so on, It is measured the more exact discharge in this experimental channel. It is considered that the dilution method is applied for the river basin which in not used the current meter and another channel in this research.

알코올성 췌장염 환자에서 CYP2E1 유전자형의 다형성

김일환,염윤기,채석,권준택,김형기,박상흠 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Cytochrome P4502E1(CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine(NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, flouorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predispodition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans with alcoholic pancreatitis patients. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 64 alcoholic pancreatitis patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroforn extraction method. The allelic frequencies of c1 and c2 in healty volunteers were 0.85 and 0.15, respectively. The allelic frequencies of c1 and c2 in alcoholic pancreatitis patients were 0.8 and 0.2, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 and 0.031 (p<0.001) in healthy volunteers and alcoholic pancreatitis patients, respectively. However, the CYP2E1 genotype showed no significant relation to the alcoholic pancreatitis patients. It was suggested that the risk of alcoholic pancreatitis diagnosed clinically seem to be not associated with the CYP2E1 genotype.

韓國 노랑초파리의 自然集團에 있어서 P elements의 分布에 관한 硏究

成耆昌,金滿在,金溶聲 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.2

Isofemale lines of Drosophila melanogaster were established from Moonsan and Osan, Korea and were tested for GD sterility. The results are as follows; 1. Using π_2 (strong P) strain and Canton-S (true M) strain as a standard strains, the frequencies of P cytotype for all isofemale lines were 37.7% (Moonsan) and 56.5%(Osan), but the activities of P factor very low. 2. The distributions of strain types by Kidwell were 62.3%, 43.5% for M' (pseudo-M) strain, and 37.7%, 56.5% for Q (weak P) strain in Moonsan and Osan, respectively. Thus, it was appeared that these populations are consisted of M' and Q strains. 3. The results suggested that the activities of P elements were regulated by their P cytotypes though the potentialities of P activity were present in these populations.