정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경북 지역의 지하수 수질에 관한 연구 3 : 용도별 지하수 수질의 특성 The Characterisrics of Groundwater by Used Types

한성욱,양득석,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

We investigated the contamination of groundwater in Gyeongbuk region about 180 points by used types and by rock types. From the view point of used types, the obtained results were as follows; The concentration of nitrate nitrogen was highest for agriculture used as 5.3mg/l and was medium for life used as 4.2mg/l while faculty used was lowest as 1.8mg/l. In case of chloride ion, the concentration was highest for agriculture use as 39.9mg/l and was medium for faculty used as 34.8mg/l, while life used was lowest as 23.5mg/l. In case of 359mg/l. In case of the concentration of pH and COD, it showed that the relationship with used types was not so good.

전두부 골절 환자의 임상적 연구

조용민,이동근,오승환,장관식,한대희,민승기 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Fracture of frontal bone is infrequent, but may have serious complications because of their proximity to the brain, eyes and noses. Fractures of the frontal area range from 5% to 15% of all facial bone fracture and include supraorbital rim and frontal sinus. As frontal bone fractures most frequently occur in the multiply injured patient, a thorough clinical and radiological examination of the patient is required before diagnosis and treatment plans are established. Sometimes coorperative treatment with other department is requried. It is specially considered that incision for access to frontal region and surgical methods for open reduction, cranialization, cannulization, sinus obliteration. After surgical or conservative treatment, it may have complication. Complication of frontal bone injury vary in severity and may occur at several years after the incidents. The major types of complications are those that occur directly at the time of injury, infection and chronic problems. This is clinical study on 31 patients with frontal bone fracture, at department of oral and maxillofacial surgery in dental hospital of Wonkwang university during past ten years. The results were as follows : 1. The sex ratio of all patients is 29 (94%) male to 2 (6%) female, the average age is 33 and the prominent groups are 2nd, 3rd decade age. 2. The causative factors are mostly traffic accident 22 cases (70%) and fall dawn, industrial accidents, so on. 3. The 17 cases has shown alert mental status, but neurologic problems is in 14 (45%) cases in initial accessment. 4. Associated facial bone fractures are prominent in the maxilla (42%) and panfacial fracture (39%). 5. Involved general problems are in department of neurologic surgery problems (65%), orthopaedic problems (23%) and ophthalmologic problems (19%) in order. 6. Open reduction has done in 15 cases and 16 cases with conservative management. 7. Postoperative complications are chronic headache (42%), esthetic problems (39%) and ophthalmologic problems (35%)in order.

Dioxin류의 반응에 대한 분자궤도함수론적 연구 : dibenzo-p-dioxin, 2,7-dichlorodibenzo-p-dioxin, dibenzofuran, 2,8-dichlorodibenzofuran 중심으로

한성욱,이길준,김복조 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

Molecular orbital studies for dibenzo-p-dioxin, 2,7-dichlorodibenzo-p-dioxin, dibenzofuran and 2,8-dichlorodibenzofuran were carried out by semiempirical PM3 method. Reaction sites for nucleophilic, electrophilic and radical reaction of dioxins were predicted and discussed by MO studies. The values of approximated superdelocalizability were 0.7802, 0.2686, 0.3104, 0.1982 for the above dioxins, respectively. And reported rate constant for the reaction of dioxins with OH radical (Eitzer et. al.. Environ, Sci. Technol. 1989, 23, 1389) was well correlated with approximated superdelocalizability.

경북 지역의 지하수 수질에 관한 연구 : 1. 지하수중에 존재하는 질산성질에 의한 오염도에 관한 연구 Ⅰ. Study on the Pollution Level by Nitrate Nitrogen in the Ground Water

한성욱,김복조,양득석 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

We investigated the contamination of ground water in Kyungbuk region about 87 points by nitrate nitrogen(NO₃-N) concentration. The obtained results were as follows; 1. Nitrate nitrogen concentration is high showed 4.43㎎/ℓ for life used. The results seemed to contaminate because of excrement of men and livestock, decomposed animal and plant and chemical fertilizer. 2. Nitrate nitrogen concentration classified with about 11 region is high 14.9㎎/ℓ in storage tank.

오리부산물과 한약재를 이용한 추출액의 영양성분 및 중금속 노출에 대한 피해 완화 효과 : (Ⅱ) 중금속 노출에 대한 오리추출액의 피해 완화 효과 (Ⅱ) Damage Mitigation Effects on Heavy-metals Exposure of Peking-Duck By-Product Extracts

한종현,이우진,조성균,이미정,정미란,전정우,김운영,박성혜 동아시아식생활학회 2003 동아시아식생활학회지 Vol.13 No.4

This study was performed to investigate the effects of peking-duck extracts added with medicinal herbs(DJ) on the intoxication of heavy metals (Hg, Pb, Cd, As) in rats. Sprague-Dawley rats weighing 150±15g, were randomly assigned to 5 groups: basal diet only in normal control group(NCG); basal diet and heavy metals without DJ injection in heavy metal control group(HMC); basal diet, heavy metals and DJ(3㎎/㎖) injection in heavy metal low duck juice group(HMLD), basal diet, heavy metals and DJ(30㎎/㎖) injection in heavy metal middle duck juice group(HMMlD); basal diet, heavy metal and DJ(300㎎/㎖) injection in heavy metal high duck juice group(HMHD). Hg and As was injected by 50ppm and Cd and Pb by 25ppm for 17days. Also DJ oral feeding was conducted for 28days. The result of this study were as follows: Food intake and body weight gain in heavy metal administered groups were lower than those of NCG. Liver, kidney and testis weights were not significantly different among 5 groups. GOT, GPT and BUN activities were significantly reduced in DJ treated groups as compared to HMC. DJ showed the suppressing effect on the accumulation of Hg, Pb and Cd in serum, liver and kidney. Fecal Hg and Cd excretions increased with DJ feeding. The results suggested that DJ may have some protective effects on Hg, Cd and Pb intoxication by reducing the accumulation m tissues and increasing excretion. This study also showed the effective way of using duck-extract and its application to the oriental medicine.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

Ellipticine과 그 이성질체들에 대한 분자궤도함수론적 연구

한성욱,이길준,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

Molecular orbital studies were carried out for the ellipticine and its isomers, known as having antitumor activity and cytotocity, by semiemperical PM3. Electrostatic potential studies have shown that the most reactive site of proton attacks was the nitrogen atom in carbazol ring. The net charge of the nitrogen was linearly correlated with the basicity of the isomers. We have predict the antitumor activity of the isomer by the basis of the dipole moment [suggested by Barone et.al. J. Mole. Stru.(Theochem) (1992), 253, 319]. And we have suggested that frontier orbital theory is valuable to explain for the formation of covalent adducts. These results may suggest clues that the method how to interpretate the mechanism of action for ellipticine and how to design new drugs.

경북 지역의 지하수 수질에 관한 연구 4 : 암반 종류에 따른 지하수 수질 특성 The Characterisrics of Groundwater by Rock Types

한성욱,이동섭,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

We investigated the contamination of groundwater in Gyeongbuk region about 180 points by rock types. From the view point of rock types, the obtained results were as follows; The mean depth of rock types were decreased as follows sedimentary > gneiss > granite > granodiorite. In case of pH, the difference of value was small. While, the concentration of COD showed that it's concentration was increased as the mean depth was increased. In the region of granite, sedimentary and gneiss, the value of nitrate nitrogen was 3.5mg/l, 3.3mg/l and 1.7mg/l, respectively. In case of chloride ion, the concentration was highest for granite as 30.5mg/l and was medium for sedimentary and gneiss as 29.8mg/l and 26.9mg/l, respectively. while granodiorite was lowest as 8.97mg/l. The EC values were as follows; In the region of granite, sedimentary, gneiss and granodiorite, the value of EC was 444mg/l, 430mg/l, 390mg/l and 242mg/l, respectively.

대구, 경북 지역의 토양 환경상태 연구 : 토양 용도별 및 토양오염지표에 의한 평가 Assessment by Soil Divisions and Soil Pollution Index

한성욱,양득석,김복조 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

We analysed the soil quality of Taegu and Kyungbuk region according to the 12 different sampling sites. The soil pH of the downtown area near road was lower than that of the other roads, which indicated that this acidification was probably attributed to the acid rain caused by the traffic exhaust gas such as SO_x and NO_x, Acidification was slightly severe in the rice paddy area than in the dry farming area. All concentration of 6 different heavy metal(Cu, As, Pb, Cd, Hg, Cr^+6) and organic contaminants (Cyanide, organic-p, PCBs, phenols) were found to be lower than the standard of soil pollution or not detected. An assessment using the SPI(Soil Pollution Index), which was developed to estimate soil quality, was performed. Each SPC(Soil Pollution Score) were evaluated with the results of the data from this study. The soil quality of most area of Taegu and kyungbuk was determined to Class 1, which indicated that the soil was healthy.