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Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells
Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4
The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.
이온선택(選擇) 전극법(電極法)과 염광광도법(炎光光度法)에서의 혈청내(血淸內) Na+K+ 농도(濃度)에 대(對)한 정상참고치설정(正常參考値設定)을 위(爲)한 시도(試圖)
정혜인 ( Hae In Jeong ),성일영 ( Il Young Sung ),이현숙 ( Hean Suk Lee ),김영희 ( Young Hee Kim ),유순임 ( Soon 1m Yu ),정악승 ( Nak Seung Chung ) 대한임상검사과학회 1984 대한임상검사과학회지(KJCLS) Vol.16 No.1
Using Corning 405 flame photometer and Corning 902 Na/K analyzer, we have studied on the normal range of Na+ and K+ level in serum by flame photometry and ion selective electrode analyzing method (1) Among the 265 healthy male and female employees, we measured mean, S.D. and obtained recalculated results with excluding those outside::t 3 S.D. The results are as follows; Na+(mEq/L), 405-Flame. 902-I.S.E. Normal range. (X±2 S.D.) 140.66+7.02 142.13+8.02 *N.R. : Normal Range. K+ (mEq/L), 405-Flame. 902-I.S.E. 4.06±0.74 4.12±0.80 Borderline (N.R.*~3 S.D.) N.R.~ ±10.53 N.R.~±12.03 N.R.~±1.11 N.R.~±12.03 (2) Also we tried to calculate the normal range applying Hoffmann`` s method based on the laboratory records of Seoul Paik Hospital during the period of Jan. 1982-Dec. 1982 by flame photometer and Jan. 1983-Dec. 1983 by ion selective electrode analyzer. It was 1, 970 cases (M: F=1. 25 : 1) for flame photometry and 2, 919 cases (M: F=1. 27 : 1) for ion selective electrode analyzing method. The range of 95% on the probability paper are as follows; Na+(mEq/L), 405-Flame. 902-I.S.E. 140.3±7.2 141.2±8.8 K+(mEq/L), 405-Flame, 902-I.S.E. 4.0+0.77 4.1+0.85 (3) After grouping of sex and age on the laboratory records, we measured mean, S.D. with exception of the groups that showed severely irregular pattern and recalculated same above (1) Na (mEq/L) (X±t2 S.D.) 405-Flame, 130.5-148.0 902-I.S.E 127.4-153.3 K (mEq/L) 405-Flame 3.5-5.5 902-I.S.E 2.6-5.4 These ranges are scattered broadly in comparison with above the results of (1), (2). Even though out-ranged groups were excluded from the statistical analysis, it is not suggested as proper method to calculate the mean value under applicated by normal distribution. The result, however, appeared significant for reference value for normal range in or out.patients.
갑상선 유두암에서 BABA 내시경 갑상선 절제술에 대한 임상적 고찰
천보성,김재홍,박경식,배수연,정성일,유영범,양정현,윤여규<SUP>1<,SUP>,Bo Sung Cheon,Jae Hong Kim,Kyoung Sik Park,Soo Youn Bae,Sung Il Jung,Young Bum Yoo,Jung-Hyun Yang,and Yeo-Kyu Youn,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.3
Purpose: The aim of this study was to evaluate the operative feasibility and safety of endoscopic thyroidectomy via bilateral axillo breast approach (BABA) compared to conventional thyroidectomy in papillary thyroid carcinoma (PTC) patients. Methods: From July 2009 to November 2010, patients underwent BABA endoscopic thyroidectomy (ET group; n=41) or conventional open thyroidectomy (OT group; n=61) for PTC. Clinical and pathologic characteristics of patients, operation time, post-operative complications, cosmetic satisfaction and thyroglobulin (TG) level were analyzed retrospectively. Results: The mean age of the patients was 40.05±9.58 years (range 25∼61 years) and 46.21±13.68 years (range 19∼79 years) for the ET and OT group, respectively. The operative extent in the ET group did not include advanced thyroid cancer or lateral neck dissection. The size of the tumor was 0.78±0.59 cm (range 0.1∼3.00 cm) and 1.54 ±1.05 cm (range 0.3∼6.00 cm) for the ET and OT group, respectively. Extrathyroidal extension and number of retrieved lymph nodes were significantly higher in the OT group. Postoperative radioactive iodine ablation was performed on 25 patients (72.43%) in the ET group and 48 patients (78.69%) in the OT group. There was no abnormal uptake on radioactive iodine scans in the iodine-treated patients and no significant differences in postoperative off-T4 TG levels between the two groups. There were no significant differences in operative time, amount of drainage, postoperative hospitalization period, hypocalcemia, and vocal cord palsy between the two groups. Cosmetic results of ET group were rated as excellent in a 3-month postoperative questionnaire by 25 (72.43%) of 35 patients. Conclusion: Endoscopic thyroidectomy via the bilateral axillo breast approach can be a feasible and effective option for PTC in selected cases. (Korean J Endocrine Surg 2011;11:158-163)
이근호 ( Keun Ho Lee ),( Eun Young Chi ),( Boonlert Viriyapak ),( Hyun Sung Kwack ),( Yoon Kyung Lee ),( Sang Il Kim1 ),( Tae Churl Park ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Objective: Autophagy plays a vital role in homeostasis by combining organelles and cellular proteins with lysosome under starvation conditions. In addition, autophagy provides tumor cells with a source of energy. Continued autophagy will induce cells death. Here we aim to see if autophagic induction has an effect on conventional chemotherapeutic agents. Methods: Rapamycin, or mammalian target of rapamycin and paclitaxel, apoptosis-inducing agents were used autophagy in HeLa cervical cancer cells. Results: Growth inhibition of cells was not observed after the application of 0, 10, 20 nM of paclitaxel with or without rapamycin. Using a 5 nM concentration of paclitaxel, rapamycin administration inhibited cell growth significantly compared to no treatment. This implies the synergic antitumor effect of paclitaxel and rapamycin. Paclitaxel itself did not show any autophagic effect on cells but did show cell apoptosis by flow cytometry. Light chain 3, a microtubule-associated protein, which reflect autophagy, was increased with 5 nM of paclitaxel after pretreatment with 10 nM of rapamycin. Conclusion: These findings suggest that the autophagic inducer, rapamycin, can potentiate autophagic cell death when added as an apoptosis-inducing chemotherapeutic agent. In conclusion, the control of autophagy may be a future target for chemotherapy.
Proportion And Characteristics Of Transient Nodules In A Retrospective Analysis Of Pulmonary Nodules
( Jin Yeong Yu ),( Su Young Chi ),( Hee Jung Ban ),( Yong Soo Kwon ),( In Jae Oh ),( Kyu Sik Kim ),( Yu Il Kim1 ),( Sung Chul Lim ),( Song Choi ),( Yun Hyeon Kim ),( Young Chul Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-
5kW급 계통연계형 단상 배터리 충전기의 구현 및 실험
안현성(Hyun-Sung An),이우종(Wujong Lee),문병호(Byung-Ho Mun),박일규(Il-Kyu Park),정선용(Seon-Yong Jung),김영록(Youngroc Kim),차한주(Hanju Cha1) 전력전자학회 2013 전력전자학회 논문지 Vol.18 No.1
This paper explains control methods of single-phase grid connected battery charger. Charging mode is control by Constant Current - Constant Voltage method and discharging mode is controlled by active-reactive power control method. Current control method is based on the synchronous reference frame(SRF) PI controller, and the second harmonic of battery current is compensated by an added L-C resonant circuit. Feasibility of the proposed control methods is verified through experiment with a prototype of 5kW single-phase grid connected battery charger.
크론병으로 인한 십이지장-대장 누공의 Endoloop과 Hemoclip을 이용한 수술 전 내시경적 결찰 증례보고
박미성 ( Mi Sung Park1 ),김원진 ( Won Jin Kim ),허지혜 ( Ji Hye Huh ),박수정 ( Soo Jung Park ),홍성필 ( Sung Pil Hong ),김태일 ( Tae Il Kim ),김원호 ( Won Ho Kim ),천재희 ( Jae Hee Cheon ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2
Duodeno-colonic fistula is an enterocolonic fistula that occurs as a complication of Crohn`s disease. Symptoms of duodeno colonic fistula are similar to those of Crohn`s disease, such as weight loss and diarrhea. The treatment of choice is surgery, although medical treatment may also be considered. However, surgery is recommended when all available medical therapies have been ineffective. In this case, we report a secondary duodeno-colonic fistula due to Crohn`s disease that was temporarily managed by an endoscopic procedure with a detached endoloop and hemoclips as a bridging therapy to final surgical repair.