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이상원,이혁우 부산대학교 사범대학 1990 교사교육연구 Vol.21 No.-
The Chirisan gneiss complex is composed of various paragneisses and small amounts of orthogneisses metamorphosed in Precambrian, which are intruded by gabbroic rock, porphyritic granite and Namwon granite. The gneiss complex was undergone multimetamorhism that early high-grade progressive metamorphism reached to upper amphibolite facies, later amphibolite and epidote-amphinbolite facies(partially to greenschist facies) were overlapped by retrogressive metamorphism. Major mineral assemblage of those gneisses are biotite-garnet,biotitie-garnet-sillimanite,biotite-garnet-cordierite,biotite-garnet-cordierite-sillimanite. Coexisting minerals of 14 samples were analysed by EPMA. Metamorphic conditions were estimated using various experimental, theoretical geothermometers and geobarometers. They show wide ranges of temperature and pressure as 600∼750℃, 720∼820℃, 420∼550℃ of biotite-garnet, cordierite-garnet, alkali feldspar-plagioclase geothermometer and 4.6~6.2Kb, 4.5~7Kb of cordierite-garnet, plagioclase-garnet geobarometer, respectively. But peak metamorphic condition is about 700℃ with 4.67Kb(X=0.40) inferred by plotting of cordierite composition to the P-T diagram under consideration of H₂0 content. The metamorphic path, according to the inferred P-T conditions with the reaction of coexisting minerals and analyses of various geothermo-barometers, is considered that progressive peak metamorphism reached to upper amphibolite facies with partial melting under 700∼750℃, 4.67Kb of temperature and pressure, and later epidote-amphibolite facies was overlapped by the retrogressive metamorphism.
이상우,박태열,김주혁 東亞大學校附設스포츠科學硏究所 1996 스포츠科學硏究論文集 Vol.14 No.-
The purpose of this study was to evaluate of the cardiorespiatory function and energy expenditure in men-rowing. The subjects were two groups; men rowing group in which career had for 5.4 ±1.13 year, Control group were college students. They did exercise with start speed of 120m/min without treadmill slope, the speed was incremental 20m/min per two minute and they were finally led to exhaustion. The results were as follows; 1. The cardiorespiratory was non-significant difference in rest, during maximum exercise ventilation was 162.6 ±11.69ℓ/min in rowing group, 142.3 ±21.34ℓ/min in control group. ?? o₂max/kg was 61.5 ±4.91㎖/kg/min in control group. The ????, RR ?? o₂, ??o₂/kg were significant difference in during maximum exercise. 2. The energy expenditure was non-significant in rest. The EQO₂was significant difference in rest. The MET in during maximum exercise was 21.2 ±2.67 in rowing group, 18.7 ±4.56 in control group, the cal/day was 5,864.5 ±341.47Kcal in rowing group, 4,662.6 ±563.67Kcal in control group.
工業敎育大學의 實驗實習施設 共同活用 및 運營에 關한 硏究
尹錫天,牟相榮,權五憲,千炳善,周赫鍾,李永臣,金健中,羅聲雄,洪錫雨,吳德成,盧泰天 충남대학교 공업교육연구소 1983 論文集 Vol.6 No.2(A)
The College of Engineering was specialized to have a sole function for supplying technical high school teachers in 1977 and referred to as the College of Industrial Education according to the Government's policy. The economic impact mainly due to the oil-crises caused a severe problem to this college, namely discrepancy of supply to demand scale. Accordingly the number of student enrollment was to be fluctuated from 479 in 1979 through 800 in 1979 and 900 in 1980 to 430 in 1981. And the engineering departments have been attached to this Engineering Education College since 1981. These circumstanses met singnificant inefficiency in facility operation. This program aims at providing an overall relocation of the college facilities and preparing the practical system to make the joint-operation possible taking into account circulation, academic stream, budget, maintenance, etc. However this study could not get optimal spacing but some trade-off, considering the current situation.
Woo, Sang Hyeok,Park, Myung-Jin,An, Sungkwan,Lee, Hyung-Chahn,Jin, Hyeon-Ok,Lee, Su-Jae,Gwak, Ho-Shin,Park, In-Chul,Hong, Seok-Il,Rhee, Chang Hun Wiley Subscription Services, Inc., A Wiley Company 2005 Journal of cellular biochemistry Vol.95 No.1
<P>Arsenic trioxide (As<SUB>2</SUB>O<SUB>3</SUB>, diarsenic oxide) has recently been reported to induce apoptosis and inhibit the proliferation of various human cancer cells derived from solid tumors as well as hematopoietic malignancies. In this study, the in vitro effects of As<SUB>2</SUB>O<SUB>3</SUB> and tetraasrsenic oxide (As<SUB>4</SUB>O<SUB>6</SUB>) on cell cycle regulation and basic fibroblast growth factor (bFGF)- or vascular endothelial growth factor (VEGF)-stimulated cell proliferation of human umbilical vein endothelial cells (HUVEC) were investigated. Significant dose-dependent inhibition of cell proliferation was observed when HUVEC were treated with either arsenical compound for 48 h, and flow cytometric analysis revealed that these two arsenical compounds induced cell cycle arrest at the G<SUB>1</SUB> and G<SUB>2</SUB>/M phases—the increases in cell population at the G<SUB>1</SUB> and G<SUB>2</SUB>/M phase were dominantly observed in As<SUB>2</SUB>O<SUB>3</SUB>- and As<SUB>4</SUB>O<SUB>6</SUB>-treated cells, respectively. In both arsenical compounds-treated cells, the protein levels of cyclin A and CDC25C were significantly reduced in a dose-dependent manner, concomitant to the reduced activities of CDK2- and CDC2-associated kinase. In G<SUB>1</SUB>-synchronized HUVEC, the arsenical compounds prevented the cell cycle progression from G<SUB>1</SUB> to S phase, which was stimulated by bFGF or VEGF, through the inhibition of growth factor-dependent signaling. These results suggest that arsenical compounds inhibit the proliferation of HUVEC via G<SUB>1</SUB> and G<SUB>2</SUB>/M phase arrest of the cell cycle. In addition, these inhibitory effects on bFGF- or VEGF-stimulated cell proliferation suggest antiangiogenic potential of these arsenical compounds. © 2005 Wiley-Liss, Inc.</P>
( Sang Myung Woo ),( Sang Hyub Lee ),( Ji Won Yoo ),( Ki Young Yang ),( Jung Gyun Seo ),( Joo Kyung Park ),( Jin Hyeok Hwang ),( Woo Jin Lee ),( Ji Kon Ryu ),( Yong Tae Kim ),( Yong Bum Yoon ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: No standard chemotherapy has been established for advanced gallbladder cancer. The authors studied the activity and tolerability of a gemcitabine and ox-aliplatin (GEMOX) combination in unresectable gallbladder cancer (GBC). Methods: Adult patients with pathologically confirmed unresectable GBC were prospectively recruited at three centers. No patient had received prior chemotherapy or radiotherapy. Patients received cycles of gemcitabine at 1,000 mg/m2 on day 1, followed by oxaliplatin at 100 mg/m2 on day 2, every 2 weeks. The primary study endpoint was time to progression. Results: Forty patients with unresect-able GBC were enrolled. The median age was 60 years (range, 38 to 79 years). All patients showed good performance status. Of the 33 analyzable patients, 12 achieved partial re-sponse (36%), 17 stable disease (52%), and four progressive disease (12%). No patient achieved a complete response. The tumor control rate was 88%. At a median follow-up of 6.8 months, the median time to progression was 5.3 months (95% confidence interval [CI], 3.7 to 6.9), and median overall survival was 6.8 months (95% CI, 6.1 to 7.5). Nine of the 40 patients (23%) experienced at least a grade-3 adverse event, but no patient experienced a grade-4 adverse event. Conclu-sions: GEMOX combination therapy is a feasible option and is well tolerated in unresectable GBC. (Gut Liver 2013;7:594-598)
Woo, Sang-Hyeok,Oh, Su-Young,Han, Song-Iy,Choi, Yung-Hyun,Kang, Kwang-Il,Yoo, Mi-Ae,Kim, Han-Do,Kang, Ho-Sung The Korean Society for Integrative Biology 2000 Korean journal of biological sciences Vol.4 No.2
The expression of $p21^{WAF1/ClP1/SDl1}$, one of the cyclin-dependent kinase inhibitors, is regulated by a variety of transcription factors including p53 and STAT. Heat shock induces the expression of p21 in a temperature- and time-dependent manner. Although the p21 induction by heat shock has been reported to be controlled by p53, a p53-independent mechanism Is also involved. To understand the p53-independent regulation of heat shock-induced p21 expression, we searched the promoter region of p21 gene and found one or two heat shock element (HSE)-like sequences in human, rat, and mouse. Electromobility shift assay (EMSA) showed that heat shock factor (HSF) could bind to these HSE-like sequences In response to heat shock, even though to a lesser extent than to HSE. In addition, p21 promoter deletion analysis revealed that heat shock activated a p21 deletion promoter construct containing the HSE-like sequences but lacking p53-binding sites, but not a promoter construct containing neither HSE-like sequences nor the p53-responsive element. Furthermore, the p21 induction by heat shook was significantly inhibited in confluent cells in which heat shock-induced HSF activation was reduced. These results suggest that the transcriptional regulation of p21 by heat shock may be mediated through activation and binding to HSE-like sequences of HSF.
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
Woo, Sang Hyeok,An, Sungkwan,Lee, Hyung-Chahn,Jin, Hyeon-Ok,Seo, Sung-Keum,Yoo, Doo-Hyun,Lee, Kee-Ho,Rhee, Chang Hun,Choi, Eui-Ju,Hong, Seok-Il,Park, In-Chul American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.45
<P>The Hsp90-associated protein p23 modulates Hsp90 activity during the final stages of the chaperone pathway to facilitate maturation of client proteins. Previous reports indicate that p23 cleavage induced by caspases during cell death triggers destabilization of client proteins. However, the specific role of truncated p23 (Delta p23) in this process and the underlying mechanisms remain to be determined. One such client protein, hTERT, is a telomerase catalytic subunit regulated by several chaperone proteins, including Hsp90 and p23. In the present study, we examined the effects of p23 cleavage on hTERT stability and telomerase activity. Our data showed that overexpression of Delta p23 resulted in a decrease in hTERT levels, and a down-regulation in telomerase activity. Serine phosphorylation of Hsp90 was significantly reduced in cells expressing high levels of Delta p23 compared with those expressing full-length p23. Mutation analyses revealed that two serine residues (Ser-231 and Ser-263) in Hsp90 are important for activation of telomerase, and down-regulation of telomerase activity by Delta p23 was associated with inhibition of cell growth and sensitization of cells to cisplatin. Our data aid in determining the mechanism underlying the regulation of telomerase activity by the chaperone complex during caspase-dependent cell death.</P>