Immobilization with Ketamine HCI and Tiletamine-Zolazepam in Cynomolgus Monkeys

Myung-cheol Kim,Sung-hyeok Hong,Soo-jin Lee,Young-suk Kim,Jae-il Lee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus MonkeysJae-il Lee, Sung-hyeok Hong, Soo-jin Lee, Young-suk Kim and Myung-cheol Kim*Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, KoreaReceived March 4, 2003 / Accepted July 2, 2003J. Vet. Sci. (2003), 4(2), 187-191JOURNAL OFVeterinaryScience*Corresponding author: Myung-cheol Kim Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-6757, Fax: +82-42-822-4216 E-mail: mckim@cnu.ac.kr

동물원에서 사육중인 Japanese Macaque (Macaca fuscata)에서 Zoletil 마취에 관한 연구

이재일,이수진,홍성혁,신남식,김덕환,박창식,전무형,조종민,김영석,김명철 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

To evaluate the effects of Zoletil (tiletamine-zolazepam) that have been widely used for the chemical restraint and anesthesia of primates, on physiologic alteration, blood gas analysis and anesthetic duration in the Japanese macaque(Macaca fuscata), this study was carried out. Zoleril was administered by intramuscular injection, Evaluation of temperature, heart rate, respiration rate and blood gas analysis were performed before administration ancl at 1,10, 20, 30, 40, 50 and 60 min after administration, and induction and maintenance time was recorded. There was no significant difference in heart rate, PCO₂PO₂after Zolcril administration and temperature, respration rate, pH were significant difference compared with those of before administration, The induction time was 2.5±l.Omin and maintenance time was 86±23.2min. It was considered that Zoletil could he usefully used for the sedation and immobilization of Japanese macaque reared in zoological garden.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

조정선수의 호흡순환 기능 및 에너지 대사

이상우,박태열,김주혁 東亞大學校附設스포츠科學硏究所 1996 스포츠科學硏究論文集 Vol.14 No.-

The purpose of this study was to evaluate of the cardiorespiatory function and energy expenditure in men-rowing. The subjects were two groups; men rowing group in which career had for 5.4 ±1.13 year, Control group were college students. They did exercise with start speed of 120m/min without treadmill slope, the speed was incremental 20m/min per two minute and they were finally led to exhaustion. The results were as follows; 1. The cardiorespiratory was non-significant difference in rest, during maximum exercise ventilation was 162.6 ±11.69ℓ/min in rowing group, 142.3 ±21.34ℓ/min in control group. ?? o₂max/kg was 61.5 ±4.91㎖/kg/min in control group. The ????, RR ?? o₂, ??o₂/kg were significant difference in during maximum exercise. 2. The energy expenditure was non-significant in rest. The EQO₂was significant difference in rest. The MET in during maximum exercise was 21.2 ±2.67 in rowing group, 18.7 ±4.56 in control group, the cal/day was 5,864.5 ±341.47Kcal in rowing group, 4,662.6 ±563.67Kcal in control group.

지리산편마암복합체의 지온 및 지압계에 관한 연구

이상원,이혁우 부산대학교 사범대학 1990 교사교육연구 Vol.21 No.-

The Chirisan gneiss complex is composed of various paragneisses and small amounts of orthogneisses metamorphosed in Precambrian, which are intruded by gabbroic rock, porphyritic granite and Namwon granite. The gneiss complex was undergone multimetamorhism that early high-grade progressive metamorphism reached to upper amphibolite facies, later amphibolite and epidote-amphinbolite facies(partially to greenschist facies) were overlapped by retrogressive metamorphism. Major mineral assemblage of those gneisses are biotite-garnet,biotitie-garnet-sillimanite,biotite-garnet-cordierite,biotite-garnet-cordierite-sillimanite. Coexisting minerals of 14 samples were analysed by EPMA. Metamorphic conditions were estimated using various experimental, theoretical geothermometers and geobarometers. They show wide ranges of temperature and pressure as 600∼750℃, 720∼820℃, 420∼550℃ of biotite-garnet, cordierite-garnet, alkali feldspar-plagioclase geothermometer and 4.6~6.2Kb, 4.5~7Kb of cordierite-garnet, plagioclase-garnet geobarometer, respectively. But peak metamorphic condition is about 700℃ with 4.67Kb(X=0.40) inferred by plotting of cordierite composition to the P-T diagram under consideration of H₂0 content. The metamorphic path, according to the inferred P-T conditions with the reaction of coexisting minerals and analyses of various geothermo-barometers, is considered that progressive peak metamorphism reached to upper amphibolite facies with partial melting under 700∼750℃, 4.67Kb of temperature and pressure, and later epidote-amphibolite facies was overlapped by the retrogressive metamorphism.

화학-기계적 우식 제거법을 이용한 유구치 우식의 치료 : 증례보고

이혁상,이재천,김영재,김정욱,김종철,장기택 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

전통적인 bur에 의한 우식치질의 삭제는 진동과 열에 의한 자극을 초래하기 때문에 아이들은 치과에 가는 것을 무서워 한다. 최근 전통적인 방법을 대체하는 방법을 개발하려는 노력이 이루어져 왔고, 화학-기계적인 우식 제거법 역시 이러한 시도 중 하나이다. Carisolv^(TM)는 세가지 아미노산과 낮은 농도의 sodium hypochlorite, 그리고 특별하게 고안된 수 기구로 구성된 제품이다. 본 증례는 Carisolv^(TM)로 치료한 두 증례를 보고한다. 우식 상아질을 Carisolv^(TM) gel과 기구로 제거하고 복합레진으로 수복하였다. The conventional drilling method of caries removal makes vibration and thermal stimuli, so that children are afraid of dental treatment. Recently, various non-invasive caries removal techniques of alternatives to traditional methods are introduced and chemo-mechanical canes removal is one of them. Carisolv^(TM) comprises a gel that is composed of three different amino acids and a low concentration of sodium hypochlorite and specially-designed hand instruments. This report describes two cases of dental caries treatment with Carisolv^(TM). The carious dentin was eliminated with Carisolv^(TM) gel with instruments and then composite resin restoration was conducted.

이황화탄소 중독자들의 노출중단 이후의 심박동수 변이

이상윤,조성일,백도명,변창범,김미정,박경근,임상혁,양길승,황창국,전형준 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 2000년도에 이황화탄소 중독증 환자들과 대조군의 심박동수 변이를 비교하여 이황화탄소 중독증 환자들의 심박동수 변이가 대조군에 비해 유의하게 낮다는 연구보고가 있었다. 당시의 연구가 이황화탄소 노출이 중단된 상태에서 이황화탄소 중독자들의 건강 문제를 연구했다는 점에 의의가 있으나 연구 결과를 해석하는데 있어 제한점들이 있었다. 이 연구는 2000년도에 수행하였던 연구의 제한점을 극복하고 이황화탄소 노출이 중단된 이후의 이황화탄소 중독자들의 심혈관계 상태를 심박동수 변이를 이용하여 평가해보고자 하였다. 방법: 이황화탄소 중독증으로 진단받은 환자 122명과 환자군의 연령대와 성별 빈도에 따라 무작위 추출한 112명을 대조군으로 선정하였다. 자기 기입식 설문지와 건강검진을 통해 연령, 성별, 신장, 체중, 흡연, 음주, 규칙적 운동, 질병력, 직업력, 흉부 방사선 촬영, 심전도 측정을 실시하였다. 연구 대상자들은 의자에 앉힌 상태에서 5분 동안 심박동수 변이를 측정하였다. 이 연구에서 측정한 심박동수 변이 지표들은 정상 RR간격의 표준편차(standard deviation of all norma-to-normal intervals, SDNN), 인접한 RR간격들의 차이를 제곱의 합의 평균의 제곱근(square root of the mean of the sum of squares of differences between adjacent normal-to-normal intervals, RMSSD). 저주파영역(low frequency power, LF: 0.04~0.15Hz), 고주파 영역 (high frequency power, HF:0.15~0.4Hz), 전체 주파수 강도(total power, TP), 저주파/고주파 비 (LF/HF ratio)이다. 결과: 단변량 분석에서 이황화탄소 중독자들의 모든 심박동수 변이 지표들이 대조군에 비하여 낮았다. 다중선형회귀분석에서 이황화탄소 중독은 RMSSD를 유의하게 감소시키는 것으로 나타났다.(P<0.05). 결론: 이 연구는 이황화탄소 노출이 중단된 상태에서도 이황화탄소 중독자들에게 심혈관계와 관련된 건강문제가 있을 수 있음을 시사한다. Objectives: A previous study conducted in 2000 measuring the heart rate variability (HRV) of carbon disulfide (CS_(2))-poisoned subjected suggested that their HRV was reduced after exposure cessation. However, the study was limited by the following procedural limitations: (1) only 71 CS_(2)-poisoned subjects participated, (2) no females participated, and (3) the CS_(2)-poisoned subjects were older than the controls. This study was therefore conducted to overcome these limitations of the earlier study. Methods: The study subjects comprised 122 retired workers with CS_(2) poisoning and the same number of age- and sex-matched controls. Information on individual age, sex, height, wight, smoking history, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups was collected though a self-administered questionnaire and a medical examination. Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency (HF), and LF/HF ratio were measured as HRV indices for 5 minutes in the sitting position. Results: Univariate analysis revealed that all HRV indices of CS_(2)-poisoned subjected were lower than those of the controls. Multiple linear regression analysis showed that CS_(2) poisoning had negative association with all HRV indices and that its association with RMSSD was statistically significant(P<0.05). Conclusions: This study suggests that CS_(2)-poisoned subjects continue to have reduced HRV, even though the exposure has ceased.

미세 전산화 단층 촬영을 이용한 글라스 아이오노머 수복물의 인접면우식 재광화 효과에 관한 장기간 연구

이혁상,김영재,김정욱,장기택 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

일개 철강 사업장에서 대사증후군의 위험요인과 γ-GTP와의 관련성

문제혁,이상준,박정덕 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 대사증후군은 심혈관계 질환의 이환과 이로 인한 사망률을 증가시키는 것으로 알려져 있으며, 비만, 고 중성지방혈증, 저 HDL-콜레스테롤혈증, 고혈압, 공복 시 고혈당 등에서 3개 항목 이상을 만족한 경우로 정의된다. 간기능 검사 중 γ-GTP는 간세포 손상에 대한 생체지표로 흔히 사용되는 검사이며, 고혈압, 제 2형 당뇨 및 뇌졸중과도 관련이 있음이 밝혀져 있다. 이번 연구에서는 일개 철강 사업장내 근로자들의 대사증후군의 유병률과 위험요인 및 대사증후군과 γ-GTP와의 관련성을 알아보았다. 방법: 수도권 소재 일개 철강 사업장 남자 근로자 1,604명을 대상으로 대사증후군의 구성요소(체질량지수, 중성지방, HDL-콜레스테롤, 수축기와 이완기 혈압, 공 복 시 혈당)와 γ-GTP, 교대근무 여부, 음주력, 흡연력, 운동 여부 및 가족병력 등을 조사하여 분석하였다. 결과: 일개 철강사업장근로자에 있어서 대사증후군의 유병률은 21.3%, 연령 보정 유병률은 15.5%이었다. 대사증후군에 영향을 미치는 역학적 요인은 연령(OR: 1.063, 95% CI: 1.033-1.094), 음주(OR: 1.657, 95% CI: 1.175. 2.337) 및 흡연(OR: 1.359, 95% CI: 1.017. 1.816) 등 이었고, 교대근무는 고혈압(OR: 1.329, 95% CI: 1.038-1.700)에만 영향을 주었다. 고 γ-GTP 혈증군에서 대사증후군의 구성인자인 비만, 고 중성지방혈증, 고혈압 및 공복시 고혈당의 위험도는 각각 2.625, 3.384, 1.887, 2.406이었고, 대사증후군의 위험도는 3.345이었다. 결론: 이번 연구결과로 볼 때, 철강 사업장에서 대사증후군에 대한 적극적인 관리를 위하여 금주와 금연 등 생활행태 개선을 위한 보건교육이 요구되었고, γ-GTP가 대사증후군의 조기 색출지표로서의 가능성이 제기되었다. Objectives: This study was performed to estimate the prevalence and possible risk factors of the metabolic syndrome in steel-mill workers, and to evaluate the relation between γ-glutamyltransferase (γ-GTP) and the metabolic syndrome. Methods: The study subjects comprised 1,604 male steel-mill workers. The indices of metabolic syndrome, such as BMI, triglyceride, HDL-cholesterol, blood pressure, fasting glucose, and γ-GTP were analyzed in each subject. We collected information about demographic characteristics, behavioral patterns, such as alcohol drinking, smoking, and exercise, and family medical history through a self-administered questionnaire. Statistical analysis was done by using the chi-square test, Mantel-Haenszel trend test and logistic regression model. Results: The crude and age-adjusted prevalences of the metabolic syndrome were 21.3% and 15.5%, respectively, in the steel-mill workers. Age (OR: 1.063, 95% CI: 1.033-1.094), alcohol drinking (OR: 1.657, 95% CI: 1.175-2.337) and smoking (OR: 1.359, 95% CI: 1.017-1.816) were risk factors for the metabolic syndrome. Meanwhile, shift work showed a significant relation with hypertension (OR: 1.329, 95% CI: 1.038-1.700), but not with other metabolic syndrome components. However, tenure, exercise and family medical history were not significant factors for the metabolic syndrome in this study. The risk ratio of the metabolic syndrome (OR: 3.345, 95 % CI: 2.534-4.416) and its components, such as obesity, hypertriglyceridemia, hypertension and hyperglycemia, were higher in the high γ-GTP group (≥63 IU/Ɩ ) than in the controls (<63 IU/Ɩ ). Conclusions: These results confirm the need for health education to control the metabolic syndrome by improving behavioral patterns, such as alcohol drinking and smoking, in factory workers. In addition, it is suggested that γ-GTP might be a useful candidate in screening for the metabolic syndrome.

전립선암과 전립선비대증 환자에서 혈청 유리 및 총전립선특이항원 측정의 의의

서혁준,박형민,권태균,정성광,김법완,이재태 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Purpose: This study was peformed to investigate whether the free to total PSA ratio(F/T PSA ratio) offers a better discriminant for the detection of patient with prostatic cancer(CaP) and those with benign prostatic hyperplasia(BPH) than serum total PSA alone. Materials and Methods: From September 1996 to February 1999, free and total PSA levels were measured on frozen sera samples of 154 men with BPH and 46 with CaP using immunoradiometric assay. Results: In all subjects, the mean total PSA was significantly higher in CaP group(72.57±66.58ng/ml) than BPH group(3.12±4.10ng/ml). The mean PSAD was significantly higher in CaP group(1.64± 1.86) than BPH group(0.08±0.01). The mean F/T PSA ratio was significantly lower in CaP group(0.19± 0.07) than BPH group(0.30±0.13). Among 41 subjects whose total PSA were between 4-20ng/ml, the mean PSAD was significantly higher in CaP group(0.37±7.16) than BPH group(0.17± 0.07), but the mean F/T PSA ratio was not significantly different between CaP(0.19± 0.10) and BPH group(0.25±7.13). By comparing the sensitivity and specificity of total PSA alone, PSAD and F/T PSA ratio on receiver operating characterislic (ROC) Cutie in all subiects and subiects with total PSA between 4-20ng/ml, F/T PSA ratio had no superiority than total PSA alone and PSAD for discrimination between CaP and BPH. Conclusions: We suggest that the F/T PSA ratio is not superior to total PSA alone and FSAD in the detection of prostatic cancer, and further evaluation of the usefulness of F/T PSA ratio should be required.