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Ji Chang Woo,Kim Nam-Jung,Lee Sang-Guei,Hwang-Yong Kim,Choi Hoon-Sik,Song In-Sun,Ko Jee Sun 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
We analyzed the chirp sound and behavior of Teleogryllus emma with observation system, which was consisted of computer, ccd-camera and microphone. Computational methods of wavelet transformation and Self-Organizing Maps (SOM) were utilized to characterized the chirp sound of insect species for automatic counting in this study. Wavelets were initially applied to feature extraction of the chirp sound. Wavelet coefficients were accordingly calculated based on the basis function (e.g., Morlet). The obtained coefficients were subsequently provided to count number of chirps in each song. Sound structure of insect specimens consisted with long chirp and short chirp and the patterns of song were grouped by frequency of long chirp and short chirp. The song patterns of insect specimens were divided by Self-Organizing Map (SOM) that was used number of chirp as input data. Application of computational methods to automatic detection of chirp sound was further discussed for obtaining objective assessment in behavior science.
2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석
이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3
목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.
스케일이 있는 급수관내의 유도초음파의 전파 특성에 관한 연구
송성진,김영환,이동훈,이현동,배철호,박정훈 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1
배관 내의 스케일은 통수비를 감소시키므로 배관을 적절히 관리하기 위해서는 스케일량에 대한 정량적인 평가가 필수적이다. 상수도 급수관내의 스케일량을 평가하기 위해서 유도초음파를 사용하였다. 가변각 웻지를 사용하여 유도 초음파의 여러 모드를 발생시키고, 노후 배관을 따라서 전파하는 특성을 분석하였다. 실험적으로 관내의 스케일이 증가함에 따라서 f×d=1.5㎒·㎜인 경우에 F(M,2) 모드들의 진폭이 크게 감소하는 것을 알 수 있었다. 본 연구의 결과로 상수도 급수관의 스케일량 평가에 적합한 유도 초음파는 F(M,2) 모드들임을 알 수 있었다. Since the scale in pipes reduces the flow rate, a quantitative evaluation of the scale is essential for the proper maintenance of pipes. Guided waves were employed to estimate the amount of scale in water supplying pipes. Using variable angle wedge, several modes of guided waves were generated and their propagation charcteristics along the pipes with scale were analyzed. It was experimentally observed that the amplitude of F(M,2) modes at f×d=1.5㎒·㎜ decreased significantly with increasing amount of scale. The present study showed that F(M,2) modes were optimal to evaluate the scale in water supplying pipes.
송효정,김성훈,김진웅 대한동의병리학회 1995 동의생리병리학회지 Vol.9 No.2
연구배경 :최근 다용되는 항암제가 여러 부작용과 면역기능저하등의 문제점이 대두 되며서 이에 대한 대책으로 생약 또는 한약축출물을 기존의 항암제와 병용하여 치료효과를 높이는데 많은 연구가 이루어지고 있는데 본 논문도 위암에 이어 두 번째의 사망률을 점하고 있는 간암에 대하여 간계질환에 널리 쓰이는 인진을 이용하여 항암 효과 및 항암제와의 병용 효과를 실험을 통하여 규명하여 실제 임상에 있어 간암 치료에 도움이 되고자 함. 연구방법 : In vitro에서 茵陳을 water, hexane, ethyl ether, ethyl acetate로 抽出한 分劃의 抗腫瘍 效果 및 抗癌劑 adriamycin(ARM), cisplatin(CPT), 5-fluo-rouracil (5-FU) 등과의 相乘作用을 MTT 法에 의해 살펴 보고, 動物 實驗에서는 ICR 생쥐에 S-180을 腹腔 注射한 後 i.p로 名層의 엑기스를 投入하여 體重變化, 生命延長率, 및 血液檢査 등을 實施함 연구결과 : 茵陳 分劃의 肝癌株에 대한 抗腫瘍 效果가 認定되나 癌株는 Hep G2, 分劃은 water層과 ethyl ether層이, 相乘 效果는 Adriamycin과의 倂用 投與에서보다 效果的인 것으로 나타났다. In order to prove the antitumor effect of fraction of Herba Artemisiae Capillaris experimentally, studies were done. The antitumor effect of fractions of Herba Artemisiae Capillaris against hepatic cancer cells such as Hep G2, Hep 3B & PLC, also the synergstric action were evaluated in the combined treatment with anticancer drugs using chiefly for the treatment of liver by measuring body weight, survival time, hematological changes in ICR bearing S-180. The results were obtained as follows: 1. In cytotoxic effect against Hep G2, inhibitory growth rate below 55% of control was recognized in concentration of 10-3g/ml of water, ethyl ether layer. the synergistic effect with adriamycin was shown in concentration of 10-5g/ml above in water layer, 10-5 g/ml above in hexane layer, 10-4g/ml above in ethyl ether layer, the synergistic effect with cisplatin was shown in concentration of of 10-5g/ml above in water layer, 10-3g/ml in ether layer, the synergistic effect with 5-fluorouracil was shown in concentration of 10-3g/ml in water, ethyl ether layer. 2. In cytotoxic effect against PLC, the concentrations showing inhibitory growth rate below 55% of control was concentration of 10-4g/ml above in water, ethyl ether layer, the synergistic effect with adriamycin was shown in concentration of 10-4g/ml above in water, ethyl ether layer, the synergistic effect with cisplatin was shown in concen-tration of 10-5g/ml above in water layer, ethyl ether layer, 10-3g/ml in hexane, ethyl acetate layer, the synergistic effect with 5-fluorouracil(5-FU) was shown in concentration of 10-3g/ml in water layer. 3. In cytotoxic effect against Hep 3B, inhibitory growth rate below 55% of control was concentration of 10-3g/ml in water layer. the synergistic effect with adriamycin was shown in concentration of 10-3g/ml in ether layer, 10-4g/ml above in water layer, hexane layer, the synergistic effect with cisplatin was shown in concentration of 10-4g/ml above in water layer, the synergistic effect with 5-fluorouracil(5-FU) was shown in concentration of 10-3g/ml in water, ethyl acetate layer 4. In vivo, the gaining of body weight were significantly suppressed in water of Herba Artemisiae Capillaris only as compared with control group bearing S-180 and ILS was 18.2% in water layer, 16% in hexane layer, 17% in ethyl ether layer respectively. 5. The number of platelet was significantly increased in water layer, ethyl ether layer and platelet aggregation was significantly increased in waster, hexane, ethyl ethers and ethyl acetate layer as compared with control group. From the above result it was concluded that fractions of Herba Artemisiae Capillaris had antitumor effect, but Hep G2 of human hepatic tumor cells, water, ethyl ether layer of all fractions and adriamycin of anticancer drugs were more effective in the antitiumor activity.
탄산음료 유발 법랑질 침식에 대한 항우식 제품의 예방 효과
송주현,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1
본 연구는 항우식 제품인 Casein phosphopeptide-amorphous calcium phosphate(CPP-ACP)를 포함하는 치아크림, 불소 바니쉬, 저농도 불소 양치액을 치아에 도포하는 것이 단시간 탄산음료에 의한 법랑질의 침식을 예방할 수 있는지 살펴보기 위해 계획되었다. 법랑질 시편에 다음과 같은 항우식 제품을 도포하였고, 인공타액에 24시간 보관한 후, 콜라에 1분 증류수에 1분씩 5회 번갈아 처리하였다. 1군: 대조군(무처치) 2군: CPP-ACP 치아크림군 3군: 불소 바니쉬군(1,000 ppm F) 4군: 저농도 불소 양치액군(227 ppm F) 5군: 불소 바니쉬 + CPP-ACP 치아크림군 6군: 저농도 불소 양치액 + CPP-ACP 치아크림군 미세경도와 침식깊이를 측정하였고, Quantitative light-induced fluorescence(QLF)를 이용하여 안정된 형광 격자에 대한 부피 형광 변화인 ΔQ를 측정하여 무기질 감소량을 평가하였다. 6일 동안 실험을 반복하여 다음과 같은 결과를 얻었다. 1. 미세경도는 1군≤2군≤4군<6군<3군≒5군 순이었다. 2. 평균 침식깊이는 5군≒3군<6군<4군≒2군≒1군 순이었다. 3. ΔQ는 1군≒2군≤4군≤6군≤3군≒5군 순이었다. ΔQ의 감소율은 1군과 2군, 4군과 6군, 3군과 5군이 각각 유사하였다. 4. ΔQ는 미세경도와 강한 양의 상관관계를 나타냈고(r=0.96, p<0.05), 침식깊이와는 강한 음의 상관관계를 보였다(r=-0.96, p<0.05). The aim of this study was to evaluate the preventive effect of commercially available anticariogenic products, specifically, the tooth cream containing Casein phosphopeptide-amorphous calcium phosphate(CPP-ACP), fluoride varnish and low-level fluoride mouthrinse on enamel erosion induced by carbonated beverage in a short period of time. Enamel specimens were treated as follows and were then kept in artificial saliva for 24 hours followed by further processing by alternately soaking them in Cola beverage and in distilled water for 1 minute each five times. Group 1: control group (no treatment) Group 2: tooth cream with CPP-ACP Group 3: fluoride varnish (1,000 ppm F) Group 4: low-level fluoride mouthrinse (227 ppm F) Group 5: fluoride varnish + tooth cream with CPP-ACP Group 6: low-level fluoride mouthrinse + tooth cream with CPP-ACP Microhardness and erosion depth were measured and the mineral loss of each specimen was evaluated by measuring the volumetric fluorescence change(ΔQ) against the stable fluorescent grid using quantitative lightinduced fluorescence(QLF). The experiment lasted for 6 days repeated each day. The results were as follows: 1. The microhardness was increased as follows: Group 1≤2≤4<6<3≒5. 2. The mean erosion depth was increased as follows: Group 5≒3<6<4≒2≒1. 3. The ΔQ was increased as follows: Group 1≒2≤4≤6≤3≒5. The decrement of ΔQ was similar between group 1 and 2, group 4 and 6 and group 3 and 5. 4. The ΔQ showed positive correlation with microhardness (r=0.96, p<0.05), while it was negatively correlated to erosion depth (r=-0.96, p<0.05).
API 기준에 근거한 RBI 절차 개발 및 소프트웨어의 구현 (Ⅱ) : 준정량적 접근법 Semi-Quantitative Approach
송정수,심상훈,권정락,윤기봉 한국산업안전학회 2002 한국안전학회지 Vol.17 No.4
During the last then years, the need has been increased for reducing maintenance cost for aged equipments and ensuring safety, efficiency and profitability of petrochemical and refinery plants. American Petroleum institute(API) developed a code, API 581 for proposing standard procedures of risk based inspection. Even though the API 581 code covers general RBI procedures, there must be some limitations. In this study, a semi-quantitative assessment algorithm for RBI based on the API 581 code was reconstructed for developing an RBI software. The user-friendly realRBI software is developed with a module for evaluating semi-quantitative risk category using the potential consequence factor and the likelihood factor. Also, inspection planning module for inspection time and inspection method for equipments are included.
아가리쿠스 버섯(Agaricus blazei Murill)의 效能 및 硏究動向에 대한 考察
宋昊哲,金東熙,金聖勳 대전대학교 한의학연구소 2000 혜화의학회지 Vol.9 No.1
Basidiomycete, Agaricus blazei murill has grown Brazil naturally. It was first cultivated 1997 in Korea. Proteoglycan or polysaccharide which have the effect of immunopotency and anticancer were extracted from it. From the mycelium of cultivated mushroom, were extracted lectin, linoleic acid, FⅢ-2-b, and simmilar to glucomannan from fruit body of Basidiomycete Agaricus blazei. Fruit body was more studied than mycelium. The experiments were most in vivo study. The effect were shown on S-180, MethA tumor, Ehrlich ascites carcinoma, Shionogi carcinoma 42, Meth A fibrosarcoma by transferation of tumor cell line, specially effectiveness on the S-180. About immunopotenciation, were shown as activation of NK cell, pancreatic T-cell, helper T cell, enhancement of population of cytotoxity T cell. It was effect on the MethA tumor cells in vitro cell cytotoxity and has induction of apoptosis. Forthermore cytotoxity of many other tumor cell line, angiognensis, cell cycle studies will be needed.
과립구 감소 환자의 감염시 Imipenem/cilastatin 단독요법의 치료효과 : Piperacillin-amikin 병합요법과의 무작위 비교
송재훈,최승원,박수길,고윤석,서철원,이규형,이정신,문희법,김상희 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.2
To evaluate the efficacy of the single agent therapy for the initial management of fever in neutropenic patients, we conducted a prospective randomized trial comparing imipenem/cilastatin alone with a combination of piperacillin and amikacin. Among 40 evauable episodes of fever, stratum A(hematologic malignancy, n=30) consisted of 15 imipenem group and 15 piperacillin plus amikacin group and stratum B consisted of 10 cases with solid tumor. There was no difference in age, sex, duration of neutropenia, initial granulocyte count and number of cases with severe neutropenia(<100/㎣) between two groups. Overall response rate to imipenem was higher(86.6%) than combination therapy group(53.5%) in stratum A, but statistical difference was not found. Overall response rate to imipenem in solid tumor was 100% whereas to combination therapy group was 40%. There was no serious toxicity on imipenem use. We conclude that imipenem monotherapy could be an effective & safe empirical therapy in the treatment of febrile neutropenic patients.