한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

입제의 수면처리에 의한 주요수도해충의 동시방제

최승윤,배상희,송유한,Choi Seung Yoon,Bae Sang Hee,Song Yoo Han 한국응용곤충학회 1970 한국식물보호학회지 Vol.9 No.1

본 시험은 유기인계 살충제인 Terracur P입제 및 Lebaycid 입제와 유기염소계 살충제인 상감마입제$(\gamma-BHC 입제)$를 수면시용 하였을때 수도요해충인 이화명충, 끝 동매미충, 애멸구 및 흰둥멸구에 대한 동시방제가능성과 방제적기를 구명하고 약제간의 방제효과를 비교코저 실시하였다. 얻어진 시험결과는 다음과 같다. 1) 약제처리후 부화직후 이화명충 접종 시험에 있어서 상감마와 Terracur P는 높은 살충율을 보였으나 Lebaycid의 살충율은 낮았다. 約 $50\%$ 살충력 잔효일수에 있어서 상감마는 8-14日이었고 Terracur P는 6일간이었다. 2) 당초 계획된 방제적기에 관한 정보는 얻을 수 없었다. 즉 주어진 일간격이 좁아 유의한 차를 얻을 수 없었다. 3) 1,2화기 이화명충에 대한 방제효과는 Terracur P=상감마>Lebaycid의 순이었다. 4) Terracur P와 Lebaycid 입제의 처리는 끝동매미충의 방제효과가 좋았으나 상감마$(\gamma-BHC 입제)$의 방제효과는 기대할 수 없었다. 끝동매미충에 대한 Terracur P와 Lebaycid입제의 잔효력은 30일 이상이었다. 5) 애멸구와 흰등별구에 대한 시험은 충의 서식밀도가 낮기 때문에 약제간 방제효과를 얻을 수 없었다. 6) 공시약제중 Terracur P와 Lebaycidd입제는 이화명충과 끌동매미충의 동시방제제로서 사용할 수 있을 것 같다. This experiment was conducted to find out the simultaneous control effect of granulated insecticides on the several major rice insect pests in Korea. The granulated insecticides used were Terracur P$5\%$ (one of the phosphoric insecticides), Lebaycid $5\%$, and Sang-gamma (gamma-BHC) $6\%$. Those insecticides were broadcasted by hand on the paddy field at the ratio of 3kg. in June and 4kg. in August per 10 a, and the date of insecticidal application was based on the maximum moth occurrence of the rice stem borer in 1969. The rice insect pests tested in this study were rice stem borer (Chilo suppressalis W.), green rice leafhopper (Nephotettix bipunctatus cincticeps U.), smiller brown planthopper (Laodelphax striatellus F.), and white back planthopper (Sogotella furcifera H.). For the study of residual effectiveness of the insecticides, the rice stem borer larvae just hatched from the eggs were installed on the sheath of rice plants collected from the paddy field after insecticidal treatment, and the mortality was made at 48 hours after installation. High mortality was observed in Terracur P and Sang-gamma treatments and low mortality in Lebaycid treatment. The duration of residual effects giving about 50% mortality was about 14 days in Sang-gamma and about 6 days in Terracur P treatments. The study on the effectiveness of the insecticides to the rice stem borer in the paddy field was made by the number of dead blades and white heads of the rice plants injured by the larvae, and the number of survival larvae in the straws after crop harvest. The order of insecticidal effectiveness to the rice stem borer was Terracur P=Sang-gamm>Lebaycid. The study on the effectiveness of the insecticides to the leafhoppers and planthoppers in the paddy field was made by the population density by sweeping (5 times) at the given day intervals after treatments. Terracur P was highly effective for the control of the green rice leafhoppers and Lebaycid was moderately effective, but Sang-gamma seemed not to be effective. The effectiveness of the insecticides tested to the planthoppers was not clear, and it seemed to related with the low insect population density. Study on the determination of proper timing of insecticidal application was not also made clear, and it seemed to be short in the range of day intervals in the insecticidal application. For the study on the control effects of the rice insect pests, rice yield per 100 hills per plot was observed. There was no statistically significant difference among the treatments in rice yields, but the order of yield (Terracur P>Sang-gamma>Lebaycid>Control) was paralleled with the tends of control effects above mentioned. In a view point of simultaneous control of the rice stem borers and green rice leafhoppers by the application of granulated insecticides, Terracur P and Lebaycid were more effective than Sang-gamma which have been used.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

Studies on the Effects of Biomedicinal Agents on Serum Concentration of Ca2+ , P and ALP Activity in Osteoporosis-Induced Rats

Sang-keun Kim,Myung-hun Lee,Man-hee Rhee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

on the Effects of Biomedicinal Agents on Serum Concentration of Ca2+, P andALP Activity in Osteoporosis-Induced RatsSang-keun Kim, Myung-hun Lee1 and Man-hee Rhee2College of Veterinary Medicine, Chungnam National University, 220 Gungdong, Yusong-Gu, Daejeon 305-764, Korea1National Veterinary Research and Quarantine Service, Anyang 430-824, Korea2College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, KoreaReceived April 3, 2003 / Accepted July 9, 2003J. Vet. Sci. (2003), 4(2), 151-154JOURNAL OFVeterinaryScience*Corresponding author: Sang-keun Kim Dept. of Vet. Med., Chungnam National University, Daejeon 305764, Korea Tel: +82-42-821-6754, Fax: +82-42-821-6754 E.-mail: kskkim@cnu.ac.kr

법치경제 개혁의 길

좌승희, 조성봉(Sung-Hee JWA),Sung Bong CHO 한국경제연구원 2004 한국경제연구원 연구보고서 Vol.2004 No.-

Sung-Hee JWA and Sung Bong CHO The establishment of the rule of law in the social and economics spheres is fundamental towards effective and practical reform of a country’s legal and institutional environment. Such reform must take place under the rule of law, and not through human or administrative discretion. We claim that establishing ‘a law-governed economy,’ which is defined as the operation of an economy under the rule of law, is an indispensible feature for Korea’s proper economic reform. In Korea, many factors presently hinder the establishment of a law-governed economy, of which the most important are the persistent government intervention into markets, the government’s excessive discretionary power, the weak check and balance among the three government branches, the absence of regulatory bodies’ independence, the unclear division of labor among government bodies, and the ‘egalitarian trap’ embedded in the Korean culture. We argue in this paper that political reform is a prerequisite to a law-governed economy. There should be a conscious effort to remove entry and exit barriers in political markets, as well as reduce significantly its high-cost structure. Through such a process, and by improving the country’s economic institutional environment, more effective economic reform, especially of corporations, will then become possible. Regarding corporate sector reform, there is a need to establish a proper market disciplinary system by strengthening the monitoring roles of various market participants, thus replacing the existing regulatory framework that aims to directly control corporate behavior.

[논문]Operational Characteristics of CO2 Laser Adopted by Superposing-Discharge

Hee-Je Kim,Hyun-Ju Chung,Byoung-Dae Min,Jong-Han Joung,Sung- lun Park 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

오늘날 현저한 CO2 레이저의 응용 추세에 발맞추어 보다 다양한 형태의 출력 제어 기술이 대두되고 있다. 본연구에서는multi-Pulse Superposing-Discharge 기술을 이용하여 다양한형태의 CO2 레이저의 펄스를 성형 하였다. 펄스 성형을 위한 방법으로 PIC one-chip microprocessor를 이용하여 삼중 PFN 모률의 SCR을 각각 고유의 지연시간을 가지도록 제어하였다. 실험에 사용된 삼중 PFN 모률의 전원 회로는 각각 캐패시터 인덕터,SCR,고압 펄스 트랜스 그리고 고압 트랜스 2차측에 브릿지 정류기로 구성 하였다. 고압 펼스 트랜스의 1차측을 제어하므로서 PFN 모률의 동작을 저 전압에서 수행 할 수 있다. 트랜스의 2차측에 연결된 전파 정류기는 펄스 에너지를 부하에 지속적으로 전달한다. 본 연구에서는 삼중 PFN 모률의 각각의 SCR을 다른 시간 가격을 두고 트리거 하므로서 다양한 Long pulse shaping을 실현하였다. 또한 약 250-1000μs 의 주기를 가지는 다양한 펄스형 레이저 빔을 얻었다.

노래부르기 음악프로그램이 정신질환자의 자아존중감과 대인관계에 미치는 영향

홍상희,윤지원,이재금,김지연 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The objective of this study was to verify the effects of the Singing program for psychiatric patients on their self-esteem and interpersonal relationship, and to provide data for the nursing intervention that is necessary for making their life better. Method: The subjects were 10 in-patients with psychotic disorders at C university hospital in Seoul, from july 3 to September 18 im 2005, and the methodology was one group pre experimental- post experimantal design. The instrument for the measurement of self-esteem is Rosenberg Self-Esteem Scale(1973), which was translated by Chun Byung Jae(1974) and the measurement of interpersoral relationship is Schleim & Guerney Relationship Change Scale(1971) which was translated by Mun Seok Mo(1980) and revised by Chun Seok Gyun(1994). SPSS program was used for the analysis of the collected data, which were analyzed by the paired t-test and one-way ANOVA. Result: Singing therapy had an effect on improvement of the self-esteem, and seemed to be more effective as the frequency of the program increased. Singing therapy had an effect on improvement of the interpersonal relatinship, and seemed to ne more effecive as the frequency of the program increased. Comclusion: Singing therapy is found out to be effective program affecting the improvement of both the self-esteem and interpersonal relationship of the psychiatric patients. Therefore the nurses can use the Singing therapy as the nursing intervention for imtrovement of the self-esteem and interpersonal relationship of the psychiatric patients in clinical practice.

Mexico y Corea del sur en el marco de la cooperacion Sur-Sur y Triangular

( Sang Hee Jung ) 한국스페인어문학회 2014 스페인어문학 Vol.0 No.70

Jung, Sang-hee(2014), Mexico y Corea del Sur en el marco de la cooperacion Sur-Sur y Triangular, Estudios Hispanicos, 70, 155-187. Este trabajo intent estudiar y promover las mejores formas de trabajo y de asociaciones mas convenientes para Mexico y Corea del Sur mediante la cooperacion Sur-Sur y Triangular. Por tanto primero se abordaran las definiciones de la cooperacion Sur-Sur y Triangular desde diversos marcos institucionales para aclara que se entendera por cooperacion Sur-Sur y Triangular. Segundo, se realizara una revision a la evolucion de las actividades principals de la cooperacion Sur-Sur y Triangular en la region de America Latina y Mexico. Tercero, en base a un analisis acerca de las experiencias concretas y relevantes de la cooperacion Sur-Sur y Triangular, llevados a cabo por Mexico y Corea del Sur se pretende valorar sue status actual, la contribucion y las implicaciones estrategicas, asi como los retos existentes. A continuacion, se plantean algunas fomulas o un possible plan de sus implementaciones en el marco de las relaciones exstentes entre Mexico y Corea Finalmente se identificaran las orientaciones y potencialidades para profundizar y desarrollar nuevas formas de cooperacion y vinculacion de ambos paises vistas desde las nuevas opciones en el ambito de la AOD.

압착방법별 포도 착즙액의 품질특성

최희돈,김성수,김경탁,홍희도,김상희 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.3

캠벨과 거봉을 이용하여 여러 가지 압착방법에 따른 착즙액의 이화학적 및 관능적 특성을 조사하였다. 수율의 경우 캠벨, 거봉이 동일하게 냉압처리보다는 온압처리가, 온압처리에서도 낮은 온도보다는 높은 온도에서 수율이 높게 나타났으며, 또 온압 · 펙틴분해 병행처리가 각각 83.5% , 87.3%로 가장 높은 수율을 나타내었다. 또한 당도와 아미노테 질소도 열처리온도의 상승 및 압착방법의 병행에 의해 감소하는 것으로 나타났다. 적정산도는 캠밸과 거봉이 압착방법에 따라 각각 0.86 ~ 1.00%, 0.60 ~ 0.69%로 거봉에 비해 캠벨의 산도가 높았으며, 열처리온도가 산도 증감에 더 큰 영향을 미치는 것으로 나타났다. 그리고 압착방법에 따른 착즙액에 대한 관능검사 결과 열처리 온도의 상승 및 착즙액에 대한 관능검사 결과 열처리온도의 상승 및 압착방법의 병행에 의해 떫은 맛과 산맛의 강도가 강하여지고 이들 처리구의 기호도가 높은 것으로 나타났다. The physicochemical and sensory properties of Campbell Early and Gerbong juices prepared by various pressing methods were studied. The yields of these juices by mixed method were 83.5% and 87.5%, the highest value of various pressing methods. And soluble solids and amino nitrogens of them decreased as heating temperature increased and was lowest when mixed method was performed. Titratable acidities of Campbell Early juice was 0.86 ~ 1.00%, higher than that of Gerbong juice, 0.60 ~ 0.69%. Also the strength of astringent taste and sour taste of Campbell Early and Gerbong juice increased as heating temperature increased, and increased strength of these tastes gave good sensory evaluation to grape juices.

통합심리치료의 인지분화훈련이 정신분열병 환자의 기초 인지기능에 미치는 영향

이희상,현명호,조현상,이연희,김태용,장순아,노규식,정기립,이만홍,유계준 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 : 정신분열별 환자들을 대상으로 통합심리치료의 소프로그램인 인지분화훈련을 실시하여 실행기능, 개념형성능력, 언어능력 및 추론력에 대한 훈련이 보다 더 하위단계의 인지기능인 주의력, 기억력, 반응시간 등을 호전시킬 수 있는 지를 알아보고자 하였다. 연구방법 : DSM-IV상 정신분열병으로 진단된 24명의 입원환자를 무작위로 양분하여 한 군은 인지분화훈련군으로 다른 한 군은 대조군으로 나누었다. 훈련군은 4주동안 1주일에 3회(매회 60분간)로 총 12회의 통합심리치료의 인지분화훈련을 받았으며 대조군은 동일한 시간동안 정신건강교육을 받았다. 훈련전후에 훈련군과 대조군을 대상으로 개정판 Wechsler 기억검사로 주의집중력, 장·단기 기억력을 측정하였고 Vienna test system중 결정반응시간검사로 반응시간, 반응결정시간, 반응운동시간을 평가하였다. 연구결과 : 1) 주의집중력에서는 훈련군과 대조군사이에 집단간 효과, 집단내 효과 및 상호작용 효과가 없었다. 2) 단기기억력에서는 훈련군과 대조군사이에 집단내 효과는 있었으나(F(1,24)=10.46. p〈.05). 집단간 효과, 상호작용 효과는 없었다. 3) 장기기억력에서는 훈련군과 대조군사이에 집단내 효과는 있었으나(F(1,24)=15.09. p〈.05). 집단간 효과, 상호작용 효과는 없었다. 4) 반응시간에서는 상호작용 효과(F(1,24)=5.18, p〈.05)가 있었다. 5) 반응운동시간에서는 집단간 효과, 집단내 효과 및 상호작용 효과가 없었다. 6) 반응결정시간에서는 상호작용 효과(F(1.24)=6.00, p〈.05)가 있었다. 결 론 : 통합심리치료의 인지분화훈련은 정신분열병 환자에서 하위단계의 인지기능 중 반응시간(특히 반응결정시간)을 단축시키는 효과가 있었다. Objectives : The purpose of this study was to investigate the effects of cognitive differentiation training of Integrated Psychological Therapy(a training program of executive function, concept formation, language, and abstraction) on micro-level cognitive function such as attention, memory and reaction time in patients time in patients with schizophrenia. Methods : Twenty-four inpatients diagnosed as schizophrenia using DSM-IV were randomly assigned to 2 groups. The training group went through a total of 12 sessions of cognitive differentiation training for 4 weeks. The control group received psychoeducation program during the same period. Wechsler Memory Scale-Revised and Decision-Reaction Timer of Vienna Test System were administered to all patients, both before and after the training program. Results : 1) In the attention and concentration scores of Wechsler Memory Scale-Revised, between group, within group and interaction effects of training were not significant. 2) In the short-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=10.46, p〈0.05), but the between group and interaction effects did not reach significance. 3) In the long-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=15.09, p〈0.05), but the between group and interaction effects did not reach significance. 4) In the reaction time scores of Decision-Reaction Timer, interaction effect of training was significant(F(1,24)=5.18, p〈0.05). 5) In the motor time scores of Decision-Reaction Timer, between group, within group and interaction effects of training were not significant. 6) In the decision time scores of Decision-Reaction Timer, interaction effect of training was significant(F(1,24)=6.00, p〈0.05). Conclusion : Our findings suggest that cognitive differentiation training of Integrated Psycho-logical Therapy is partly effective on improving micro-level cognitive functions such as reaction time(especially, decision time) in patents with schizophrenia.