염증성 근섬유모세포종의 증례보고

은상아,박혁,차인호,김현실,정호걸,김기덕,박창서 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.3

The inflammatory myofibroblastic tumor (inflammatory pseudotumor) is a rarely occurring soft tissue lesion of unknown etiology. It can be of any location, but commonly it is found in lungs. It has been considered as a nonneoplastic reactive inflammatory lesion, but nowadays, confusion and dispute about its character is increasing due to its high recurrence rate and metastasis. We present a patient who had been diagnosed with an inflammatory pseudotumor in the right maxilla area, 1 year before visiting our hospital. After that, her pain and swelling did not resolved and she visit our hospital. On radiographic examination, aggressively infiltrative growth of the lesion with destruction of adjacent bony structure was noted. We found unusual aggressiveness of the inflammatory myofibroblastic tumor of the head and neck region. Because the typical behavior of the inflammatory myofibroblastic tumor is not defined yet, we recommend the surgical excision of the lesion and close follow-up.

구내 표준 방사선사진을 이용한 구내방사선촬영기의 선질 평가

이상섭,권혁락,심우현,오승현,이지연,전국진,김기덕,박창서 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : This study was to evaluate the beam quality of intraoral X-ray equipments used at Yonsei University Dental Hospital (YUDH) using the half value layer (HVL) and the characteristic curve of intraoral standard X-ray film. Materials and Methods : The study was done using the intraoral X-ray equipments used at each clinical department at YUDH. Aluminum filter was used to determine the HVL. Intraoral standard film was used to get the characteristic curve of each intraoral X-ray equipment. Results : Most of the HVLs of intraoral X-ray equipments were higher than the least recommended thickness, but the REX 601 model used at the operative dentistry department and the X-707 model used at the pediatric dentistry department had HVLs lower than the recommended thickness. The slopes of the characteristic curves of films taken using the PANPAS 601 model and REX 601 model at operative dentistry department, the X-705 model of prosthodontic dentistry department, and the REX601 model at the student clinic were relatively low. Conclusion : HVL and the characteristic curve of X-ray film can be used to evaluate the beam quality of intraoral X-ray equipment. In order to get the best X-ray films with the least radiation exposure to patients and best diagnostic information in clinical dentistry, X-ray equipment should be managed in the planned and organized fashion. (Korean J Oral Maxillofac Radiol 2000; 30: 183-188)

치수 치근단 병소의 전구 위험요인으로서의 제 2 형 당뇨의 역할에 관한 소고

김진희,배광식,서덕규,홍성태,이윤,홍삼표,금기연 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.3

Diabetes Mellitus (DM) is a syndrome accompanied with the abnormal secretion or function of insulin, a hormone that plays a vital role in controlling the blood glucose level (BGL). Type 1 and 2 DM are most common form and the prevalence of the latter is recently increasing. The aim of this article was to assess whet her Type 2 DM could act as a predisposing risk factor on the pulpo-periapical pathogenesis. Previous literature on the pathologic changes of blood vessels in DM was thoroughly reviewed. Furthermore, a histopathologic analysis of artificially-induced periapical specimens obtained from Type 2 diabetic and DM-resistant rats was compared. Histopathologic results demonstrate that the size of periapical bone destruction was larger and the degree of pulpal inflammation was more severe in diabetic rats, indicating that Type 2 DM itself can be a predisposing risk factor that makes the host more susceptible to pulpal infection. The possible reasons may be that in diabetic state the lumen of pulpal blood vessels are thickened by atheromatous deposits, and microcirculation is hindered. The function of polymorphonuclear leukocyte is also impaired and the migration of immune cells is blocked. leading to increased chance of pulpal infection. Also, lack of collateral circulation of pulpal blood vessels makes the pulp more susceptible to infection. These decrease the regeneration capacity of pulpal cells or tissues, delaying the healing process. Therefore, when restorative treatment is needed in Type 2 DM patients, dentists should minimize irritation to the pulpal tissue under control of BGL. 당뇨(Diabetes Mellitus)란 혈당을 조절하는 인슐린의 분비나 기능에 장애를 야기하는 질환으로 인슐린 의존성 여부에 따라 제 1 형과 제 2 형으로 분류된다. 본 종설은 최근 증가 추세에 있는 제 2 형 당뇨가 치수 치근단 병소의 병인 과정에 전구 위험 요인으로 작용할 수 있는지를 평가 하고자 문헌고찰을 통해 당뇨의 병인 과정에서 특징적으로 나타나는 혈관 합병증에 관해 알아보고, 부가적으로 제 2 형 당뇨 쥐 모델에서 인위적인 치수감염 후 얻은 치근단 조직의 조직병리학적 분석을 시행하였다. 조직학적 관찰 결과 제 2 형 당뇨 쥐에서 대조군에 비해 치수 치근단 병소의 크기가 증가하였고, 치수 염증 반응도 심하게 나타난 것으로 보아 당뇨 자체가 숙주를 감염에 취약한 상태로 만드는 전구 위험요소로 작용하였음을 알 수 있었다. 이러한 이유로는 첫째, 당뇨 시 전반적으로 나타나는 혈관 내 죽상 침착(atheromatous deposits)에 의해 혈관 내벽의 두께가 두꺼워져 미세 순환의 장애는 물론 탐식 세포의 기능 저하, 면역 세포의 혈류 이동이 차단되어 치수 감염 시 쉽게 치근단 병소로 이환될 가능성이 높고, 둘째 치수 혈관에서 특징인 측부 순환(collateral circulation)의 부재에 따른 살균성 다형핵 백혈구의 활동 억제를 포함한 미세 혈관계의 취약성으로 인해 치수 조직의 재생능이 저하되어 추가적인 감염원의 공격에 대한 방어 및 치유 저하를 더욱 심화시키기 때문인 것으로 사료된다. 따라서 제 2 형 당뇨 환자의 수복치료 시 치과의사는 당뇨 조절 하에서 치수 조직의 자극을 최소화하기 위한 세심한 처치가 필요하다.

중풍으로 유발된 배뇨,배변장애에 양격산화탕을 위주로 한 치험 1례

김상진 ( Kim Sang Jin ),김민수 ( Kim Min Su ),서부일 ( Seo Bu Il ),구덕모 ( Gu Deog Mo ),서해경 ( Seo Hae Gyeong ),안희덕 ( An Hui Deog ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3

Objectives : We got a good effect on one patient with urinary and bowel dysfunction following cerebrovascular accident by oriental medical methods. Methods : We employed oriental medical treatments; herb-medication ( YungkyLLksanwh-tang), acupuncture. moxibustion and cupping therapy. Results : Urinary and bowel dysfunction was recovered after this treatments. Sense of urination and defecation was improved, also urinary and fecal incontinence was dtxreased. Conclusions : U e expected that therapeutic value of treatment according to symptom -complex(證) of urinary and bowel dysfunction following cerebrovascular accident will be higher if more clinical studiesand researches are accomplished.

급성림프구성백혈병의 면역학적 분류 및 림프아세포의 시험관내 분화유도에 관한 연구

서인석,조덕연,강원권,김삼용,이복희,이복수,백상기,김영진,이천배 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

The theory that various hematologic malignancies, such as acute and chronic leukemias and lymphomas, are characterized by monoclonal expansion of neoplastic cells arrested at different levels along the hemo-lymphopoietic differentiation pathway is widly accepted. It has also been supported by immunoglobulin gene rearrangement and phenotyping with specific antibodies to surface markers of lymphocytes concerning the lymphoid malignancies. In cope with these developments, the immunologic classification of acute lymphocytic leukemia had become more clarified. The author studied the immunologic classification of 15 patients with acute lymphocytic leukemia(ALL) with monoclonal antibodies against surface markers for lymphoid cells, and tried the in vitro induction of differentiation of progenitor-B cell ALL and T-cell ALL with TPA(12-0-tetradecanoyl phobol-13-acetate), a well known tumor promoter and known as a differentiation inducer also. Monoclonal antibodies for surface markers, used in this study, were Leu-9 for T-cell All and anti-Ia, anti-CALLA, anti-SIg(surface immunoglobulin), anti-BI, and anti-B4 for B-cell lineage ALL. Leu-9 positive cases were classified as T-cell ALL, Ia only positive cases were classified as progenitor-B cell ALL, Ia and CALLA positive cases were classified as common ALL, and Ia and SIg positive cases were classified as B-cell ALL. The results were as followings. 1. In this study, 5 cases were classified as common ALL, 3 each cases were B-cell and progenitor-B cell ALL, and 4 cases were T-cell ALL. 2. All 3 cases of B-cell ALL were L2 by FAB classification, and this findings was discordant with the conventional knowledge. 3. Leukocyte count in pheripheral blood of T-cell ALL patients at diagnosis was higher than that of non-T cell ALL(p<0.05). 4. All 5 cases of common ALL and 3 cases of B-cell ALL, 2 of 3 cases of progenitor-B cell ALL, and 1 of 4 cases of T-cell ALL achieved complete remission. So, T-cell ALL showed lower remission rate than that of common ALL and B-cell ALL. 5. One case of progenitor-B cell ALL, which is positive to only Ia, newly expressed B4, CALLA, BI and SIg after culture with TPA. This results suggest that TPA induce the differentiation of progenitor B-cells to more differentiated stage. 6. One case of T-cell ALL, which is positive to only Leu-9, newly expressed T3 after culture TPA and PHA. This results suggest that TPA and PHA induce the differentiation of early thymocyte to mature thymocyte.

Biofilm-forming associated genotypic and phenotypic characteristics of <i>Staphylococcus</i> spp. isolated from animals and air

Seo, Yeon-Soo,Lee, Deog Yong,Rayamahji, Nabin,Kang, Mi Lan,Yoo, Han Sang Elsevier 2008 Research in veterinary science Vol.85 No.3

<P><B>Abstract</B></P><P>Biological monitoring is performed to detect and analyze microorganisms that have continuously made an effort to survive in the environment. Of such microorganisms, <I>Staphylococcus</I> spp. is considered a common cause of nosocomial and environmental infections., Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) are required for the adhesion and biofilm formation of Staphylococci. Thirty-six and thirty-five Staphylococci isolated from animals and air, respectively, were analyzed. Biofilm formation and ten MSCRAMM genes were investigated using Congo red agar, tissue culture plate methods, and PCR. Airborne isolates were shown to have higher adherence and stronger biofilm formation than those from animals. The prevalence of MSCRAMM genes from air isolates was also higher than those from animals. Of the genes, <I>eno</I> was mainly associated with biofilm formation in both animals and airborne isolates (<I>P</I><0.05). Moreover, the rate of airborne isolates harboring the <I>eno</I> gene was higher than in animal isolates. These results indicated that analysis of MSCRAMM genes with a phenotypic assay might be a helpful bacterial control system for the environment.</P>

Diagnosis of Sjögren's syndrome from a xerostomia case accompanied by multiple dental caries.

Seo, Deog-Gyu,Kim, Jin,Lee, Chan-Young,Park, Sung-Ho University of Washington, School of Dentistry] 2009 Operative dentistry Vol.34 No.3

Safety and efficacy of nilotinib in adult patients with chronic myeloid leukemia: a post-marketing surveillance study in Korea

Seo-Yeon Ahn,Sang Kyun Son,Gyu Hyung Lee,Inho Kim,June-Won Cheong,Won Sik Lee,Byung Soo Kim,Deog-Yeon Jo,Chul Won Jung,Chu Myoung Seong,Jae Hoon Lee,Young Jin Yuh,Min Kyoung Kim,Hun-Mo Ryoo,Moo-Rim Pa 대한혈액학회 2022 Blood Research Vol.57 No.2

Background Nilotinib is a tyrosine kinase inhibitor approved by the Ministry of Food and Drug Safety for frontline and 2nd line treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This study aimed to confirm the safety and efficacy of nilotinib in routine clinical practice within South Korea. Methods An open-label, multicenter, single-arm, 12-week observational post-marketing surveillance (PMS) study was conducted on 669 Korean adult patients with Ph+ CML from December 24, 2010, to December 23, 2016. The patients received nilotinib treatment in routine clinical practice settings. Safety was evaluated by all types of adverse events (AEs) during the study period, and efficacy was evaluated by the complete hematological response (CHR) and cytogenetic response. Results During the study period, AEs occurred in 61.3% (410 patients, 973 events), adverse drug reactions (ADRs) in 40.5% (271/669 patients, 559 events), serious AEs in 4.5% (30 patients, 37 events), and serious ADRs in 0.7% (5 patients, 8 events). Furthermore, unexpected AEs occurred at a rate of 6.9% (46 patients, 55 events) and unexpected ADRs at 1.2% (8 patients, 8 events). As for the efficacy results, CHR was achieved in 89.5% (442/494 patients), and minor cytogenetic response or major cytogenetic response was achieved in 85.8% (139/162 patients). Conclusion This PMS study shows consistent results in terms of safety and efficacy compared with previous studies. Nilotinib was well tolerated and efficacious in adult Korean patients with Ph+ CML in routine clinical practice settings.

Breeding of mulberry variety “Shimgang” showing resistance to popcorn disease

( Sung Gyoo Byung ),( Seo Sang Deog ),( Kim Yong Soon ),( Ju Wan Taek ),( Kim Hyun Bok ),( Kim Kee Young ) 한국잠사학회 2016 International Journal of Industrial Entomology Vol.33 No.2

We bred a mulberry cultivar named Shimgang, through local adaptability test, which is under registration as a new cultivar for fruit production. Local adaptability test had been carried out at four local places(Suwon, Chuncheon, Buan and Jinju) for five years from 2011. This variety `Shimgang` belongs to Morus Microphylla Buckl. selected from seedlings imported from USA. Shimgang was resistant to popcorn disease and high yielding variety in fruit productivity by 111% compared to control cultivar `Shimheung(Morus alba L.)` for three years. Although fruits of `Shimgang` was smaller in size and lower in sugar content of mulberry fruits, it showed stronger resistance than that of `Shimheung`. It is adaptable to every where except the places where cold and late frost damage happen frequently.

Evaluation of Agri-Environmental Performance of Convention on Biological Diversity Using Winter Paddy Field in Korea

( Deog Bae Lee ),( Sang Hyun Park ),( Kee Kyung Kang ),( Byong Gu Ko ),( Kwang Lai Park ),( Myeong Cheol Seo ),( Jong Gil Kim ) 한국환경농학회 2008 한국환경농학회지 Vol.27 No.4

Winter migratory birds gather in paddy rice fields to feed shed rice grains. The Korean Ministry of Environment has practiced a policy program Contract on Paddy Field Management (CPFM) during winter fallow since 2002. This program starts with a contract between local governments and farmers, and the government pays a differential subsidy to farmers who finish spreading rice straw, cultivating barley, letting the whole rice plant without harvest, and submerging paddy fields for winter migratory birds. As more local governments have operated CPFM program, the total area on the contract and subsidy budget has increased yearly since 2002. This program could have its stable position as a successful policy by giving profits to farmers. With the program extended, the population of winter migratory birds has been greatly. For the evaluation of environmental performance of a policy, we analyzed this CPFM program by introducing some indicators in the form of Driving Force-State-Response Framework. The indicators were composed of 3 categorized indicators; the area of paddy land contracted under this program as `driving force` indicator, population of birds, the number of bird species and the amount of feces as `state` indicators, and the size of monetary support, the number of farmers or local governments participating, and public perception as `response` indicators. The contract area of paddy field under CPFM could be a good biodiversity indicator reflecting potential performance of this policy measure in the light of its linkage to the population of winter migratory birds. And the share of CPFM land of the whole agricultural land might also be used as a useful indicator of policy evaluation for improvement of wildlife diversity. The `state` indicators such as population of birds and the number of bird species could be matched to `driving force` indicator, but the total CPFM area of each site could not reflect the effect of areas under different management practices. However, the amount of bird feces could reflect differences in environmental performance with management practices as `state` indicators. The development of indicators indicating `response` such as farmers` behavior, public perception, and policy makers` willingness is also needed to support a successful implementation and improvement of this policy measure with the development of `performance` indicators integrating all these indicators.