http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박범정(Bum Jung Park),주형로(Hyung Rho Joo),박일석(Il-Seok Park),김진환(Jin-Whan Kim),노영수(Young-Soo Rho) 대한두경부종양학회 2007 대한두경부 종양학회지 Vol.23 No.2
Objectives and Background :Aims of this studies are to collect and analyze the lawful restriction against cancer registration and to suggest the model promoting the cancer registry. Materials and Methods :Total 16 countries, the members of OECD, including the U.S. are evaluated. the sta-tus of cancer registration of the evaluated countries are analyzed. The legislated laws, protect the individual’s information, of the evaluated countries are analyzed. The cases any registries were impaired with the law to protect privacy are searched and analyzed. Results :All of the evaluated countries have some kinds of privacy protecting laws. For cancer registration, 11 of 16 countries implement some lawful authorities. Some of countries have experienced restriction of registration by the law of protecting individual’s health data. All countries have performed cancer registry and 6 of 16 countries have nearly 100% population-based cancer registration. Conclusions :The cancer registry has to be the national effort. The informed consent of the data subjects and the permission of any special institutes are the difference to perform the registration. So, it is necessary to legi-slate any law supporting the cancer registration and establish any independent institutes to protect the individual’s health data and support the cancer registry.
박재범(Jea-Bum Park),태동현,노대석(Dae-Seok Rho),박성민(Seong-Min Park),박진엽(Jin-Yeop Park) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.- No.-
기존의 원자력 발전소의 비상용 전원공급장치에서는 납축전지를 사용하고 있는데, 수명과 보수유지 측면 에서 많은 문제점을 안고 있어, 장수명과 우수한 성능을 가진 리튬이온전지로의 교체가 요구되고 있는 실 정이다. 따라서 본 논문에서는 원전용 리튬이온전지의 기술기준을 개발하기 위하여, 기존의 원전용 납축 전지 기술기준(KEPIC)과 리튬이온전지에 대한 국내외 기술기준을 분석 하였다.
Park, Jiyoung,Rho, Ho Kyung,Kim, Kang Ho,Choe, Sung Sik,Lee, Yun Sok,Kim, Jae Bum American Society for Microbiology 2005 Molecular and cellular biology Vol.25 No.12
<B>ABSTRACT</B><P>Glucose-6-phosphate dehydrogenase (G6PD) produces cellular NADPH, which is required for the biosynthesis of fatty acids and cholesterol. Although G6PD is required for lipogenesis, it is poorly understood whether G6PD in adipocytes is involved in energy homeostasis, such as lipid and glucose metabolism. We report here that G6PD plays a role in adipogenesis and that its increase is tightly associated with the dysregulation of lipid metabolism and insulin resistance in obesity. We observed that the enzymatic activity and expression levels of G6PD were significantly elevated in white adipose tissues of obese models, including <I>db/db</I>, <I>ob/ob</I>, and diet-induced obesity mice. In 3T3-L1 cells, G6PD overexpression stimulated the expression of most adipocyte marker genes and elevated the levels of cellular free fatty acids, triglyceride, and FFA release. Consistently, G6PD knockdown via small interfering RNA attenuated adipocyte differentiation with less lipid droplet accumulation. Surprisingly, the expression of certain adipocytokines such as tumor necrosis factor alpha and resistin was increased, whereas that of adiponectin was decreased in G6PD overexpressed adipocytes. In accordance with these results, overexpression of G6PD impaired insulin signaling and suppressed insulin-dependent glucose uptake in adipocytes. Taken together, these data strongly suggest that aberrant increase of G6PD in obese and/or diabetic subjects would alter lipid metabolism and adipocytokine expression, thereby resulting in failure of lipid homeostasis and insulin resistance in adipocytes.</P>
Formalin이 넙치(Paralichthys olivaceus) 난 발생 및 부화자어에 미치는 영향
박창범,나오수,이치훈,김병호,이영돈,허문수,이정재,정상철,이기완,노섬,송춘복,최광식,이제희,여인규,전유진 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.1
Effects of formalin treatment on embryogenesis and larvae growing in fertilized eggs and hatched larvae of olive flounder, Paralichthys olivaceus were investigated. Fertilized eggs and hatched larvae were exposed to aqueous solution with 100, 200, 400, 800 and 1,000 ppm of nominal formalin concentration. They were kept in sea water of 16, 18 and 22℃, respectively. Survival rate and hatchability of fertilized eggs were high in control groups more than formalin treated groups in 16, 18 and 22℃, respectively (P<0.05). A similar effect that survival rate of hatched larvae was also observed for control and treatment groups. On the other hand, fertilized eggs treated with 400ppm formalin, were all death in kept in 22℃. These results suggest that high-dose of formalin in fertilized eggs and hatched larvae in olive flounder, Paralichthys olivaceus was inhibited the normal embryogenesis for fertilized eggs and growing for hatched larvae. Also, these inhibited effects was promoted in higher temperature.
Park, Hyo Young,Lee, Min Young,Jeong, Hyo Young,Rho, Yong Sook,Song, Sang Jin,Choi, Bum-Chae The Korean Society for Reproductive Medicine 2015 Clinical and Experimental Reproductive Medicine Vol.42 No.2
Objective: To evaluate the effect of a gonadotropin-releasing hormone (GnRH) antagonist protocol using corifollitropin alfa in women undergoing assisted reproduction. Methods: Six hundred and eighty-six in vitro fertilization-embryo transfer (IVF)/ intracytoplasmic sperm injection (ICSI) cycles were analyzed. In 113 cycles, folliculogenesis was induced with corifollitropin alfa and recombinant follicle stimulating hormone (rFSH), and premature luteinizing hormone (LH) surges were prevented with a GnRH antagonist. In the control group (573 cycles), premature LH surges were prevented with GnRH agonist injection from the midluteal phase of the preceding cycle, and ovarian stimulation was started with rFSH. The treatment duration, quality of oocytes and embryos, number of embryo transfer (ET) cancelled cycles, risk of ovarian hyperstimulation syndrome (OHSS), and the chemical pregnancy rate were evaluated in the two ovarian stimulation protocols. Results: There were no significant differences in age and infertility factors between treatment groups. The treatment duration was shorter in the corifollitropin alfa group than in the control group. Although not statistically significant, the mean numbers of matured (86.8% vs. 85.1%) and fertilized oocytes (84.2% vs. 83.1%), good embryos (62.4% vs. 60.3%), and chemical pregnancy rates (47.2% vs. 46.8%) were slightly higher in the corifollitropin alfa group than in the control group. In contrast, rates of ET cancelled cycles and the OHSS risk were slightly lower in the corifollitropin alfa group (6.2% and 2.7%) than in the control group (8.2% and 3.5%), although these differences were also not statistically significant. Conclusion: Although no significant differences were observed, the use of corifollitropin alfa seems to offer some advantages to patients because of its short treatment duration, safety, lower ET cancellation rate and reduced risk of OHSS.
철도 노선 간 통행 배정 모형과 노선 계획 간의 관계에 관한 연구
박범환(Bum Hwan Park),김충수(Chung-Soo Kim),노학래(Hag-Lae Rho) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.11월
This study deals with the relation between traffic assignment and line planning model in railway network. Traffic assignment in railway network means the distribution of OD demand to all lines under assumption that some train operation plans including especially the frequency of each line are given. And then, line planning model calculates the frequency of each line based on the result of traffic assignment. However the inconsistency occurs frequently between the supposed frequency in traffic assignment and resulting frequency of line planning. This study describes the inconsistency between traffic assignment and line planning using some typical traffic assignment models and cost-minimizing line planning model
박범환(Bum Hwan Park),김충수(Chung-Soo Kim),노학래(Hag-Lae Rho) 한국철도학회 2010 한국철도학회 학술발표대회논문집 Vol.2010 No.7
This study is about developing a transit assignment model on railway network. Current transit assignment models are mainly focused on road or urban transportation so that these models, for example, transit assignment model based on optimal strategy generates unrealistic transit assignment. Especially, since the advent of KTX, more passengers are using the transfer route containing KTX but most transit assignment models have a shortcoming that transfer is not considered or is overestimated. We present a new stochastic transit assignment model based on LOGIT considering transfer resistance.
정차 패턴이 주어진 경우의 노선 계획을 위한 최적화 모형
박범환(Bum Hwan Park),김충수(Chung-Soo Kim),서용일(Yong Il Seo),노학래(Hag-Lae Rho) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.11월
This study is about line planning model which determines the frequency of each train so that it could meet the OD demand minimizing the related costs. In most of line planning models, all-stop patterns are assumed and the model can be formulated into a model such that leg traffic load should be covered by sufficient frequency. But in order to minimize the passenger travelling time, we should consider the various halting patterns, and to do so, the line planning model should be constructed in terms of not leg traffic loads but OD demands. However it is very hard to solve the model which can make various halting patterns and frequency, simultaneously. So, we present a line planning model and algorithm when k patterns are given. This model can be formulated into minimum cost network flow model with discrete capacity assignment. And we present the simulation result applied to KTX network.
( Jumi Park ),( Yeonmi Lee ),( Joosung Shin ),( Hyeon-jeong Lee ),( Young-bum Son ),( Bong-wook Park ),( Deokhoon Kim ),( Gyu-jin Rho ),( Eunju Kang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.12
Ethical and safety issues have rendered mesenchymal stem cells (MSCs) popular candidates in regenerative medicine, but their therapeutic capacity is lower than that of induced pluripotent stem cells (iPSCs). This study compared original, dental tissue-derived MSCs with re-differentiated MSCs from iPSCs (iPS-MSCs). CD marker expression in iPS-MSCs was similar to original MSCs. iPS-MSCs expressed higher in pluripotent genes, but lower levels in mesodermal genes than MSCs. In addition, iPS-MSCs did not form teratomas. All iPSCs carried mtDNA mutations; some shared with original MSCs and others not previously detected therein. Shared mutations were synonymous, while novel mutations were non-synonymous or located on RNA-encoding genes. iPS-MSCs also harbored mtDNA mutations transmitted from iPSCs. Selected iPS-MSCs displayed lower mitochondrial respiration than original MSCs. In conclusion, screening for mtDNA mutations in iPSC lines for iPS-MSCs can identify mutation-free cell lines for therapeutic applications. [BMB Reports 2019; 52(12): 689-694]