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( Yunyun Jiang ),( Fazheng Ren ),( Songling Liu ),( Liang Zhao ),( Huiyuan Guo ),( Caiyun Hou ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3
Acid stress can affect the viability of probiotics, especially Bifidobacterium. This study aimed to improve the acid tolerance of Bifidobacterium longum BBMN68 using adaptive evolution. The stress response, and genomic differences of the parental strain and the variant strain were compared by acid stress. The highest acid-resistant mutant strain (BBMN68m) was isolated from more than 100 asexual lines, which were adaptive to the acid stress for 10th, 20th, 30th, 40th, and 50th repeats, respectively. The variant strain showed a significant increase in acid tolerance under conditions of pH 2.5 for 2 h (from 7.92 to 4.44 log CFU/ml) compared with the wildtype strain (WT, from 7.87 to 0 log CFU/ml). The surface of the variant strain was also smoother. Comparative whole-genome analysis showed that the galactosyl transferase D gene (cpsD, bbmn68_1012), a key gene involved in exopolysaccharide (EPS) synthesis, was altered by two nucleotides in the mutant, causing alteration in amino acids, pI (from 8.94 to 9.19), and predicted protein structure. Meanwhile, cpsD expression and EPS production were also reduced in the variant strain (p < 0.05) compared with WT, and the exogenous WT-EPS in the variant strain reduced its acid-resistant ability. These results suggested EPS was related to acid responses of BBMN68.
Numerical Simulation of Spray Flow in Injector For the Steamjet Engine
( Xu Sheng Shang ),( Jiang Hong Li ),( Ren Hou Zhao ),( Xu Ze Shang ),( Jie Hong Li ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
In this paper, according to the work mechanism of SteamJet, With the certain small scaled turbojet for an influence, along flying trajectory calculating mass of import air and injection water, establishing the spray physics model/ mathematics model. Based on the equation of three-dimension Renault average N-S, air to adopt the limited physical volume method, the liquid adopts to the Lagrangian orbit model, with straight injecting the current method ,Simulate the field of air/ liquid two phase flow field to distribute of inlet to carry on mutually. The results indicate that spray have an effect on flow field configuration. It is concluded that the numerical model and CFD method for modeling spray flow processes in gas/liquid injector will be satisfactory. Similar to the SteamJet the United States puts forward, adopting water injection can satisfy to import the conditional request for pressure and temperature of compressor.
Park, Soo-Heon,Cho, Chul-Soo,Lee, Oh-Young,Jun, Jae-Bum,Lin, San-Ren,Zhou, Li-Ya,Yuan, Yao-Zong,Li, Zhao-Shen,Hou, Xiao-Hua,Zhao, Hong-Chuan,Kachintorn, Udom,Kositchaiwat, Chomsri,Lertkupinit, Comson the Society for Free Radical Research Japan 2007 Journal of clinical biochemistry and nutrition Vol.40 No.2
<P>Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endogenous prostaglandins. The prophylactic effect of rebamipide on NSAID-induced gastrointestinal complications is unknown. The aim of this study was to compare NSAID-induced gastrointestinal complications in rebamipide- and misoprostol-treated groups. Patients were randomized to two groups and took a conventional NSAID plus rebamipide or misoprostol for 12 weeks. Gastric mucosal damage was evaluated by endoscopy at screening and the end of the study. The prevalences of active gastric ulcer were 7/176 (3.9%) in the rebamipide group and 3/156 (1.9%) in the misoprostol group. The prevalences of peptic ulcer were 8/176 (4.5%) in the rebamipide group and 7/156 (4.4%) in the misoprostol group. The cumulative incidences of peptic ulcer in the high-risk subgroup were 6/151 (4.0%) for rebamipide and 6/154 (3.9%) for misoprostol. In conclusion, rebamipide prevented NSAID-induced peptic ulcer as effectively as misoprostol in patients on long-term NSAID therapy. Rebamipide may be a useful therapeutic option for the prevention of NSAID-induced gastrointestinal ulcer because of its therapeutic effect and safety.</P>