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( Martin Humberto Munoz Ortega ),( Raul Wiliberto Llamas Ramirez ),( Norma Isabel Romero Delgadillo ),( Tania Guadalupe Elias Flores ),( Edgar De Jesus Tavares Rodriguez ),( Maria Del Rosario Campos E 대한소화기기능성질환·운동학회 2016 Gut and Liver Vol.10 No.1
Background/Aims: The development of therapeutic strategies for the treatment of cirrhosis has become an important focus for basic and clinical researchers. Adrenergic receptor antagonists have been evaluated as antifibrotic drugs in rodent models of carbon tetrachloride (CCl4)-induced cirrhosis. The aim of the present study was to evaluate the effects of carvedilol and doxazosin on fibrosis/cirrhosis in a hamster animal model. Methods: Cirrhotic-induced hamsters were treated by daily administration of carvedilol and doxazosin for 6 weeks. Hepatic function and histological evaluation were conducted by measuring biochemical markers, including total bilirubin, aspartate aminotransferase, alanine aminotransferase and albumin, and liver tissue slices. Additionally, transforming growth factor β (TGF-β) immunohistochemistry was analyzed. Results: Biochemical markers revealed that hepatic function was restored after treatment with doxazosin and carvedilol. Histological evaluation showed a decrease in collagen type I deposits and TGF-β-secreting cells. Conclusions: Taken together, these results suggest that the decrease in collagen type I following treatment with doxazosin or carvedilol is achieved by decreasing the profibrotic activities of TGF-β via the blockage of α1- and β-adrenergic receptor. Consequently, a diminution of fibrotic tissue in the CCl4-induced model of cirrhosis is achieved. (Gut Liver 2016;10:101-108)
( Ana Maria Teixeira ),( Raul Martins ),( Mafalda Martins ),( Maria Do Rosario Cunha ) 한국스포츠정책과학원(구 한국스포츠개발원) 2008 International Journal of Applied Sports Sciences Vol.20 No.2
This study analysed the influence of a 19 week exercise program in the functional fitness, salivary IgA and mood states of an elderly population. Thirty three subjects with ambulatory capacity and without any medical contraindications to exercise aged between 68 and 95 years old participated and were distributed into 2 groups: 15 subjects performed aerobic exercise that included low-impact rhythmic work sequences with music, three times a week, and 18 remained sedentary. The exercising group attained improvements in all components of functional fitness with significant differences registered for aerobic endurance, lower and upper body strength. The exercising group also showed improvements in the mood states, with statistically significant less depression, less tension, less fatigue, more vigour and less anger. On the other hand, the sedentary control group showed an increase in confusion and a loss of vigour. For the exercising group salivary IgA levels were higher after the 19 week exercise program with no changes for the control group. This study shows a positive effect of exercise on physical, psychological and mucosal immune parameters in elderly populations which may improve quality of life.
Erasmo Saucedo Uribe,Samuel Enrique Olivares Mundo,Raul Ricardo Medrano Garza,Fernando Diaz Gonzalez-Colmenero,Lorena Martinez Sanchez,Cesar Bigran Espinosa Cantu,Martin Moreno Arellano,Yessica Yaneth 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12
Objective To find the safety of long-acting injectable antipsychotics (LAIs) compared to each other, and/or placebo in the treatment of schizophrenia (SCZ) and/or schizoaffective disorder (SZA).Methods We performed a systematic review and a network meta-analysis of randomized controlled trials (RCTs) comparing the safety of LAIs versus other LAIs or placebo in adults diagnosed with SCZ or SZA. The primary outcomes were treatment emergent adverse events (TEAEs), serious treatment emergent adverse events (STEAEs), and deaths. The secondary outcomes included treatment discontinuations due to adverse events and all-cause discontinuations.Results Seventeen RCTs were included (n=7,908). There were no significant differences between LAIs and placebo in the risk of presenting TEAEs. LAIs had a significant lower risk of presenting STEAEs except for aripiprazole. No significant differences in deaths were found. LAIs showed a significant protective effect against all-cause discontinuation, except for haloperidol. Only aripiprazole had a significantly lower risk of treatment discontinuation due to adverse events.Conclusion We found no significant differences in the risk of presenting TEAEs between LAIs and placebo. The majority of LAIs had a significantly lower risk of presenting STEAEs than placebo. Development of international guidelines for the report of safety outcomes related to antipsychotics especially for LAIs in clinical trials could minimize report and interpretation biases and improve the accuracy of posterior meta-analysis.