Some Observations of the Influence Factors on the Response of Pile Groups

Qian-qing Zhang,Shi-min Zhang,Fayun Liang,Qian Zhang,Fei Xu 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.6

A simplified approach for nonlinear analysis of the load-displacement response of pile groups embedded in multilayered soils is presented in this work. A hyperbolic model is used to capture the relationship between unit skin friction and pile-soil relative displacement developed along the pile-soil interface and the stress-displacement relationship developed at the pile end. Considering interactive effect among piles, the parameters related to the hyperbolic model of an individual pile in a group can be computed. As to the analysis of the response of pile groups, a highly effective iterative computer program is developed using the hyperbolic model of an individual pile in a group. The efficiency and accuracy of the present method is verified using a well-documented field test. Furthermore, a parametric study is conducted to capture the influence of pile spacing and number of piles on the load-settlement response of the pile groups connected to a rigid cap. The pile-group settlement ratio and the pile-group resistance ratio are analyzed to assess the interaction effect among individual piles.

Original Article: Food Science/Microbiology : Antioxidant and Antimicrobial Activities of Camellia Oleifera Seed Oils

( Qing Fen Zhou ),( Xue Jing Jia ),( Qian Qian Li ),( Rui Wu Yang ),( Li Zhang ),( Yong Hong Zhou ),( Chun Bang Ding ) 한국응용생명화학회(구 한국농화학회) 2014 Journal of Applied Biological Chemistry (J. Appl. Vol.57 No.2

The antioxidant and antimicrobial activities of Camellia oleifera seed oil were studied. Four kinds of seed oil samples were prepared, crude oil and refined oil, extracted by cold pressing method (CPC, CPR), and organic solvent extraction (OSC, OSR). Antioxidant activity analysis was measured in 2,2-azinobis (3- ethylbenzothiazoline-6-sulfonic acid)-diammonium salt, ferric reducing Ability of Plasma, and 2,2-diphenyl-1-picrylhydrazyl assays. Besides, the percentage of inhibition of red blood cells hemolysis induced by 2,2´-azobis(2-amidnopropane) dihydrochlorid, the lag time of LDL conjugated dienes formation in vitro, and the inhibitors of loss in tryptophan fluorescence were all used to estimate the antioxidant activity of the samples. The total phenolic contents (TPC) were detemined by Folin-Ciocalteu method. The TPC of the C. oleifera seed oils can be arranged in descending order: CPC (1.9172 μg/mL) > OSC (1.5218 μg/mL) > CPR (1.0611 μg/mL) > OSR (0.6782 μg/mL). And the oils were investigated for activity against Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae and Aspergillus niger. The results showed the antioxidant activity of crude oil by cold pressing method was stronger than others, and all oils did inhibit activity of the top three bacteria expert A. niger. The further significance of the study contributes to measure the antioxidant and antimicrobial activity of the potential health benefits by the different methods of preparation and the oil of C. oleifera seeds acting as free radical scavenger, pharmaceuticals and preservatives may offer some information in medicine and cosmetic not just in food field.

먹는샘물 소비자의 식생활 라이프스타일이 선택속성 및 행동의도에 미치는 영향

이청천(Li Qing qian),유세란(Yoo Se Ran),고재윤(Ko Jae Youn) 한국외식경영학회 2017 외식경영연구 Vol.20 No.2

본 연구에서는 한국과 중국 먹는샘물 구매 경험이 있는 소비자를 대상으로 국적에 따라 먹는샘물 소비자의 식생활 라이프스타일에 따른 선택속성의 상관관계를 분석하고, 또는 선택속성이 행동의도에 미치는 영향을 파악하여 소비자의 니즈를 정확하게 파악함으로써 먹는샘물 시장을 활성화 하여 기업의 브랜드 구축에 기여하고자 한다. 또한, 한국의 먹는샘물 생산기업이 중국 시장 진출을 위한 기업 실무적인 마케팅전략 기초자료로 제시하고자 하였다. 연구의 목적을 달성하기 위해 480부를 최종분석에 사용하였으며, SPSS 20.0을 이용하여 요인분석, 정준상관분석, 다중회귀분석 등을 실시하였다. 연구결과 먹는샘물 소비자의 식생활 라이프스타일은 6가지 요인으로, 선택속성은 7가지 요인으로 확인되었다. 그리고 이들 변인 간 상관관계는 유의한 것으로 나타났으며, 선택속성과 행동의도 간 영향관계 또한 유의한 것으로 확인되었다. 본 연구를 통해 국내 및 중국 먹는샘물 시장 간의 관계를 도출해 국가 간 비교를 통한각 국가별 맞춤 마케팅 전략을 수립 할 수 있으며, 또는 추후 중국 시장에 진출하려는 한국의 먹는샘물 관련 기업들에게 주요 시사점을 제공할 수 있다고 사료된다. The significance of this study is that analyze the relationships between Food-related Lifestyle and selection attribute, with the effect of selection attribute and behavior intention of bottled water consumers, And it would be attempted to compare the differences of bottled water consumers between Korea and China. Moreover, the purpose of this study is to provide bottled water’s information to Korean marketers and companies to help their decision making China bottled water market process in future. For data collection, a total of 480 copies of questionnaires were collected by convenience sampling in the area of Seoul and Shanghai. To evaluate the hypothesis, the data were analyzed by using SPSS 20.0. run canonical correlation analysis and regression analysis were performed and the frequency. the reliability and the factor analysis were also carried out for more detailed analysis to meet the proof of this study.

The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis

Qian Ding,Xiao-Li Xie,Miao-Miao Wang,Jie Yin,Jin-Mei Tian,Xiao-Yu Jiang,Di Zhang,Jing Han,Yun Bai,Zi-Jin Cui,Hui-Qing Jiang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of clearing injured mitochondria that plays an important role in apoptosis. However, the role of mitophagy in apoptosis in HSCs and hepatic fibrosis is still unclear. Here, we show that mitophagy is enhanced in parallel with increased apoptosis in hepatic stellate cells during the reversal of hepatic fibrosis. The inhibition of mitophagy suppressed apoptosis in HSCs and aggravated hepatic fibrosis in mice. In contrast, the activation of mitophagy induced apoptosis in HSCs. Furthermore, we confirmed that BCL-B, which is a member of the BCL-2 family, is a regulator mediating mitophagy-related apoptosis. The knockdown of BCL-B resulted in increased apoptosis and mitophagy in HSCs, while the overexpression of BCL-B caused the opposite effects. BCL-B inhibited the phosphorylation of Parkin (a key regulator of mitophagy) and directly bound phospho-Parkin. Altogether, enhanced mitophagy promotes apoptosis in HSCs during the reversal of hepatic fibrosis. BCL-B suppresses mitophagy in HSCs by binding and suppressing phospho-Parkin, thereby inhibiting apoptosis. BCLB- dependent mitophagy is a new pathway for the regulation of apoptosis in HSCs during the regression of hepatic fibrosis

Effects of injection rate on combustion and emissions of a pilot ignited direct injection natural gas engine

Qian Wang,Changsheng Shao,Qing Liu,Zhourong Zhang,Zhixia He 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.4

Effects of Injection rates on combustion process and emissions of engines operating with directly injected natural gas and pilot diesel were numerically investigated. Injection rates of natural gas and diesel were investigated separately utilizing five types of injection rates. An impact factor was defined to present the effects of the initial and terminal injection rates of diesel and natural gas on the combustion and emissions more intuitionally. Based on the simulation results, cylinder pressure and temperature were more sensitive to terminal injection rates of pilot diesel than initial injection rates, and lower terminal injection rates of pilot diesel can achieve lower NO and Soot emission level. However, there is a trade-off between NO and Soot emissions affected by different natural gas injection rates. The impact factors of pilot diesel injection rates on pressure show a double-peak trend. However, the impact factors of natural gas injection rates on pressure show a single-peak trend.

ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease

Qian Zhang,Changpeng Hu,Jingbin Huang,Wuyi Liu,Wenjing Lai,Faning Leng,Qin Tang,Yali Liu,Qing Wang,Min Zhou,Fangfang Sheng,Guobing Li,Rong Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of themidbrain and the striatum and is an important pathologic basis of Parkinson’s disease (PD). Recent research has shownthat dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission plays a crucial role in dopaminergicnerve cell apoptosis. However, the upstream regulatory mechanism remains unclear. Our study showed that Drp1knockdown inhibited aberrant mitochondrial fission and apoptosis. Importantly, we found that ROCK1 was activated inan MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1dephosphorylation/activation. Our in vivo study confirmed that Y-27632 significantly improved symptoms in a PDmouse model by inhibiting Drp1-mediated aberrant mitochondrial fission and apoptosis. Collectively, our findingssuggest an important molecular mechanism of PD pathogenesis involving ROCK1-regulated dopaminergic nerve cellapoptosis via the activation of Drp1-induced aberrant mitochondrial fission.

Evaluating Model of Extenics and Its Application to The Applicability of Underground Space

( Qian Che ),( Qing Wang ),( Jian Ping Chen ) 대한지질공학회 2007 국제학술발표회 논문집 Vol.2007 No.-

Clinical significance and prognostic value of C-reactive protein/albumin ratio in gastric cancer

Qian Yu,Ke-zhi Li,Yan-jun Fu,Yanping Tang,Xin-qiang Liang,Zhi-qing Liang,Ji-hong Bai 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.6

Purpose: This study was aimed to evaluate the clinical significance and prognostic value of CRP/albumin ratio (CAR) in patients with gastric cancer. Methods: The data of 205 gastric cancer patients who underwent surgery was analyzed retrospectively. The association of CAR with the clinical features and prognostic value in gastric cancer was analyzed. The data of this study was combined with previous studies to further determine the prognostic value of CAR in patients with gastric cancer using a metaanalysis method. Results: Cox analysis revealed that preoperative CAR was an independent prognosis indicator in patients with gastric cancer. High expression of CAR indicated a shorter survival time than in those with lower expression. CAR has a higher prognostic value in the 1-, 3-, and 5-year overall survival in patients with gastric cancer. CAR showed significant difference regarding the gastric cancer patients’ age, M stage, and clinical stage. The discriminate value of CAR in M stage of gastric cancer was high (area under the curve, 0.809). A meta-analysis combining previous data and our data showed that preoperative CAR demonstrated a significant association with the overall survival of patients with gastric cancer. Conclusion: This study demonstrated that preoperative CAR could serve as an important prognostic indicator in patients with gastric cancer.

Phase Transition and Magnetic Transport Properties for Single Crystal of (Ca<SUB>0.42</SUB>Sr<SUB>0.58</SUB>)₃Ru₂O₇

Qing Ji,Ming Fu,Jianjian Ge,Bin Qian,Zhe Qu,Z.Q. Mao,X.S. Wu 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Synthesis and In Vitro Cytotoxicity of Cis-[Pt(NH3)(NH2OH)Cl2]

Qing-Song Ye,Xi-Zhu Chen,Yao Yu,Qiao-Wen Chang,Shu-Qian Hou,Wei-Ping Liu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6

A novel mixed NH3/NH2OH platinum(II) complex cis-[Pt(NH3)(NH2OH)Cl2] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and 1H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.