부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

개의 심장사상충증 발생례

김명철,이수진,이재일,박창식,전무형,김덕환,임승평 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

A 5 year old, 13kg, Jindo dogs was presented with clinical signs of anorexia, weakness and exercise intolerance, and diagnosed as dirofilariasis by hematology, blood chemistry and ultrasonography. In hematology and blood chemistry, the presence of microfilariae in the blood. anemia, leukocytosis, hemoglobinuria and jaundice were revealed. In ultrasonography, heartworms were found in the right ventricle artery and pulmonary artery as structures of hyperechoic dots or streaks. Because of the dog's poor physical status, the owner requested euthanasia. In autopsy, fifty odd of heartworms were ascertained in the right ventricle and pulmonary artery. Tricuspid valve in the orifice of right ventricle and right atrium, and chordae tendineae were deliquesced.

고등학교 체육수업에서의 수행평가 적용상 문제점 분석

김이수,김평석,류수림,노덕선 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

This study aims to understand and analyze problems on applying performance assessment to physical education in high school, and to offer basic data to seek for measures to settle performance assessment in physical education. The specific themes are, first, we analyze the present condition of reflection of the assessment in physical training. knowledge. and attitude in physical education. Second. we analyze teachers' implementation of performance assessment. Third, we compare the recognition of performance assessment according to students' gender. Fourth, we compare the recognition of performance assessment according to the type of schools. For the research, twelve high schools in the Metropolitan area were randomly selected, and 50 physical education teachers and 305 high school students in third grade were polled. Collected data from teachers were classified by type after frequency study. and the data from the students were analyzed in terms of frequency. by the means of Independent T-test for verification of average deviation between male and female students and by means of one-way ANOVA for analysis of school type-related results. When there was any significant difference among groups, Tukey method was applied for the aftermath verification. The results are as follows. First, the reflection rate of assessment on physical training. knowledge and attitude in physical education was found to be 60: 30: 10. Second, teachers implement physical training assessment mostly in two sports per semester. Most teachers assess focusing on the record (the number of times), and implement the assessment twice per each sport. Classroom assessment and assignment assessment are implemented if required. As for exam questions for knowledge assessment. most teachers gave only multiple-choice type questions. Most teachers also implement knowledge assessment with various other measures such as experiment. drill, physical training test and report. Assessment of attitude is mostly implemented by teachers. They evaluate such factors as uniform, participation, attendance, absence, and lateness. Students' behavior and attitude during classes are also mostly reflected in assessment. 68.8% (thirty three) respondents answered that they evaluated students' attitude every class. Third. as for the awareness of performance assessment according to students' gender, both boys and girls are found to be well aware of the assessment. They showed positive responses toward the number of assessment, fairness and accuracy of self assessment and peer assessment; toward humanistic education and academic achievement which are results of performance assessment, boys showed positive responses whereas girls showed negative ones. Fourth, the comparison of awareness of performance assessment according to school type shows that respondents from all types of boys', girls' and co-ed high schools responded positively, and especially respondents from boys' high school answered more positively. As for the reflection of students' interest on the assessment, respondents from all types of boys', girls', and co-ed high schools responded negatively, and especially respondents from co-ed high schools answered more negatively. Respondents from all types of high school, especially those from girls' high schools answered positively to the question regarding standards, function of performance assessment, appropriateness of reflection rate and the number of assessment of students' knowledge and attitude. With regard to fairness of performance assessment and accuracy of self assessment and peer assessment, respondents from both boys' and girls' high schools answered positively, especially there were more positive answers from girls' high schools. Respondents from boys' and girls' high schools answered more negatively than those from co-ed high schools to the question regarding effectiveness of group assessment in performance assessment. To the question of contribution of performance assessment to humanistic education, respondents from co-ed high schools answered more negatively than those from boys' and girls' high schools. Respondents from boys' and girls' high schools showed positive responses on the contribution of performance assessment to academic achievement, whereas respondents from coeducational high schools showed negative responses. which is statistically significant(F=3.909, p= .021). However, aftermath verification showed that only respondents from boys' and coeducational high schools showed significant difference (p= .020).

개의 심장사상충증 발생례

김명철,이수진,이재일,박창식,전무형,김덕환,임승평 충남대학교 수의과대학 동물의과학연구소 2003 動物醫科學硏究誌 Vol.11 No.-

A 5 year old, 13kg, Jindo dogs was presented with clinical signs of anorexia, weakness and exercise intolerance, and diagnosed as dirofilariasis by hematology, blood chemistry and ultrasonography. In hematology and blood chemistry, the presence of microfilariae in the blood, anemia, leukocytosis, hemoglobinuria and jaundice were revealed. In ultrasonography, heartworms were found in the right ventricle artery and pulmonary artery as structures of hyperechoic dots or streaks. Because of the dog's poor physical status, the owner requested euthanasia. In autopsy, fifty odd of heartworms were ascertained in the right ventricle and pulmonary artery. Tricuspid valve in the orifice of right ventricle and right atrium, and chordae tendineae were deliquesced.

고등학교 체육특기·적성 교육활동에 관한 운영 분석

김평석,김이수,최현영,노덕선 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The objective of this research is a place where it examines the participation actual condition regarding the physical training specialty-an aptitude education activity of the high school students and a satisfactory degree. In the research object currently the high school south which are to Seoul - Inch'on - Kyonggi-Do. about it set at the royal tomb which points out specifically the students and u, the ticket house method the house Rag radio ticket house law (cluster random sampling) with total 405 people was ticket collected goods. In order to analyze the data of the research which it sees it uses a SPSS 11.0 for windows statistical program with the statistical technique which it uses ! and frequency analysis (frequency analysis), x²verification, and independent group t- verification (independent group t-test) it is a back. With above same research method and process it leads and it gets and the position conclusion with afterwords is same. First, participation objective the south student the motion technology advancement and health and the physical strength increase showed a high ratio, the schoolgirl in order with the friends together description below, the and hold was doing the motion technology advancement, the person who gives the place effect which selects from a physical training department south. about as the student all friend the student answer back appeared highly. physical training relation station the map the physical training teacher the other side which is visible a most high ratio it wants the coaching staff with the fact that it prefers the leader which equips a specialty map ability. Second, physical training specialty- aptitude education activity problem point, the diversification and the schoolgirl of program the map method south student of the coaching staff was investigated recognition of physical training pure with. third, physical training activity which participates with the fact that it will receive a many help in study it led and motor function and physical strength increase and health and. Function improvement and physical strength increase, against a study help the south student, the schoolgirl appeared in small quantity highly from healthy help. physical training activity which participates it led and school life it was it is joyful. satisfactory in intimate feeling and friend relationship of stress solution and the teacher and became the many help, it will appear, that even after words it will be active from the physical training relation station, the student answer back highly was investigated and even from multi problem point inside satisfactory boat song it was investigated with the high thing.

시장지향성과 전략적 포지션의 관계와 병원성과에 미치는 영향

김평웅,류규수,이용기,김문주 대한보건협회 2002 대한보건연구 Vol.28 No.2

The purpose of this study is to prove that market orientation and strategic positioning are the main factors for obtaining a competitive advantage among hospitals, and to find out co-relationship between market orientation and strategic positioning (strategic differentiation, low-cost strategy/lowering price) among the selected hospitals. First, the analysis of co-relationship between market orientation and differentiation strategy(drawing a distinction from others providing specialized care), the market orientation is more effective on co-relationship compared to the differentiation strategy. Second, among market orientation, differentiation strategy and the low-cost strategy(lowering price), the differentiation strategy is the most effective on the hospital's performance while the market orientated efforts came in second, and the low-cost strategy was last. Third, in the relationship between market orientation and the effect on the hospital's performance, there was no co-relationship among the market orientation, differentiation strategy and the low-cost strategy, however, only the differentiation strategy proved to be playing an intermediary role.

신성고혈압쥐에서 혈관내피층이 Phorbol Ester에 의한 수축에 미치는 영향

정수아,김형,차경훈,전제열,윤평진,염철호,박진,조남수,홍순표 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

肝吸蟲에 대한 Albendazole의 殺蟲效果에 관한 實驗的 硏究

裵平元,金洙鎭,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

Newly developed albendazole(zentel®) is a broad spectrum anthelmintic which high activity against intestinal nematodas as well as trematodes and cesstodes infections. The present study was undertaken to evaluato in vitro and in vivo activities of albendazoles against adult worms of clonorchis sinensis. The morphological change of C. sinensis obtained from experimentally infected rats treated with various dosages of albendazole were studied by means of scaning and transmission electron microscope. The results are as follows: 1. The adult worms of C. sinensis were incubated in the medium containing albendazole with various concentrations. By 24 hours after incubation, none of the worms were dead in concentrations of 0.01μg/ml of albendazole. 2. In order to evaluate the effect of albendazole in vivo, experimentally infected rats with 50 metacencariae of C. sinensis each were treated orally with various dosages of albendazole. In the result, anthelmintic effect was confirmed at the dosage of albendazole with 2×25㎎/㎏×2 days (total amounts 100㎎/㎏). 3. Macrocopital examination was to the clonorchis worms which were collected from the bile ducts of the rats autopsied at 24 hours after treatment with albendazole. The lack of intestinal contents was observed in most of worms from the groups treated with 1×200 ㎎/㎏ and 2×25 ㎎/㎏×2 or 4 days, and the elongation of the anterior portion of the worm body was also observed n the worms from the groups treated with 2×25 ㎎/㎏×2 or 4 days. 4. In the scanning electron microscopic observation, many blebs were fromed on the surface of the damaged tegument of the worms at 24 huors after treatment with albendazole(1×200 ㎎/㎏ and 2×25 ㎎/㎏×2 or days). 5. The transmissions electron microscopic observation indicated that degeneration of mitochonriae and destruction of tegumental syncytium of the worms at 24 hours after treatment with albendazole(1×200 ㎎/㎏ and 2×25㎎/㎏ or 4 days). Inaddition to the findings the degeneration of the intestinal lamellae in the caeca was also observed in the worms from the groups treated with same dosages of albendazole.

여성인적자원개발 전문가 양성 프로그램 개발을 위한 교육 · 훈련 요구 분석 : 여성직업훈련기관을 중심으로

유평준,김수경,백민숙 淑明女子大學校 亞細亞女性問題硏究所 2008 아시아여성연구 Vol.47 No.1

저출산 ·고령화'가 우리사회 내 핵심 이슈로 등장하면서, 잠재되어 있는 여성인적자원을 개발하고 활용하는 것이 국가경쟁력 강화 차원에서 핵심적인 과제로 부각되고 있다. 그러나 기존의 HRD연구들은 성인지적 관점이 배제된 채 남성중심으로 이루어져 있으며, 남성과는 다른 여성의 생애 ·노동주기를 고려하지 못하고 있다. 이러한 시점에서, 본 연구는 여성직업훈련기관 종사자를 대상으로 성인지적 관점에서 여성 HRD 전문가의 교육 요구 분석을 실시하였다. 본 연구의 내용과 결과를 요약하면 다음과 같다 첫째, 여성HRD분야에서 종사하고 있는 여성HRD 전문가들은 본인의 업무수행능력을 향상시키기 위해 추가적인 교육 · 훈련이 매우 필요하다고 인식하고 있었다. 둘째, 여성HRD 전문가에게 가장 필요한 능력으로 교육과정의 기획 ·편성 능력, 상담 능력, 교육과정 평가 능력을, 교육과정 운영 시 가장 필요한 교육 분야로서 취업상담 및 정보제공, 고충상담 분야로 인식하고 있었다. 셋째, 여성HRD전문가들은 평일 집체교육, 이러닝, 블랜디드 학습 순으로 교육프로그램 운영 방법을 선호하고 있었으며 워크숍, 현장견학의 순으로 교수-학습 방법을 선호하고 있었다. 한편 현장경험이 풍부한 강사진을 선호하고 있었으며, 실제적이고 실무적인 학습내용을 선호하고 있었다. 넷째, 여성HBD전문가가 수행해야 하는 직무 분석 결과를 중심으로 각 영역별 교육 요구를 수행빈도 순, 중요도 순, 교육요구도 순으로 분석한 결과, 여성HRD 전문가들은 여성HRD기획, 상담, 성과관리 순으로 수행빈도가 높은 것으로 나타났으며, 여성HRD기획, 상담, 프로그램 개발 및 운영 순으로 중요하다고 인식하고 있었다. 또한 교육에 대한 요구도는 여성HRD기획, 프로그램 개발 및 운영, 상담 순으로 나타났다. 여성HRD기획과 상담 영역은 수행빈도, 중요도, 교육요구도 모두가 높게 나타나, 여성 인력개발센터와 여성회관에서 중요한 직무로서 교육요구도가 높은 영역으로 분석되었다. 다섯째, 여성HRD전문가들의 수행빈도-중요도와의 차이를 분석한 결과, 인력관리, 네트워크 및 파트너십 형성, 여성HRD기획 순으로, 수행빈도-교육요구도와의 차이를 분석한 결과, 인력관리, 프로그램 개발 및 운영, 네트워크 및 파트너십 형성 순으로 차이가 큰 것으로 나타났다. 일곱째, 직무영역별 기초교과목으로 상담, 여성HRD기획, 인력관리 순으로, 심화교과목으로는 인력관리, 상담, 조직관리 순으로 교과목을 원하고 있는 것으로 나타났다. 결론적으로 여성HED전문가 직무 분석에서 도출된 교과목들이 현장에서도 요구되고 있음을 확인할 수 있었다. 본 연구는 여성HRD전문가가 요구하는 교육과정 운영방식, 교육내용, 교과목을 분석함으로써, 여성HRD전문가의 전문성을 실질적으로 향상시킬 수 있는 여성HRD전문가 양성 교육프로그램을 체계화하는 기초 자료를 제공하였다는데 의의가 있다.