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RISS 인기검색어
- 검색키워드
- 저자 : ( Pumjoon Kim ) (검색결과 2 건)
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S-256 NT- proBNP complements the ACEF Score in Predicting 3-Year Mortality following AMI
( Da Won Kim ),( Kwan Yong Lee ),( Mineok Chang ),( Young Choi ),( Ha-Wook Park ),( Young Soo Lee ),( Young Kyoung Sa ),( Jaeho Byeon ),( Tae-Hoon Kim ),( Yoon Seok Koh ),( Hun-Jun Park ),( PumJoon Ki 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: The ACEF score and NT-proBNP are useful in predicting mortality in ACS. But few data exists regarding acute MI. We aimed to use ACEF score and NT-proBNP level to predict risk of long term mortality after AMI. Methods: We enrolled AMI patients who had PCI between January 2004 and December 2009 from 9 university hospitals in South Korea. Patients were ACEF scored and serum NT-proBNP was checked. The primary endpoint was all-cause mortality during a median follow-up of 3.38 years. Results: Of 3217 patients,the all-cause mortality was 18.59% and was significantly related to higher ACEF scores (p<0.001). Higher NT-proBNP level was associated with increased mortality (p<0.001). In a Cox proportional hazards model, the independent predictors of all-cause death included the ACEF score[adjusted HR 1.829, 95% CI 1.603-2.087; p<0.001] and NT-proBNP[adjusted HR 1.657, 95% CI 1.461-1.879; p<0.001]. When NT-proBNP was added to the individual components of the ACEF score,it displaced many factors in the score. The Kaplan-Meier survival curve related to whether the patients had a below or above-median ACEF score and a below or above-median NT-proBNP level (pooled over strata,log rank 301.8, p<0.001). The combination of ACEF score and NT-proBNP improved risk prediction for mortality[AUC, 0.75 (95% CI, 0.734-0.765); p<0.001], which significantly exceeded ACEF score and NT-proBNP (p<0.001). Conclusions: NT-proBNP complements ACEF score for predicting long term mortality.Inclusion of NT-proBNP is useful in risk-stratifying patients following AMI.
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Worsening renal function, association with long-term mortality in stable post-MI 1-year survivors
( Seung Won Ahn ),( Kwan Yong Lee ),( Sungmin Lim ),( Tae Hoon Kim ),( Yoon Seok Koh ),( Hun Jun Park ),( Pumjoon Kim ),( Kiyuk Chang ),( Wook Sung Chung ),( Doo Sun Sim ),( Keun Ho Park ),( Ju Han Ki 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Impaired renal function is associated with adverse clinical outcome in patient with acute Myocardial infarction. However, few data exist on the association of worsening renal function and long-term mortality in patients who survived at 1 year after index AMI. Methods: We consecutively enrolled AMI patients who underwent percutaneous coronary intervention (PCI) between January 2004-December 2009 from 9 universityhospitals in S.Korea. Patients who were alive and did not experience a recurrent MI or stroke during the first 365 days post-index MI were analyzed. We excluded 169 patients with estimated glomerular filtration rate (eGFR) below 15 mL/min/m2. We divided patients to quintiles according to the degree of changes in the eGFR value between index AMI and 1 year later. The primary endpoint was all-cause mortality from Day 366 to study completion. Results: of 4.748 AMI patients, 1,929 patients were alive and their GFR values were available for the assessment of all-cause mortality. The median change of eGFR was -0.7 mL/min/m2. All-cause mortality from 1 to 4 year of index AMI was 10.6% in the 1st quintile (≥ 20% decline in eGFR values) and 4.5% in the remained quintiles [Unadjusted HR (95% CI) 2.38 (1.61-3.50), p <0.001]. In multivariable Cox proportional regression analysis, older age [Adjusted HR (95% CI) 4.40 (2.69-7.21), p<0.001], not taking dual antiplatelet agent at 1 year [2.09 (1.40-3.10), p<0.001], non-ST-segment elevation myocardial infarction at index events [1.83 (1.24-2.69), p=0.002], and worsening eGFR within the first year [1.51 (1.01-2.26), p=0.04] were the predictors of long-term mortality. Conclusions: Worsening renal function within the first year after index AMI was associated with long-term mortality in stable post-MI 1-year survivors.
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