중국 기업공시제도의 개선방향에 관한 연구

홍기용,박희선 한국세무회계학회 2002 세무회계연구 Vol.11 No.-

중국은 1980년대에 증권시장이 형성된 후 상장회사의 운영이 더욱 확대되었으며, 그동안 증권법을 제정하였고 관련법규들도 개정을 하는 등 각종 제도를 정비해 왔다. 이 과정에서 기업정보의 공시도 많은 발전을 가져왔지만 아직도 공시제도의 운영이나 관리가 선진국가들에 비해 미흡한 수준이다. 최근 중국은 시장경제의 발전 특히 WTO의 가입으로 국제경쟁력강화와 국제관례에 부합되도록 기존의 회계 및 경제법규들을 점진적으로 개정하여 가고 있다. 그러나 효율적 증권시장의 운영과 투자자 권익을 보호하기 위한 현행 기업공시제도에 대한 개정은 개정의 폭이나 내용의 중요성 측면에서 볼 때 부분개정의 형식에 의한 것으로서 증권법체계가 완전히 정비되지는 못하였다고 할 수 있다. 따라서 이 논문은 문헌연구를 통하여 현행 중국의 기업공시제도 문제점을 검토 및 분석하고 향후 개선방향을 아래와 같이 제시하였다. 첫째, 정부주도의 공시관리체제를 민간관리체제로 이양, 둘째, 전자매체공시의 보편화를 추진, 셋째, 공시되는 정보의 정확성을 제고, 넷째, 회계정보의 다양성 및 적시성을 확보, 다섯째, 공시책임자제도의 도입 등이다.

Enhanced Bioavailability of Verapamil after Oral Administration with Hesperidin in Rats

Yong-Ji Piao,Jun-Shik Choi 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4

The aim of this study was to investigate the effects of hesperidin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. The pharmacokinetic parameters of verapamil and norverapamil in rats were measured after the oral administration of verapamil (9 mg/kg) in the presence or absence of hesperidin (3 or 10 mg/kg). Compared to the control group, the presence of hesperidin significantly (p<0.01) increased the area under the plasma concentration-time curve (AUC) of verapamil by 71.1–96.8% and the peak concentration (Cmax) of verapamil by 98.3-105.2%. Hesperidin significantly (p<0.01) decreased the total plasma clearance (CL/F) of verapamil by 41.6-49.2% in rats. However there was no significant change in the time to reach the peak plasma concentration (Tmax), the elimination rate constant (Kel) and the terminal half-life (T1/2) of verapamil in the presence of hesperidin. The AUC and Cmax of norverapamil were significantly (p<0.05) higher in rats coadministrated with hesperidin than those of the control. Consequently hesperidin significantly enhanced bioavailability of verapamil in rats. These results might be due to the decreased efflux and metabolism of verapamil in the intestine. Drug interactions should be concerned in the clinical setting when verapamil is used concomitantly with hesperidin or hesperidin-containing dietary

Studies on the Landscape Planning of Wetland in the Yellow River Delta

( Yong Ji Piao ),( Tao Zhou ) 한국녹지환경디자인학회 2006 녹지환경학회지 Vol.2 No.1

Building ecological protective region is an effective approach to build wetland landscape and protect the bird and fish wholly. The planning of ecological protective region should protect natural scene with might and main, lay out natural characteristics fully and harmonize the relationship between the style and custom. This article analyzes the actuality and characteristics of landscape resources of wetland in the Yellow River delta and puts forward the planning principles and imaginations according to its landscape resources characteristics with the theory of humanism, science and art, which can be basic data to build Wetland Park in the Yellow River delta.

Effects of morin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine in rats.

Piao, Yong-Ji,Choi, Jun-Shik Pharmaceutical Society of Great Britain 2008 Journal of pharmacy and pharmacology Vol.60 No.5

<P>This study investigated the effects of orally administered morin, an inhibitor of cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp), on the pharmacokinetics of orally and intravenously administered nicardipine in rats. Nicardipine is reportedly a substrate for CYP3A4 and P-gp. Nicardipine was administered orally (12 mgkg(-1)) with or without orally administered morin (1.5, 7.5 and 15 mgkg(-1)), and intravenously (4 mgkg(-1)) with or without orally administered morin (7.5 and 15 mgkg(-1)). In the presence of morin, the pharmacokinetic parameters of nicardipine were significantly altered in the oral group but not in the intravenous group, suggesting that CYP3A-mediated metabolism of nicardipine in the liver is not significantly inhibited by morin. The presence of 7.5 and 15 mgkg(-1) of morin significantly increased (P < 0.01, 67.8-112%) the area under the plasma concentration-time curve and the peak plasma concentration (P < 0.01, 53.5-93.1%) of orally administered nicardipine. The presence of 7.5 and 15 mgkg(-1) of morin significantly decreased (P < 0.01, 40.4-52.8%) the total body clearance of orally administered nicardipine compared with the control group. The enhanced oral bioavailability of nicardipine suggests that intestinal-mediated CYP3A4 metabolism and P-gp-mediated efflux of nicardipine are inhibited by morin. Based on these results, concomitant use of morin or morin-containing dietary supplements with nicardipine may require close monitoring for potential drug interactions.</P>

Enhanced Bioavailability of Verapamil after Oral Administration with Hesperidin in Rats

Piao, Yong-Ji,Choi, Jun-Shik 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4

The aim of this study was to investigate the effects of hesperidin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. The pharmacokinetic parameters of verapamil and norverapamil in rats were measured after the oral administration of verapamil (9 mg/kg) in the presence or absence of hesperidin (3 or 10 mg/kg). Compared to the control group, the presence of hesperidin significantly (p<0.01) increased the area under the plasma concentration-time curve (AUC) of verapamil by 71.1-96.8% and the peak concentration $(C_{max})$ of verapamil by 98.3-105.2%. Hesperidin significantly (p<0.01) decreased the total plasma clearance (CL/F) of verapamil by 41.6-49.2% in rats. However there was no significant change in the time to reach the peak plasma concentration $(T_{max})$, the elimination rate constant $(K_{el})$ and the terminal half-life $(T_{1/2})$ of verapamil in the presence of hesperidin. The AUC and $C_{max}$ of norverapamil were significantly (p<0.05) higher in rats coadministrated with hesperidin than those of the control. Consequently hesperidin significantly enhanced bioavailability of verapamil in rats. These results might be due to the decreased efflux and metabolism of verapamil in the intestine. Drug interactions should be concerned in the clinical setting when verapamil is used concomitantly with hesperidin or hesperidin-containing dietary.

Effects of epigallocatechin on the pharmacokinetics of verapamU after oral and intravenous administration in rats

CHOI Jun-shik,PIAO Yong-ji 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2

關于樹총配置及其園林應用的硏究

박영길 ( Yong Ji Piao ),왕애평 ( Ai Ping Wang ),안승원 ( Seoung Won Ann ) 한국녹지환경디자인학회 2008 학술발표회 Vol.2008 No.-

關于樹叢配置及其園林應用的硏究

박영길 ( Yong Ji Piao ),왕애평 ( Ai Ping Wang ),안승원 ( Seoung Won Ann ) 한국녹지환경디자인학회 2008 녹지환경학회지 Vol.4 No.2

Gardenbosk is a widely used and chiefly disposed plants landscape type in landscape green spaces. It has important meanings in improving aesthetical and ornamental qualities of urban plants landscape. This paper analyzed the types, forming characteristics and landscape applying states of gardenbosk through researching its landscape applying actuality in Taian and Jinan`s gardenparks, systematacially discussed existent problems of gardenbosks` application in green spaces. And proposed countermeasures to solve those problems.

Muscle Activities in the Lower Limbs for the Different Movement Patterns on an Unstable Platform

Piao, Yong-Jun,Choi, Youn-Jung,Kwon, Tae-Kyu,Hwang, Ji-Hye,Kim, Jung-Ja,Kim, Dong-Wook,Kim, Nam-Gyun The Korean Society of Medical and Biological Engin 2007 의공학회지 Vol.28 No.5

We performed experimental studies on the muscle activities in the lower limbs for the different movement patterns on an unstable platform. A training system for postural control using an unstable platform that we previously developed was applied for the experiments. This unstable platform provides 360 degrees of movement allowing for training of posture in various directions and provides simultaneous excitations to visual sensory, somatic sensation and vestibular organs. Compare with the stable platform, keeping body balance on the unstable platform requests more effective sensation from vision, vestibular sense and somatic sense. Especially, the somatosensory inputs from the muscle proprioceptors and muscle force are crucial. To study the muscle activities for the different movement patterns and find the best training method for improving the ability of postural control through training and improving the lower extremity muscular strength, fifteen young healthy participants went through trainings and experiments. The participants were instructed to move the center of pressure following the appointed movement pattern while standing on the unstable platform. The electromyographies of the muscles in the lower limbs were recorded and analyzed in the time and the frequency domain. Our experimental results showed the significant differences in muscle activities for the different movement patterns. Especially, the spectral energy of electromyography signals in muscle for the movement pattern in anterior-posterior direction was significantly higher than those occurred in the other patterns. The muscles in the lower leg, especially tibialis anterior and gastrocnemius were more activated compared to the others for controlling the balance of body on the unstable platform. The experimental results suggest that, through the choice of different movement pattern, the training for lower extremity strength could be performed on specific muscles in different intensity. And, the ability of postural control could be improved by the training for lower extremity strength.

Crystal structure of a clip-domain serine protease and functional roles of the clip domains

Piao, Shunfu,Song, Young-Lan,Kim, Jung Hyun,Park, Sam Yong,Park, Ji Won,Lee, Bok Leul,Oh, Byung-Ha,Ha, Nam-Chul Wiley (John WileySons) 2005 The EMBO journal Vol.24 No.24

<P>Clip-domain serine proteases (SPs) are the essential components of extracellular signaling cascades in various biological processes, especially in embryonic development and the innate immune responses of invertebrates. They consist of a chymotrypsin-like SP domain and one or two clip domains at the N-terminus. Prophenoloxidase-activating factor (PPAF)-II, which belongs to the noncatalytic clip-domain SP family, is indispensable for the generation of the active phenoloxidase leading to melanization, a major defense mechanism of insects. Here, the crystal structure of PPAF-II reveals that the clip domain adopts a novel fold containing a central cleft, which is distinct from the structures of defensins with a similar arrangement of cysteine residues. Ensuing studies demonstrated that PPAF-II forms a homo-oligomer upon cleavage by the upstream protease and that the clip domain of PPAF-II functions as a module for binding phenoloxidase through the central cleft, while the clip domain of a catalytically active easter-type SP plays an essential role in the rapid activation of its protease domain.</P>