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- 저자 : ( P. Petersen ) (검색결과 9 건)
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Han, T H,Tang, Y,Park, Y H,Maynard, J,Li, P,Akbulut, H,Petersen, L,Deisseroth, A Macmillan Publishers Limited 2010 Bone marrow transplantation Vol.45 No.3
We have developed a vaccine, which is designed to induce tumor-associated antigen (TAA)-specific T cells and antibodies in the setting of profound lymphopenia induced by myeloablative therapy and T-cell-depleted bone marrow transplantation. Test mice were injected subcutaneously (sc) with the 32DP210Bcr-Abl cell line, which is positive for the p210Bcr-Abl protein (Group 1). In Group 2, 7 days after injection of the 32DP210Bcr-Abl positive cell line, the mice received 900 cGy total body irradiation (TBI) followed in 1 h by the intravenous infusion of 10 million T-cell-depleted syngeneic bone marrow cells (TCDBMT) (Group 2). The leukemia-bearing group received an intravenous injection of 10 million spleen cells (donor lymphocyte infusions) from unvaccinated (Group 3) and TAA/ecdCD40L-vaccinated (Group 4) syngeneic mice 3 days after completion of the TBI and TCDBMT. Groups 3 and 4 mice received three additional sc vaccinations at 7-day intervals with the TAA/ecdCD40L vaccine, in which the TAA was taken from the junctional peptide of the P210bcr-Abl protein. The survival of Groups 3 and 4 mice was significantly longer than that in Groups 1 and 2 mice. Vaccinated mice from Group 4, which developed complete responses, survived up to 350 days post-injection of the leukemia cells without any evidence of leukemia regrowth.
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Sousa, Josane F,Nam, Ki Taek,Petersen, Christine P,Lee, Hyuk-Joon,Yang, Han-Kwang,Kim, Woo Ho,Goldenring, James R BMJ Publishing Group Ltd 2016 Gut Vol.65 No.6
<P>Objective Intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia (SPEM) are considered neoplastic precursors of gastric adenocarcinoma and are both marked by gene expression alterations in comparison to normal stomach. Since miRNAs are important regulators of gene expression, we sought to investigate the role of miRNAs on the development of stomach metaplasias. Design We performed miRNA profiling using a quantitative reverse transcription-PCR approach on laser capture microdissected human intestinal metaplasia and SPEM. Data integration of the miRNA profile with a previous mRNA profile from the same samples was performed to detect potential miRNA-mRNA regulatory circuits. Transfection of gastric cancer cell lines with selected miRNA mimics and inhibitors was used to evaluate their effects on the expression of putative targets and additional metaplasia markers. Results We identified several genes as potential targets of miRNAs altered during metaplasia progression. We showed evidence that HNF4 gamma (upregulated in intestinal metaplasia) is targeted by miR-30 and that miR-194 targets a known co-regulator of HNF4 activity, NR2F2 (downregulated in intestinal metaplasia). Intestinal metaplasia markers such as VIL1, TFF2 and TFF3 were downregulated after overexpression of miR-30a in a HNF4 gamma-dependent manner. In addition, overexpression of HNF4 gamma was sufficient to induce the expression of VIL1 and this effect was potentiated by downregulation of NR2F2. Conclusions The interplay of the two transcription factors HNF4 gamma and NR2F2 and their coordinate regulation by miR-30 and miR-194, respectively, represent a miRNA to transcription factor network responsible for the expression of intestinal transcripts in stomach cell lineages during the development of intestinal metaplasia.</P>
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Miyasaka, Yoko,Barnes, Marion E,Petersen, Ronald C,Cha, Stephen S,Bailey, Kent R,Gersh, Bernard J,Casaclang-Verzosa, Grace,Abhayaratna, Walter P,Seward, James B,Iwasaka, Toshiji,Tsang, Teresa S M Academic Press 2007 European Heart Journal Vol. No.
<P>AIMS: To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. METHODS AND RESULTS: Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detection of dementia. Interim stroke was censored in the analyses. Of 2837 subjects (71 +/- 15 years old) diagnosed with first AF and without any evidence of cognitive dysfunction or stroke at the time of AF onset, 299 were diagnosed with dementia during a median follow-up of 4.6 years [interquartile (IQR) range 1.5-7.9 years], and 1638 died. The Kaplan-Meier cumulative rate of dementia was 2.7% at 1 year and 10.5% at 5 years. After adjustment for age and sex, dementia was strongly related to advancing age [hazard ratio (HR)/10 years, 2.8; 95% confidence interval (CI), 2.5-3.2], but did not vary with sex (P = 0.52). The occurrence of post-AF dementia was associated with significantly increased mortality risk (HR 2.9; 95% CI 2.5-3.3), even after adjustment for multiple comorbidities, and did not vary with age (P = 0.75) or sex (P = 0.33). CONCLUSION: Dementia appeared common following the diagnosis of first AF, and was associated with premature death.</P>
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Genetic Characterization of Indigenous Goats of Sub-saharan Africa Using Microsatellite DNA Markers
Chenyambuga, S.W.,Hanotte, O.,Hirbo, J.,Watts, P.C.,Kemp, S.J.,Kifaro, G.C.,Gwakisa, P.S.,Petersen, P.H.,Rege, J.E.O. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.4
Genetic diversity of sub-Saharan African goats was assessed using 19 microsatellite markers. Breeds were sampled from eastern Africa (Maasai, Kigezi, Mubende, North West Highland, Arsi-Bale), southern Africa (Ndebele, Pafuri) and West Africa (West African Dwarf, Maure, Djallonke). European breeds (Grisons Striped, Toggenburg), Asian breeds (Mongolian Cashmere, Bandipur) and a Middle East breed (Arab) were also included. The mean number of alleles per locus and average gene diversity ranged from 5.26$\pm$0.464 (Djallonke) to 7.05$\pm$0.516 (Mubende) and from 0.542$\pm$0.036 (Pafuri) to 0.672$\pm$0.031 (Ndebele), respectively. The between breeds variation evaluated using $$G_{ST}$$ and $\theta$ were found to account for 14.6% ($\theta$) and 15.7% ($$G_{ST}$$) of the total genetic variation. The $D_{A}$ measure of genetic distance between pairs of breeds indicated that the largest genetic distance was between Pafuri and Djallonke while the lowest genetic distance was between Arsi-Bale and North West Highland. A neighbour-joining tree of breed relationships revealed that the breeds were grouped according to their geographic origins. Principal component analysis supported the grouping of the breeds according to their geographic origins. It was concluded that the relationships of sub-Saharan African goat breeds were according to their geographical locations implying that the goats of eastern Africa, West Africa and southern Africa are genetically distinct. Within each sub-region, goat populations could be differentiated according to morphological characteristics.
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Choi, E.,Petersen, C.P.,Lapierre, L.A.,Williams, J.A.,Weis, V.G.,Goldenring, J.R.,Nam, K.T. American Association of Pathologists and Bacteriol 2015 The American journal of pathology Vol.185 No.8
Doublecortin-like kinase 1 (Dclk1) is considered a reliable marker for tuft cells in the gastrointestinal tract. We investigated the dynamic changes of tuft cells associated with mouse models of oxyntic atrophy and metaplasia in the stomach. Increases in the numbers of Dclk1-positive tuft cells were observed in several models of parietal cell loss. However, the expanded population of Dclk1-expressing cells showed a morphologically distinct structure in apical microvilli and acetylated microtubules, which was not seen in the tuft cells present in the normal gastric mucosa. These microvillar sensory cells (MVSCs) showed no evidence of proliferation. The expansion of the MVSCs induced by oxyntic atrophy was reversible after the return of parietal cells. More important, expansion of MVSCs after induced parietal cell loss was not observed in Gast<SUP>-/-</SUP> mice. Although the Dclk1-expressing cells in the normal gastric mucosa were in part derived from Lrig1-expressing stem cells, the Lrig1-lineaged cells did not produce the expanded Dclk1-expressing cells associated with oxyntic atrophy. These studies indicate that loss of parietal cells leads to the reversible emergence of a novel Dclk1-expressing sensory cell population in the gastric mucosa.
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이성욱,T.Rogers,P. Petersen,임철수 한국수소및신에너지학회 2014 한국수소 및 신에너지학회논문집 Vol.25 No.6
Two types of fuel supply method ar used in CNG vehicles. One is premixed ignition and the otheris gas-jet ignition. In premixed ignition, the fuel is introduced with intake air so that homogeneous air-fuel mixturemay form. The ignitability of this method depends on the global equivalence ratio. In gas-jet ignition, CNG isintroduced directly into the engine combustion chamber. The overall mixture is stratified by retarded fuel injection. In this study, a visualization technique was employed to obtain fundamental properties regarding overall mixtureformation of direct injected CNG fuel inside a constant volume chamber. Jet angles, penetrations and projectedjet area with respect to ambient pressure are investigated. The penetration decreases apparently and the time reachingthe CVC wall was delayed as the chamber pressure increases. This is caused by the higher inertia of the fluidelements that the injected fluid must accelerate and push aside. It is same to liquid fuel such as diesel and gasoline,but this phenomenon is far more prominent for the gaseous fuel.
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( Sandzhar Abdullaev ),( T. M. Welzel ),( J. Petersen ),( K. Herzer ),( P. Ferenci ),( M. Gschwantler ),( M. Cornberg ),( P. Ingiliz ),( T. Berg ),( U. Spengler ),( O. Weiland ),( M. Van Der Valk ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The all-oral, pan-genotypic combination of daclatasvir+sofosbuvir± ribavirin (DCV+SOF±RBV) demonstrated high sustained virologic response rates at posttreatment Week 12 (SVR12) in phase 3 studies of patients with chronic HCV. We report efficacy and safety results from a large European compassionate use program that provided DCV+SOF±RBV therapy to patients with chronic HCV infection and severe liver disease. Methods: Eligible patients were adults with chronic HCV infection at a high risk of hepatic decompensation or death within 12 months if left untreated, or urgent need of viral clearance due to extrahepatic manifestations or comorbidities, and with no available treatment options. Patients received DCV(60mg)+SOF(400mg) once daily for 24 weeks; RBV addition or reduced treatment duration was the physician’s choice. The primary efficacy outcome was SVR12. Results: Efficacy data were available for 436/485 patients enrolled. Most patients were HCV treatment experienced (70%) with mean HCV RNA 5.5 log10 IU/mL. 388 (80%) patients had confirmed cirrhosis( Child-Pugh class B or C, 165 (43%); MELD scores>15, 37 (10%)) , 87 patients (18%) had received liver transplants and 55 (11%) were HIV/HCV coinfected. SVR12 was achieved by 394/436 (90%) patients (table). There were 13 relapses and 1 on-treatment virologic failure. SVR12 rates were similar with/without ribavirin and comparable across HCV GT, presence of cirrhosis, liver transplant status, HIV coinfection, and other baseline characteristics. There were 28 deaths over treatment or follow-up (none considered treatment-related), 91 experienced serious adverse events (11 considered treatment-related), and 38 discontinued treatment or died due to adverse events (10 treatment- related). Most deaths and serious adverse events were directly or indirectly associated with advanced liver disease. Adverse events (any grade) occurring in ≥5% of patients were fatigue, anaemia, headache, nausea, and diarrhoea. Conclusions: The all-oral regimen of DCV+SOF±RBV was highly effective and well tolerated in this large European real-world cohort of patients with advanced liver disease.
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