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RISS 인기검색어
- 검색키워드
- 저자 : ( Osman Demir ) (검색결과 11 건)
- 무료
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( Ali Pekcan Demiröz ),( Reyhan Öztürk ),( Şener Barut ),( Salih Cesur ),( Semanur Ayyıldız ),( Vildan Fidancı ),( Osman Demir ),( Ferdi Güneş ),( Laser Şanal ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic hepatitis B (CHB) and C (CHC) are leading causes of liver cirrhosis and hepatocellular cancer. Defining of inflammatory activity and severity of disease is important for commencing antiviral treatment and monitoring the patient. Currently noninvasive serological markers to define disease activity are of great interest. In this study we aimed to determine soluble urokinase plasminogen activator receptor (suPAR) levels of patients with CHB and CHC, compare its levels with those of controls and to find if suPAR levels correlated with some laboratory parameters, histologic activity index (HAI) and fibrosis stage. Methods: Twenty-eight patients with CHB, 11 patients with CHC and 41 healthy subjects, eighty subjects in total, were included in the study. suPAR levels of all subjects were determined using commercial ELISA kits according to manufacturer’s instructions. Correlation between suPAR levels and parameters including AST, ALT, leukocyte count, thrombocyte count and liver histology scores were statistically analyzed. Results: Fifty percent of CHB patients were on oral antiviral treatment. Serum suPAR levels of both CHB and CHC patients were higher than controls (p< 0,001). Age, suPAR, HAI, AST, ALT, leukocyte and thrombocyte counts of subjects in different groups (CHB, CHC patients and controls) were shown in table 1. When we divided patients into two groups according to HBV DNA, suPAR levels were not different between patients with HBV DNA >1000 IU/ml and those with HBV DNA<1000 IU/ml. suPAR levels were not found to be correlated with AST, ALT levels, thrombocyte and leukocyte counts or histologic findings. Conclusions: In both CHB and CHC patients, suPAR levels were determined to be higher than healthy controls although suPAR was not found to be correlated with diseae activity or severity related parameters. However new wide scale studies are needed to investigate the relation between suPAR and disease activity or fibrosis stage.
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Incidence of Fusarium verticillioides and Levels of Fumonisin B1 and B2 in Corn in Turkey
Cavidan Demir,Osman Simsek,Muhammet Arici 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4
A total of 100 corn samples conforming collected from local farmers and markets from districts of Samsun, Turkey, were analyzed for Fusarium verticillioides,fumonisin B1 and B2 contamination. Ninety-three corn samples were found to contain F. verticillioides, 52samples fumonisin B1, and 25 samples fumonisin B2. Fumonisin B1 contamination ranged from 0.05 to 25.72mg/kg and B2 from 0.05 to 5.7 mg/kg, respectively. This figure indicated widespread contamination of fumonisin B1and B2 in maize grown in different areas of Samsun,Turkey.
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Melek Belevcikli,Halenur Altan,Osman Demir 대한치과마취과학회 2023 Journal of Dental Anesthesia and Pain Medicine Vol.23 No.1
Backgrounds: Pain management is one of the most important factors affecting the success of pediatric dentistry. Therefore, new needle- and pain-free local anesthesia techniques have been developed in parallel with technological advancements. The purpose of this study is to compare the pain perception and dental anxiety levels associated with a needle-free injection system (Comfort-inTM) and the classic needle method during treatment-required infiltration anesthesia in children. Methods: This randomized controlled crossover split-mouth clinical study included 94 children who required dental treatment with local anesthesia using a dental needle or needle-free injection system for the bilateral primary molars. The Wong-Baker Scale (WBS) was used to measure pain perception at different times, and the Modified Child Dental Anxiety Scale (MCDAS) was used to measure the anxiety level of the child. A statistical software package was used to process the data. Statistical significance was set at P < 0.05. Results: There was no significant difference between the needle-free injection system and dental needle method during the induction stage for filling and pulpotomy (P > 0.05). “Pain on postoperative 1st day” was similar in both types of anesthesia (P = 0.750). Conclusions: The needle-free injection system was as effective as the dental needle method. The Comfort-inTM system was an acceptable alternative for patients during the postoperative period. Understanding how pain management may be provided during local anesthesia administration and a child’s fear and anxiety regarding the dentist may lead to better dental compliance.
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Sencan, Savas,Edipoglu, Ipek Saadet,Demir, Fatma Gul Ulku,Yolcu, Gunay,Gunduz, Osman Hakan The Korean Pain Society 2019 The Korean Journal of Pain Vol.32 No.4
Background: Ganglion impar blockade is a reliable and effective treatment option used in patients with coccydynia. Our primary objective was to specify the role of corticosteroids in impar blockade. We compared applications of local anesthetic with the local anesthetic + corticosteroid combination in terms of treatment efficiency in patients with chronic coccydynia. Methods: Our study was a prospective randomize double-blind study. The patients were divided into 2 groups after randomization. The first group (group SL) was made up of patients where a corticosteroid + local anesthetic were used during ganglion impar blockade. In the second group (group L) we used only local anesthetic. We evaluated numeric rating scale (NRS) and Beck depression scale, which were employed before the procedure and in 1st and 3rd months after the procedure. Results: Seventy-three patients were included in the final analysis. We detected a significantly greater decrease in NRS values in the 1st month in group SL than in group L (P = 0.001). In the same way, NRS values in the 3rd month were significantly lower in the group with steroids (P = 0.0001). During the evaluation of the Beck test, we detected significantly greater decreases in the 1st month (P = 0.017) and 3rd month (P = 0.021) in the SL group than in the L group. Conclusions: Ganglion impar blockade decreases pain in the treatment of chronic coccydynia and improve depression. Addition of steroids in a ganglion impar blockade is required for treatment response that should accumulate over a long period of time.
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Hayrettin Kuscu,Ahmet Turhan,Nese Ozmen,Pinar Aydinol,Ali Osman Demir 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.2
The main goal of this study was to evaluate the effects of different levels of irrigation water and nitrogenon yield, quality, and water productivity of processing tomato grown in clay-loam soil. Three water levels of panevaporation (Epan) replenishment applied via drip irrigation (1.00 × Epan, 0.75 × Epan, and 0.50 × Epan) and four Napplication rates with fertigation (0, 60, 120, and 180 kg N·ha-1) were tested in the sub-humid climate conditions ofTurkey during the 2010 and 2011 growing seasons. The highest marketable yields were observed with full irrigation(1.00 × Epan) for each season. Decreasing irrigation rate generally improved dry matter, total soluble solids, totalsugars, titratable acidity, lycopene and total carotene, and decreased fruit NO3-N content and fruit total proteincontent slightly. The highest water productivity was obtained with a moderate soil water deficit (0.75 × Epan). The 180kg N·ha-1 fertilization rate produced the highest values for marketable yield, fruit size, total soluble solids yield, NO3-N,and total protein content. Increasing N rate also increased the values of fruit total sugars and titratable acidity. Increasing both irrigation and N levels increased the NO3-N and protein contents. The higher lycopene and totalcarotene values were obtained in the treatments of 60 and 120 kg N·ha-1. Increasing N supply improved the waterproductivity with the 3 irrigation application ratios. Considering the quantity and quality for the processing and waterproductivity, the 0.75 × Epan irrigation regime and a 120 or 180 kg·ha-1 nitrogen supply can considered optimal.
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Savas Sencan,Ipek Saadet Edipoglu,Fatma Gul Ulku Demir,Gunay Yolcu,Osman Hakan Gunduz 대한통증학회 2019 The Korean Journal of Pain Vol.32 No.4
Background: Ganglion impar blockade is a reliable and effective treatment option used in patients with coccydynia. Our primary objective was to specify the role of corticosteroids in impar blockade. We compared applications of local anesthetic with the local anesthetic + corticosteroid combination in terms of treatment efficiency in patients with chronic coccydynia. Methods: Our study was a prospective randomize double-blind study. The patients were divided into 2 groups after randomization. The first group (group SL) was made up of patients where a corticosteroid + local anesthetic were used during ganglion impar blockade. In the second group (group L) we used only local anesthetic. We evaluated numeric rating scale (NRS) and Beck depression scale, which were employed before the procedure and in 1st and 3rd months after the procedure. Results: Seventy-three patients were included in the final analysis. We detected a significantly greater decrease in NRS values in the 1st month in group SL than in group L (P = 0.001). In the same way, NRS values in the 3rd month were significantly lower in the group with steroids (P = 0.0001). During the evaluation of the Beck test, we detected significantly greater decreases in the 1st month (P = 0.017) and 3rd month (P = 0.021) in the SL group than in the L group. Conclusions: Ganglion impar blockade decreases pain in the treatment of chronic coccydynia and improve depression. Addition of steroids in a ganglion impar blockade is required for treatment response that should accumulate over a long period of time.
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Altan, Ahmet,Akkoc, Sumeyra,Erdil, Aras,Colak, Sefa,Demir, Osman,Altan, Halenur The Korean Dental Society of Anesthsiology 2019 Journal of Dental Anesthesia and Pain Medicine Vol.19 No.6
Background: In dentistry, pain is a factor that negatively affects treatments and drug use. The aim of this study was to evaluate the correlations of the postoperative analgesic use with pain catastrophizing and anxiety in patients who underwent removal of an impacted mandibular third molar. Methods: We recruited 92 patients who underwent the extraction of impacted mandibular third molar. In this study, the Pederson index was used to preoperatively determine the difficulty of surgical extraction. Patients were asked to note the number of analgesics used for 7 postoperative days. Patients were divided into two groups based on the Pain Catastrophizing Scale: low and high score groups. State-Trait Anxiety Inventory-trait and State-Trait Anxiety Inventory-state questionnaires were used to determine the anxiety levels of the patients. The obtained data were examined to evaluate the correlations of pain catastrophizing and anxiety with the postoperative analgesic use. Results: In this study, 92 patients, including 60 women and 32 men, were recruited. The analgesic use was higher in women than in men but with no significant difference (P > 0.05). Pain Catastrophizing Scale scores were higher in women than in men but with no significant difference (P > 0.05). The analgesic use was higher in patients with high pain catastrophizing than in those with low pain catastrophizing but with no significant difference (P > 0.05). State-Trait Anxiety Inventory-trait scores were higher in women than in men but with no significant difference. However, state-Trait Anxiety Inventory-state scores were significantly higher in women than in men (P < 0.05). Conclusion: The postoperative analgesic use may be higher in patients who catastrophize pain than in others. Knowing the patient's catastrophic characteristics preoperatively would contribute to successful pain management and appropriate drug selection.
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Bilge, Serap,Yilmaz, Resul,Karaslan, Erhan,Ozer, Samet,Ates, Omer,Ensari, Emel,Demir, Osman The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.3
Purpose: Obesity is defined as the abnormal or excessive accumulation of fat over acceptable limits. Leptin is a metabolic hormone present in the circulation in amounts proportional to fat mass. Leptin reduces food intake and increases energy expenditure, thus regulating body weight and homeostasis. Various polymorphisms are present in the leptin gene and its receptor. These polymorphisms may be associated with obesity. This study aimed to show the association of leptin (+19) AG, leptin (2548) GA, and Gln223Arg leptin receptor polymorphisms with obesity and metabolic syndrome in Turkish children aged 6-17 years, and to conduct further investigations regarding the genetic etiology of obesity. Methods: A total of 174 patients diagnosed with obesity and 150 healthy children who were treated at Tokat Gaziosmanpasa Medical School Hospital between September 2014 and March 2015 were included in this study. The ages of the children were between 6 and 17 years, and anthropometric and laboratory results were recorded. Genotyping of leptin (+19) AG, leptin (2548) GA, and leptin receptor Gln223Arg polymorphisms was performed by polymerase chain reaction. Results: An association between leptin receptor Gln223Arg gene polymorphism and obesity was detected. Conclusion: Further studies are needed to determine the role of genetic etiologies and to indicate the role of leptin signal transmission impairment in the pathogenesis of obesity. We hope that gene therapy can soon provide a solution for obesity.
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