자간전증 및 자간증의 고뇨산혈증에 관한 임상적 연구

최욱환 부산의대 1983 부산의대잡지 - 부산대학교 의과대학 Vol.23 No.2

Expression of Nitric Oxide Synthase and Endothelin-1 in Human Uterine Artery from Full-Term Pregnancies

Choi, Ook-Hwan,Lee, Sun-Hee,Kim, Eun-Jin,Kim, Koan-Hoi,Rhim, Byung-Yong The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.3

The aim of this study was to determine the roles of ET-1 and NO on uterine blood flow in pregnancy. Uterine arteries were isolated from 17 nonpregnant and 12 pregnant women. Nonpregnant group included patients with median age of $48.6{\pm}2.3$ years who underwent hysterectomy, because of myoma. Pregnant group included patients with median age of $31.3{\pm}1.4$ years undergoing cesarean delivery. ET-1 and ET-2 induced concentration-dependent contraction in isolated nonpregnant and pregnant uterine arteries. The contractile response and maximal contraction were increased in pregnant uterine arteries. In nonpregnant uterine arteries, there was no contraction in response to ET-3, whereas pregnancy induced concentration-dependent contraction by ET-3. Tissue nitrite/nitrate level and immunohistochemical staining of eNOS and iNOS were increased in pregnant uterine arteries, compared with nonpregnant uterine arteries. In addition, the expressions of eNOS and iNOS mRNA were significantly increased in pregnancy. Moreover, contractions by ET isopeptides, including ET-1, were enhanced, and immunohistochemical staining of ET-1 and ET-1 mRNA expression was increased in pregnant uterine arteries. These results suggest that NO production by increased NOS activity, especially eNOS activity, is related to placental and uterine blood flow. Furthermore, ET-1 appears to play a pathophysiological role in pregnant complications such as hypertension.

Expression of Nitric Oxide Synthase and Endothelin-1 in Human Uterine Artery from Full-Term Pregnancies

Ook-Hwan Choi,Sun Hee Lee,Eun Jin Kim,Koan Hoi Kim,Byung Yong Rhim 대한생리학회-대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.3

The aim of this study was to determine the roles of ET-1 and NO on uterine blood flow in pregnancy. Uterine arteries were isolated from 17 nonpregnant and 12 pregnant women. Nonpregnant group included patients with median age of 48.6⁑2.3 years who underwent hysterectomy, because of myoma. Pregnant group included patients with median age of 31.3⁑1.4 years undergoing cesarean delivery. ET-1 and ET-2 induced concentration-dependent contraction in isolated nonpregnant and pregnant uterine arteries. The contractile response and maximal contraction were increased in pregnant uterine arteries. In nonpregnant uterine arteries, there was no contraction in response to ET-3, whereas pregnancy induced concentration-dependent contraction by ET-3. Tissue nitrite/nitrate level and immunohistochemical staining of eNOS and iNOS were increased in pregnant uterine arteries, compared with nonpregnant uterine arteries. In addition, the expressions of eNOS and iNOS mRNA were significantly increased in pregnancy. Moreover, contractions by ET isopeptides, including ET-1, were enhanced, and immunohistochemical staining of ET-1 and ET-1 mRNA expression was increased in pregnant uterine arteries. These results suggest that NO production by increased NOS activity, especially eNOS activity, is related to placental and uterine blood flow. Furthermore, ET-1 appears to play a pathophysiological role in pregnant complications such as hypertension.

줄기세포 치료의 연구 현황 및 최신 지견

최욱환 (Ook Hwan Choi),장성규 (Sung Kyoo Jang) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.4

월반성 무월경에 대한 임상적 및 세포유전학적 고찰

최욱환(Ook Hwan Choi),이규섭(Kyu Sup Lee),윤만수(Man Soo Yoon),김원희(Won Whe Kim) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11

N/A The purpose of this study was to determine the frequency of chromosomal or genetic causes of primary amenorrhea, and was made to assess the etiology of disorders in those patients whose chromosome appeared normal. Sixty eight patients with primary amenorrhea were evaluated clinically and cytogenetically, which were refered to our Cytogenetic Laboratory in Department of Obstetrics and Gynecology, Pusan National University Hospital, from Aug. 1988 to Dec. 1996. The results were as follows. l. Out of 68 cases with primary amenorrhea, 40 cases (58.9%) had the normal chromosome constitutions and 28 cases (41.1%) had the abnormal chromosome constitutions including 46, XY. 2. Turner's syndrome was found in 25 cases (36.7%), consisting of 11 cases (16.1%) of 45,X, 3 cases (4.3%) of 46,X,i (Xq), 1 case (1.5%) of 46,X, inv (X), 1 case (1.5%) of 46,X, del (Xq), 1 case (1.5%) of 46,X, del (Xp), 1 case (1.5%) of 46,X, tel (Xq), 1 case (1.5%) of 45,X/46,XX, 1 case (1.5%) of 45,X/46,XY, 1 case (1.5%) of 45, X/47,XXX, 2 cases (2.9%) of 45,X/46,X, del (Xq), I case (1.5%) of 45,X/46,X, del (Xq), 1 case (1.5%) of 45,X/46,X, r (X). 3. 3 cases (4.3%) had the 46,XY chromosome constitution consisting of 2 cases (2.9%) of testicular feminization syndrome and 1 case (1.5%) of pure gonadal dysgenesis. 4. Among 40 patients whose chromosome are normal, the etiologies of amenorrhea were assumed to be caused by 11 cases (27.5%) of hypogonadotropic hypogonadism (idiopathic), 10 cases (25.0%) of congenital absence of vagina, 5 cases (12.5%) of pure gonadal dysgenesis in order of frequency.

사람 자궁의 동맥혈관 평활근의 Endothelin 에 의한 수축반응에 관한 연구

최욱환(Ook Hwan Choi),장미경(Mi Kyung Jang),임병용(Byung Yong Rhim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3

N/A Objective: We examined the vasoconstricting poperties of endothelin (ET) on isolated arteries from pregnant as well as non-pregnant uterus. Methods: Arteries of the uterus were obtained from both hysterectomized uterus and during pregnany hysterectomy for control group and cesarean section for pregnant group. Rings of uterine artery were suspended on muscle chambers at their optimal length for generating tension and contractile properties were examined. Results: ET-1 and ET-2 induced concentration-dependent constriction of both isolated arterial strips from non-pregnant and pregnant uterus. The contraction to ET-1 and ET-2 were more enhanced in full-term pregnancy. Furthermore, in pregnant group, sarafotoxin S6c and IRL 1620, ET. agonists, induced a dose-dependent contraction, which was not shown in those from non-pregnant human. Pretreatment of human uterine arterial strips from pregnant uterus with BQ610, an ET. antagonist, for 10 min resulted in a dose-related rightward shift of ET-1 response curve with diminution of maximal response. Schild plot analysis yielded a pA value of 7.29 with a slope of 0.98. However, BQ788, an ET antagonist, did not produce any rightward shift. The contraction to lower concentration (10-8~3*10-7 M) of sarafotoxin S6c was not affected by BQ788, whereas that to higher concentration (10-s-8*10-7 M) was marked diminished. However, BQ610 did not exnt any efFect on sarafotoxin S6c-induced contraction in arterial staips from pregnant uterus. When the bath solution was replaced with Ca-free physiological salt solution (PSS) containing 1 mM EGTA for 10 min prior to adding sarafotoxin S6c, sarafotoxin S6c-induced contraction was completely abolished. Sarafotoxin S6c (10 nM)-induced contraction was prefetentially blocked by a protein kinase C antagonist, H-7, whereas it was less sensitive to a calmodulin antagonist, calmidazolium, Conclusion: Based on above results, we concluded that ET plays an important role in regulating uterine blood flow through the activation of ETa and ETB receptors. Furthermote, ETB receptors may predominantly contribute to the modulation of human uterine circulation in full-term pregnancy.

임신성 고혈압 치료의 최신지견

최욱환 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20

Pregnancy induced hypertension is classified into gestational hypertension, preeclampsia and eclampsia. The diagnosis of gestational hypertension is made in women whose blood pressure reaches 140/90 mmHg or greater for the first time during pregnancy but in whom proteinuria is not identified, and the blood pressure has returned to normal by 12 weeks' postpartum. The final diagnosis is usually made several weeks after delivery. Eclampsia is termed when the oneset of convulsions in a woman with preeclampsia that cannot be attributed to other causes. Preeclampsia is one of the most common cause of death and disability in mothers and infants. It is diagnosed by the development of hypertension, proteinuria, or both after 20 weeks of gestation in a woman with previously normal blood pressure. Once the diagnosis of preeclampsia has been made, the management options are limited. So much attention has focused on the prediction of preeclampsia and development of preventive strategies. Many methods like rollover test, increased vascular reactivity to intravenous infusion of angiotensin Ⅱ, serum inhibin, maternal serum a-fetoprotein, fibronectin, soluble fms-like tyrosine kinase and Doppler velocimetry of the uterine vessels have been used to predict preeclampsia. But none of these predictive tests is used alone in clinical practice because they do not meet the criteria as a good predictor. For the prevention of preeclampsia, many strategies like diet therapy, use of antioxidant, low-dose aspirin and diuretics were used. But no single strategy has yet proven beneficial for the prevention of preeclampsia. The author have reviewed the current prediction, prevention and treatment of preeclampsia.

Performance evaluation of 2 × 2 MIMO handset antenna arrays for mobile WiMAX applications

Choi, Jung-Hwan,Shin, Yong-Sun,Park, Seong-Ook Wiley Subscription Services, Inc., A Wiley Company 2009 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.51 No.6

<P>This article presents the performance analysis of the multiple-input–multiple-output antenna systems for mobile WiMAX handset applications. To investigate the effect of changing antenna arrangements on the antenna performance, we propose four kinds of two antenna structures considering the practical ground size of a mobile handset. To estimate the proposed structures, mutual coupling and envelope correlations were considered. Also the channel capacity and correlation were measured in the reverberation chamber. The relations between all parameters were analyzed based on the measured results. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1558–1561, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24344</P>

골반 방선균증에 대한 임상적 고찰

최욱환,주종길 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Objective: Pelvic actinomycosis is a rare disease, which makes chronic granulomatous suppurative pelvic abscess caused by an anaerobic Gram positive organism. Actinomyces israelii are usually associated with intra-uterine devices, and it is difficult to diagnose exactly before operation. Pelvic actinomycosis is frequently confused with gynecologic malignancy, leading to misdiagnosis and overtreatment. We have experienced 13 cases of pelvic actinomycosis and so provide the advice for treatment of pelvic actinomycosis. Methods: We reviewed retrospectively 13 cases which had visited to Department of Obstetrics and Gynecology, Pusan National University Hospital from January 1998 to January 2008. Results: The mean age of patients was 41.2 years old. Main symptoms were abdominal pain, palpable mass and diarrhea. Twelve cases had used the intrauterine devices for 1-20 years. In one case, patient had not used intrauterine device. A case was diagnosed preoperatively by endometrial biopsy and the others suspected to be tuboovarian abscess or malignancy, and then their diagnoses were confirmed by operation. All cases were treated by operation following antibiotics therapy, and 1 case by antibiotics without operation. All cases were completely cured. Conclusion: In treatment of pelvic actinomycosis, accurate preoperative diagnosis is most important for decreasing complication such as bowel, bladder, and other pelvic organ injury. If the diagnosis was established during operation, postoperative high dose antibiotic therapy will be needed for several months.

Characterizing the Impact of Moving Mode-Stirrers on the Doppler Spread Spectrum in a Reverberation Chamber

Jung-Hwan Choi,Jee-Hoon Lee,Seong-Ook Park IEEE 2010 IEEE antennas and wireless propagation letters Vol.9 No.-

<P>A moving mode-stirrer in a reverberation chamber (RC) not only changes the field distributions within the reverberation chamber, but also causes a Doppler effect. In this letter, the Doppler spread spectrum of a received signal in a reverberation chamber is characterized according to the radius and rotational velocity of the mode-stirrers and TX antenna positions.</P>