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      • Poster Session : PS 0308 ; Geriatrics : HIP Fracture Prognosis in Patients with and Without Hyponatremia

        ( Nora Angelica Fuentes ),( Diego Hernan Giunta ),( Cristina Maria Elizondo ),( Fernan Gonzalez Bernaldo De Quiros ),( Gabriel Dario Waisman ),( Juan Carlos Ayus ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Hip Fracture (HF) is a leading cause of morbidity and mortality in elderly. Related complications are cardiovascular (CVD), sepsis and venous thromboembolism (VTE), deep venous thrombosis (DVT) and pulmonary embolism (PE). In recent studies, chronic hyponatremia was observed to be an independent risk factor for hip fracture, nevertheless there is no evidence on prognosis of these patients compared to patients without hyponatremia. Objective: To compare the prognosis and complications of HF in normonatremic patients (N) and hyponatremic patients (H). Methods: Retrospective cohort of hospitalized patients with HF, followed up to 30 days after diagnosis, at Hospital Italiano of Buenos Aires. Presence of complications (sepsis, DVT, PE, and CVD), hospital length of stay, mortality and readmission were evaluated. Results: 1571 patients were included, 76, 7% (1205) for N and 23, 3% (366) for H. Most patients were female, 82. 5% and 79. 8% for H and N respectively. H were older, 85 vs. 82 years (p<0. 001). Sepsis was the most frequent complication for H (OR 1. 7, 95% CI: 1. 13-2. 6). Length of stay was 7 days vs. 8 days (p=0. 053) for N and H. Readmissions were 12. 9% for N vs. 15. 8% for H (p=0. 14). Hospital mortality was minor for N than for H (14. 7% vs. 19. 9%; p=0. 016), crude OR was 1. 45 (1. 07-1. 96) and adjusted OR was 1. 15 (0. 84-1. 6). Survival was higher for N than for H (p<0. 001). Crude hazard ratio (HR) of death for H compared to N was 1. 8 (1. 4-2. 35) and adjusted HR was 1. 45 (1. 1-1. 9). Conclusions: Hyponatremic patients have higher risk of sepsis, hospital length of stay and mortality. Thus hyponatremia could represent a marker of severity of underlying diseases or be a consequence of treatments during the surgical procedures, it could serve as alert for potential risk on outcome of these patients.

      • Poster Session : PS 0467 ; Genetics ; Quality of Life in Patients with Hereditary Hemorrhagic Telangiectasia

        ( Cristina Maria Elizondo ),( Carla Scarano ),( Constanza Franceschini ),( Nora Angelica Fuentes ),( Hernan Diego Giunta ),( Liliana Rojas ),( Marcelo Martin Serra ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant systemic disorder that affects 1/5000-8000 individuals worldwide. It is characterized by recurrent epistaxis, mucocutaneous telangiectasias and arteriovenous malformations (AVMs) in organs such as lung, liver, central nervous system (CNS) and gastrointestinal tract (GI); their clinical manifestations and possible complications added, frequently alters quality of life of these patients. Objective: To identify associated factors with lower quality of life in adult patients with HHT. Methods: Cross-sectional study, from 2010 to 2013, of prospectively evaluated patients, from the institutional registry of HHT at Hospital Italiano, Buenos Aires. Quality of life (QoL) was measured with the EuroQol and visual analog scale (AVS) validated for the country. Presence of epistaxis, anemia, AVMs in CNS, lung, liver, GI tract, symptoms and related complications were evaluated. Results: 127 patients were included: 33% were men, with a median age of 47 years (IQR:16). Median for QoL measured by the VAS was 69 (ICR:20.3). From the total, 96,1% presented epistaxis, from which 33,9% had severe epistaxis; 60% had anemia, 65,15% pulmonary AVMs, 39,4% were symptomatic; 19,6% had AVMs in CNS; 73,5% had hepatic AVMs and 63% had GI AVMs from which 27,6% presented symptoms. Signifi cant association was found between de median of QoL measured by VAS with: anemia (62 vs. non-anemic 77.8, p=0.001), pulmonary AVMs (62.3 vs. 71.27 without pulmonary AVMs, p=0.056), hepatic AVMs (64.67 vs. 78.15 without AVMs, p=0.012), GI AVMs (60 vs. 70 without AVMs, p=0.043) and correlation coefficient age was -0.349 age (p<0.001). Conclusions: Factors associated to decrease QoL in HHT were anemia and hepatic, pulmonary and GI AVMs. There was no difference in QoL related to epistaxis, but this could be attributed to the low number of patients without epistaxis.

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