18세기 초 조선연행사(朝鮮燕行使)의 진상의(陳尙義) 해적집단 관련 정보 수집활동

정신남 ( Ding Chen-nan ) 연세대학교 국학연구원 2017 동방학지 Vol.178 No.-

陳尙義 해적집단은 “四口通商의 시대”가 시작된 이래 廣東에서 출발하여 중국 동부 연해 전체에 걸쳐 활동했으며, 특히 조선과 가까운 遼東과 山東연해에서 활동한 해적들이었다. 조선에서는 이 해적집단의 존재를 파악하기 전부터 이미 중국 동부 연해에 나타나는 해적에 대해 상당한 관심을 가지고 관련 정보를 모으고 있었다. 따라서 연행사의 정보수집 활동을 통해서 陳尙義 해적집단을 알게 된 것은 결코 우연이 아니었다. 그 이후로도 이 해적집단에 대해서 지속적인 관심을 가졌으며, 그들이 재차 소요를 일으켰다는 정보도 입수하였다. 조선연행사는 陳尙義 해적집단 관련 정보 수집활동에서 주로 현지인 탐문을 진행하거나 청조의 공문서를 구입하거나 필사하는 등 방법을 활용하였다. 그리하여 조선 측 사료, 특히 연행록에는 陳尙義 해적집단과 관련된 기사가 다수실리게 되었다. 조선연행사에 의해 수집된 題本, 塘報와 같은 일부 청조 공문서는 그 眞僞를 더 검토해야 하지만 현재 중국에도 남아 있지 않는 희귀한 자료로서 그 나름의 가치를 지니고 있다. 조선연행사들의 관련 정보 수집활동 사례를 분석하는 것은 중국에서 발생한 특정 사건에 대한 조선사절단의 정보수집활동의 전모를 밝힐 수 있을 뿐만 아니라, 조선 측 사료에 실린 중국 기록의 가치를 역시 잘 보여줄 수 있다고 본다. Chen-Shangyi (陳尙義) pirates group rose from Guangdong Province in 168 4,the times of Four Port Trade System, and then expanded to the whole eastern coast with frequent activities covering Liaodong and Shandong, near Korea. The Joseon government had already got substantial information on pirates` rampancy on Chinese eastern coast before overhearing Chen-Shangyi pirates group through Joseon Emissaries` information collection. After that the government kept an eye on this pirate group and got the news of their rebellion again. Joseon Emissaries` obtained the information of Chen-Shangyi pirates group` activities mainly by inquiring local people as well as buying and copying Qing`s official documents, hence Korean historical documents, especially the Records of Trips to Beijing (燕行錄) include a lot of information on Chen-Shangyi pirates group. Although it is still need to recheck the facticity of Qing`s official documents such as Ti-Ben (題本) and Tang-Bao (塘報), these precious Korean documents that no longer exist in China have unique value. Through analyzing Joseon Emissaries` intelligence gathering of Chen-Shangyi pirates group, one can get a full view of Joseon Emissaries` process of intelligence gathering on China, and realize the value of the records relating to China in Korean historical documents.

A heat shock protein 70 protects the green peach aphid (Myzus persicae) against high-temperature stress

Chen Nan,Tan Jia-Yu,Wang Ying,Qi Ming-Hui,Peng Jiang-Nan,Chen De-Xin,Liu Su,Li Mao-Ye 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.4

Heat shock proteins (HSPs) are encoded by Hsp genes and are important in insect tolerance to heat stress. The green peach aphid, Myzus persicae, is an important agricultural pest. The functions of Hsp genes in the thermal tolerance of M. persicae are unknown. This study identified an Hsp70 gene (MpHsp70a) and analyzed its role in protection against high-temperature stress. MpHsp70a encoded a protein consisting of 659 amino acid residues. The protein had three signature motifs of the HSP70 family and was predicted to be localized in the cytoplasm. The highest expression level of MpHsp70a was in adults, and differences in the mRNA levels between apterous and alate adults were not significant. Exposure to high temperatures (30, 35 and 40 ◦ C) for one hour and treatment with 40 ◦ C for different times (0.5, 1 and 2 h) all resulted in a greatly elevated expression level of MpHsp70a, suggesting that the gene is heat-inducible. The transcriptional level of MpHsp70a was suppressed by injection with double-stranded RNA (dsRNA), and knockdown of MpHsp70a significantly increased the suscep tibility of apterous adults to 40 ◦ C. These results indicate that MpHsp70a is required for tolerance to hightemperature stress in M. persicae. Our findings highlight the molecular mechanism underlying Hsp70-mediated thermal adaptation in M. persicae.

Optimization of the Growth Rate of Probiotics in Fermented Milk Using Genetic Algorithms and Sequential Quadratic Programming Techniques

Chen, Ming-Ju,Chen, Kun-Nan,Lin, Chin-Wen Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.6

Prebiotics (peptides, N-acetyglucoamine, fructo-oligosaccharides, isomalto-oligosaccharides and galactooligosaccharides) were added to skim milk in order to improve the growth rate of contained Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium longum and Bifidobacterium bifidum. The purpose of this research was to study the potential synergy between probiotics and prebiotics when present in milk, and to apply modern optimization techniques to obtain optimal design and performance for the growth rate of the probiotics using a response surface-modeling technique. To carry out response surface modeling, the regression method was performed on experimental results to build mathematical models. The models were then formulated as an objective function in an optimization problem that was consequently optimized using a genetic algorithm and sequential quadratic programming approach to obtain the maximum growth rate of the probiotics. The results showed that the quadratic models appeared to have the most accurate response surface fit. Both SQP and GA were able to identify the optimal combination of prebiotics to stimulate the growth of probiotics in milk. Comparing both methods, SQP appeared to be more efficient than GA at such a task.

Globalization Context and the Evolution of Petty Bourgeois Factors in Chinese Films

Chen, Nan(진남) 대한중국학회 2018 중국학 Vol.62 No.-

本文为探究“小资”要素在中国电影发展各时期中的异同,分别以毛时代、邓时代和全球化 时代为背景,勾画出社会政治经济环境的变化对“小资”要素演变的影响。在毛时代“文艺为工农 兵服务”的创作导向指引下,“个人主义、批判现实主义、感伤主义”等小资产阶级文艺要素在电 影作品中被摒弃和遮蔽。城市小资产阶级是当时主要的观影群,却不是电影创作的主体。在邓时 代,随着社会商品经济体制的改革,具有“个人主义和感伤主义”特征的伤痕电影迎来大众观影 潮。特别是1980年代后期兴起的“王朔文学”电影,描写中国当代社会中的一个特殊青年阶层- “痞子”,揭开了“新”小资时代的序幕。随着1995年好莱坞电影重返中国市场,中国电影进入了 全球化媒介时代。带有浪漫、反叛、感伤、搞笑等特征的“新”小资电影成为了中国多元电影市场 的组成部分,具有“新”小资特征的大中学生和城市青年作为“新”小资电影的观影主体而崛起, 令中国影视创作主体从单一的工农兵和伟人形象朝着多元大众形象更近了一步,具有进步意义。 In order to explore the similarities and differences among the Petty bourgeois factors in the various periods of Chinese film, this paper traces the evolution of the Petty bourgeois factors in the context of the Mao era, the Deng era, and the globalization era, respectively. First of all, under the Guidance of Literature and Art Serving the Workers, Peasants and Soldiers in the Mao era, film became a tool for propagating the ideology of class struggle. Elements of petty bourgeoisie literature such as Individualism, Critical Realism, Sentimentalism were abandoned and obscured in the film. The urban petty bourgeoisie was the main cinema audiences at the time, but it was not the subject of film creation. Second, in the era of Deng, as the reform of the social commodity economy, the traumatic literature film with the characteristics of Individualism and Sentimentalism was popular with the public. Petty bourgeois elements of literature and art abandoned by the Mao era began to return to the stage of history. Especially in the late 1980s, the Wang Shuo Literature movie, which depicts a special youth class in modern Chinese society, opened the prelude to the new Petty bourgeois era. Finally, with the return of Hollywood films to the Chinese market in 1995, Chinese films entered the era of globalization. Hollywood films produced a large amount of new petty bourgeois with the aesthetic taste of Western middle class. With the rise of new petty bourgeois, films which expressed romance, rebellion, sentimental, comedy have become part of China’s diversified film market. Students and urban youth with “new” petty bourgeois character became the subject of the “new” petty-bourgeois films. The main body of Chinese film creation has taken a step closer to the image of a multi-faceted public image.

Significant Association of Alpha-Methylacyl-CoA Racemase Gene Polymorphisms with Susceptibility to Prostate Cancer: a Meta-Analysis

Chen, Nan,Wang, Jia-Rong,Huang, Lin,Yang, Yang,Jiang, Ya-Mei,Guo, Xiao-Jiang,He, Ya-Zhou,Zhou, Yan-Hong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

Background: Alpha-methylacyl-CoA racemase(AMACR) is thought to play key roles in diagnosis and prognosis of prostate cancer. However, studies of associations between AMACR gene polymorphisms and prostate cancer risk reported inconsistent results. Therefore, we conducted the present meta-analysis to clarify the link between AMACR gene polymorphisms and prostate cancer risk. Materials and Methods: A literature search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of any association between AMACR polymorphisms and prostate cancer risk. Subgroup analyses by ethnicity, source of controls, quality control and sample size were also conducted. Results: Five studies covering 3,313 cases and 3,676 controls on five polymorphisms (D175G, M9V, S201L, K277E and Q239H) were included in this meta-analysis. Significant associations were detected between prostate cancer and D175G (dominant model: OR=0.89, 95%CI=0.80-0.99, P=0.04) and M9V (dominant model: OR=0.87, 95%CI=0.78-0.97, P=0.01) polymorphisms as well as that in subgroup analyses. We also observed significant decreased prostate cancer risk in the dominant model (OR=0.90, 95%CI=0.81-0.99, P=0.04) for the S201L polymorphism. However, K277E and Q239H polymorphisms did not appear to be related to prostate cancer risk. Conclusions: The current meta-analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. The S201L polymorphism might also be linked with prostate cancer risk to some extent. However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer.

A Novel Molecular Grading Model: Combination of Ki67 and VEGF in Predicting Tumor Recurrence and Progression in Non-invasive Urothelial Bladder Cancer

Chen, Jun-Xing,Deng, Nan,Chen, Xu,Chen, Ling-Wu,Qiu, Shao-Peng,Li, Xiao-Fei,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Purpose: To assess efficacy of Ki67 combined with VEGF as a molecular grading model to predict outcomes with non-muscle invasive bladder cancer (NMIBC). Materials: 72 NMIBC patients who underwent transurethral resection (TUR) followed by routine intravesical instillations were retrospectively analyzed in this study. Univariate and multivariate analyses were performed to confirm the prognostic values of the Ki67 labeling index (LI) and VEGF scoring for tumor recurrence and progression. Results: The novel molecular grading model for NMIBC contained three molecular grades including mG1 (Ki67 $LI{\leq}25%$, VEGF $scoring{\leq}8$), mG2 (Ki67 LI>25%, VEGF $scoring{\leq}8$; or Ki67 $LI{\leq}25%$, VEGF scoring > 8), and mG3 (Ki67 LI > 25%, VEGF scoring > 8), which can indicate favorable, intermediate and poor prognosis, respectively. Conclusions: The described novel molecular grading model utilizing Ki67 LI and VEGF scoring is helpful to effectively and accurately predict outcomes and optimize personal therapy.

Prospective Comparison of Redo Microvascular Decompression and Percutaneous Balloon Compression as Primary Surgery for Recurrent Trigeminal Neuralgia

Chen, Jing-nan,Yu, Wen-hua,Du, Hang-gen,Jiang, Li,Dong, Xiao-qiao,Cao, Jie The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.6

Objective : To prospectively compare facial pain outcomes for patients having either a repeat microvascular decompression (MVD) or percutaneous balloon compression (PBC) as their surgery for trigeminal neuralgia (TN) recurrence. Methods : Prospective cohort study of 110 patients with TN recurrence who had either redo MVD (n=68) or PBC (n=42) from July 2010 until September 2016. The mean follow-up was 45.6 months. Results : After redo MVD, 65 patients (95.6%) experienced immediate relief of pain. After PBC, 34 patients (81%) were immediately relieved of their neuralgia. After 1 month, the clinical effect of redo MVD was better than PBC (p<0.01). Patients who had redo MVD more commonly were pain free off medications (93.4% at 1 year, 78.2% at 4 years) compared with the PBC patients (85.1% at 1 year, 59.3% at 4 years). However, mean length of stay was longer (p>0.05). Patients after PBC who occurred developed herpes simplex (35.7%), facial numbness (76.2%), and annoying dysesthesia (21.4%) more frequently compared with patients after redo MVD who occurred developed herpes simplex (14.7%), facial numbness (8.8%), and hypoesthesia (5.9%) (p<0.05). The symptoms recurred respectively in 15 patients (22.1%) and 19 patients (45.2%) after redo MVD and PBC within the entire 6-year follow-up period. Conclusion : For the patients with TN recurrence, redo MVD was a more effective procedure than PBC. The cure rate and immediate relief of pain were better, and the incidence of complications was lower.

Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal Sarcoma

Nan Kang,Yinli Zhang,Shichao Guo,Ran Chen,Fangzhou Kong,Shuchun Wang,Mingming Yuan,Rongrong Chen,Danhua Shen,Jianliu Wang 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose The unique chromosomal rearrangements of endometrial stromal sarcoma (ESS) make it possible to distinguish high-grade ESS (HGESS) and low-grade ESS (LGESS) from the molecular perspective. Analysis of ESS at the genomic and transcriptomic levels can help us achieve accurate diagnosis of ESS and provide potential therapy options for ESS patients.Materials and Methods A total of 36 ESS patients who conducted DNA- and/or RNA-based next-generation sequencing were retrospectively enrolled in this study. The molecular characteristics of ESS at genomic and transcriptomic levels, including mutational spectrum, fusion profiles, gene expression and pathway enrichment analysis and features about immune microenvironment were comprehensively explored.Results <i>TP53</i> and <i>DNMT3A</i> mutations were the most frequent mutations. The classical fusions frequently found in <i>HGESS</i> (<i>ZC3H7B-BCOR</i> and <i>NUTM2B-YWHAE</i>) and LGESS (<i>JAZF1-SUZ12</i>) were detected in our cohort. <i>CCND1</i> was significantly up-regulated in HGESS, while the expression of <i>GPER1</i> and <i>PGR</i> encoding estrogen receptor (ER) and progesterone receptor (PR) did not differ significantly between HGESS and LGESS. Actionable mutations enriched in homologous recombination repair, cell cycle, and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways were detected in 60% of HGESS patients. Genes with up-regulated expression in HGESS were significantly enriched in five immune-related pathways. Most HGESS patients (85.7%) had positive predictors of immunotherapy efficacy. Moreover, immune microenvironment analysis showed that HGESS had relatively high immune infiltration. The degree of immune infiltration in HGESS patients with <i>ZC3H7B-BCOR</i> fusion was relatively higher than that of those with <i>NUTM2B-YWHAE</i> fusion.Conclusion This study investigated the molecular characteristics of ESS patients at the genomic and transcriptomic levels and revealed the potentially high sensitivity of targeted therapy and immunotherapy in a subset of HGESS with specific molecular features, providing a basis for guiding decision-making of treatment and the design of future clinical trials on precision therapy.

Impact of geometrical parameters on SGEMP responses in cylinder model

Chen Jian-Nan,Zhang Jun-Jie 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.9

This paper is aimed to find out the impact of the geometrical parameters, mainly the radius and the height of a cylinder, on the SGEMP response including the famous scaling law in the classical cylinder model using a homemade PIC code UNIPIC-3D. We computed the electric fields at the center and at the edge on the emission head face with different radii and heights under normal X-rays incidence. The results show that the electric field will increase with the radius but decrease with the height. We analyze the scaling law that links the electric field product and fluence product, and whereafter an irreconcilable contradiction raises when the radius is changeable, which limits the application range of the scaling law. Moreover, the field-height-radius relation is found and described by a combination of logarithmic and minus one-quarter numerical fitting law firstly. Particle and magnetic field distributions are used to explain all the behaviors of the fields reasonably. All the findings will assist the evaluation of SGEMP response in spacecraft protection.

Design and Implementation of Middleware Based on ID and IP Address for Actuator Networks

Chen Nan,YunJung Lee,Faiza Tila,Do Hyeun Kim 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.1

Recently, the intelligent services demands interactions with the sensor networks, actuator networks, and context aware applications. Actuator network supports an infrastructure to have an immediate access to information for controlling the physical world and its objects using sensor networks and context aware applications. Actuator network middleware supports the command message transfer for controlling the behavior of the environment or physical systems. In this paper, we design and implement the actuator network middleware based on ID(IDentification) and IP(Internet Protocol) address for control the environment using multiple actuator devices. Also, this middleware assigns ID for identifying each actuator nodes, and uses an IP address for transferring control messages between application and actuator networks. And, the presented middleware provides to connect between actuator ID and IP address using the mapping table. We design the middleware using sequence diagram and state diagram, and implement it based on .Net framework. The middleware supports to transfer command messages between application and actuator networks.