http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토
박노정,김남재,이경태,서성훈 경희대학교 경희동서약학연구소 2001 경희약대 논문집 Vol.29 No.-
This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin administration. The identification of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmax) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursinol after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.
당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토
박노정,김남재,이경태,서성훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin admimistration. The identification of decursional isolated from Angelica gigas was carried out by GC/MS and the concentration of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmas) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursional after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.
위험평가(Risk Assessment)에 의한 업종별 위험(Risk)의 구분
박동욱,박덕묵,정광수,윤충식,김태형,노영만,이경남,이송권,김현욱 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2
A total of 514 workplaces in 17 industries were inbestigated through walk-through survey. These industries were all small companies with less than five workers and didn't have work environmental measurement data. These industries were ranked by risk that was evaluated by combination of toxicity and possibility of exposure to chemical hazardous agents produced at operations of industry. Risk Index(RI) was qualitatively combined by the combination between hazard and potential of exposure to chemical hazardous agents. Industries that were regarded as having the highest risk were wood and products of wood, chemicals and chemical products, basic metals, other vehicles, trailers and semi-trailers, and fumiture manufacturing. These industries were found to have operations with higher risk than other industries. This study found that more attentions should be paid to these industries with that more attentions should be paid to these industries with high risk.
P232 : Clinical and pathological study of seborrheic keratosis in Korean patients
( Nam Kyung Roh ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yu Na Lee ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin that may occur singly or more often in multitude. Histologically, SK is divided into six major variants; acanthotic, hyperkeratotic, adenoid, irritated, clonal, and melanoacanthoma. However, investigation of histopathological subtypes and sites of the SKs to detect any possible correlations have been rarely documented. Objectives: To analyze the clinical and histopathological features of a large number of cases of SK diagnosed in Korean patients. Methods: Total of 271 pathology slides of clinically diagnosedSK and 206 cases of biopsy-proven SK were analyzed. Cases of biopsy-proven SK were assessed for histopathologicalsub-classification. Results: The most frequent histopathological subtype was the acanthotic type, followed by hyperkeratotic, melanoacanthoma, clonal, irritated type, and adenoid types. Of them, adenoid type was more common in sun-exposed site than sun-protected site. Overall, premalignant and malignant entities together represented 24.2% of the clinic-pathological mismatch cases. The frequency of a mismatch for the sun-exposed area was significantly higher than that of the non-sun exposed area (p=0.043). Conclusion: Adenoid type was more common in sun-exposed area. High frequency of mismatch is associated with SKs situated on sun-exposed area. We should take a biopsy particularly in lesions situated on sun-exposed area to exclude either premalignant or malignant diseases.
Cutaneous hodgkin`s disease: a case report
( Nam Kyung Roh ),( Byung Gon Choi ),( Song Hee Han ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Hodgkin’s disease usually presents as painless cervical, supraclavicular, and/or mediastinal lymphadenopathy. Cutaneous Hodgkin’s disease is quite rare condition in patients with Hodgkin’s disease. Skin involvement ranges from erythematous rash to spectrum of papular, plaque-like, nodular, nodular-ulcerative, and infiltrative lesions. Although cutaneous Hodgkin’s disease is usually associated with poor prognosis, in some cases it can be indolent. Cutaneous Hodgkin’s disease mostly develops late in the course of disease and the incidence of primary cutaneous disease or skin only disease is extremely rare. Herein, we report a rare case of primary cutaneous Hodgkin’s disease in a 30-year-old-man.
( Nam Kyung Roh ),( Byung Gon Choi ),( Song Hee Han ),( Min Jung Kim ),( Hae Jeong Youn ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: The use of radiofrequency devices for noninvasive skin rejuvenation is continually under development. Objectives: To evaluate the rhytide-reducing effects and safety of 4-MHz mono-polar thermal radiofrequency and multi-polar fractional radiofrequency (RF) device applied to human periorbital skin. Methods: Seventy patients were treated randomly with 4MHz mono-polar thermal radiofrequency on the periorbital area on one side of the face and 4MHz multi-polar fractional radiofrequency on the other side. We performed a series of three treatment sessions, spaced 2 weeks apart. Periorbital rhytides were evaluated 4 weeks after the last treatment session. Results: Periorbital rhytides were significantly reduced after both treatments. The treatment was well tolerated and no serious adverse events related to the procedure were reported. Conclusion: The findings show that 4MHz mono-polar thermal radiofrequency and multi-polar fractional radiofrequency are considered remarkably effective and safe for the treatment of periorbital rhytides.
ORIGINAL ARTICLE : Clinical and Histopathological Investigation of Seborrheic Keratosis
( Nam Kyung Roh ),( Hyung Jin Hahn ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.2
Background: Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location. Objective: The aim of this study was to analyze the clinical and histopathological features of a relatively large number of cases of diagnosed SK. Methods: Two hundred and seventy-one pathology slides of skin tissue from patients with clinically diagnosed SK and 206 cases of biopsy-proven SK were analyzed. The biopsy-proven cases of SK were assessed for histopathological subclassification. The demographic, clinical, and histopathological data of the patients were collected for analysis of associated factors. Results: The most frequent histopathological subtype was the acanthotic type, followed by mixed, hyperkeratotic, melanoacanthoma, clonal, irritated, and adenoid types; an unexpectedly high percentage (9.2%) of the melanoacanthoma variant was observed. The adenoid type was more common in sun-exposed sites than in sun-protected sites (p=0.028). Premalignant and malignant entities together represented almost one-quarter (24.2%) of the clinicopathological mismatch cases (i.e., mismatch between the clinical and histopathological diagnoses). Regarding the location of SK development, the frequency of mismatch for the sun-exposed areas was significantly higher than that for sun-protected areas (p=0.043). Conclusion: The adenoid type was more common in sun-exposed sites. Biopsy sampling should be performed for lesions situated in sun-exposed areas to exclude other premalignant or malignant diseases.(Ann Dermatol 28(2) 152∼158, 2016)
( Nam Kyung Roh ),( Song Hee Han ),( Min Jung Kim ),( Gyeong-hun Park ),( Bark-lynn Lew ),( Eung Ho Choi ),( Hyun Chang Ko ),( Young Lip Park ),( Sang Wook Son ),( Young Jun Seo ),( Yang Won Lee ),( S 대한피부과학회 2016 Annals of Dermatology Vol.28 No.6
Background: Physicians can play a crucial role in the knowledge that patients have about a disease and its prognosis. Recently, patients with atopic dermatitis (AD) are increasingly turning from western medicine to oriental herbal medicine. However, their awareness of AD and attitude toward Western medicine and oriental herbal medicine clinics are scarcely reported. Objective: The aim of this study was to determine the understanding of AD among patients and their parents and to identify their awareness of and attitude toward Western medicine and oriental herbal medicine as treatments for AD. Methods: An online questionnaire was administered to 500 consenting respondents with AD (age, 16∼49 years) and parents of children with AD (age, 0∼15 years). Results: The mean percentage of correct answers to questions about AD was 52.54%. A parental history of AD was independently associated with higher respondent`s knowledge about the disease and its treatment. The satisfaction with treatment outcomes was highest among patients treated at private clinic of dermatology specialists (49.4%), while lowest among those treated at oriental herbal medicine clinics (38.4%). Many participants were aware that oriental herbal medicine requires a longer treatment period for a cure and does not burden the skin, while steroid phobia was seen in most of participants. Conclusion: Physicians need to educate AD patients and their parents about the disease and its treatment. Misconceptions for Western medicine and oriental herbal medicine among AD patients and parents should be corrected to improve their prognosis. (Ann Dermatol 28(6) 725∼732, 2016)