베타-글루쿠로니다제에 의한 황련ㆍ황금 공침물의 가수분해 및 생체이용률 증가

김미정,김남순,김영일,김대근,양재헌 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

During the preparation of decoction from the mixture of Coptidis Rhizoma and Scutellariae Radix, insoluble copreciptate was formed. The coprecipitated product(COP) was composed of berberine and baicalin which was the active ingredient of Coptidis Rhizoma and Scutellariae Radix, respectively. COP was slightly soluble in water and could not be well absorbed after oral administration. This poor bioavailibility might be associated with its poor aqueous solubility. With the purpose of increasing the solubility and bioavailibility of COP, hydrolysis of COP by β-glucuronidase was carried out. Hydrolyzed products (HOP) of COP were identified and assayed for active ingredients. The partition coefficient study, in situ absorption test, and pharmacokinetic study after oral administration were also performed. COP was found to be consisted of berberine and baicalin with molecular ratio or 1 to 1. This compound was hydrolyzed to berberine and baicalin by β-glucuronidase. The rate of hydrolysis was higher at higher temperature up to 50℃ and higher concentration of β-glucuronidase up to 2500 unit under our experimental conditions. Baicalein, which is more liphophilic than baicalin, showed greater absorption in small intestine than baicalin did. The plasma concentrations of berberine and baicalein after oral administration of HOP were significantly higher than those of COP. The possible mechanism of increased bioavailibility of berberine and baicalein could be the hydrolysis of COP by β-glucuronidase. On the basis of the above results, it might be said that HOP should be a suitable preparation for increasing the bioavailibility of Coptidis Rhizoma and Scutellariae Radix.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

엘리트 체육정책에 따른 체육인의 의식조사

김현태,남태호,이근모 釜山大學校 附設 體育科學硏究所 1995 體育科學硏究所 論文集 Vol.11 No.-

The purpose of this was to determine effect of physical education policy of elite athletes on physical educator's attitudes in Pusan. For this study, subject were the elite athletes(senior high school and university students) and physical educators. The result of this was found as follows; 1. Unsatisfied attitudes were found in university students, physical educators, and senior high school students as order regarding the Ministry of Education, each sport federation of government body, school budget policies for promotion of elite athletes. 2. Regarding reduction of national competition policy, unsatisfied attitudes were found in senior high school students, university students, and physical educators as order. Also, the past elite athletes were agree reduction of national competition policy, but the non-past elite athletes were not. 3. Regarding athletes absent in the class, university students, physical educators, and senior high school students were disagreed with it as order. 4. Regarding the purpose of physical education and sport for all are different but both groups should promote for public health and social we lfare, senior high school students, university students, and physical educators were agreed with it as order. 5. Regarding the number of senior high school and university athletic teams were more decreasing than the number of semi-pro team and pro team, university students, physical educators, and senior high school students were mentioned that it is abnormal as order. 6. Regarding sport facilities for promoting athletic teams, university students, physical educators, and senior high school students were dissatisfied as order. The non-past elite athletes were more unsatisfied than the past elite athletes. 7. When some one dissatisfied facilities, significant difference was found that among groups. Physical educators preferred public facilities. University students preferred facilities near the school. And senior high school students preferred unsettled sport facilities. 8. Regarding ideal way of promoting elite athletes, there was significant difference between males and females. Both groups think that most ideal way of promoting elite athletes was department of cultural physical education support. 9. Regarding 40 points requirement of SAT for athletes, there was significant difference between groups of the elite and non-elite athletes. University students and physical educators preferred higher than 40 points. However, senior high school students preferred that 40 points requirement system is not good. The past elite athletes preferred breaking down 40 points of requirement, but the non-past elite athletes preferred higher scores than 40 points.

국제 경기를 통한 스포츠 산업의 활성화 방안

김인형,최동일,남희은,이근모,김찬룡 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

This study was mainly focused on the relationship between sports industry and international games. According to the category of both sports information ·service industry and sports technology industry. The way of activating sports industry by international games is proposed as follows; 1. Sports information · service industry 1) Sports Event (1) Expending the inducement of sports event sponsored by domestic international enterprises. (2) Improving image of enterprise by activating character industry. (3) Elevating the mood of international games by pre-event and post-event. (4) Attracting tourist during games session by opening various cultural and artistic events. 2. Media (1) Establishment of Media facilities such as international broadcasting center or media center. (2) Providing best media services by digitalizing every kind of broadcasts. (3) Using aggressive internet advertisement of game's information, cultural events, tourism, and etc. 3. Sports Event Tourism (1) Providing sports event package tourism. (2) Rehabilitating accomodation and convenience facility at the level of advanced country. (3) Building sports theme complex well international sports heros are taken as theme. (4) Building sports mall well every sports-related businesses can be a solved as one-stop service. 2. Sports technology industry 1) Sports Facility (1) Founding the organization of which mission is to induce long-term fund for building and repairing sports facilities. (2) Acquiring economic benefit by selling the right to call sports facilities after company names. (3) Building all weather and multi-purpose sports facilities and practically using after games. 2) Sports Goods (1) Following consumers' demand for design and colors of goods. (2) Developing marketing strategy by opening sports goods expo. (3) Reinforcing the information network among company groups. (4) Acquiring government support for developing sports goods marketers. (5) Developing new kind of leisure goods.

解放後 濟州硏究槪觀(Ⅲ) : 社會科學分野

金榮敦,高南旭,夫萬根,申幸澈,金泰保,許鐵洙 제주대학교 탐라문화연구소 1985 탐라문화 Vol.0 No.4

乳齒列期 齒列穹 形態에 關한 硏究

金旺根,金南洪 大韓小兒齒科學會 1985 大韓小兒齒科學會誌 Vol.12 No.1

This study was to investigate the fitness of the primary dental arch to the parabola. The samples of 91 plaster casts were obtained which were taken from children with normal occlusion, aging from 3 to 5 years. Landmarks on the stone casts were marked on measuring glass which was superimposed on the stone casts, and transfered and measured to the tracing paper. The points on the tracing papers were digitized, and scattergrams and statistics were performed by the computer; PRIME 750, IBM Co., U.S.A.. The results were as follows: 1. The fitness of the primary ental arch to the parabola was above 92% in the upper dental arch, and was above 91% in the lower dental arch. 2. Constant value A of upper dental arch line passing the midpoints of primary dentition was -0.54 and that of lower ental arch was -0.59, and the upper dental arch showed more expended parabola than the lower dental arch. 3. The dental arch line passing the buccal cusp tips of the primary posteriors and the midpoints of he primary incisors were more fit to the parabola than the dental arch line passing the midpoints of the primary teeth. 4. The ratio of oblique arch length to intermilar width was divided into 4 groups by the quaters, and the mean parabolic equations and curves were calculated and drawn.

자일리톨 섭취에 따른 Streptococcus mutans의 글루칸 생성관련 유전자 발현 억제효과

김지혜,이영은,안상헌,최연희,남순현,송근배 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

본 연구에서는 장기적인 자일리톨의 섭취가 Streptococcus mutans의 대표적인 독성인자 중 하나인 글루칸 생성에 미치는 영향을 알아보기 위하여 글루칸 합성효소인 glucosyltansferase의 mRNA 발현을 실시간 역전사 중합효소 연쇄반응을 통해 평가하여 다음과 같은 결과를 얻었다. 1. 24개월 동안 자일리톨껌을 섭취한 군에서 타액 내 Streptococcus mutans의 colony 수는 통계적으로 유의하게 감소하였다(p<0.05). 2. 비수용성 글루칸 합성에 관여하는 유전자인 gtfB, gtfC의 발현은 자일리톨껌을 섭취한 군에서 시간이 지남에 따라 유의 하게 감소하였다(p<0.05). 특히 gtfB의 발현은 12개월과 24개월째 대조군에 비하여 통계적으로 유의하게 낮았고, gtfC의 발현은 24개월째 대조군에 비하여 통계적으로 유의하게 낮았다(p<0.05). 3. 수용성 글루칸 합성에 관여하는 유전자인 gtfD의 발현 역시 자일리톨껌을 섭취한 군에서 시간이 지남에 따라 유의하게 감소하였다(p<0.05). 또한 gtfD의 발현은 12개월과 24개월째 대조군에 비하여 통계적으로 유의하게 낮았다(p<0.05). 이상의 결과들을 종합해 보았을 때, 자일리톨의 섭취는 구강 내 Streptococcus mutans의 글루칸 합성 관련 유전자들의 발현을 억제시킴으로써 Streptococcus mutans의 수적인 감소를 가져오는 것으로 생각된다. Xylitol has the ability to reduce the adherence of Streptococcus mutans(S. mutans), which can make it easier to remove plaque, decrease acid production and inhibit dental caries. There are few reports on the effects of xylitol on the expression of the virulence related genes in S. mutans. This study examined the inhibitory effect of chewing gum containing xylitol on glucan synthesis related gene expression of S. mutans. Participants were voluntarily recruited for a women's oral health prevention program, classified into two groups(a control and a xylitol group), and then followed for 2 years. Twenty salivary samples were randomly selected from each group. Colony count and real-time reverse transcription polymerase chain reaction were used to analyze the characteristics of S. mutans. The following results were obtained: The S. mutans counts decreased steadily in the xylitol group over the study period(p<0.05). The expression of the virulence related genes (gtfB, gtfC and gtfD) was significantly lower in the xylitol group than in the control groups (p<0.05). In conclusion, these results suggest that chewing xylitol gum for a long period of time may reduce the expression of the genes associated with S. mutans virulence, which can result in a decrease growth of S. mutans colonies as a result.

가상현실을 이용한 뇌졸중 환자의 균형장애 평가와 임상평가 지수와의 상관성 연구

김연희,박지원,정준용,우영근,최종덕,김남균 최신의학사 2003 最新醫學 Vol.46 No.11-12

스포츠이벤트의 경제적 효과와 발전 방향

남희은,김윤숙,이근모 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

Although sports events have so many extend effect on the field of politics, diplomatic, social, culture, and economic, especially the economic effect is very important. In this view, this study was researched that the economic effect through sports events and development direction to induce a long term effects. The economic effect through the sports events are as follows; 1. Direct effect of economic : construction, arrangement of the lower part and traffic, etc. 2. Effect related consume : public business fund, operation fund related event facilities, participation fee, and ticket fee, selling income of gift related events, food, information service, rental service, insurance service, income of transport and lodging. 3. The effect of sports industry development : sports products, the advance of technological industry, facilities, information technique. 4. The effect of employment promotion : promotion for short period, social resource for a long term effect with accumulation of brain and management know-how. The way for advance to maximize the economic effect of sports events are as follows; 1. Correspondence for periodic request. 2. participants of sports events should prepare proper event facilities. 3. Correspondence for the movement from urban-centered sports events to local events. 4. A pattern of event which have from of enterprise that a enterprise will use the sports events as means of advertisement. Sports events should present the innovation vision for new-life to get original meaning and function.

Oxolamine Acetate(Pebron)의 鎭咳效果에 對한 臨床硏究

南松鉉,沈永秀,金建烈 최신의학사 1983 最新醫學 Vol.26 No.11