리네졸리드와 반코마이신을 교대로 투여하여 치료한 지속성 메티실린 내성 황색포도알균 균혈증 1예

김낙현,김문석,장은선,강유민,김가연,장희창,박완범,김의종,김남중,오명돈 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Persistent Staphylococcus aureus bacteremia is frequently defined as bacteremia persisting for ≥7 days despite proper antibiotic therapy. Its treatment includes removal of all infection foci and proper antibiotic therapy. Vancomycin remains the antibiotic of choice in MRSA bacteremia. Alternative agents, linezolid or daptomycin, are available, but a consensus regarding management of persistent MRSA bacteremia on vancomycin failure is still lacking. We report a case of a 60-year-old male who received thoracoabdominal aorta replacement operation due to dissecting aneurysm of the ascending and descending aorta. Surgical site infection and bacteremia caused by MRSA occured, and wound debridement operations were performed. The patient was treated with vancomycin in therapeutic doses but MRSA bacteremia persisted for 168 days in a row. Although the inserted aortic graft was the most probable source of persistent bacteremia, surgical removal was impossible. Linezolid was administered as an alternative antibiotic but had to be discontinued from time to time due to thrombocytopenia induced by this agent. In the end, MRSA bacteremia was successfully managed by alternating vancomycin-linezolid therapy.

Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

Soung, Nak-Kyun,Kim, Hye-Min,Asami, Yukihiro,Kim, Dong Hyun,Cho, Yangrae,Naik, Ravi,Jang, Yerin,Jang, Kusic,Han, Ho Jin,Ganipisetti, Srinivas Rao,Cha-Molstad, Hyunjoo,Hwang, Joonsung,Lee, Kyung Ho,Ko, Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.2

<▼1><P>Hypoxia-inducible factor-1α (HIF-1α) mediates tumor cell adaptation to hypoxic conditions and is a potentially important anticancer therapeutic target. We previously developed a method for synthesizing a benzofuran-based natural product, (R)-(-)-moracin-O, and obtained a novel potent analog, MO-460 that suppresses the accumulation of HIF-1α in Hep3B cells. However, the molecular target and underlying mechanism of action of MO-460 remained unclear. In the current study, we identified heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) as a molecular target of MO-460. MO-460 inhibits the initiation of HIF-1α translation by binding to the C-terminal glycine-rich domain of hnRNPA2B1 and inhibiting its subsequent binding to the 3’-untranslated region of <I>HIF-1α</I> mRNA. Moreover, MO-460 suppresses HIF-1α protein synthesis under hypoxic conditions and induces the accumulation of stress granules. The data provided here suggest that hnRNPA2B1 serves as a crucial molecular target in hypoxia-induced tumor survival and thus offer an avenue for the development of novel anticancer therapies.</P></▼1><▼2><P><B>Cancer: How a plant metabolite analog suppresses tumor growth</B></P><P>A synthetic analog of a chemical found in fruit suppresses tumor growth by targeting an RNA-binding protein (hnRNPA2B1) and preventing the production of a pro-cancer regulatory factor. Nak-Kyun Soung from the Korea Research Institute of Bioscience and Biotechnology, Cheongju, South Korea, and coworkers built on their previous discovery that a compound derived from a medicinal plant metabolite can suppress the activity of hypoxia-inducible factor-1α (HIF-1α). This protein, which is involved in many aspects of cancer biology, is activated in the low-oxygen microenvironments found inside tumors. The researchers show that the compound binds to a protein that helps with the conversion of HIF-1α–encoding RNA transcripts into HIF-1α proteins. Liver cancer cells treated with the compound grew slowly and produced less HIF-1α under both normal and low-oxygen culture conditions, highlighting the potential of this anti-cancer strategy.</P></▼2>

열하중을 받는 복합재료 적층판의 손상에 대한 열-음향방출해석

김영복,민대홍,이덕보,최낙삼 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.3

열-음향방출(thermo-AE) 기법을 이용하여 두께 3㎜, [+456/-456]S 복합재료 적층판의 열응력 유기 손상에 대해 비파괴평가의 유효성을 연구하였다. 반복적인 열부하 사이클에 의해서 thermo-AE 사상수가 감소하는 경향이 뚜렷하게 나타나서 열부하에 따른 카이저효과가 관찰되었다. 열부하사이클중의 thermo-AE 거동을 분석하여 복합재료의 응력자유온도를 결정할 수 있었다. 초음파 C스캔, 광학현미경, 주사형 전자현미경을 통해 섬유파단과 모재파손이 관찰되었으며, 이들 파손 인자는 thermo-AE 신호의 단시간 퓨리에 변환처리에 의해 생성된 3종류의 서로 다른 시간-주파수 특성과 대응하였다. 이 특성을 이용하여 복합재료의 냉각열처리 및 반복 열부하사이클시의 손상발생과정 및 내부 마찰 거동 내역을 추적할 수 있었다.

Virtual FRF를 이용한 채터강성 해석에 관한 연구

김성운,정낙신,이강재,양민양 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

The prediction of chatter stable region is a significant requirement for the manufacturing industry. Usually, the chatter stability lobes are obtained by measuring the frequency response function(FRF) of a machining center using impulse test or exciter test. However, these tests are not only spent much time, but also performed after machining center is manufactured. This paper presents virtual FRF using by F.E.M for the prediction of chatter stable region. The proposed method enables a designer to estimate the chatter resistance of machine tools at the early stage of design.

유방암의 뇌하수체 전이에 의한 양안 시력소실 1 예

최낙원,안명주,김재민,박동우,박용욱 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Pituitary gland metastasis is a rare clinical diagnosis, usually made in the setting of known primary systemic cancer with widespread metastasis to other organs. But visual loss as a presenting symptom of metastasis to the pituitary gland is unusal. We report here a case of 45-year-old woman who had been diagnosed as having metastatic breast cancer involving bone and liver 2 years ago, and received high dose chemotherapy with peripheral blood stem cell transplantation, developed sudden bilateral complete visual loss. At initial presentation, the patient had no light perception and no pupillary response to light in both eyes, but without evidence of panhypopituitarism, or diabetes insipidus. Brain MRI showed a large enhanced mass invasion to the cavernous sinus and extension to the suprasella portion without dura or base-of-skull metastasis. Pathologic examination showed metastatic breast cancer. Despite the transsphenoidal decompression surgery of metastatic tumor, the visual loss was not improved.

우리나라 지방정부의 정보화와 효율성 : Evidence from Korean Local Governments

성낙일,김민창 한국산업조직학회 2003 産業組織硏究 Vol.11 No.4

정보기술(information technology)의 생산성 향상효과는 지난 수십 년에 걸쳐 경제학의 중요 연구대상의 하나니었으며, 최근 신경제(ndw economy)의 부상 및 곧 이은 퇴조와 함께 다시 세계적 관심사로 대두하고 있다. 이와 같은 관점에서 정보화지수가 존재하는 우리나라 지방정부의 통계자료는 매우 유용한 연구자료를 제공한다. 본 연구의 목적은 우리나라 중소도시 지방정부의 기술적 효율성(technical effiency)을 측정하고 지방정부의 정보화지수를 사용해 정보화 수준과 기술적 효율성의 관계를 분석하는데 있다. 이를 위해 먼저 본 연구는 자료포락분석법(data envelopment analysis)을 이용하여 65개 중소도시 행정서비스의 기술적 효율성을 측정한다. 분석기간은 1999년과 2000년이다. 이 효율성 측정결과에 따르면 대도시 주변의 위성도시에 소재한 지방정부들이 비장 소도시에 지방정부에 비해 효율적인 행정서비스를 공급하고 있는 것으로 나타났다. 다음으로 본 연구는 각 지방정부의 기술적 효율성이 다양한 도시특성변수와 지방정부의 정보화 정도에 따라 어떤 영향을 받았는지를 분석하였다. 그 분석결과에 따르면, 도시의 인구밀도가 높거나 인구규모가 클수록 해당 지방정부는 보다 효율적이었다. 또한 지방정부의 정보화 수준, 특히 정보화 설비의 측정정도가 지방정부의 효율성에 긍정적 영향을 미쳤다. 본 연구는 정보기술이 정보기술 생산부문뿐만 아니라 정보기술 활용부문에 대해서도 긍정적 파급효과를 미친다는 사실을 확인하고 있다. This study attempts to estimate difference in technical efficiency among Korean local governments or urban public services and also, to examine the effects of informatisation on the efficiency. Empirical analysis is carried out by applying the DEA(data envelope analysis) to 65 Korean small and medium-sized local governments over the period 1999-2000. One of the principal findings is that large or satellite cities tended to perform better than small cities surrounded with rural areas. Also, the study indicates that population densities and levels had positive effects on the efficiency of Korean local governments. In other words, the production of urban public services may have economies of scale and density. More importantly, the study shows that the efficiency of Korean local governments was positively correlated with their informatisation, especially the amount of IT(information technology) equipment. That is, IT exerted positive spillover effects on Korean urban public services. These empirical findings are relevant to some public policy issues and also, contribute to the IT productivity literature.

農村 靑少年의 家庭生活에 관한 價値觀

崔敏浩,鄭址雄,金性洙,李洛薰,金鎭模 서울大學校 農科大學 1985 서울대농학연구지 Vol.10 No.2

The purposes of the study were to investigate the values of the rural youth in relation to family living, and to compare changes in the values with the similar study of the reseacher of 1970 in Korea. Data were collected by undergraduate and graduate students of the Seoul National University from randomly selected 993 rural youths of 13 to 24 years of age through questionnaire method. The data were analyzed by HP 3000 Computer in the College of Agriculture, Seoul National University. Major statistical techniques used for the study were frequency, percentile, chi square test. Statistical significance was tested at 0.05 level. The major findings of the study were as follows; 1. It was revealed that values on family living were changed into modern democratic ideals from traditional Confucian values 2. The view of respondents that the first son should take care of parents has decreased from 32.8% in 1970 to 23.8% in 1984. The Respondents who think that one of sons should take care of parents has increased from 45.8% in 1970 to 60.8% in 1984. 3. The rate of respondents claiming that the head of a family should govern the family with authority and dignity has increased from 61.1%in 1970 to 68.3% in 1984. 4. The respondents claiming that the head of a family should decide the important things of family living dogmatically has decreased from 16.9% in 1970 to 8.1% in 1984. 5. The rate of respondents claiming that father should respect mother's opinion in family has increased from 78.6% in 1970 to 90.5% in 1984. 6. The rate of respondents claiming that fathers should understand the things of children with maximum degree has increased from 86.8% in 1970 to 93.8% in 1984.

자살 시도의 심각도와 혈청 지질농도의 관련성

이헌정,최낙경,김린,이민수,김용구 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 낮은 혈청 콜레스트롤 농도와 자살과 같은 폭력적 행동에 관한 관련성에 관한 논란이 있어왔다. 본 연구는 자살 시도 후 응급실로 내원한 환자에서 혈청 총 콜레스테롤 농도만이 아닌 전반적인 혈청 지질 농도의 저하 여부를 조사하였으며, 자살 시도 상황을 평가하는 객관적 척도를 통하여 자살 시도 상황에서 자살 시도의 심각도와 혈청 지질 농도의 관계에 대하여 연구하였다. 방 법 : 1998년 7월부터 1999년 6월 사이에 자살 시도후 고려대학교 의료원 응급실로 내원한 50명의 자살 시도자를 연구대상으로 하였다. 이들은 정신과 의사의 면담을 통하여 정신과적 진단을 받았으며 동시에 위험-구조척도(RRR). HDRS, BPRS 등이 평가되었다. 또한 동 기간에 본원 정신과에서 입원 치료를 받은 자살 시도가 없었던 환자중, 대상군과 나이, 성별, 진단을 맞추어서 50명의 환자를 선정하여 정신과 환자 대조군으로 하였다. 자살 시도군과 대조군의 혈청 지질농도가 t-test를 통하여 비교되었으며, RRR점수와 혈청 지질 농도, HDRS,BPRS와의 사이의 연관성 Spearman순위 상관계수로 분석되었다. 결 과 : 자살 시도자중 주요우울증이 29명, 정신분열병이 2명, 인격장애가 19명이었으며, 자살 시도군의 혈청 총 콜레스트롤 농도(t=---3.29, p=.001). 총 지질 농도(t=-2.62, p=.01), LDL농도(t=-2.64, p=.011)가 대조군보다 유의하게 낮았다. 진단별로는 주요우울증에서는 총 콜레스트롤 농도, 총 지질 농도, LDL 농도가 대조군에 비하여 낮았으나, 인격장애에서는 혈청 콜레스트롤 농돤이 대조군보다 낮았다. 자살 시도군에서 RRR 점수는 혈청 콜레스테롤 농도와 부적 상관관계를 보였으나 (γ=.-293,p=.039), BPRS(γ=.544, p<.001)와 HDRS(γ=.488, p=.001)와는 정적 상관관계를 보였다. 결 론 : 자살 시도군에서 혈청 지질 농도 중 총 콜레스테롤, 총 지질, LDL농도가 유의하게 저하되어있음을 확인하였다. 또한 자살의 심각도를 평가한 RRR 정수가 혈청 총 콜레스테롤 농도와 유의하게 상관성이 있음이 확인되었다. 이는 낮은 혈청 총 콜레스테롤 농도가 심각한 자살 시도와 연관이 있음을 보여주는 것이다. Objectives : Many studies have demonstrated that suicide is related to low serum cholesterol level, whereas conflicting results have also reported. The aims of the present study are to determine whether suicidal attempters have low lipid concentration and to identify the relationship between suicidal attempt severity and serum lipid levels. Methods: Subjects were 50 suicidal attempters who visited the emergency room in Korea University Medical Center between July 1998 and June 1999. All subjects had been interviewed by psychiatrist and evaluated with Risk-rescue rating, HDRS and BPRS. They were diagnosed as major depressive disorder(n=29), personality disorder(n=19), and schizophrenia(n-=2). Serum lipid levels in 50 suicidal attempters were compared with those in 50 nonsuicidal psychiatric inpatients corresponding to the age, sex and diagnosis of the suicidal attempters. We also examined the Spearman's rank correlations between serum lipid levels and risk-rescue score. Results : The serum total cholesterol level(t=-3.29, p=.001), total lipid level(t=-2.62, p=.01), and LDL level(t=-2.64, p=.011) in suicidal attempters were significantly lower compared with nonsuicidal controls. In major depressive patients, total cholesterol level, total lipid level, and LDL level in suicidal attempters were significantly lower than those of nonsuicidal controls. In personality disorder patients, however, only serum total cholesterol level was significantly lower. Risk-rescue rating score was negatively correlated with serum total cholesterol level(p=.-293, p=.039), and positively correlated with BPRS(p=.544, p<.001), and HDRS(p=.488, p=.001). Conclusion : The lipid levels in suicidal attempter were significantly lower. Suicidal attempt severity was also significantly correlated with serum total cholesterol level. These findings suggest that low serum cholesterol should be related with severs violent suicidal attempt.

무증상의 현미경적 혈뇨의 비뇨기과적 고찰

구자현,서병욱,김영호,송윤섭,전윤수,김민의,이남규,박영호 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

We intended to know whether all of the patients with asymptomatic microscopic hematuria should be urologically investigated routinely. We reviewed the medical records with asmptomatic microscopic hematuria from January 1995 to December 1997. Urological studies included intravenous urography or ultrasonography, urine cytology, cystoscopy and biopsy, urine AFB smear and culture and urine PCR for AFB. The age with patients ranged from 9 to 74 years(mean age: 39.7 years). Benign diseases were found in elderly patients and patients with high degree of hematuria, but there was no patients who had urological malignant disease. According to the results, we suggest that follow-up with urine cytology is sufficient to younger patients or low degree of hematuria with asymptomatic microscopic hematuria.

산성강하물의 침착현상에 관한 연구

최금찬,성낙창,김장호,서정민,황성욱 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

We get the conclusion of the ionic components of sample and the concentration of metal elements which is collected for acid composition substances using Dry Deposion, Dust Jar method at five points in Pusan. It appears higher ionic concentration from the last of February to the middle of May. It appears higher ionic concentration according to the increasing of collecting period in cation. It is higher ionic concentration according to the passing of the time at all sites in anion. The sum of cation equivalent concentration is higher than the sum of anion equivalent concentration in comparing ionic equivalent concentration. The equivalent concentration of SO₄^(2-), NO^(3-) that is gussed acid density is predominient in anion.