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Liver Transplantation for Combined Hepatocellular Carcinoma and Cholangiocarcinoma in Korea
( Jong Man Kim ),( Dong Jin Joo ),( Shin Hwang ),( Nam-joon Yi ),( Je Ho Ryu ),( Yang Won Na ),( Dong-sik Kim ),( Doo Jin Kim ),( Young Kyoung Yoo ),( Hee Chul Yu ),( Myoung Soo Kim ) 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma in Korea
Jong Man KIM,Dong Jin JOO,Shin HWANG,Nam-Joon YI,Je Ho RYU,Yang Won NA,Dong-Sik KIM,Doo Jin KIM,Young Kyoung YOO,Hee Chul YU,Myoung Soo KIM 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-
p, p-DDT induce apoptosis in human endometrial stromal cells through oxidative stress
( Sun Yi Choe ),( Yeon Jean Cho ),( Myoung Seok Han ),( Jong Woon Bae ),( Jung Woo Park ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Organochlorines, such as dichlorodiphenyltrichloroethane (DDT), can cause a various effects on the cells by triggering estrogen receptor. Because of their long half-lives, DDT and its metabolites are still found throughout the world. DDT is associated with reduced mean luteal-phase length, spontaneous abortion, early age at menopause, and reduced duration of lactation. However, their effect on endometrium is not clearly revealed. Here we studied whether DDT causes oxidative stress and apoptosis in human endometrial cells. Methods: Human endometrial stromal cells were obtained from reproductive aged women with normal menstrual cycle. Our study was design to find out whether DDT causes oxidative stress and apoptosis and to investigate its effects on modulators of antioxidative enzymes and caspase pathway in human endometrial cell. Also we have studied association between DDT and estrogen receptors (ER) and NF-B pathways in human endometrium. Results: From flow cytometric analysis, we found that DDT contributed to apoptosis. Fluorescence microscopy showed that DDT induced formation of apoptotic bodies and DNA fragmentation. After exposure to DDT, Bcl-2 with anti-apoptotic potential decreased and BAX, an apoptotic regulator, showed a dose-dependent increase. The expression of caspase-3, 6, 8, and 10 were also significantly increased. Treatment of endometrial cells with DDT resulted in a significant increase in DCF fluorescence and showed significant decrease in GPX and SOD expression. Regarding ER, DDT down-regulated the expression of ER- and reversed by antagonist treatment. Conclusion: Our study showed that when DDT is exposed to human endometrial cells, apoptosis can occur by producing oxidative enzyme and modulating estrogen receptors. Changes in mediators of antioxidative enzymes and caspase pathway also lead to apoptosis. These reactions will have significant effects on human endometrial environment which can determine the pathogenesis of diseases involving endometrium.
Stimulation of Innate Immune Function by <i>Panax ginseng</i> after Heat Processing
Shin, Myoung-Sook,Song, Ji Hoon,Choi, Pilju,Lee, Jong Hun,Kim, Song-Yi,Shin, Kwang-Soon,Ham, Jungyeob,Kang, Ki Sung American Chemical Society 2018 Journal of agricultural and food chemistry Vol.66 No.18
<P><I>Panax ginseng</I> Meyer has been used for the treatment of immune diseases and for strengthening the immune function. In this study, we evaluated the innate immune-stimulating functions and action mechanisms of white ginseng (WG) and heat-processed ginseng (HPG) in RAW264.7 cells. According to LC-MS analysis results, WG contained typical ginsenosides, such as Rb1, Rc, Rb2, Rd, and Rg1, whereas HPG contained Rg3, Rk1, and Rg5 as well as typical ginsenosides. HPG, not WG, enhanced NF-κB transcriptional activity, cytokine production (IL-6 and TNF-α), and MHC class I and II expression in RAW264.7 cells. In addition, HPG phosphorylated MAPKs and NF-kB pathways. In experiments with inhibitors, the ERK inhibitor completely suppressed the effect of HPG on IL-6 and TNF-α production. HPG-induced c-Jun activation was suppressed by an ERK inhibitor and partially suppressed by JNK, p38, and IκBα inhibitors. Collectively, these results suggested that HPG containing Rg3, Rg5, and Rk1 increased macrophage activation which was regulated by the ERK/c-Jun pathway in RAW264.7 cells.</P> [FIG OMISSION]</BR>